Skip to main page content
  1. Speidell AP, Demby T, Lee Y, Rodriguez O, Albanese C, Mandelblatt J, Rebeck GW. Development of a Human APOE Knock-in Mouse Model for Study of Cognitive Function After Cancer Chemotherapy. Neurotox Res. 2019 Feb;35(2):291-303. doi: 10.1007/s12640-018-9954-7. Epub 2018 Oct 4. PubMed PMID: 30284204; PubMed Central PMCID: PMC6333492.
  2. Jones NS, Rebeck GW. The Synergistic Effects of APOE Genotype and Obesity on Alzheimer's Disease Risk. Int J Mol Sci. 2018 Dec 24;20(1). doi: 10.3390/ijms20010063. Review. PubMed PMID: 30586872; PubMed Central PMCID: PMC6337558.
  3. Chernick D, Ortiz-Valle S, Jeong A, Swaminathan SK, Kandimalla KK, Rebeck GW, Li L. High-density lipoprotein mimetic peptide 4F mitigates amyloid-β-induced inhibition of apolipoprotein E secretion and lipidation in primary astrocytes and microglia. J Neurochem. 2018 Dec;147(5):647-662. doi: 10.1111/jnc.14554. Epub 2018 Nov 26. PubMed PMID: 30028014; PubMed Central PMCID: PMC6314045.
  4. DiBattista AM, Dumanis SB, Newman J, Rebeck GW. Identification and modification of amyloid-independent phenotypes of APOE4 mice. Exp Neurol. 2016 Jun;280:97-105. doi: 10.1016/j.expneurol.2016.04.014. Epub 2016 Apr 14. PubMed PMID: 27085394; PubMed Central PMCID: PMC4860139.
  5. Di Battista AM, Heinsinger NM, Rebeck GW. Alzheimer's Disease Genetic Risk Factor APOE-ε4 Also Affects Normal Brain Function. Curr Alzheimer Res. 2016;13(11):1200-1207. Review. PubMed PMID: 27033053; PubMed Central PMCID: PMC5839141.
  6. DiBattista AM, Dumanis SB, Song JM, Bu G, Weeber E, Rebeck GW, Hoe HS. Very low density lipoprotein receptor regulates dendritic spine formation in a RasGRF1/CaMKII dependent manner. Biochim Biophys Acta. 2015 May;1853(5):904-17. doi: 10.1016/j.bbamcr.2015.01.015. Epub 2015 Jan 31. PubMed PMID: 25644714; PubMed Central PMCID: PMC4580245.
  7. Zhou Y, Zhao W, Al-Muhtasib N, Rebeck GW. APOE Genotype Alters Immunoglobulin Subtypes in Knock-In Mice. J Alzheimers Dis. 2015;46(2):365-74. doi: 10.3233/JAD-142184. PubMed PMID: 25737044; PubMed Central PMCID: PMC4963980.
  8. Burrell TC, Divekar SD, Weeber EJ, Rebeck GW. Fyn tyrosine kinase increases Apolipoprotein E Receptor 2 levels and phosphorylation. PLoS One. 2014;9(10):e110845. doi: 10.1371/journal.pone.0110845. eCollection 2014. PubMed PMID: 25340851; PubMed Central PMCID: PMC4207760.
  9. DiBattista AM, Stevens BW, Rebeck GW, Green AE. Two Alzheimer's disease risk genes increase entorhinal cortex volume in young adults. Front Hum Neurosci. 2014;8:779. doi: 10.3389/fnhum.2014.00779. eCollection 2014. PubMed PMID: 25339884; PubMed Central PMCID: PMC4186290.
  10. Trotter JH, Lussier AL, Psilos KE, Mahoney HL, Sponaugle AE, Hoe HS, Rebeck GW, Weeber EJ. Extracellular proteolysis of reelin by tissue plasminogen activator following synaptic potentiation. Neuroscience. 2014 Aug 22;274:299-307. doi: 10.1016/j.neuroscience.2014.05.046. Epub 2014 Jun 2. PubMed PMID: 24892761; PubMed Central PMCID: PMC4381833.
  11. Zhao W, Zhang J, Davis EG, Rebeck GW. Aging reduces glial uptake and promotes extracellular accumulation of Aβ from a lentiviral vector. Front Aging Neurosci. 2014;6:210. doi: 10.3389/fnagi.2014.00210. eCollection 2014. PubMed PMID: 25177293; PubMed Central PMCID: PMC4133689.
  12. Stevens BW, DiBattista AM, William Rebeck G, Green AE. A gene-brain-cognition pathway for the effect of an Alzheimer׳s risk gene on working memory in young adults. Neuropsychologia. 2014 Aug;61:143-9. doi: 10.1016/j.neuropsychologia.2014.06.021. Epub 2014 Jun 23. PubMed PMID: 24967550; PubMed Central PMCID: PMC4337824.
  13. Rodriguez GA, Tai LM, LaDu MJ, Rebeck GW. Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition. J Neuroinflammation. 2014 Jun 19;11:111. doi: 10.1186/1742-2094-11-111. PubMed PMID: 24948358; PubMed Central PMCID: PMC4077554.
  14. Green AE, Gray JR, Deyoung CG, Mhyre TR, Padilla R, Dibattista AM, William Rebeck G. A combined effect of two Alzheimer's risk genes on medial temporal activity during executive attention in young adults. Neuropsychologia. 2014 Apr;56:1-8. doi: 10.1016/j.neuropsychologia.2013.12.020. Epub 2014 Jan 2. PubMed PMID: 24388797; PubMed Central PMCID: PMC4420146.
  15. Zhao W, Dumanis SB, Tamboli IY, Rodriguez GA, Jo Ladu M, Moussa CE, William Rebeck G. Human APOE genotype affects intraneuronal Aβ1-42 accumulation in a lentiviral gene transfer model. Hum Mol Genet. 2014 Mar 1;23(5):1365-75. doi: 10.1093/hmg/ddt525. Epub 2013 Oct 23. PubMed PMID: 24154541; PubMed Central PMCID: PMC3919009.
  16. Nwabuisi-Heath E, Rebeck GW, Ladu MJ, Yu C. ApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitro. ASN Neuro. 2014 Jan 13;6(1):e00134. doi: 10.1042/AN20130043. PubMed PMID: 24328732; PubMed Central PMCID: PMC3891498.
  17. Tai LM, Mehra S, Shete V, Estus S, Rebeck GW, Bu G, LaDu MJ. Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk. Mol Neurodegener. 2014 Jan 4;9:2. doi: 10.1186/1750-1326-9-2. Review. PubMed PMID: 24386905; PubMed Central PMCID: PMC3897976.
  18. Nelson PT, Pious NM, Jicha GA, Wilcock DM, Fardo DW, Estus S, Rebeck GW. APOE-ε2 and APOE-ε4 correlate with increased amyloid accumulation in cerebral vasculature. J Neuropathol Exp Neurol. 2013 Jul;72(7):708-15. doi: 10.1097/NEN.0b013e31829a25b9. PubMed PMID: 23771217; PubMed Central PMCID: PMC3715146.
  19. Rodriguez GA, Burns MP, Weeber EJ, Rebeck GW. Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex. Learn Mem. 2013 Apr 16;20(5):256-66. doi: 10.1101/lm.030031.112. PubMed PMID: 23592036; PubMed Central PMCID: PMC3630489.
  20. Rogers JT, Zhao L, Trotter JH, Rusiana I, Peters MM, Li Q, Donaldson E, Banko JL, Keenoy KE, Rebeck GW, Hoe HS, D'Arcangelo G, Weeber EJ. Reelin supplementation recovers sensorimotor gating, synaptic plasticity and associative learning deficits in the heterozygous reeler mouse. J Psychopharmacol. 2013 Apr;27(4):386-95. doi: 10.1177/0269881112463468. Epub 2012 Oct 26. PubMed PMID: 23104248; PubMed Central PMCID: PMC3820099.
  21. Manaye KF, Mouton PR, Xu G, Drew A, Lei DL, Sharma Y, Rebeck GW, Turner S. Age-related loss of noradrenergic neurons in the brains of triple transgenic mice. Age (Dordr). 2013 Feb;35(1):139-47. doi: 10.1007/s11357-011-9343-0. Epub 2011 Nov 30. PubMed PMID: 22127507; PubMed Central PMCID: PMC3543748.
  22. Dumanis SB, DiBattista AM, Miessau M, Moussa CE, Rebeck GW. APOE genotype affects the pre-synaptic compartment of glutamatergic nerve terminals. J Neurochem. 2013 Jan;124(1):4-14. doi: 10.1111/j.1471-4159.2012.07908.x. Epub 2012 Sep 28. PubMed PMID: 22862561; PubMed Central PMCID: PMC3509249.
  23. Youmans KL, Tai LM, Nwabuisi-Heath E, Jungbauer L, Kanekiyo T, Gan M, Kim J, Eimer WA, Estus S, Rebeck GW, Weeber EJ, Bu G, Yu C, Ladu MJ. APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease. J Biol Chem. 2012 Dec 7;287(50):41774-86. doi: 10.1074/jbc.M112.407957. Epub 2012 Oct 11. PubMed PMID: 23060451; PubMed Central PMCID: PMC3516726.
  24. Herman AM, Khandelwal PJ, Rebeck GW, Moussa CE. Wild type TDP-43 induces neuro-inflammation and alters APP metabolism in lentiviral gene transfer models. Exp Neurol. 2012 May;235(1):297-305. doi: 10.1016/j.expneurol.2012.02.011. Epub 2012 Feb 28. PubMed PMID: 22402344; PubMed Central PMCID: PMC3434705.
  25. Minami SS, Clifford TG, Hoe HS, Matsuoka Y, Rebeck GW. Fyn knock-down increases Aβ, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD mice. Neurobiol Aging. 2012 Apr;33(4):825.e15-24. doi: 10.1016/j.neurobiolaging.2011.05.014. Epub 2011 Jul 7. PubMed PMID: 21741124; PubMed Central PMCID: PMC3192904.
  26. Zhu Y, Nwabuisi-Heath E, Dumanis SB, Tai LM, Yu C, Rebeck GW, LaDu MJ. APOE genotype alters glial activation and loss of synaptic markers in mice. Glia. 2012 Apr;60(4):559-69. doi: 10.1002/glia.22289. Epub 2012 Jan 6. PubMed PMID: 22228589; PubMed Central PMCID: PMC3276698.
  27. Dumanis SB, Chamberlain KA, Jin Sohn Y, Jin Lee Y, Guénette SY, Suzuki T, Mathews PM, Pak DTs, Rebeck GW, Suh YH, Park HS, Hoe HS. FE65 as a link between VLDLR and APP to regulate their trafficking and processing. Mol Neurodegener. 2012 Mar 19;7:9. doi: 10.1186/1750-1326-7-9. PubMed PMID: 22429478; PubMed Central PMCID: PMC3379943.
  28. Khandelwal PJ, Dumanis SB, Herman AM, Rebeck GW, Moussa CE. Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models. Mol Cell Neurosci. 2012 Jan;49(1):44-53. doi: 10.1016/j.mcn.2011.09.002. Epub 2011 Sep 14. PubMed PMID: 21945393; PubMed Central PMCID: PMC3246111.
  29. Babus LW, Little EM, Keenoy KE, Minami SS, Chen E, Song JM, Caviness J, Koo SY, Pak DT, Rebeck GW, Turner RS, Hoe HS. Decreased dendritic spine density and abnormal spine morphology in Fyn knockout mice. Brain Res. 2011 Sep 30;1415:96-102. doi: 10.1016/j.brainres.2011.07.059. Epub 2011 Aug 5. PubMed PMID: 21872217; PubMed Central PMCID: PMC3607202.
  30. Minami SS, Hoe HS, Rebeck GW. Fyn kinase regulates the association between amyloid precursor protein and Dab1 by promoting their localization to detergent-resistant membranes. J Neurochem. 2011 Sep;118(5):879-90. doi: 10.1111/j.1471-4159.2011.07296.x. Epub 2011 May 25. PubMed PMID: 21534960; PubMed Central PMCID: PMC3155659.
  31. Rogers JT, Rusiana I, Trotter J, Zhao L, Donaldson E, Pak DT, Babus LW, Peters M, Banko JL, Chavis P, Rebeck GW, Hoe HS, Weeber EJ. Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density. Learn Mem. 2011 Sep;18(9):558-64. doi: 10.1101/lm.2153511. Print 2011 Sep. PubMed PMID: 21852430; PubMed Central PMCID: PMC3166788.
  32. Khandelwal PJ, Herman AM, Hoe HS, Rebeck GW, Moussa CE. Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated Abeta in AD models. Hum Mol Genet. 2011 Jun 1;20(11):2091-102. doi: 10.1093/hmg/ddr091. Epub 2011 Mar 4. PubMed PMID: 21378096; PubMed Central PMCID: PMC3090189.
  33. Reddy SS, Connor TE, Weeber EJ, Rebeck W. Similarities and differences in structure, expression, and functions of VLDLR and ApoER2. Mol Neurodegener. 2011 May 9;6:30. doi: 10.1186/1750-1326-6-30. PubMed PMID: 21554715; PubMed Central PMCID: PMC3113299.
  34. Herman AM, Khandelwal PJ, Stanczyk BB, Rebeck GW, Moussa CE. β-amyloid triggers ALS-associated TDP-43 pathology in AD models. Brain Res. 2011 Apr 22;1386:191-9. doi: 10.1016/j.brainres.2011.02.052. Epub 2011 Mar 2. PubMed PMID: 21376022; PubMed Central PMCID: PMC3073036.
  35. Dumanis SB, Cha HJ, Song JM, Trotter JH, Spitzer M, Lee JY, Weeber EJ, Turner RS, Pak DT, Rebeck GW, Hoe HS. ApoE receptor 2 regulates synapse and dendritic spine formation. PLoS One. 2011 Feb 15;6(2):e17203. doi: 10.1371/journal.pone.0017203. PubMed PMID: 21347244; PubMed Central PMCID: PMC3039666.
  36. Loane DJ, Washington PM, Vardanian L, Pocivavsek A, Hoe HS, Duff KE, Cernak I, Rebeck GW, Faden AI, Burns MP. Modulation of ABCA1 by an LXR agonist reduces β-amyloid levels and improves outcome after traumatic brain injury. J Neurotrauma. 2011 Feb;28(2):225-36. doi: 10.1089/neu.2010.1595. PubMed PMID: 21175399; PubMed Central PMCID: PMC3037807.
  37. Khandelwal PJ, Dumanis SB, Feng LR, Maguire-Zeiss K, Rebeck G, Lashuel HA, Moussa CE. Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model. Mol Neurodegener. 2010 Nov 4;5:47. doi: 10.1186/1750-1326-5-47. PubMed PMID: 21050448; PubMed Central PMCID: PMC2987994.
  38. Minami SS, Sidahmed E, Aid S, Shimoji M, Niikura T, Mocchetti I, Rebeck GW, Prendergast JS, Dealwis C, Wetzel R, Bosetti F, Matsuoka Y, Hoe HS, Turner RS. Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease. J Neuroinflammation. 2010 Sep 28;7:57. doi: 10.1186/1742-2094-7-57. PubMed PMID: 20920207; PubMed Central PMCID: PMC2955708.
  39. Burns MP, Rebeck GW. Intracellular cholesterol homeostasis and amyloid precursor protein processing. Biochim Biophys Acta. 2010 Aug;1801(8):853-9. doi: 10.1016/j.bbalip.2010.03.004. Epub 2010 Mar 19. Review. PubMed PMID: 20304094; PubMed Central PMCID: PMC2886153.
  40. Minami SS, Cordova A, Cirrito JR, Tesoriero JA, Babus LW, Davis GC, Dakshanamurthy S, Turner RS, Pak DTs, Rebeck GW, Paige M, Hoe HS. ApoE mimetic peptide decreases Abeta production in vitro and in vivo. Mol Neurodegener. 2010 Apr 20;5:16. doi: 10.1186/1750-1326-5-16. PubMed PMID: 20406479; PubMed Central PMCID: PMC2890633.
  41. Tomidokoro Y, Rostagno A, Neubert TA, Lu Y, Rebeck GW, Frangione B, Greenberg SM, Ghiso J. Iowa variant of familial Alzheimer's disease: accumulation of posttranslationally modified AbetaD23N in parenchymal and cerebrovascular amyloid deposits. Am J Pathol. 2010 Apr;176(4):1841-54. doi: 10.2353/ajpath.2010.090636. Epub 2010 Mar 12. PubMed PMID: 20228223; PubMed Central PMCID: PMC2843474.
  42. Cartagena CM, Burns MP, Rebeck GW. 24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury. Brain Res. 2010 Mar 10;1319:1-12. doi: 10.1016/j.brainres.2009.12.080. Epub 2010 Jan 4. PubMed PMID: 20053345; PubMed Central PMCID: PMC2826556.
  43. Rebeck GW, Hoe HS, Moussa CE. Beta-amyloid1-42 gene transfer model exhibits intraneuronal amyloid, gliosis, tau phosphorylation, and neuronal loss. J Biol Chem. 2010 Mar 5;285(10):7440-6. doi: 10.1074/jbc.M109.083915. Epub 2010 Jan 13. PubMed PMID: 20071340; PubMed Central PMCID: PMC2844192.
  44. Minami SS, Sung YM, Dumanis SB, Chi SH, Burns MP, Ann EJ, Suzuki T, Turner RS, Park HS, Pak DT, Rebeck GW, Hoe HS. The cytoplasmic adaptor protein X11alpha and extracellular matrix protein Reelin regulate ApoE receptor 2 trafficking and cell movement. FASEB J. 2010 Jan;24(1):58-69. doi: 10.1096/fj.09-138123. Epub 2009 Aug 31. PubMed PMID: 19720620; PubMed Central PMCID: PMC2797038.
  45. Dumanis SB, Tesoriero JA, Babus LW, Nguyen MT, Trotter JH, Ladu MJ, Weeber EJ, Turner RS, Xu B, Rebeck GW, Hoe HS. ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo. J Neurosci. 2009 Dec 2;29(48):15317-22. doi: 10.1523/JNEUROSCI.4026-09.2009. PubMed PMID: 19955384; PubMed Central PMCID: PMC2846754.
  46. Pocivavsek A, Mikhailenko I, Strickland DK, Rebeck GW. Microglial low-density lipoprotein receptor-related protein 1 modulates c-Jun N-terminal kinase activation. J Neuroimmunol. 2009 Sep 29;214(1-2):25-32. doi: 10.1016/j.jneuroim.2009.06.010. Epub 2009 Jul 7. PubMed PMID: 19586665; PubMed Central PMCID: PMC2745483.
  47. Pocivavsek A, Rebeck GW. Inhibition of c-Jun N-terminal kinase increases apoE expression in vitro and in vivo. Biochem Biophys Res Commun. 2009 Sep 25;387(3):516-20. doi: 10.1016/j.bbrc.2009.07.048. Epub 2009 Jul 15. PubMed PMID: 19615334; PubMed Central PMCID: PMC2745314.
  48. Burns MP, Zhang L, Rebeck GW, Querfurth HW, Moussa CE. Parkin promotes intracellular Abeta1-42 clearance. Hum Mol Genet. 2009 Sep 1;18(17):3206-16. doi: 10.1093/hmg/ddp258. Epub 2009 May 29. PubMed PMID: 19483198; PubMed Central PMCID: PMC2733820.
  49. Tractenberg RE, Aisen PS, Hancock GR, Rebeck GW. No cross-sectional influence of APOE epsilon4 dose on clinical tests in Alzheimer's disease. Neurobiol Aging. 2009 Aug;30(8):1327-8. doi: 10.1016/j.neurobiolaging.2007.11.006. Epub 2008 Feb 20. PubMed PMID: 18083276; PubMed Central PMCID: PMC2740902.
  50. Hoe HS, Lee KJ, Carney RS, Lee J, Markova A, Lee JY, Howell BW, Hyman BT, Pak DT, Bu G, Rebeck GW. Interaction of reelin with amyloid precursor protein promotes neurite outgrowth. J Neurosci. 2009 Jun 10;29(23):7459-73. doi: 10.1523/JNEUROSCI.4872-08.2009. PubMed PMID: 19515914; PubMed Central PMCID: PMC2759694.