My Bibliography

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Woods PC, Swank DM, Miller MS. Stretch activation combats force loss from fatigue in fast-contracting mouse skeletal muscle fibers. J Gen Physiol. 2025 Sep 1;157(5). doi: 10.1085/jgp.202413679. Epub 2025 Aug 11. PubMed PMID: 40788262; PubMed Central PMCID: PMC12406957.

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Bell KM, Brown AT, Van Houten SK, Blice-Baum AC, Kronert WA, Loya AK, Camillo JRT, Cammarato A, Corr DT, Bernstein SI, Swank DM. A Drosophila cardiac myosin increases jump muscle stretch activation and shortening deactivation. Biophys J. 2025 Feb 18;124(4):651-666. doi: 10.1016/j.bpj.2025.01.001. Epub 2025 Jan 10. PubMed PMID: 39799399; PubMed Central PMCID: PMC11900181.

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Loya AK, Van Houten SK, Glasheen BM, Swank DM. Shortening deactivation: quantifying a critical component of cyclical muscle contraction. Am J Physiol Cell Physiol. 2022 Apr 1;322(4):C653-C665. doi: 10.1152/ajpcell.00281.2021. Epub 2021 Dec 29. PubMed PMID: 34965153; PubMed Central PMCID: PMC8977141.

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Trujillo AS, Hsu KH, Puthawala J, Viswanathan MC, Loya A, Irving TC, Cammarato A, Swank DM, Bernstein SI. Myosin dilated cardiomyopathy mutation S532P disrupts actomyosin interactions, leading to altered muscle kinetics, reduced locomotion, and cardiac dilation in Drosophila. Mol Biol Cell. 2021 Aug 19;32(18):1690-1706. doi: 10.1091/mbc.E21-02-0088. Epub 2021 Jun 3. PubMed PMID: 34081531; PubMed Central PMCID: PMC8684735.

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Jarvis KJ, Bell KM, Loya AK, Swank DM, Walcott S. Force-velocity and tension transient measurements from Drosophila jump muscle reveal the necessity of both weakly-bound cross-bridges and series elasticity in models of muscle contraction. Arch Biochem Biophys. 2021 Apr 15;701:108809. doi: 10.1016/j.abb.2021.108809. Epub 2021 Feb 18. PubMed PMID: 33610561; PubMed Central PMCID: PMC7986577.

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Bell KM, Huang A, Kronert WA, Bernstein SI, Swank DM. Prolonged myosin binding increases muscle stiffness in Drosophila models of Freeman-Sheldon syndrome. Biophys J. 2021 Mar 2;120(5):844-854. doi: 10.1016/j.bpj.2020.12.033. Epub 2021 Jan 30. PubMed PMID: 33524372; PubMed Central PMCID: PMC8008270.

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Guo Y, Kronert WA, Hsu KH, Huang A, Sarsoza F, Bell KM, Suggs JA, Swank DM, Bernstein SI. Drosophila myosin mutants model the disparate severity of type 1 and type 2B distal arthrogryposis and indicate an enhanced actin affinity mechanism. Skelet Muscle. 2020 Aug 15;10(1):24. doi: 10.1186/s13395-020-00241-6. PubMed PMID: 32799913; PubMed Central PMCID: PMC7429702.

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Viswanathan MC, Schmidt W, Franz P, Rynkiewicz MJ, Newhard CS, Madan A, Lehman W, Swank DM, Preller M, Cammarato A. A role for actin flexibility in thin filament-mediated contractile regulation and myopathy. Nat Commun. 2020 May 15;11(1):2417. doi: 10.1038/s41467-020-15922-5. PubMed PMID: 32415060; PubMed Central PMCID: PMC7229152.

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Palmer BM, Swank DM, Miller MS, Tanner BCW, Meyer M, LeWinter MM. Enhancing diastolic function by strain-dependent detachment of cardiac myosin crossbridges. J Gen Physiol. 2020 Apr 6;152(4). doi: 10.1085/jgp.201912484. PubMed PMID: 32197271; PubMed Central PMCID: PMC7141588.

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Straight CR, Bell KM, Slosberg JN, Miller MS, Swank DM. A myosin-based mechanism for stretch activation and its possible role revealed by varying phosphate concentration in fast and slow mouse skeletal muscle fibers. Am J Physiol Cell Physiol. 2019 Dec 1;317(6):C1143-C1152. doi: 10.1152/ajpcell.00206.2019. Epub 2019 Sep 18. PubMed PMID: 31532715; PubMed Central PMCID: PMC6957385.

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Bell KM, Kronert WA, Huang A, Bernstein SI, Swank DM. The R249Q hypertrophic cardiomyopathy myosin mutation decreases contractility in Drosophila by impeding force production. J Physiol. 2019 May;597(9):2403-2420. doi: 10.1113/JP277333. Epub 2019 Apr 4. PubMed PMID: 30950055; PubMed Central PMCID: PMC6487941.

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Newhard CS, Walcott S, Swank DM. The load dependence of muscle's force-velocity curve is modulated by alternative myosin converter domains. Am J Physiol Cell Physiol. 2019 Jun 1;316(6):C844-C861. doi: 10.1152/ajpcell.00494.2018. Epub 2019 Mar 13. PubMed PMID: 30865518; PubMed Central PMCID: PMC6620577.

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Kronert WA, Bell KM, Viswanathan MC, Melkani GC, Trujillo AS, Huang A, Melkani A, Cammarato A, Swank DM, Bernstein SI. Prolonged cross-bridge binding triggers muscle dysfunction in a Drosophila model of myosin-based hypertrophic cardiomyopathy. Elife. 2018 Aug 13;7. doi: 10.7554/eLife.38064. PubMed PMID: 30102150; PubMed Central PMCID: PMC6141233.

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Glasheen BM, Ramanath S, Patel M, Sheppard D, Puthawala JT, Riley LA, Swank DM. Five Alternative Myosin Converter Domains Influence Muscle Power, Stretch Activation, and Kinetics. Biophys J. 2018 Mar 13;114(5):1142-1152. doi: 10.1016/j.bpj.2017.12.045. PubMed PMID: 29539400; PubMed Central PMCID: PMC5883554.

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Glasheen BM, Eldred CC, Sullivan LC, Zhao C, Reedy MK, Edwards RJ, Swank DM. Stretch activation properties of Drosophila and Lethocerus indirect flight muscle suggest similar calcium-dependent mechanisms. Am J Physiol Cell Physiol. 2017 Dec 1;313(6):C621-C631. doi: 10.1152/ajpcell.00110.2017. Epub 2017 Aug 23. PubMed PMID: 28835434; PubMed Central PMCID: PMC5814588.

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Suggs JA, Melkani GC, Glasheen BM, Detor MM, Melkani A, Marsan NP, Swank DM, Bernstein SI. A Drosophila model of dominant inclusion body myopathy type 3 shows diminished myosin kinetics that reduce muscle power and yield myofibrillar defects. Dis Model Mech. 2017 Jun 1;10(6):761-771. doi: 10.1242/dmm.028050. Epub 2017 Mar 3. PubMed PMID: 28258125; PubMed Central PMCID: PMC5483004.

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Zhao C, Swank DM. The Drosophila indirect flight muscle myosin heavy chain isoform is insufficient to transform the jump muscle into a highly stretch-activated muscle type. Am J Physiol Cell Physiol. 2017 Feb 1;312(2):C111-C118. doi: 10.1152/ajpcell.00284.2016. Epub 2016 Nov 23. PubMed PMID: 27881413; PubMed Central PMCID: PMC5336591.

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Achal M, Trujillo AS, Melkani GC, Farman GP, Ocorr K, Viswanathan MC, Kaushik G, Newhard CS, Glasheen BM, Melkani A, Suggs JA, Moore JR, Swank DM, Bodmer R, Cammarato A, Bernstein SI. A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila. J Mol Biol. 2016 Jun 5;428(11):2446-2461. doi: 10.1016/j.jmb.2016.04.021. Epub 2016 Apr 20. PubMed PMID: 27107639; PubMed Central PMCID: PMC4884507.

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Koppes RA, Swank DM, Corr DT. A new experimental model for force enhancement: steady-state and transient observations of the Drosophila jump muscle. Am J Physiol Cell Physiol. 2015 Oct 15;309(8):C551-7. doi: 10.1152/ajpcell.00202.2015. Epub 2015 Aug 19. PubMed PMID: 26289752; PubMed Central PMCID: PMC4609653.

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Eldred CC, Katzemich A, Patel M, Bullard B, Swank DM. The roles of troponin C isoforms in the mechanical function of Drosophila indirect flight muscle. J Muscle Res Cell Motil. 2014 Aug;35(3-4):211-23. doi: 10.1007/s10974-014-9387-8. Epub 2014 Aug 19. PubMed PMID: 25134799; PubMed Central PMCID: PMC4232998.

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Koppes RA, Swank DM, Corr DT. A new experimental model to study force depression: the Drosophila jump muscle. J Appl Physiol (1985). 2014 Jun 15;116(12):1543-50. doi: 10.1152/japplphysiol.01029.2013. Epub 2014 May 1. PubMed PMID: 24790016; PubMed Central PMCID: PMC4064377.

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Wang Q, Newhard CS, Ramanath S, Sheppard D, Swank DM. An embryonic myosin converter domain influences Drosophila indirect flight muscle stretch activation, power generation and flight. J Exp Biol. 2014 Jan 15;217(Pt 2):290-8. doi: 10.1242/jeb.091769. Epub 2013 Oct 10. PubMed PMID: 24115062; PubMed Central PMCID: PMC3898625.

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Zhao C, Swank DM. An embryonic myosin isoform enables stretch activation and cyclical power in Drosophila jump muscle. Biophys J. 2013 Jun 18;104(12):2662-70. doi: 10.1016/j.bpj.2013.04.057. PubMed PMID: 23790374; PubMed Central PMCID: PMC3686345.

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Eldred CC, Naber N, Pate E, Cooke R, Swank DM. Conformational changes at the nucleotide site in the presence of bound ADP do not set the velocity of fast Drosophila myosins. J Muscle Res Cell Motil. 2013 Feb;34(1):35-42. doi: 10.1007/s10974-012-9331-8. Epub 2012 Dec 1. PubMed PMID: 23203294; PubMed Central PMCID: PMC3552063.

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Swank DM. Mechanical analysis of Drosophila indirect flight and jump muscles. Methods. 2012 Jan;56(1):69-77. doi: 10.1016/j.ymeth.2011.10.015. Epub 2011 Nov 7. Review. PubMed PMID: 22079350; PubMed Central PMCID: PMC3288703.

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Wang Q, Zhao C, Swank DM. Calcium and stretch activation modulate power generation in Drosophila flight muscle. Biophys J. 2011 Nov 2;101(9):2207-13. doi: 10.1016/j.bpj.2011.09.034. Epub 2011 Nov 1. PubMed PMID: 22067160; PubMed Central PMCID: PMC3207158.

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Ramanath S, Wang Q, Bernstein SI, Swank DM. Disrupting the myosin converter-relay interface impairs Drosophila indirect flight muscle performance. Biophys J. 2011 Sep 7;101(5):1114-22. doi: 10.1016/j.bpj.2011.07.045. PubMed PMID: 21889448; PubMed Central PMCID: PMC3164139.

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Clark KA, Lesage-Horton H, Zhao C, Beckerle MC, Swank DM. Deletion of Drosophila muscle LIM protein decreases flight muscle stiffness and power generation. Am J Physiol Cell Physiol. 2011 Aug;301(2):C373-82. doi: 10.1152/ajpcell.00206.2010. Epub 2011 May 11. PubMed PMID: 21562304; PubMed Central PMCID: PMC3154547.

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Purcell TJ, Naber N, Franks-Skiba K, Dunn AR, Eldred CC, Berger CL, Málnási-Csizmadia A, Spudich JA, Swank DM, Pate E, Cooke R. Nucleotide pocket thermodynamics measured by EPR reveal how energy partitioning relates myosin speed to efficiency. J Mol Biol. 2011 Mar 18;407(1):79-91. doi: 10.1016/j.jmb.2010.11.053. Epub 2010 Dec 23. PubMed PMID: 21185304; PubMed Central PMCID: PMC3347976.

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Yang C, Kaplan CN, Thatcher ML, Swank DM. The influence of myosin converter and relay domains on cross-bridge kinetics of Drosophila indirect flight muscle. Biophys J. 2010 Sep 8;99(5):1546-55. doi: 10.1016/j.bpj.2010.06.047. PubMed PMID: 20816067; PubMed Central PMCID: PMC2931743.

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Eldred CC, Simeonov DR, Koppes RA, Yang C, Corr DT, Swank DM. The mechanical properties of Drosophila jump muscle expressing wild-type and embryonic Myosin isoforms. Biophys J. 2010 Apr 7;98(7):1218-26. doi: 10.1016/j.bpj.2009.11.051. PubMed PMID: 20371321; PubMed Central PMCID: PMC2849092.

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Miller MS, Dambacher CM, Knowles AF, Braddock JM, Farman GP, Irving TC, Swank DM, Bernstein SI, Maughan DW. Alternative S2 hinge regions of the myosin rod affect myofibrillar structure and myosin kinetics. Biophys J. 2009 May 20;96(10):4132-43. doi: 10.1016/j.bpj.2009.02.034. PubMed PMID: 19450484; PubMed Central PMCID: PMC2712142.

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Yang C, Ramanath S, Kronert WA, Bernstein SI, Maughan DW, Swank DM. Alternative versions of the myosin relay domain differentially respond to load to influence Drosophila muscle kinetics. Biophys J. 2008 Dec;95(11):5228-37. doi: 10.1529/biophysj.108.136192. Epub 2008 Sep 19. PubMed PMID: 18805920; PubMed Central PMCID: PMC2586575.

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Kronert WA, Dambacher CM, Knowles AF, Swank DM, Bernstein SI. Alternative relay domains of Drosophila melanogaster myosin differentially affect ATPase activity, in vitro motility, myofibril structure and muscle function. J Mol Biol. 2008 Jun 6;379(3):443-56. doi: 10.1016/j.jmb.2008.04.010. Epub 2008 Apr 10. PubMed PMID: 18462751; PubMed Central PMCID: PMC2528879.

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Swank DM, Vishnudas VK, Maughan DW. An exceptionally fast actomyosin reaction powers insect flight muscle. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17543-7. doi: 10.1073/pnas.0604972103. Epub 2006 Nov 3. PubMed PMID: 17085600; PubMed Central PMCID: PMC1859965.

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Hao Y, Miller MS, Swank DM, Liu H, Bernstein SI, Maughan DW, Pollack GH. Passive stiffness in Drosophila indirect flight muscle reduced by disrupting paramyosin phosphorylation, but not by embryonic myosin S2 hinge substitution. Biophys J. 2006 Dec 15;91(12):4500-6. doi: 10.1529/biophysj.106.088492. Epub 2006 Sep 29. PubMed PMID: 17012313; PubMed Central PMCID: PMC1779912.

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Swank DM, Braddock J, Brown W, Lesage H, Bernstein SI, Maughan DW. An alternative domain near the ATP binding pocket of Drosophila myosin affects muscle fiber kinetics. Biophys J. 2006 Apr 1;90(7):2427-35. doi: 10.1529/biophysj.105.075184. Epub 2006 Jan 6. PubMed PMID: 16399836; PubMed Central PMCID: PMC1403199.

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Miller BM, Zhang S, Suggs JA, Swank DM, Littlefield KP, Knowles AF, Bernstein SI. An alternative domain near the nucleotide-binding site of Drosophila muscle myosin affects ATPase kinetics. J Mol Biol. 2005 Oct 14;353(1):14-25. doi: 10.1016/j.jmb.2005.08.012. PubMed PMID: 16154586.

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Liu H, Miller MS, Swank DM, Kronert WA, Maughan DW, Bernstein SI. Paramyosin phosphorylation site disruption affects indirect flight muscle stiffness and power generation in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10522-7. doi: 10.1073/pnas.0500945102. Epub 2005 Jul 14. PubMed PMID: 16020538; PubMed Central PMCID: PMC1180758.

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Swank DM, Kronert WA, Bernstein SI, Maughan DW. Alternative N-terminal regions of Drosophila myosin heavy chain tune muscle kinetics for optimal power output. Biophys J. 2004 Sep;87(3):1805-14. doi: 10.1529/biophysj.103.032078. PubMed PMID: 15345559; PubMed Central PMCID: PMC1304585.

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Swank DM, Maughan DW. Rates of force generation in Drosophila fast and slow muscle types have opposite responses to phosphate. Adv Exp Med Biol. 2003;538:459-67; discussion 467-8. doi: 10.1007/978-1-4419-9029-7_42. PubMed PMID: 15098691.

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Swank DM, Knowles AF, Kronert WA, Suggs JA, Morrill GE, Nikkhoy M, Manipon GG, Bernstein SI. Variable N-terminal regions of muscle myosin heavy chain modulate ATPase rate and actin sliding velocity. J Biol Chem. 2003 May 9;278(19):17475-82. doi: 10.1074/jbc.M212727200. Epub 2003 Feb 26. PubMed PMID: 12606545.

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Littlefield KP, Swank DM, Sanchez BM, Knowles AF, Warshaw DM, Bernstein SI. The converter domain modulates kinetic properties of Drosophila myosin. Am J Physiol Cell Physiol. 2003 Apr;284(4):C1031-8. doi: 10.1152/ajpcell.00474.2002. Epub 2002 Dec 11. PubMed PMID: 12477668.

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Swank DM, Knowles AF, Suggs JA, Sarsoza F, Lee A, Maughan DW, Bernstein SI. The myosin converter domain modulates muscle performance. Nat Cell Biol. 2002 Apr;4(4):312-6. doi: 10.1038/ncb776. PubMed PMID: 11901423.

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Swank DM, Rome LC. The influence of thermal acclimation on power production during swimming. II. Mechanics of scup red muscle under in vivo conditions. J Exp Biol. 2001 Feb;204(Pt 3):419-30. doi: 10.1242/jeb.204.3.419. PubMed PMID: 11171295.

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Rome LC, Swank DM. The influence of thermal acclimation on power production during swimming. I. In vivo stimulation and length change pattern of scup red muscle. J Exp Biol. 2001 Feb;204(Pt 3):409-18. doi: 10.1242/jeb.204.3.409. PubMed PMID: 11171294.

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Swank DM, Bartoo ML, Knowles AF, Iliffe C, Bernstein SI, Molloy JE, Sparrow JC. Alternative exon-encoded regions of Drosophila myosin heavy chain modulate ATPase rates and actin sliding velocity. J Biol Chem. 2001 May 4;276(18):15117-24. doi: 10.1074/jbc.M008379200. Epub 2000 Dec 27. PubMed PMID: 11134017.

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Swank DM, Wells L, Kronert WA, Morrill GE, Bernstein SI. Determining structure/function relationships for sarcomeric myosin heavy chain by genetic and transgenic manipulation of Drosophila. Microsc Res Tech. 2000 Sep 15;50(6):430-42. doi: 10.1002/1097-0029(20000915)50:6<430::AID-JEMT2>3.0.CO;2-E. Review. PubMed PMID: 10998634.

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Rome LC, Swank DM, Coughlin DJ. The influence of temperature on power production during swimming. II. Mechanics of red muscle fibres in vivo. J Exp Biol. 2000 Jan;203(Pt 2):333-45. doi: 10.1242/jeb.203.2.333. PubMed PMID: 10607543.

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Swank DM, Rome LC. The influence of temperature on power production during swimming. I. In vivo length change and stimulation pattern. J Exp Biol. 2000 Jan;203(Pt 2):321-31. doi: 10.1242/jeb.203.2.321. PubMed PMID: 10607542.