My Bibliography

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Dammer EB. Transforming tissue transcriptomes, delivering on the promise of machine learning. Brain. 2025 Oct 3;148(10):3433-3434. doi: 10.1093/brain/awaf323. PubMed PMID: 40899008; PubMed Central PMCID: PMC12493043.

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Afshar S, Dammer EB, Bian S, Bennett DA, Mohs R, Beauregard D, Dwyer J, Hales CM, Goldstein FC, Parker MW, Trammell AR, Watson CM, Golde TE, Seyfried NT, Roberts BR, Manzanares CM, Lah JJ, Levey AI, Johnson ECB. Plasma proteomic associations with Alzheimer's disease endophenotypes. Nat Aging. 2025 Oct;5(10):2104-2124. doi: 10.1038/s43587-025-00965-4. Epub 2025 Sep 10. PubMed PMID: 40931114; PubMed Central PMCID: PMC12532695.

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McEachin ZT, Chung M, Stratton SA, Han C, Kim WJ, Sheth U, Thomas EV, Issenberg E, Kamra T, Merino P, Levites Y, Raj N, Dammer EB, Duong DM, Ping L, Shantaraman A, Trautwig AN, Gadhavi J, Assefa E, Gearing M, Kelly KM, Roemer SF, DeTure M, Asress S, Kukar T, Fournier C, Dickson DW, Petrucelli L, Golde TE, Oskarsson B, Gendron TF, Seyfried NT, Glass JD. Molecular impact of antisense oligonucleotide therapy in C9orf72-associated ALS. Cell. 2025 Nov 13;188(23):6424-6435.e17. doi: 10.1016/j.cell.2025.07.045. Epub 2025 Aug 26. PubMed PMID: 40865525; PubMed Central PMCID: PMC13054592.

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Trautwig AN, Shantaraman A, Chung M, Dammer EB, Ping L, Duong DM, Petrucelli L, Ward ME, Glass JD, Nelson PT, Levey AI, McEachin ZT, Seyfried NT. Molecular subtyping based on hippocampal cryptic exon burden reveals proteome-wide changes associated with TDP-43 pathology across the spectrum of LATE and Alzheimer's Disease. bioRxiv. 2025 Jul 2;. doi: 10.1101/2025.05.30.656396. PubMed PMID: 40501554; PubMed Central PMCID: PMC12157639.

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Saloner R, Staffaroni AM, Dammer EB, Johnson ECB, Paolillo EW, Wise A, Heuer HW, Forsberg LK, Lario-Lago A, Webb JD, Vogel JW, Santillo AF, Hansson O, Kramer JH, Miller BL, Li J, Loureiro J, Sivasankaran R, Worringer KA, Seyfried NT, Yokoyama JS, Spina S, Grinberg LT, Seeley WW, VandeVrede L, Ljubenkov PA, Bayram E, Bozoki A, Brushaber D, Considine CM, Day GS, Dickerson BC, Domoto-Reilly K, Faber K, Galasko DR, Gendron T, Geschwind DH, Ghoshal N, Graff-Radford N, Hales CM, Honig LS, Hsiung GR, Huey ED, Kornak J, Kremers W, Lapid MI, Lee SE, Litvan I, McMillan CT, Mendez MF, Miyagawa T, Pantelyat A, Pascual B, Masdeu J, Paulson HL, Petrucelli L, Pressman P, Rademakers R, Ramos EM, Rascovsky K, Roberson ED, Savica R, Snyder A, Sullivan AC, Tartaglia MC, Vandebergh M, Boeve BF, Rosen HJ, Rojas JC, Boxer AL, Casaletto KB, ALLFTD Consortium. Author Correction: Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration. Nat Aging. 2025 Jul;5(7):1372. doi: 10.1038/s43587-025-00931-0. PubMed PMID: 40624197; PubMed Central PMCID: PMC12270897.

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Montoliu-Gaya L, Bian S, Dammer EB, Alcolea D, Sauer M, Martá-Ariza M, Ashton NJ, Belbin O, Fuchs J, Watson CM, Ping L, Duong DM, Nilsson J, Barroeta I, Lantero-Rodriguez J, Videla L, Benejam B, Roberts BR, Blennow K, Seyfried NT, Levey AI, Carmona-Iragui M, Gobom J, Lleó A, Wisniewski T, Zetterberg H, Fortea J, Johnson ECB. Proteomic analysis of Down syndrome cerebrospinal fluid compared to late-onset and autosomal dominant Alzheimer´s disease. Nat Commun. 2025 Jul 1;16(1):6003. doi: 10.1038/s41467-025-61054-z. PubMed PMID: 40595720; PubMed Central PMCID: PMC12214755.

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Bar S, Wilson KA, Hilsabeck TAU, Alderfer S, Dammer EB, Burton JB, Shah S, Holtz A, Carrera EM, Beck JN, Chen JH, Kauwe G, Seifar F, Shantaraman A, Tracy TE, Seyfried NT, Schilling B, Ellerby LM, Kapahi P. Neuronal glycogen breakdown mitigates tauopathy via pentose-phosphate-pathway-mediated oxidative stress reduction. Nat Metab. 2025 Jul;7(7):1375-1391. doi: 10.1038/s42255-025-01314-w. Epub 2025 Jun 30. PubMed PMID: 40588539; PubMed Central PMCID: PMC12795109.

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Raza SA, Enose-Akahata Y, Blazier A, Guerra LM, Beck ES, Gaítan MI, Ngouth N, Drijvers JM, Dammer EB, Moodley D, Johnson KR, Absinta M, Turner TJ, Ransohoff RM, Jacobson S, Ofengeim D, Cahir-McFarland E, Reich DS. Maintenance of chronic neuroinflammation in multiple sclerosis via interferon signaling and CD8 T cell-mediated cytotoxicity. bioRxiv. 2025 Jun 11;. doi: 10.1101/2025.06.09.658729. PubMed PMID: 40568143; PubMed Central PMCID: PMC12190403.

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Saloner R, Staffaroni AM, Dammer EB, Johnson ECB, Paolillo EW, Wise A, Heuer HW, Forsberg LK, Lario-Lago A, Webb JD, Vogel JW, Santillo AF, Hansson O, Kramer JH, Miller BL, Li J, Loureiro J, Sivasankaran R, Worringer KA, Seyfried NT, Yokoyama JS, Spina S, Grinberg LT, Seeley WW, VandeVrede L, Ljubenkov PA, Bayram E, Bozoki A, Brushaber D, Considine CM, Day GS, Dickerson BC, Domoto-Reilly K, Faber K, Galasko DR, Gendron T, Geschwind DH, Ghoshal N, Graff-Radford N, Hales CM, Honig LS, Hsiung GR, Huey ED, Kornak J, Kremers W, Lapid MI, Lee SE, Litvan I, McMillan CT, Mendez MF, Miyagawa T, Pantelyat A, Pascual B, Masdeu J, Paulson HL, Petrucelli L, Pressman P, Rademakers R, Ramos EM, Rascovsky K, Roberson ED, Savica R, Snyder A, Sullivan AC, Tartaglia MC, Vandebergh M, Boeve BF, Rosen HJ, Rojas JC, Boxer AL, Casaletto KB, ALLFTD Consortium. Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration. Nat Aging. 2025 Jun;5(6):1143-1158. doi: 10.1038/s43587-025-00878-2. Epub 2025 May 16. PubMed PMID: 40380000; PubMed Central PMCID: PMC12234358.

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Trautwig AN, Fox EJ, Dammer EB, Shantaraman A, Ping L, Duong DM, Watson CM, Wu F, Asress S, Guo Q, Levey AI, Lah JJ, Verde F, Doretti A, Ratti A, Ticozzi N, Ly CV, Miller TM, Garret MA, Berry JD, Thomas EV, Fournier CN, McEachin ZT, Seyfried NT, Glass JD. Network analysis of the cerebrospinal fluid proteome reveals shared and unique differences between sporadic and familial forms of amyotrophic lateral sclerosis. Mol Neurodegener. 2025 May 15;20(1):58. doi: 10.1186/s13024-025-00838-9. PubMed PMID: 40375307; PubMed Central PMCID: PMC12082929.

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Bangs MC, Gadhavi J, Carter EK, Ping L, Duong DM, Dammer EB, Wu F, Shantaraman A, Fox EJ, Johnson ECB, Lah JJ, Levey AI, Seyfried NT. Proteomic Subtyping of Alzheimer's Disease CSF links Blood-Brain Barrier Dysfunction to Reduced levels of Tau and Synaptic Biomarkers. bioRxiv. 2025 Mar 15;. doi: 10.1101/2025.03.14.643332. PubMed PMID: 40161719; PubMed Central PMCID: PMC11952530.

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Moore J, Wu T, Dhindsa J, El Fadel O, Le A, Perez A, Amoh B, Tarkunde A, Zhu KF, Avalos M, Dammer EB, Duong DM, Seyfried NT, Shulman JM, Al-Ramahi I, Botas J. Longitudinal multi-omics in alpha-synuclein Drosophila model discriminates disease- from age-associated pathologies in Parkinson's disease. NPJ Parkinsons Dis. 2025 Mar 11;11(1):46. doi: 10.1038/s41531-025-00899-z. PubMed PMID: 40069190; PubMed Central PMCID: PMC11897226.

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Ramelow CC, Dammer EB, Xiao H, Cheng L, Kumar P, Espinosa-Garcia C, Sampson MM, Nelson RS, Malepati S, Kour D, Kumari R, Guo Q, Bagchi P, Duong DM, Seyfried NT, Sloan SA, Rangaraju S. Simultaneous profiling of native-state proteomes and transcriptomes of neural cell types using proximity labeling. bioRxiv. 2025 Feb 1;. doi: 10.1101/2025.01.29.635500. PubMed PMID: 39974879; PubMed Central PMCID: PMC11838394.

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Shapley SM, Shantaraman A, Kearney MA, Dammer EB, Duong DM, Bowen CA, Bagchi P, Guo Q, Rangaraju S, Seyfried NT. Proximity labeling of the Tau repeat domain enriches RNA-binding proteins that are altered in Alzheimer's disease and related tauopathies. bioRxiv. 2025 Jan 22;. doi: 10.1101/2025.01.22.633945. PubMed PMID: 39896523; PubMed Central PMCID: PMC11785194.

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Carey KM, Young CD, Clark AJ, Dammer EB, Singh R, Lillard JW Jr. Subtype-specific analysis of gene co-expression networks and immune cell profiling reveals high grade serous ovarian cancer subtype linkage to variable immune microenvironment. J Ovarian Res. 2024 Dec 3;17(1):240. doi: 10.1186/s13048-024-01556-4. PubMed PMID: 39627836; PubMed Central PMCID: PMC11613732.

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Seifar F, Fox EJ, Shantaraman A, Liu Y, Dammer EB, Modeste E, Duong DM, Yin L, Trautwig AN, Guo Q, Xu K, Ping L, Reddy JS, Allen M, Quicksall Z, Heath L, Scanlan J, Wang E, Wang M, Linden AV, Poehlman W, Chen X, Baheti S, Ho C, Nguyen T, Yepez G, Mitchell AO, Oatman SR, Wang X, Carrasquillo MM, Runnels A, Beach T, Serrano GE, Dickson DW, Lee EB, Golde TE, Prokop S, Barnes LL, Zhang B, Haroutunian V, Gearing M, Lah JJ, De Jager P, Bennett DA, Greenwood A, Ertekin-Taner N, Levey AI, Wingo A, Wingo T, Seyfried NT. Large-scale deep proteomic analysis in Alzheimer's disease brain regions across race and ethnicity. Alzheimers Dement. 2024 Dec;20(12):8878-8897. doi: 10.1002/alz.14360. Epub 2024 Nov 13. PubMed PMID: 39535480; PubMed Central PMCID: PMC11667503.

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Shantaraman A, Dammer EB, Ugochukwu O, Duong DM, Yin L, Carter EK, Gearing M, Chen-Plotkin A, Lee EB, Trojanowski JQ, Bennett DA, Lah JJ, Levey AI, Seyfried NT, Higginbotham L. Correction: Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer's disease. Mol Neurodegener. 2024 Oct 11;19(1):71. doi: 10.1186/s13024-024-00765-1. PubMed PMID: 39394136; PubMed Central PMCID: PMC11470643.

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Guo Q, Ping L, Dammer EB, Duong DM, Yin L, Xu K, Shantaraman A, Fox EJ, Golde TE, Johnson ECB, Roberts BR, Lah JJ, Levey AI, Seyfried NT. Heparin-enriched plasma proteome is significantly altered in Alzheimer's disease. Mol Neurodegener. 2024 Oct 8;19(1):67. doi: 10.1186/s13024-024-00757-1. PubMed PMID: 39380021; PubMed Central PMCID: PMC11460197.

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Frick EA, Emilsson V, Jonmundsson T, Steindorsdottir AE, Johnson ECB, Puerta R, Dammer EB, Shantaraman A, Cano A, Boada M, Valero S, García-González P, Gudmundsson EF, Gudjonsson A, Pitts R, Qiu X, Finkel N, Loureiro JJ, Orth AP, Seyfried NT, Levey AI, Ruiz A, Aspelund T, Jennings LL, Launer LJ, Gudmundsdottir V, Gudnason V. Author Correction: Serum proteomics reveal APOE-ε4-dependent and APOE-ε4-independent protein signatures in Alzheimer's disease. Nat Aging. 2024 Oct;4(10):1509. doi: 10.1038/s43587-024-00718-9. PubMed PMID: 39285016; PubMed Central PMCID: PMC11485289.

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Reddy JS, Heath L, Linden AV, Allen M, Lopes KP, Seifar F, Wang E, Ma Y, Poehlman WL, Quicksall ZS, Runnels A, Wang Y, Duong DM, Yin L, Xu K, Modeste ES, Shantaraman A, Dammer EB, Ping L, Oatman SR, Scanlan J, Ho C, Carrasquillo MM, Atik M, Yepez G, Mitchell AO, Nguyen TT, Chen X, Marquez DX, Reddy H, Xiao H, Seshadri S, Mayeux R, Prokop S, Lee EB, Serrano GE, Beach TG, Teich AF, Haroutunian V, Fox EJ, Gearing M, Wingo A, Wingo T, Lah JJ, Levey AI, Dickson DW, Barnes LL, De Jager P, Zhang B, Bennett D, Seyfried NT, Greenwood AK, Ertekin-Taner N. Bridging the gap: Multi-omics profiling of brain tissue in Alzheimer's disease and older controls in multi-ethnic populations. Alzheimers Dement. 2024 Oct;20(10):7174-7192. doi: 10.1002/alz.14208. Epub 2024 Aug 30. PubMed PMID: 39215503; PubMed Central PMCID: PMC11485084.

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Frick EA, Emilsson V, Jonmundsson T, Steindorsdottir AE, Johnson ECB, Puerta R, Dammer EB, Shantaraman A, Cano A, Boada M, Valero S, García-González P, Gudmundsson EF, Gudjonsson A, Pitts R, Qiu X, Finkel N, Loureiro JJ, Orth AP, Seyfried NT, Levey AI, Ruiz A, Aspelund T, Jennings LL, Launer LJ, Gudmundsdottir V, Gudnason V. Serum proteomics reveal APOE-ε4-dependent and APOE-ε4-independent protein signatures in Alzheimer's disease. Nat Aging. 2024 Oct;4(10):1446-1464. doi: 10.1038/s43587-024-00693-1. Epub 2024 Aug 21. PubMed PMID: 39169269; PubMed Central PMCID: PMC11485263.

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Levites Y, Dammer EB, Ran Y, Tsering W, Duong D, Abreha M, Gadhavi J, Lolo K, Trejo-Lopez J, Phillips J, Iturbe A, Erquizi A, Moore BD, Ryu D, Natu A, Dillon K, Torrellas J, Moran C, Ladd T, Afroz F, Islam T, Jagirdar J, Funk CC, Robinson M, Rangaraju S, Borchelt DR, Ertekin-Taner N, Kelly JW, Heppner FL, Johnson ECB, McFarland K, Levey AI, Prokop S, Seyfried NT, Golde TE. Integrative proteomics identifies a conserved Aβ amyloid responsome, novel plaque proteins, and pathology modifiers in Alzheimer's disease. Cell Rep Med. 2024 Aug 20;5(8):101669. doi: 10.1016/j.xcrm.2024.101669. Epub 2024 Aug 9. PubMed PMID: 39127040; PubMed Central PMCID: PMC11384960.

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Shantaraman A, Dammer EB, Ugochukwu O, Duong DM, Yin L, Carter EK, Gearing M, Chen-Plotkin A, Lee EB, Trojanowski JQ, Bennett DA, Lah JJ, Levey AI, Seyfried NT, Higginbotham L. Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer's disease. Mol Neurodegener. 2024 Aug 6;19(1):60. doi: 10.1186/s13024-024-00749-1. PubMed PMID: 39107789; PubMed Central PMCID: PMC11302177.

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de Ávila C, Suazo C, Nolz J, Nicholas Cochran J, Wang Q, Velazquez R, Dammer E, Readhead B, Mastroeni D. Reduced PIN1 expression in neocortical and limbic brain regions in female Alzheimer's patients correlates with cognitive and neuropathological phenotypes. Neurobiol Aging. 2024 Sep;141:160-170. doi: 10.1016/j.neurobiolaging.2024.06.007. Epub 2024 Jun 29. PubMed PMID: 38964013.

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Dammer EB, Shantaraman A, Ping L, Duong DM, Gerasimov ES, Ravindran SP, Gudmundsdottir V, Frick EA, Gomez GT, Walker KA, Emilsson V, Jennings LL, Gudnason V, Western D, Cruchaga C, Lah JJ, Wingo TS, Wingo AP, Seyfried NT, Levey AI, Johnson ECB. Proteomic analysis of Alzheimer's disease cerebrospinal fluid reveals alterations associated with APOE ε4 and atomoxetine treatment. Sci Transl Med. 2024 Jun 26;16(753):eadn3504. doi: 10.1126/scitranslmed.adn3504. Epub 2024 Jun 26. PubMed PMID: 38924431; PubMed Central PMCID: PMC12175351.

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Johnson AG, Dammer EB, Webster JA, Duong DM, Seyfried NT, Hales CM. Proteomic networks of gray and white matter reveal tissue-specific changes in human tauopathy. Ann Clin Transl Neurol. 2024 Aug;11(8):2138-2152. doi: 10.1002/acn3.52134. Epub 2024 Jun 24. PubMed PMID: 38924699; PubMed Central PMCID: PMC11330236.

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Pybus AF, Bitarafan S, Brothers RO, Rohrer A, Khaitan A, Moctezuma FR, Udeshi K, Davies B, Triplett S, Griffin MN, Dammer EB, Rangaraju S, Buckley EM, Wood LB. Profiling the neuroimmune cascade in 3xTg-AD mice exposed to successive mild traumatic brain injuries. J Neuroinflammation. 2024 Jun 13;21(1):156. doi: 10.1186/s12974-024-03128-1. PubMed PMID: 38872143; PubMed Central PMCID: PMC11177462.

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Daskalakis NP, Iatrou A, Chatzinakos C, Jajoo A, Snijders C, Wylie D, DiPietro CP, Tsatsani I, Chen CY, Pernia CD, Soliva-Estruch M, Arasappan D, Bharadwaj RA, Collado-Torres L, Wuchty S, Alvarez VE, Dammer EB, Deep-Soboslay A, Duong DM, Eagles N, Huber BR, Huuki L, Holstein VL, Logue MW, Lugenbühl JF, Maihofer AX, Miller MW, Nievergelt CM, Pertea G, Ross D, Sendi MSE, Sun BB, Tao R, Tooke J, Wolf EJ, Zeier Z, PTSD Working Group of Psychiatric Genomics Consortium**, Berretta S, Champagne FA, Hyde T, Seyfried NT, Shin JH, Weinberger DR, Nemeroff CB, Kleinman JE, Ressler KJ, PTSD Working Group of Psychiatric Genomics Consortium. Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood. Science. 2024 May 24;384(6698):eadh3707. doi: 10.1126/science.adh3707. Epub 2024 May 24. PubMed PMID: 38781393; PubMed Central PMCID: PMC11203158.

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Wojtas AM, Dammer EB, Guo Q, Ping L, Shantaraman A, Duong DM, Yin L, Fox EJ, Seifar F, Lee EB, Johnson ECB, Lah JJ, Levey AI, Levites Y, Rangaraju S, Golde TE, Seyfried NT. Proteomic changes in the human cerebrovasculature in Alzheimer's disease and related tauopathies linked to peripheral biomarkers in plasma and cerebrospinal fluid. Alzheimers Dement. 2024 Jun;20(6):4043-4065. doi: 10.1002/alz.13821. Epub 2024 May 7. PubMed PMID: 38713744; PubMed Central PMCID: PMC11180878.

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Seifar F, Fox EJ, Shantaraman A, Liu Y, Dammer EB, Modeste E, Duong DM, Yin L, Trautwig AN, Guo Q, Xu K, Ping L, Reddy JS, Allen M, Quicksall Z, Heath L, Scanlan J, Wang E, Wang M, Linden AV, Poehlman W, Chen X, Baheti S, Ho C, Nguyen T, Yepez G, Mitchell AO, Oatman SR, Wang X, Carrasquillo MM, Runnels A, Beach T, Serrano GE, Dickson DW, Lee EB, Golde TE, Prokop S, Barnes LL, Zhang B, Haroutunian V, Gearing M, Lah JJ, Jager P, Bennett DA, Greenwood A, Ertekin-Taner N, Levey AI, Wingo A, Wingo T, Seyfried NT. Large-scale Deep Proteomic Analysis in Alzheimer's Disease Brain Regions Across Race and Ethnicity. bioRxiv. 2024 Apr 26;. doi: 10.1101/2024.04.22.590547. PubMed PMID: 38712030; PubMed Central PMCID: PMC11071432.

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Reddy JS, Heath L, Vander Linden A, Allen M, de Paiva Lopes K, Seifar F, Wang E, Ma Y, Poehlman WL, Quicksall ZS, Runnels A, Wang Y, Duong DM, Yin L, Xu K, Modeste ES, Shantaraman A, Dammer EB, Ping L, Oatman SR, Scanlan J, Ho C, Carrasquillo MM, Atik M, Yepez G, Mitchell AO, Nguyen TT, Chen X, Marquez DX, Reddy H, Xiao H, Seshadri S, Mayeux R, Prokop S, Lee EB, Serrano GE, Beach TG, Teich AF, Haroutunian V, Fox EJ, Gearing M, Wingo A, Wingo T, Lah JJ, Levey AI, Dickson DW, Barnes LL, De Jager P, Zhang B, Bennett D, Seyfried NT, Greenwood AK, Ertekin-Taner N. Bridging the Gap: Multi-Omics Profiling of Brain Tissue in Alzheimer's Disease and Older Controls in Multi-Ethnic Populations. bioRxiv. 2024 Apr 20;. doi: 10.1101/2024.04.16.589592. PubMed PMID: 38659743; PubMed Central PMCID: PMC11042309.

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Kumar P, Goettemoeller AM, Espinosa-Garcia C, Tobin BR, Tfaily A, Nelson RS, Natu A, Dammer EB, Santiago JV, Malepati S, Cheng L, Xiao H, Duong DD, Seyfried NT, Wood LB, Rowan MJM, Rangaraju S. Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer's pathology. Nat Commun. 2024 Apr 1;15(1):2823. doi: 10.1038/s41467-024-47028-7. PubMed PMID: 38561349; PubMed Central PMCID: PMC10985119.

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Guo Q, Ping L, Dammer EB, Yin L, Xu K, Shantaraman A, Fox EJ, Golde TE, Johnson ECB, Roberts BR, Lah JJ, Levey AI, Seyfried NT. Heparin-enriched plasma proteome is significantly altered in Alzheimer's Disease. Res Sq. 2024 Feb 23;. doi: 10.21203/rs.3.rs-3933136/v1. PubMed PMID: 38464223; PubMed Central PMCID: PMC10925398.

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Chung M, Carter EK, Veire AM, Dammer EB, Chang J, Duong DM, Raj N, Bassell GJ, Glass JD, Gendron TF, Nelson PT, Levey AI, Seyfried NT, McEachin ZT. Cryptic exon inclusion is a molecular signature of LATE-NC in aging brains. Acta Neuropathol. 2024 Feb 3;147(1):29. doi: 10.1007/s00401-023-02671-0. PubMed PMID: 38308693; PubMed Central PMCID: PMC10838224.

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Shantaraman A, Dammer EB, Ugochukwu O, Duong DM, Yin L, Carter EK, Gearing M, Chen-Plotkin A, Lee EB, Trojanowski JQ, Bennett DA, Lah JJ, Levey AI, Seyfried NT, Higginbotham L. Network Proteomics of the Lewy Body Dementia Brain Reveals Presynaptic Signatures Distinct from Alzheimer's Disease. bioRxiv. 2024 Jan 24;. doi: 10.1101/2024.01.23.576728. PubMed PMID: 38328211; PubMed Central PMCID: PMC10849701.

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Wilson KA, Bar S, Dammer EB, Carrera EM, Hodge BA, Hilsabeck TAU, Bons J, Brownridge GW 3rd, Beck JN, Rose J, Granath-Panelo M, Nelson CS, Qi G, Gerencser AA, Lan J, Afenjar A, Chawla G, Brem RB, Campeau PM, Bellen HJ, Schilling B, Seyfried NT, Ellerby LM, Kapahi P. OXR1 maintains the retromer to delay brain aging under dietary restriction. Nat Commun. 2024 Jan 11;15(1):467. doi: 10.1038/s41467-023-44343-3. PubMed PMID: 38212606; PubMed Central PMCID: PMC10784588.

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Wojtas AM, Dammer EB, Guo Q, Ping L, Shantaraman A, Duong DM, Yin L, Fox EJ, Seifar F, Lee EB, Johnson ECB, Lah JJ, Levey AI, Levites Y, Rangaraju S, Golde TE, Seyfried NT. Proteomic Changes in the Human Cerebrovasculature in Alzheimer's Disease and Related Tauopathies Linked to Peripheral Biomarkers in Plasma and Cerebrospinal Fluid. medRxiv. 2024 Jan 11;. doi: 10.1101/2024.01.10.24301099. PubMed PMID: 38260316; PubMed Central PMCID: PMC10802758.

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Levites Y, Dammer EB, Ran Y, Tsering W, Duong D, Abreha M, Gadhavi J, Lolo K, Trejo-Lopez J, Phillips JL, Iturbe A, Erqiuzi A, Moore BD, Ryu D, Natu A, Dillon KD, Torrellas J, Moran C, Ladd TB, Afroz KF, Islam T, Jagirdar J, Funk CC, Robinson M, Borchelt DR, Ertekin-Taner N, Kelly JW, Heppner FL, Johnson EC, McFarland K, Levey AL, Prokop S, Seyfried NT, Golde TE. Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer's Disease. bioRxiv. 2023 Dec 7;. doi: 10.1101/2023.11.29.568318. PubMed PMID: 38076912; PubMed Central PMCID: PMC10705437.

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Frick EA, Emilsson V, Jonmundsson T, Steindorsdottir AE, Johnson ECB, Puerta R, Dammer EB, Shantaraman A, Cano A, Boada M, Valero S, García-González P, Gudmundsson EF, Gudjonsson A, Loureiro JJ, Orth AP, Seyfried NT, Levey AI, Ruiz A, Aspelund T, Jennings LL, Launer LJ, Gudmundsdottir V, Gudnason V. Serum proteomics reveals APOE dependent and independent protein signatures in Alzheimer's disease. medRxiv. 2023 Nov 9;. doi: 10.1101/2023.11.08.23298251. PubMed PMID: 37986771; PubMed Central PMCID: PMC10659486.

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Bar S, Wilson KA, Hilsabeck TAU, Alderfer S, Dammer EB, Burton JB, Shah S, Holtz A, Carrera EM, Beck JN, Chen JH, Kauwe G, Tracy TE, Seyfried NT, Schilling B, Ellerby LM, Kapahi P. Neuronal Glycogen Breakdown Mitigates Tauopathy via Pentose Phosphate Pathway-Mediated Oxidative Stress Reduction. Res Sq. 2023 Nov 8;. doi: 10.21203/rs.3.rs-3526342/v1. PubMed PMID: 37986935; PubMed Central PMCID: PMC10659530.

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Dammer EB, Shantaraman A, Ping L, Duong DM, Gerasimov ES, Ravindran SP, Gudmundsdottir V, Frick EA, Gomez GT, Walker KA, Emilsson V, Jennings LL, Gudnason V, Western D, Cruchaga C, Lah JJ, Wingo TS, Wingo AP, Seyfried NT, Levey AI, Johnson ECB. Proteomic Network Analysis of Alzheimer's Disease Cerebrospinal Fluid Reveals Alterations Associated with APOE ε4 Genotype and Atomoxetine Treatment. medRxiv. 2023 Oct 30;. doi: 10.1101/2023.10.29.23297651. PubMed PMID: 37961720; PubMed Central PMCID: PMC10635242.

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Higginbotham L, Carter EK, Dammer EB, Haque RU, Johnson ECB, Duong DM, Yin L, De Jager PL, Bennett DA, Felsky D, Tio ES, Lah JJ, Levey AI, Seyfried NT. Unbiased classification of the elderly human brain proteome resolves distinct clinical and pathophysiological subtypes of cognitive impairment. Neurobiol Dis. 2023 Oct 1;186:106286. doi: 10.1016/j.nbd.2023.106286. Epub 2023 Sep 7. PubMed PMID: 37689213; PubMed Central PMCID: PMC10750427.

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Borkowski K, Seyfried NT, Arnold M, Lah JJ, Levey AI, Hales CM, Dammer EB, Blach C, Louie G, Kaddurah-Daouk R, Newman JW. Integration of plasma and CSF metabolomics with CSF proteomic reveals novel associations between lipid mediators and central nervous system vascular and energy metabolism. Sci Rep. 2023 Aug 23;13(1):13752. doi: 10.1038/s41598-023-39737-8. PubMed PMID: 37612324; PubMed Central PMCID: PMC10447532.

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Modeste ES, Ping L, Watson CM, Duong DM, Dammer EB, Johnson ECB, Roberts BR, Lah JJ, Levey AI, Seyfried NT. Quantitative proteomics of cerebrospinal fluid from African Americans and Caucasians reveals shared and divergent changes in Alzheimer's disease. Mol Neurodegener. 2023 Jul 19;18(1):48. doi: 10.1186/s13024-023-00638-z. PubMed PMID: 37468915; PubMed Central PMCID: PMC10355042.

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Sung YJ, Yang C, Norton J, Johnson M, Fagan A, Bateman RJ, Perrin RJ, Morris JC, Farlow MR, Chhatwal JP, Schofield PR, Chui H, Wang F, Novotny B, Eteleeb A, Karch C, Schindler SE, Rhinn H, Johnson ECB, Oh HS, Rutledge JE, Dammer EB, Seyfried NT, Wyss-Coray T, Harari O, Cruchaga C. Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer's disease. Sci Transl Med. 2023 Jul 5;15(703):eabq5923. doi: 10.1126/scitranslmed.abq5923. Epub 2023 Jul 5. PubMed PMID: 37406134; PubMed Central PMCID: PMC10803068.

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Hurst CD, Dunn AR, Dammer EB, Duong DM, Seyfried NT, Kaczorowski CC, Johnson ECB. Genetic background influences the 5XFAD Alzheimer's disease mouse model brain proteome. bioRxiv. 2023 Jun 13;. doi: 10.1101/2023.06.12.544646. PubMed PMID: 37398142; PubMed Central PMCID: PMC10312637.

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Wynne ME, Ogunbona O, Lane AR, Gokhale A, Zlatic SA, Xu C, Wen Z, Duong DM, Rayaprolu S, Ivanova A, Ortlund EA, Dammer EB, Seyfried NT, Roberts BR, Crocker A, Shanbhag V, Petris M, Senoo N, Kandasamy S, Claypool SM, Barrientos A, Wingo A, Wingo TS, Rangaraju S, Levey AI, Werner E, Faundez V. APOE expression and secretion are modulated by mitochondrial dysfunction. Elife. 2023 May 12;12. doi: 10.7554/eLife.85779. PubMed PMID: 37171075; PubMed Central PMCID: PMC10231934.

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Watson CM, Dammer EB, Ping L, Duong DM, Modeste E, Carter EK, Johnson ECB, Levey AI, Lah JJ, Roberts BR, Seyfried NT. Quantitative Mass Spectrometry Analysis of Cerebrospinal Fluid Protein Biomarkers in Alzheimer's Disease. Sci Data. 2023 May 9;10(1):261. doi: 10.1038/s41597-023-02158-3. PubMed PMID: 37160957; PubMed Central PMCID: PMC10170100.

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Ponnusamy M, Wang S, Yuksel M, Hansen MT, Blazier DM, McMillan JD, Zhang X, Dammer EB, Collier L, Thinakaran G. Loss of forebrain BIN1 attenuates hippocampal pathology and neuroinflammation in a tauopathy model. Brain. 2023 Apr 19;146(4):1561-1579. doi: 10.1093/brain/awac318. PubMed PMID: 36059072; PubMed Central PMCID: PMC10319775.

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Sunna S, Bowen C, Zeng H, Rayaprolu S, Kumar P, Bagchi P, Dammer EB, Guo Q, Duong DM, Bitarafan S, Natu A, Wood L, Seyfried NT, Rangaraju S. Cellular Proteomic Profiling Using Proximity Labeling by TurboID-NES in Microglial and Neuronal Cell Lines. Mol Cell Proteomics. 2023 Jun;22(6):100546. doi: 10.1016/j.mcpro.2023.100546. Epub 2023 Apr 14. PubMed PMID: 37061046; PubMed Central PMCID: PMC10205547.