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Pittet P, Fruh D, Tissieres V, Bunzli J. Isomerization kinetics of lanthanide(III) complexes with the pendant-arm macrocyclic ligand 1,4,7,10-tetrakis(2-hydroxyethyl)-1,4,7,10-tetraazacyclododecane. Journal of the Chemical Society, Dalton Transactions. 1997; (5):895-900. doi: 10.1039/A606117F.
Eykyn TR, Früh D, Bodenhausen G. Identification of spin diffusion pathways in isotopically labeled biomolecules. J Magn Reson. 1999 Jun;138(2):330-3. doi: 10.1006/jmre.1999.1736. PubMed PMID: 10341139.
Früh D, Tolman JR, Bodenhausen G, Zwahlen C. Cross-correlated chemical shift modulation: a signature of slow internal motions in proteins. J Am Chem Soc. 2001 May 23;123(20):4810-6. doi: 10.1021/ja003487k. PubMed PMID: 11457291.
Bytchenkoff D, Chiarparin E, Früh D, Rüdisser S, Bodenhausen G. Temperature dependence of internucleotide nitrogen-nitrogen scalar couplings in RNA. Magnetic resonance in chemistry : MRC. 2002 March; 40(5):377-379. doi: 10.1002/mrc.1018.
Fruh D, Chiarparin E, Pelupessy P, Bodenhausen G. Measurement of long-range cross-correlation rates using a combination of single- and multiple-quantum NMR spectroscopy in one experiment. J Am Chem Soc. 2002 Apr 17;124(15):4050-7. doi: 10.1021/ja011790v. PubMed PMID: 11942843.
Frueh DP. Internal motions in proteins and interference effects in nuclear magnetic resonance. Progress in nuclear magnetic resonance spectroscopy. 2002 December; 41(3-4):305-324. doi: 10.1016/S0079-6565(02)00051-1.
Vugmeyster L, Perazzolo C, Wist J, Frueh D, Bodenhausen G. Evidence of slow motions by cross-correlated chemical shift modulation in deuterated and protonated proteins. J Biomol NMR. 2004 Feb;28(2):173-7. doi: 10.1023/B:JNMR.0000013828.58005.8a. PubMed PMID: 14755161.
Wist J, Frueh D, Tolman JR, Bodenhausen G. Triple quantum decoherence under multiple refocusing: slow correlated chemical shift modulations of C' and N nuclei in proteins. J Biomol NMR. 2004 Mar;28(3):263-72. doi: 10.1023/B:JNMR.0000013699.48099.38. PubMed PMID: 14752259.
Rovnyak D, Frueh DP, Sastry M, Sun ZY, Stern AS, Hoch JC, Wagner G. Accelerated acquisition of high resolution triple-resonance spectra using non-uniform sampling and maximum entropy reconstruction. J Magn Reson. 2004 Sep;170(1):15-21. doi: 10.1016/j.jmr.2004.05.016. PubMed PMID: 15324754.
Frueh DP, Ito T, Li JS, Wagner G, Glaser SJ, Khaneja N. Sensitivity enhancement in NMR of macromolecules by application of optimal control theory. J Biomol NMR. 2005 May;32(1):23-30. doi: 10.1007/s10858-005-3592-0. PubMed PMID: 16041480.
Sun ZY, Frueh DP, Selenko P, Hoch JC, Wagner G. Fast assignment of 15N-HSQC peaks using high-resolution 3D HNcocaNH experiments with non-uniform sampling. J Biomol NMR. 2005 Sep;33(1):43-50. doi: 10.1007/s10858-005-1284-4. PubMed PMID: 16222556.
Frueh DP, Arthanari H, Wagner G. Unambiguous assignment of NMR protein backbone signals with a time-shared triple-resonance experiment. J Biomol NMR. 2005 Nov;33(3):187-96. doi: 10.1007/s10858-005-3204-z. PubMed PMID: 16331423.
Frueh DP, Vosburg DA, Walsh CT, Wagner G. Determination of all nOes in 1H-13C-Me-ILV-U-2H-15N proteins with two time-shared experiments. J Biomol NMR. 2006 Jan;34(1):31-40. doi: 10.1007/s10858-005-5338-4. PubMed PMID: 16505962.
Frueh DP, Sun ZY, Vosburg DA, Walsh CT, Hoch JC, Wagner G. Non-uniformly sampled double-TROSY hNcaNH experiments for NMR sequential assignments of large proteins. J Am Chem Soc. 2006 May 3;128(17):5757-63. doi: 10.1021/ja0584222. PubMed PMID: 16637644; PubMed Central PMCID: PMC2527460.
Gelev V, Aktas H, Marintchev A, Ito T, Frueh D, Hemond M, Rovnyak D, Debus M, Hyberts S, Usheva A, Halperin J, Wagner G. Mapping of the auto-inhibitory interactions of protein kinase R by nuclear magnetic resonance. J Mol Biol. 2006 Dec 1;364(3):352-63. doi: 10.1016/j.jmb.2006.08.077. Epub 2006 Sep 1. PubMed PMID: 17011579; PubMed Central PMCID: PMC3622519.
Marintchev A, Frueh D, Wagner G. NMR methods for studying protein-protein interactions involved in translation initiation. Methods Enzymol. 2007;430:283-331. doi: 10.1016/S0076-6879(07)30012-8. PubMed PMID: 17913643.
Selenko P, Frueh DP, Elsaesser SJ, Haas W, Gygi SP, Wagner G. In situ observation of protein phosphorylation by high-resolution NMR spectroscopy. Nat Struct Mol Biol. 2008 Mar;15(3):321-9. doi: 10.1038/nsmb.1395. Epub 2008 Feb 24. PubMed PMID: 18297086.
Thakur JK, Arthanari H, Yang F, Pan SJ, Fan X, Breger J, Frueh DP, Gulshan K, Li DK, Mylonakis E, Struhl K, Moye-Rowley WS, Cormack BP, Wagner G, Näär AM. A nuclear receptor-like pathway regulating multidrug resistance in fungi. Nature. 2008 Apr 3;452(7187):604-9. doi: 10.1038/nature06836. PubMed PMID: 18385733.
Arthanari H, Frueh D, Wagner G, Pryor B, Khaneja N. Fourier synthesis techniques for NMR spectroscopy in inhomogeneous fields. J Chem Phys. 2008 Jun 7;128(21):214503. doi: 10.1063/1.2927905. PubMed PMID: 18537429.
Rey Castellanos ER, Frueh DP, Wist J. Selective polarization transfer using a single rf field. J Chem Phys. 2008 Jul 7;129(1):014504. doi: 10.1063/1.2939572. PubMed PMID: 18624480.
Koglin A, Löhr F, Bernhard F, Rogov VV, Frueh DP, Strieter ER, Mofid MR, Güntert P, Wagner G, Walsh CT, Marahiel MA, Dötsch V. Structural basis for the selectivity of the external thioesterase of the surfactin synthetase. Nature. 2008 Aug 14;454(7206):907-11. doi: 10.1038/nature07161. PubMed PMID: 18704089; PubMed Central PMCID: PMC2854587.
Frueh DP, Arthanari H, Koglin A, Vosburg DA, Bennett AE, Walsh CT, Wagner G. Dynamic thiolation-thioesterase structure of a non-ribosomal peptide synthetase. Nature. 2008 Aug 14;454(7206):903-6. doi: 10.1038/nature07162. PubMed PMID: 18704088; PubMed Central PMCID: PMC2597408.
Kang S, Kang J, Kwon H, Frueh D, Yoo SH, Wagner G, Park S. Effects of redox potential and Ca2+ on the inositol 1,4,5-trisphosphate receptor L3-1 loop region: implications for receptor regulation. J Biol Chem. 2008 Sep 12;283(37):25567-75. doi: 10.1074/jbc.M803321200. Epub 2008 Jul 17. PubMed PMID: 18635540.
Frueh DP, Arthanari H, Koglin A, Walsh CT, Wagner G. A double TROSY hNCAnH experiment for efficient assignment of large and challenging proteins. J Am Chem Soc. 2009 Sep 16;131(36):12880-1. doi: 10.1021/ja9046685. PubMed PMID: 19702261; PubMed Central PMCID: PMC2749991.
Hyberts SG, Frueh DP, Arthanari H, Wagner G. FM reconstruction of non-uniformly sampled protein NMR data at higher dimensions and optimization by distillation. J Biomol NMR. 2009 Nov;45(3):283-94. doi: 10.1007/s10858-009-9368-1. Epub 2009 Aug 25. PubMed PMID: 19705283; PubMed Central PMCID: PMC2858293.
Frueh DP, Leed A, Arthanari H, Koglin A, Walsh CT, Wagner G. Time-shared HSQC-NOESY for accurate distance constraints measured at high-field in (15)N-(13)C-ILV methyl labeled proteins. J Biomol NMR. 2009 Nov;45(3):311-8. doi: 10.1007/s10858-009-9372-5. PubMed PMID: 19728110; PubMed Central PMCID: PMC2778061.
Takeuchi K, Frueh DP, Hyberts SG, Sun ZY, Wagner G. High-resolution 3D CANCA NMR experiments for complete mainchain assignments using C(alpha) direct detection. J Am Chem Soc. 2010 Mar 10;132(9):2945-51. doi: 10.1021/ja907717b. PubMed PMID: 20155902; PubMed Central PMCID: PMC2832079.
Takeuchi K, Frueh DP, Sun ZY, Hiller S, Wagner G. CACA-TOCSY with alternate 13C-12C labeling: a 13Calpha direct detection experiment for mainchain resonance assignment, dihedral angle information, and amino acid type identification. J Biomol NMR. 2010 May;47(1):55-63. doi: 10.1007/s10858-010-9410-3. Epub 2010 Apr 10. PubMed PMID: 20383561; PubMed Central PMCID: PMC2868269.
Takeuchi K, Heffron G, Sun ZY, Frueh DP, Wagner G. Nitrogen-detected CAN and CON experiments as alternative experiments for main chain NMR resonance assignments. J Biomol NMR. 2010 Aug;47(4):271-82. doi: 10.1007/s10858-010-9430-z. Epub 2010 Jun 17. PubMed PMID: 20556482; PubMed Central PMCID: PMC2946331.
Shaw BF, Arthanari H, Narovlyansky M, Durazo A, Frueh DP, Pollastri MP, Lee A, Bilgicer B, Gygi SP, Wagner G, Whitesides GM. Neutralizing positive charges at the surface of a protein lowers its rate of amide hydrogen exchange without altering its structure or increasing its thermostability. J Am Chem Soc. 2010 Dec 15;132(49):17411-25. doi: 10.1021/ja9067035. Epub 2010 Nov 19. PubMed PMID: 21090618; PubMed Central PMCID: PMC3135700.
Kang S, Kwon H, Wen H, Song Y, Frueh D, Ahn HC, Yoo SH, Wagner G, Park S. Global dynamic conformational changes in the suppressor domain of IP3 receptor by stepwise binding of the two lobes of calmodulin. FASEB J. 2011 Mar;25(3):840-50. doi: 10.1096/fj.10-160705. Epub 2010 Nov 17. PubMed PMID: 21084695.
Crenshaw CM, Wade JE, Arthanari H, Frueh D, Lane BF, Núñez ME. Hidden in plain sight: subtle effects of the 8-oxoguanine lesion on the structure, dynamics, and thermodynamics of a 15-base pair oligodeoxynucleotide duplex. Biochemistry. 2011 Oct 4;50(39):8463-77. doi: 10.1021/bi201007t. Epub 2011 Sep 8. PubMed PMID: 21902242; PubMed Central PMCID: PMC3188433.
Frueh DP, Goodrich AC, Mishra SH, Nichols SR. NMR methods for structural studies of large monomeric and multimeric proteins. Curr Opin Struct Biol. 2013 Oct;23(5):734-9. doi: 10.1016/j.sbi.2013.06.016. Epub 2013 Jul 11. Review. PubMed PMID: 23850141; PubMed Central PMCID: PMC3805735.
Goodrich AC, Nichols SR, Frueh DP. eMagRes. Harris RK, Wasylishen RE, editors. Hoboken, New Jersey: John Wiley & Sons, Ltd; 2014.
Harden BJ, Frueh DP. SARA: a software environment for the analysis of relaxation data acquired with accordion spectroscopy. J Biomol NMR. 2014 Feb;58(2):83-99. doi: 10.1007/s10858-013-9807-x. Epub 2014 Jan 10. PubMed PMID: 24408364; PubMed Central PMCID: PMC4075063.
Frueh DP. Practical aspects of NMR signal assignment in larger and challenging proteins. Prog Nucl Magn Reson Spectrosc. 2014 Apr;78:47-75. doi: 10.1016/j.pnmrs.2013.12.001. Epub 2013 Dec 15. Review. PubMed PMID: 24534088; PubMed Central PMCID: PMC3951217.
Harden BJ, Nichols SR, Frueh DP. Facilitated assignment of large protein NMR signals with covariance sequential spectra using spectral derivatives. J Am Chem Soc. 2014 Sep 24;136(38):13106-9. doi: 10.1021/ja5058407. Epub 2014 Sep 16. PubMed PMID: 25226241; PubMed Central PMCID: PMC4183633.
Mishra SH, Harden BJ, Frueh DP. A 3D time-shared NOESY experiment designed to provide optimal resolution for accurate assignment of NMR distance restraints in large proteins. J Biomol NMR. 2014 Dec;60(4):265-74. doi: 10.1007/s10858-014-9873-8. Epub 2014 Nov 9. PubMed PMID: 25381567; PubMed Central PMCID: PMC4245328.
Goodrich AC, Frueh DP. A nuclear magnetic resonance method for probing molecular influences of substrate loading in nonribosomal peptide synthetase carrier proteins. Biochemistry. 2015 Feb 10;54(5):1154-6. doi: 10.1021/bi501433r. Epub 2015 Jan 29. PubMed PMID: 25620398; PubMed Central PMCID: PMC4378656.
Mishra SH, Frueh DP. Assignment of methyl NMR resonances of a 52 kDa protein with residue-specific 4D correlation maps. J Biomol NMR. 2015 Jul;62(3):281-90. doi: 10.1007/s10858-015-9943-6. Epub 2015 May 8. PubMed PMID: 25953312; PubMed Central PMCID: PMC4496284.
Goodrich AC, Harden BJ, Frueh DP. Solution Structure of a Nonribosomal Peptide Synthetase Carrier Protein Loaded with Its Substrate Reveals Transient, Well-Defined Contacts. J Am Chem Soc. 2015 Sep 23;137(37):12100-9. doi: 10.1021/jacs.5b07772. Epub 2015 Sep 15. PubMed PMID: 26334259; PubMed Central PMCID: PMC4689197.
Harden BJ, Mishra SH, Frueh DP. Effortless assignment with 4D covariance sequential correlation maps. J Magn Reson. 2015 Nov;260:83-8. doi: 10.1016/j.jmr.2015.09.007. Epub 2015 Sep 21. PubMed PMID: 26432397; PubMed Central PMCID: PMC4628886.
Craik DJ, Horne J, Scanlon MJ, Nichols SR, Frueh DP. Multidimensional Nuclear Magnetic Resonance of Biomolecules . In: Encyclopedia of Analytical Chemistry. New York City, NY: John Wiley & Sons, Ltd; 2016. p.1-26.
Zeng H, Xu J, Yadav NN, McMahon MT, Harden B, Frueh D, van Zijl PC. (15)N Heteronuclear Chemical Exchange Saturation Transfer MRI. J Am Chem Soc. 2016 Sep 7;138(35):11136-9. doi: 10.1021/jacs.6b06421. Epub 2016 Aug 26. PubMed PMID: 27548755.
Harden BJ, Frueh DP. Molecular Cross-Talk between Nonribosomal Peptide Synthetase Carrier Proteins and Unstructured Linker Regions. Chembiochem. 2017 Apr 4;18(7):629-632. doi: 10.1002/cbic.201700030. Epub 2017 Feb 22. PubMed PMID: 28120469; PubMed Central PMCID: PMC5380562.
Goodrich AC, Meyers DJ, Frueh DP. Molecular impact of covalent modifications on nonribosomal peptide synthetase carrier protein communication. J Biol Chem. 2017 Jun 16;292(24):10002-10013. doi: 10.1074/jbc.M116.766220. Epub 2017 Apr 28. PubMed PMID: 28455448; PubMed Central PMCID: PMC5473208.
Harden BJ, Frueh DP. Covariance NMR Processing and Analysis for Protein Assignment. Methods Mol Biol. 2018;1688:353-373. doi: 10.1007/978-1-4939-7386-6_16. PubMed PMID: 29151217.
Kancherla AK, Frueh DP. Covariance nuclear magnetic resonance methods for obtaining protein assignments and novel correlations. Concepts Magn Reson Part A Bridg Educ Res. 2017 Mar;46A(2). doi: 10.1002/cmr.a.21437. Epub 2018 Sep 16. PubMed PMID: 30288152; PubMed Central PMCID: PMC6167751.
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