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Vojtech L, Zhang M, Dave V, Levy C, Hughes SM, Wang R, Calienes F, Prlic M, Nance E, Hladik F. Extracellular vesicles in human semen modulate antigen-presenting cell function and decrease downstream antiviral T cell responses. PLOS ONE. Forthcoming;
Pattacini L, Woodward Davis A, Czartoski J, Mair F, Presnell S, Hughes SM, Hyrien O, Lentz GM, Kirby AC, Fialkow MF, Hladik F, Prlic M, Lund JM. A pro-inflammatory CD8+ T-cell subset patrols the cervicovaginal tract. Mucosal Immunol. 2019 Sep;12(5):1118-1129. doi: 10.1038/s41385-019-0186-9. Epub 2019 Jul 16. PubMed PMID: 31312028; PubMed Central PMCID: PMC6717561.
Cao S, Slack SD, Levy CN, Hughes SM, Jiang Y, Yogodzinski C, Roychoudhury P, Jerome KR, Schiffer JT, Hladik F, Woodrow KA. Hybrid nanocarriers incorporating mechanistically distinct drugs for lymphatic CD4+ T cell activation and HIV-1 latency reversal. Sci Adv. 2019 Mar;5(3):eaav6322. doi: 10.1126/sciadv.aav6322. eCollection 2019 Mar. PubMed PMID: 30944862; PubMed Central PMCID: PMC6436934.
Heffron R, Stalter R, Pyra M, Nanda K, Erikson DW, Hladik F, Blue SW, Davis NL, Mugo N, Kourtis AP, Lingappa JR, Baeten JM. HIV risk associated with serum medroxyprogesterone acetate levels among women in East and southern Africa. AIDS. 2019 Mar 15;33(4):735-744. doi: 10.1097/QAD.0000000000002123. PubMed PMID: 30585845; PubMed Central PMCID: PMC6399047.
Jauregui R, Srinivasan S, Vojtech LN, Gammill HS, Chiu DT, Hladik F, Stayton PS, Lai JJ. Temperature-Responsive Magnetic Nanoparticles for Enabling Affinity Separation of Extracellular Vesicles. ACS Appl Mater Interfaces. 2018 Oct 10;10(40):33847-33856. doi: 10.1021/acsami.8b09751. Epub 2018 Sep 27. PubMed PMID: 30152229; PubMed Central PMCID: PMC6538933.
Hughes SM, Ferre AL, Yandura SE, Shetler C, Baker CAR, Calienes F, Levy CN, Astronomo RD, Shu Z, Lentz GM, Fialkow M, Kirby AC, McElrath MJ, Sinclair E, Rohan LC, Anderson PL, Shacklett BL, Dezzutti CS, Gao D, Hladik F. Cryopreservation of human mucosal tissues. PLoS One. 2018;13(7):e0200653. doi: 10.1371/journal.pone.0200653. eCollection 2018. PubMed PMID: 30059507; PubMed Central PMCID: PMC6066204.
Cao S, Jiang Y, Levy CN, Hughes SM, Zhang H, Hladik F, Woodrow KA. Optimization and comparison of CD4-targeting lipid-polymer hybrid nanoparticles using different binding ligands. J Biomed Mater Res A. 2018 May;106(5):1177-1188. doi: 10.1002/jbm.a.36315. Epub 2018 Jan 10. PubMed PMID: 29271128; PubMed Central PMCID: PMC6038932.
Reeves DB, Duke ER, Hughes SM, Prlic M, Hladik F, Schiffer JT. Anti-proliferative therapy for HIV cure: a compound interest approach. Sci Rep. 2017 Jun 21;7(1):4011. doi: 10.1038/s41598-017-04160-3. PubMed PMID: 28638104; PubMed Central PMCID: PMC5479830.
Astronomo RD, Santra S, Ballweber-Fleming L, Westerberg KG, Mach L, Hensley-McBain T, Sutherland L, Mildenberg B, Morton G, Yates NL, Mize GJ, Pollara J, Hladik F, Ochsenbauer C, Denny TN, Warrier R, Rerks-Ngarm S, Pitisuttithum P, Nitayapan S, Kaewkungwal J, Ferrari G, Shaw GM, Xia SM, Liao HX, Montefiori DC, Tomaras GD, Haynes BF, McElrath JM. Neutralization Takes Precedence Over IgG or IgA Isotype-related Functions in Mucosal HIV-1 Antibody-mediated Protection. EBioMedicine. 2016 Dec;14:97-111. doi: 10.1016/j.ebiom.2016.11.024. Epub 2016 Nov 21. PubMed PMID: 27919754; PubMed Central PMCID: PMC5161443.
Shu Z, Hughes SM, Fang C, Hou Z, Zhao G, Fialkow M, Lentz G, Hladik F, Gao D. Determination of the Membrane Permeability to Water of Human Vaginal Mucosal Immune Cells at Subzero Temperatures Using Differential Scanning Calorimetry. Biopreserv Biobank. 2016 Aug;14(4):307-13. doi: 10.1089/bio.2015.0079. Epub 2016 Mar 15. PubMed PMID: 26977578; PubMed Central PMCID: PMC4991588.
Hughes SM, Shu Z, Levy CN, Ferre AL, Hartig H, Fang C, Lentz G, Fialkow M, Kirby AC, Adams Waldorf KM, Veazey RS, Germann A, von Briesen H, McElrath MJ, Dezzutti CS, Sinclair E, Baker CA, Shacklett BL, Gao D, Hladik F. Cryopreservation of Human Mucosal Leukocytes. PLoS One. 2016;11(5):e0156293. doi: 10.1371/journal.pone.0156293. eCollection 2016. PubMed PMID: 27232996; PubMed Central PMCID: PMC4883784.
Shu Z, Hughes SM, Fang C, Huang J, Fu B, Zhao G, Fialkow M, Lentz G, Hladik F, Gao D. A study of the osmotic characteristics, water permeability, and cryoprotectant permeability of human vaginal immune cells. Cryobiology. 2016 Apr;72(2):93-9. doi: 10.1016/j.cryobiol.2016.03.003. Epub 2016 Mar 11. PubMed PMID: 26976225; PubMed Central PMCID: PMC4829375.
Ramanathan R, Park J, Hughes SM, Lykins WR, Bennett HR, Hladik F, Woodrow KA. Effect of Mucosal Cytokine Administration on Selective Expansion of Vaginal Dendritic Cells to Support Nanoparticle Transport. Am J Reprod Immunol. 2015 Oct;74(4):333-44. doi: 10.1111/aji.12409. Epub 2015 Jun 27. PubMed PMID: 26118309; PubMed Central PMCID: PMC4599983.
Satthakarn S, Hladik F, Promsong A, Nittayananta W. Vaginal innate immune mediators are modulated by a water extract of Houttuynia cordata Thunb. BMC Complement Altern Med. 2015 Jun 16;15:183. doi: 10.1186/s12906-015-0701-9. PubMed PMID: 26077233; PubMed Central PMCID: PMC4466860.
Hladik F. A new hypothesis on HIV cure. F1000Res. 2015;4:77. doi: 10.12688/f1000research.4529.1. eCollection 2015. PubMed PMID: 26380071; PubMed Central PMCID: PMC4560250.
Hladik F, Burgener A, Ballweber L, Gottardo R, Vojtech L, Fourati S, Dai JY, Cameron MJ, Strobl J, Hughes SM, Hoesley C, Andrew P, Johnson S, Piper J, Friend DR, Ball TB, Cranston RD, Mayer KH, McElrath MJ, McGowan I. Mucosal effects of tenofovir 1% gel. Elife. 2015 Feb 3;4. doi: 10.7554/eLife.04525. PubMed PMID: 25647729; PubMed Central PMCID: PMC4391502.
Chevillet JR, Kang Q, Ruf IK, Briggs HA, Vojtech LN, Hughes SM, Cheng HH, Arroyo JD, Meredith EK, Gallichotte EN, Pogosova-Agadjanyan EL, Morrissey C, Stirewalt DL, Hladik F, Yu EY, Higano CS, Tewari M. Quantitative and stoichiometric analysis of the microRNA content of exosomes. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14888-93. doi: 10.1073/pnas.1408301111. Epub 2014 Sep 29. PubMed PMID: 25267620; PubMed Central PMCID: PMC4205618.
Mitchell CM, McLemore L, Westerberg K, Astronomo R, Smythe K, Gardella C, Mack M, Magaret A, Patton D, Agnew K, McElrath MJ, Hladik F, Eschenbach D. Long-term effect of depot medroxyprogesterone acetate on vaginal microbiota, epithelial thickness and HIV target cells. J Infect Dis. 2014 Aug 15;210(4):651-5. doi: 10.1093/infdis/jiu176. Epub 2014 Mar 20. PubMed PMID: 24652495; PubMed Central PMCID: PMC4172039.
Seaton KE, Ballweber L, Lan A, Donathan M, Hughes S, Vojtech L, Moody MA, Liao HX, Haynes BF, Galloway CG, Richardson BA, Karim SA, Dezzutti CS, McElrath MJ, Tomaras GD, Hladik F. HIV-1 specific IgA detected in vaginal secretions of HIV uninfected women participating in a microbicide trial in Southern Africa are primarily directed toward gp120 and gp140 specificities. PLoS One. 2014;9(7):e101863. doi: 10.1371/journal.pone.0101863. eCollection 2014. PubMed PMID: 25054205; PubMed Central PMCID: PMC4108330.
Vojtech L, Woo S, Hughes S, Levy C, Ballweber L, Sauteraud RP, Strobl J, Westerberg K, Gottardo R, Tewari M, Hladik F. Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions. Nucleic Acids Res. 2014 Jun;42(11):7290-304. doi: 10.1093/nar/gku347. Epub 2014 May 16. PubMed PMID: 24838567; PubMed Central PMCID: PMC4066774.
McKinnon LR, Hughes SM, De Rosa SC, Martinson JA, Plants J, Brady KE, Gumbi PP, Adams DJ, Vojtech L, Galloway CG, Fialkow M, Lentz G, Gao D, Shu Z, Nyanga B, Izulla P, Kimani J, Kimwaki S, Bere A, Moodie Z, Landay AL, Passmore JA, Kaul R, Novak RM, McElrath MJ, Hladik F. Optimizing viable leukocyte sampling from the female genital tract for clinical trials: an international multi-site study. PLoS One. 2014;9(1):e85675. doi: 10.1371/journal.pone.0085675. eCollection 2014. PubMed PMID: 24454917; PubMed Central PMCID: PMC3893217.
Hladik F. Advances in HIV mucosal immunology: challenges and opportunities. [Internet]. PLOS Journals; 2014. Available from: .
Hladik F. Capturing participant information for mucosal sampling: an investigator’s guide. Global HIV Vaccine Enterprise Publications; 2014. Available from: .
McElrath MJ, Smythe K, Randolph-Habecker J, Melton KR, Goodpaster TA, Hughes SM, Mack M, Sato A, Diaz G, Steinbach G, Novak RM, Curlin ME, Lord JD, Maenza J, Duerr A, Frahm N, Hladik F. Comprehensive assessment of HIV target cells in the distal human gut suggests increasing HIV susceptibility toward the anus. J Acquir Immune Defic Syndr. 2013 Jul 1;63(3):263-71. doi: 10.1097/QAI.0b013e3182898392. PubMed PMID: 23392465; PubMed Central PMCID: PMC3683090.
McGowan I, Hoesley C, Cranston RD, Andrew P, Janocko L, Dai JY, Carballo-Dieguez A, Ayudhya RK, Piper J, Hladik F, Mayer K. A phase 1 randomized, double blind, placebo controlled rectal safety and acceptability study of tenofovir 1% gel (MTN-007). PLoS One. 2013;8(4):e60147. doi: 10.1371/journal.pone.0060147. Epub 2013 Apr 3. PubMed PMID: 23573238; PubMed Central PMCID: PMC3616022.
Dezzutti CS, Hladik F. Use of human mucosal tissue to study HIV-1 pathogenesis and evaluate HIV-1 prevention modalities. Curr HIV/AIDS Rep. 2013 Mar;10(1):12-20. doi: 10.1007/s11904-012-0148-2. Review. PubMed PMID: 23224426; PubMed Central PMCID: PMC4242793.
Doehle BP, Chang K, Fleming L, McNevin J, Hladik F, McElrath MJ, Gale M Jr. Vpu-deficient HIV strains stimulate innate immune signaling responses in target cells. J Virol. 2012 Aug;86(16):8499-506. doi: 10.1128/JVI.00424-12. Epub 2012 May 30. PubMed PMID: 22647704; PubMed Central PMCID: PMC3421769.
Hladik F. HIV in the genital tract. Microbe (Washington, D.C.). 2012 May; 7(5):229-232.
Bhardwaj N, Hladik F, Moir S. The immune response to HIV. [Internet]. Nature Reviews Immmunology; 2012. Available from: .
Ballweber L, Robinson B, Kreger A, Fialkow M, Lentz G, McElrath MJ, Hladik F. Vaginal langerhans cells nonproductively transporting HIV-1 mediate infection of T cells. J Virol. 2011 Dec;85(24):13443-7. doi: 10.1128/JVI.05615-11. Epub 2011 Oct 5. PubMed PMID: 21976645; PubMed Central PMCID: PMC3233146.
Dezzutti CS, Hendrix CW, Marrazzo JM, Pan Z, Wang L, Louissaint N, Kalyoussef S, Torres NM, Hladik F, Parikh U, Mellors J, Hillier SL, Herold BC. Performance of swabs, lavage, and diluents to quantify biomarkers of female genital tract soluble mucosal mediators. PLoS One. 2011;6(8):e23136. doi: 10.1371/journal.pone.0023136. Epub 2011 Aug 12. PubMed PMID: 21858008; PubMed Central PMCID: PMC3155537.
Veronese F, Anton P, Fletcher CV, DeGruttola V, McGowan I, Becker S, Zwerski S, Burns D. Implications of HIV PrEP trials results. AIDS Res Hum Retroviruses. 2011 Jan;27(1):81-90. doi: 10.1089/AID.2010.0226. Epub 2010 Dec 12. PubMed PMID: 20969483; PubMed Central PMCID: PMC3014767.
Hladik F, Sakchalathorn P, McElrath MJ. Front-line defenders. [Internet]. Cell Press; 2011. Available from: .
Hladik F, Doncel GF. Preventing mucosal HIV transmission with topical microbicides: challenges and opportunities. Antiviral Res. 2010 Dec;88 Suppl 1:S3-9. doi: 10.1016/j.antiviral.2010.09.011. Review. PubMed PMID: 21109065; PubMed Central PMCID: PMC3032991.
McElrath MJ, Ballweber L, Terker A, Kreger A, Sakchalathorn P, Robinson B, Fialkow M, Lentz G, Hladik F. Ex vivo comparison of microbicide efficacies for preventing HIV-1 genomic integration in intraepithelial vaginal cells. Antimicrob Agents Chemother. 2010 Feb;54(2):763-72. doi: 10.1128/AAC.00891-09. Epub 2009 Nov 30. PubMed PMID: 19949052; PubMed Central PMCID: PMC2812173.
Doehle BP, Hladik F, McNevin JP, McElrath MJ, Gale M Jr. Human immunodeficiency virus type 1 mediates global disruption of innate antiviral signaling and immune defenses within infected cells. J Virol. 2009 Oct;83(20):10395-405. doi: 10.1128/JVI.00849-09. Epub 2009 Aug 12. PubMed PMID: 19706707; PubMed Central PMCID: PMC2753137.
Nittayananta W, Hladik F, Klausner M, Harb S, Dale BA, Coombs RW. HIV type 1 fails to trigger innate immune factor synthesis in differentiated oral epithelium. AIDS Res Hum Retroviruses. 2009 Oct;25(10):1013-21. doi: 10.1089/aid.2009.0032. PubMed PMID: 19842793; PubMed Central PMCID: PMC2828236.
Zhu J, Hladik F, Woodward A, Klock A, Peng T, Johnston C, Remington M, Magaret A, Koelle DM, Wald A, Corey L. Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition. Nat Med. 2009 Aug;15(8):886-92. doi: 10.1038/nm.2006. Epub 2009 Aug 2. PubMed PMID: 19648930; PubMed Central PMCID: PMC2723183.
Hladik F, Hope TJ. HIV infection of the genital mucosa in women. Curr HIV/AIDS Rep. 2009 Feb;6(1):20-8. Review. PubMed PMID: 19149993.
Speelmon EC, Livingston-Rosanoff D, Desbien AL, Lee J, Wick WD, Hladik F, McElrath MJ. Impaired viral entry cannot explain reduced CD4+ T cell susceptibility to HIV type 1 in certain highly exposed individuals. AIDS Res Hum Retroviruses. 2008 Nov;24(11):1415-27. doi: 10.1089/aid.2007.0256. PubMed PMID: 19000021; PubMed Central PMCID: PMC2764523.
Hladik F, Dezzutti CS. Can a topical microbicide prevent rectal HIV transmission?. PLoS Med. 2008 Aug 5;5(8):e167. doi: 10.1371/journal.pmed.0050167. PubMed PMID: 18684009; PubMed Central PMCID: PMC2494564.
Hladik F, McElrath MJ. Setting the stage: host invasion by HIV. Nat Rev Immunol. 2008 Jun;8(6):447-57. doi: 10.1038/nri2302. Review. PubMed PMID: 18469831; PubMed Central PMCID: PMC2587276.
Zhu J, Koelle DM, Cao J, Vazquez J, Huang ML, Hladik F, Wald A, Corey L. Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation. J Exp Med. 2007 Mar 19;204(3):595-603. doi: 10.1084/jem.20061792. Epub 2007 Feb 26. PubMed PMID: 17325200; PubMed Central PMCID: PMC2137910.
Hladik F, Sakchalathorn P, Ballweber L, Lentz G, Fialkow M, Eschenbach D, McElrath MJ. Initial events in establishing vaginal entry and infection by human immunodeficiency virus type-1. Immunity. 2007 Feb;26(2):257-70. doi: 10.1016/j.immuni.2007.01.007. PubMed PMID: 17306567; PubMed Central PMCID: PMC1885958.
Liu H, Carrington M, Wang C, Holte S, Lee J, Greene B, Hladik F, Koelle DM, Wald A, Kurosawa K, Rinaldo CR, Celum C, Detels R, Corey L, McElrath MJ, Zhu T. Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule: effects on HIV-1 susceptibility. J Infect Dis. 2006 Mar 1;193(5):698-702. doi: 10.1086/499820. Epub 2006 Jan 27. PubMed PMID: 16453266.
Hladik F, Jurecka W, Hayek B, Stingl G, Volc-Platzer B. Atopic dermatitis with increased severity along a line of Blaschko. J Am Acad Dermatol. 2005 Nov;53(5 Suppl 1):S221-4. doi: 10.1016/j.jaad.2005.01.004. PubMed PMID: 16227095.
Hladik F, Liu H, Speelmon E, Livingston-Rosanoff D, Wilson S, Sakchalathorn P, Hwangbo Y, Greene B, Zhu T, McElrath MJ. Combined effect of CCR5-Delta32 heterozygosity and the CCR5 promoter polymorphism -2459 A/G on CCR5 expression and resistance to human immunodeficiency virus type 1 transmission. J Virol. 2005 Sep;79(18):11677-84. doi: 10.1128/JVI.79.18.11677-11684.2005. PubMed PMID: 16140745; PubMed Central PMCID: PMC1212613.
Liu H, Hladik F, Andrus T, Sakchalathorn P, Lentz GM, Fialkow MF, Corey L, McElrath MJ, Zhu T. Most DC-SIGNR transcripts at mucosal HIV transmission sites are alternatively spliced isoforms. Eur J Hum Genet. 2005 Jun;13(6):707-15. doi: 10.1038/sj.ejhg.5201409. PubMed PMID: 15812562.
Hladik F, Desbien A, Lang J, Wang L, Ding Y, Holte S, Wilson A, Xu Y, Moerbe M, Schmechel S, McElrath MJ. Most highly exposed seronegative men lack HIV-1-specific, IFN-gamma-secreting T cells. J Immunol. 2003 Sep 1;171(5):2671-83. doi: 10.4049/jimmunol.171.5.2671. PubMed PMID: 12928421.
Schmechel SC, Russell N, Hladik F, Lang J, Wilson A, Ha R, Desbien A, McElrath MJ. Immune defence against HIV-1 infection in HIV-1-exposed seronegative persons. Immunol Lett. 2001 Nov 1;79(1-2):21-7. doi: 10.1016/s0165-2478(01)00262-0. PubMed PMID: 11595286.
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