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Karagöz GE, Acosta-Alvear D, Walter P. The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum. Cold Spring Harb Perspect Biol. 2019 Sep 3;11(9). doi: 10.1101/cshperspect.a033886. Review. PubMed PMID: 30670466; PubMed Central PMCID: PMC6719602.
Harnoss JM, Le Thomas A, Shemorry A, Marsters SA, Lawrence DA, Lu M, Chen YA, Qing J, Totpal K, Kan D, Segal E, Merchant M, Reichelt M, Ackerly Wallweber H, Wang W, Clark K, Kaufman S, Beresini MH, Laing ST, Sandoval W, Lorenzo M, Wu J, Ly J, De Bruyn T, Heidersbach A, Haley B, Gogineni A, Weimer RM, Lee D, Braun MG, Rudolph J, VanWyngarden MJ, Sherbenou DW, Gomez-Bougie P, Amiot M, Acosta-Alvear D, Walter P, Ashkenazi A. Disruption of IRE1α through its kinase domain attenuates multiple myeloma. Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16420-16429. doi: 10.1073/pnas.1906999116. Epub 2019 Aug 1. PubMed PMID: 31371506; PubMed Central PMCID: PMC6697881.
Acosta-Alvear D, Karagöz GE, Fröhlich F, Li H, Walther TC, Walter P. The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1. Elife. 2018 Dec 24;7. doi: 10.7554/eLife.43036. PubMed PMID: 30582518; PubMed Central PMCID: PMC6336407.
Karagöz GE, Acosta-Alvear D, Nguyen HT, Lee CP, Chu F, Walter P. An unfolded protein-induced conformational switch activates mammalian IRE1. Elife. 2017 Oct 3;6. doi: 10.7554/eLife.30700. PubMed PMID: 28971800; PubMed Central PMCID: PMC5699868.
Tufanli O, Telkoparan Akillilar P, Acosta-Alvear D, Kocaturk B, Onat UI, Hamid SM, Çimen I, Walter P, Weber C, Erbay E. Targeting IRE1 with small molecules counteracts progression of atherosclerosis. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1395-E1404. doi: 10.1073/pnas.1621188114. Epub 2017 Jan 30. PubMed PMID: 28137856; PubMed Central PMCID: PMC5338400.
Sherbenou DW, Aftab BT, Su Y, Behrens CR, Wiita A, Logan AC, Acosta-Alvear D, Hann BC, Walter P, Shuman MA, Wu X, Atkinson JP, Wolf JL, Martin TG, Liu B. Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells. J Clin Invest. 2016 Dec 1;126(12):4640-4653. doi: 10.1172/JCI85856. Epub 2016 Nov 14. PubMed PMID: 27841764; PubMed Central PMCID: PMC5127683.
Peschek J, Acosta-Alvear D, Mendez AS, Walter P. A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing. EMBO Rep. 2015 Dec;16(12):1688-98. doi: 10.15252/embr.201540955. Epub 2015 Oct 19. PubMed PMID: 26483401; PubMed Central PMCID: PMC4687415.
Acosta-Alvear D, Cho MY, Wild T, Buchholz TJ, Lerner AG, Simakova O, Hahn J, Korde N, Landgren O, Maric I, Choudhary C, Walter P, Weissman JS, Kampmann M. Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits. Elife. 2015 Sep 1;4:e08153. doi: 10.7554/eLife.08153. PubMed PMID: 26327694; PubMed Central PMCID: PMC4602331.
Mendez AS, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV, Bernales S, Shokat KM, Walter P. Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic. Elife. 2015 May 19;4. doi: 10.7554/eLife.05434. PubMed PMID: 25986605; PubMed Central PMCID: PMC4436593.
Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki JE. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol Cancer Ther. 2015 Mar;14(3):642-8. doi: 10.1158/1535-7163.MCT-14-0650. Epub 2015 Jan 6. PubMed PMID: 25564440; PubMed Central PMCID: PMC4456214.
Lu M, Lawrence DA, Marsters S, Acosta-Alvear D, Kimmig P, Mendez AS, Paton AW, Paton JC, Walter P, Ashkenazi A. Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis. Science. 2014 Jul 4;345(6192):98-101. doi: 10.1126/science.1254312. PubMed PMID: 24994655; PubMed Central PMCID: PMC4284148.
Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn BR, Li H, Gamache K, Gallagher CM, Ang KK, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin MR, Renslo AR, Sonenberg N, Walter P. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife. 2013 May 28;2:e00498. doi: 10.7554/eLife.00498. PubMed PMID: 23741617; PubMed Central PMCID: PMC3667625.
Behrman S, Acosta-Alvear D, Walter P. A CHOP-regulated microRNA controls rhodopsin expression. J Cell Biol. 2011 Mar 21;192(6):919-27. doi: 10.1083/jcb.201010055. Epub 2011 Mar 14. PubMed PMID: 21402790; PubMed Central PMCID: PMC3063143.
Tsikitis M, Acosta-Alvear D, Blais A, Campos EI, Lane WS, Sánchez I, Dynlacht BD. Traf7, a MyoD1 transcriptional target, regulates nuclear factor-κB activity during myogenesis. EMBO Rep. 2010 Dec;11(12):969-76. doi: 10.1038/embor.2010.154. Epub 2010 Oct 15. PubMed PMID: 20948544; PubMed Central PMCID: PMC2999857.
Asp P, Acosta-Alvear D, Tsikitis M, van Oevelen C, Dynlacht BD. E2f3b plays an essential role in myogenic differentiation through isoform-specific gene regulation. Genes Dev. 2009 Jan 1;23(1):37-53. doi: 10.1101/gad.1727309. PubMed PMID: 19136625; PubMed Central PMCID: PMC2632163.
Blais A, van Oevelen CJ, Margueron R, Acosta-Alvear D, Dynlacht BD. Retinoblastoma tumor suppressor protein-dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exit. J Cell Biol. 2007 Dec 31;179(7):1399-412. doi: 10.1083/jcb.200705051. PubMed PMID: 18166651; PubMed Central PMCID: PMC2373492.
Acosta-Alvear D, Zhou Y, Blais A, Tsikitis M, Lents NH, Arias C, Lennon CJ, Kluger Y, Dynlacht BD. XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks. Mol Cell. 2007 Jul 6;27(1):53-66. doi: 10.1016/j.molcel.2007.06.011. PubMed PMID: 17612490.
Blais A, Tsikitis M, Acosta-Alvear D, Sharan R, Kluger Y, Dynlacht BD. An initial blueprint for myogenic differentiation. Genes Dev. 2005 Mar 1;19(5):553-69. doi: 10.1101/gad.1281105. Epub 2005 Feb 10. PubMed PMID: 15706034; PubMed Central PMCID: PMC551576.
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