My Bibliography

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Betsou F, Chuaqui R, De-Wilde A, Grizzle W, Kiehntopf M, Linsen L, Mathieson W, Moldovan I, Aguilar-Quesada R, Shea K, Singh P, Somiari S, Spyropoulos D, Tayal J, Tebbakha R, Valyi-Nagy K, Wadhwa L. Standard PREanalytical Code Version 4.0. Biopreserv Biobank. 2025 Aug;23(4):328-332. doi: 10.1089/bio.2024.0010. Epub 2024 Aug 12. PubMed PMID: 39133809; PubMed Central PMCID: PMC12416493.

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Temkin AM, Evans S, Spyropoulos DD, Naidenko OV. A pilot study of chlormequat in food and urine from adults in the United States from 2017 to 2023. J Expo Sci Environ Epidemiol. 2024 Mar;34(2):317-321. doi: 10.1038/s41370-024-00643-4. Epub 2024 Feb 15. PubMed PMID: 38355783; PubMed Central PMCID: PMC11142907.

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Nair-Menon J, Daulagala AC, Connor DM, Rutledge L, Penix T, Bridges MC, Wellslager B, Spyropoulos DD, Timmers CD, Broome AM, Kourtidis A. Predominant Distribution of the RNAi Machinery at Apical Adherens Junctions in Colonic Epithelia Is Disrupted in Cancer. Int J Mol Sci. 2020 Apr 7;21(7). doi: 10.3390/ijms21072559. PubMed PMID: 32272708; PubMed Central PMCID: PMC7177752.

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Bowers RR, Delaney JR, Spyropoulos DD. Treating the Disease, Not the Symptom: Beyond NSAIDs. Trends Cancer. 2020 May;6(5):363-365. doi: 10.1016/j.trecan.2020.02.008. Epub 2020 Mar 12. PubMed PMID: 32348732.

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McNabb NA, Bernhard MC, Brunell A, Lowers RH, Katsu Y, Spyropoulos DD, Kohno S. Oil dispersant Corexit 9500 is weakly estrogenic, but does not skew the sex ratio in Alligator mississippiensis. J Appl Toxicol. 2020 Feb;40(2):245-256. doi: 10.1002/jat.3900. Epub 2019 Sep 4. PubMed PMID: 31486105.

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Temkin AM, Bowers RR, Ulmer CZ, Penta K, Bowden JA, Nyland J, Baatz JE, Spyropoulos DD. Increased adiposity, inflammation, metabolic disruption and dyslipidemia in adult male offspring of DOSS treated C57BL/6 dams. Sci Rep. 2019 Feb 6;9(1):1530. doi: 10.1038/s41598-018-38383-9. PubMed PMID: 30728429; PubMed Central PMCID: PMC6365642.

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Betsou F, Bilbao R, Case J, Chuaqui R, Clements JA, De Souza Y, De Wilde A, Geiger J, Grizzle W, Guadagni F, Gunter E, Heil S, Kiehntopf M, Koppandi I, Lehmann S, Linsen L, Mackenzie-Dodds J, Quesada RA, Tebbakha R, Selander T, Shea K, Sobel M, Somiari S, Spyropoulos D, Stone M, Tybring G, Valyi-Nagy K, Wadhwa L. Standard PREanalytical Code Version 3.0. Biopreserv Biobank. 2018 Feb;16(1):9-12. doi: 10.1089/bio.2017.0109. Epub 2018 Jan 29. PubMed PMID: 29377712; PubMed Central PMCID: PMC11708182.

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Wang K, Xu R, Schrandt J, Shah P, Gong YZ, Preston C, Wang L, Yi JK, Lin CL, Sun W, Spyropoulos DD, Rhee S, Li M, Zhou J, Ge S, Zhang G, Snider AJ, Hannun YA, Obeid LM, Mao C. Correction: Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain. PLoS Genet. 2018 Jan;14(1):e1007190. doi: 10.1371/journal.pgen.1007190. eCollection 2018 Jan. PubMed PMID: 29360825; PubMed Central PMCID: PMC5779643.

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Williams CE, McNabb NA, Brunell A, Lowers RH, Katsu Y, Spyropoulos DD, Kohno S. Feminizing effects of exposure to Corexit-enhanced water-accommodated fraction of crude oil in vitro on sex determination in Alligator mississippiensis. Gen Comp Endocrinol. 2018 Sep 1;265:46-55. doi: 10.1016/j.ygcen.2017.11.019. Epub 2017 Dec 5. PubMed PMID: 29208362.

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Wu M, Ingram L, Tolosa EJ, Vera RE, Li Q, Kim S, Ma Y, Spyropoulos DD, Beharry Z, Huang J, Fernandez-Zapico ME, Cai H. Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis. J Biol Chem. 2016 Dec 2;291(49):25749-25760. doi: 10.1074/jbc.M116.753129. Epub 2016 Oct 19. PubMed PMID: 27760825; PubMed Central PMCID: PMC5207270.

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Toyota K, McNabb NA, Spyropoulos DD, Iguchi T, Kohno S. Toxic effects of chemical dispersant Corexit 9500 on water flea Daphnia magna. J Appl Toxicol. 2017 Feb;37(2):201-206. doi: 10.1002/jat.3343. Epub 2016 May 25. PubMed PMID: 27225887.

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Bowers RR, Temkin AM, Guillette LJ, Baatz JE, Spyropoulos DD. The commonly used nonionic surfactant Span 80 has RXRα transactivation activity, which likely increases the obesogenic potential of oil dispersants and food emulsifiers. Gen Comp Endocrinol. 2016 Nov 1;238:61-68. doi: 10.1016/j.ygcen.2016.04.029. Epub 2016 Apr 27. PubMed PMID: 27131391.

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Betsou F, Bulla A, Cho SY, Clements J, Chuaqui R, Coppola D, De Souza Y, De Wilde A, Grizzle W, Guadagni F, Gunter E, Heil S, Hodgkinson V, Kessler J, Kiehntopf M, Kim HS, Koppandi I, Shea K, Singh R, Sobel M, Somiari S, Spyropoulos D, Stone M, Tybring G, Valyi-Nagy K, Van den Eynden G, Wadhwa L. Assays for Qualification and Quality Stratification of Clinical Biospecimens Used in Research: A Technical Report from the ISBER Biospecimen Science Working Group. Biopreserv Biobank. 2016 Oct;14(5):398-409. doi: 10.1089/bio.2016.0018. Epub 2016 Apr 5. PubMed PMID: 27046294; PubMed Central PMCID: PMC5896556.

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Bilir B, Osunkoya AO, Wiles WG 4th, Sannigrahi S, Lefebvre V, Metzger D, Spyropoulos DD, Martin WD, Moreno CS. SOX4 Is Essential for Prostate Tumorigenesis Initiated by PTEN Ablation. Cancer Res. 2016 Mar 1;76(5):1112-21. doi: 10.1158/0008-5472.CAN-15-1868. Epub 2015 Dec 23. PubMed PMID: 26701805; PubMed Central PMCID: PMC4779598.

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Wang K, Xu R, Schrandt J, Shah P, Gong YZ, Preston C, Wang L, Yi JK, Lin CL, Sun W, Spyropoulos DD, Rhee S, Li M, Zhou J, Ge S, Zhang G, Snider AJ, Hannun YA, Obeid LM, Mao C. Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain. PLoS Genet. 2015 Oct;11(10):e1005591. doi: 10.1371/journal.pgen.1005591. eCollection 2015 Oct. PubMed PMID: 26474409; PubMed Central PMCID: PMC4608763.

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Temkin AM, Bowers RR, Magaletta ME, Holshouser S, Maggi A, Ciana P, Guillette LJ, Bowden JA, Kucklick JR, Baatz JE, Spyropoulos DD. Effects of Crude Oil/Dispersant Mixture and Dispersant Components on PPARγ Activity in Vitro and in Vivo: Identification of Dioctyl Sodium Sulfosuccinate (DOSS; CAS #577-11-7) as a Probable Obesogen. Environ Health Perspect. 2016 Jan;124(1):112-9. doi: 10.1289/ehp.1409672. Epub 2015 Jul 2. PubMed PMID: 26135921; PubMed Central PMCID: PMC4710608.

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Lottes RG, Newton DA, Spyropoulos DD, Baatz JE. Lactate as substrate for mitochondrial respiration in alveolar epithelial type II cells. Am J Physiol Lung Cell Mol Physiol. 2015 May 1;308(9):L953-61. doi: 10.1152/ajplung.00335.2014. Epub 2015 Mar 6. PubMed PMID: 25747963; PubMed Central PMCID: PMC4421781.

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Wiles WG 4th, Mou Z, Du Y, Long AB, Scharer CD, Bilir B, Spyropoulos DD, Jenkins NA, Copeland NG, Martin WD, Moreno CS. Mutation of murine Sox4 untranslated regions results in partially penetrant perinatal lethality. In Vivo. 2014 Sep-Oct;28(5):709-18. PubMed PMID: 25189881; PubMed Central PMCID: PMC4237010.

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Shojaii R, Bacopulos S, Yang W, Karavardanyan T, Spyropoulos D, Raouf A, Martel A, Seth A. Reconstruction of 3-dimensional histology volume and its application to study mouse mammary glands. J Vis Exp. 2014 Jul 26;(89):e51325. doi: 10.3791/51325. PubMed PMID: 25145969; PubMed Central PMCID: PMC4415371.

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Baatz JE, Newton DA, Riemer EC, Denlinger CE, Jones EE, Drake RR, Spyropoulos DD. Cryopreservation of viable human lung tissue for versatile post-thaw analyses and culture. In Vivo. 2014 Jul-Aug;28(4):411-23. PubMed PMID: 24982205; PubMed Central PMCID: PMC5937261.

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Atanelishvili I, Liang J, Akter T, Spyropoulos DD, Silver RM, Bogatkevich GS. Thrombin increases lung fibroblast survival while promoting alveolar epithelial cell apoptosis via the endoplasmic reticulum stress marker, CCAAT enhancer-binding homologous protein. Am J Respir Cell Mol Biol. 2014 May;50(5):893-902. doi: 10.1165/rcmb.2013-0317OC. PubMed PMID: 24279877; PubMed Central PMCID: PMC4068946.

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Lottes RG, Newton DA, Spyropoulos DD, Baatz JE. Alveolar type II cells maintain bioenergetic homeostasis in hypoxia through metabolic and molecular adaptation. Am J Physiol Lung Cell Mol Physiol. 2014 May 15;306(10):L947-55. doi: 10.1152/ajplung.00298.2013. Epub 2014 Mar 28. PubMed PMID: 24682450; PubMed Central PMCID: PMC4025059.

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Temkin AM, Spyropoulos DD. Induced pluripotent stem cell technology and aquatic animal species. Comp Biochem Physiol C Toxicol Pharmacol. 2014 Jun;163:3-13. doi: 10.1016/j.cbpc.2014.02.003. Epub 2014 Feb 15. Review. PubMed PMID: 24548888.

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Chatterjee S, Bacopulos S, Yang W, Amemiya Y, Spyropoulos D, Raouf A, Seth A. Loss of Igfbp7 causes precocious involution in lactating mouse mammary gland. PLoS One. 2014;9(2):e87858. doi: 10.1371/journal.pone.0087858. eCollection 2014. PubMed PMID: 24505323; PubMed Central PMCID: PMC3913705.

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Sutter AG, Palanisamy AP, Kurtz N, Spyropoulos DD, Chavin KD. Efficient method of genotyping ob/ob mice using high resolution melting analysis. PLoS One. 2013;8(11):e78840. doi: 10.1371/journal.pone.0078840. eCollection 2013. PubMed PMID: 24236058; PubMed Central PMCID: PMC3827293.

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Annalaura Mancia, Spyropoulos DD, McFee WE, Newton DA, Baatz JE. Cryopreservation and in vitro culture of primary cell types from lung tissue of a stranded pygmy sperm whale (Kogia breviceps). Comp Biochem Physiol C Toxicol Pharmacol. 2012 Jan;155(1):136-42. doi: 10.1016/j.cbpc.2011.04.002. Epub 2011 Apr 9. PubMed PMID: 21501697; PubMed Central PMCID: PMC3158290.

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Moussa O, LaRue AC, Abangan RS Jr, Williams CR, Zhang XK, Masuya M, Gong YZ, Spyropoulos DD, Ogawa M, Gilkeson G, Watson DK. Thrombocytopenia in mice lacking the carboxy-terminal regulatory domain of the Ets transcription factor Fli1. Mol Cell Biol. 2010 Nov;30(21):5194-206. doi: 10.1128/MCB.01112-09. Epub 2010 Sep 7. PubMed PMID: 20823267; PubMed Central PMCID: PMC2953061.

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Grek CL, Newton DA, Spyropoulos DD, Baatz JE. Hypoxia up-regulates expression of hemoglobin in alveolar epithelial cells. Am J Respir Cell Mol Biol. 2011 Apr;44(4):439-47. doi: 10.1165/rcmb.2009-0307OC. Epub 2010 May 27. PubMed PMID: 20508070; PubMed Central PMCID: PMC3095918.

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Grek CL, Newton DA, Qiu Y, Wen X, Spyropoulos DD, Baatz JE. Characterization of alveolar epithelial cells cultured in semipermeable hollow fibers. Exp Lung Res. 2009 Mar;35(2):155-74. doi: 10.1080/01902140802495870. PubMed PMID: 19263283; PubMed Central PMCID: PMC3366342.

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Ellett JD, Evans ZP, Zhang G, Chavin KD, Spyropoulos DD. A rapid PCR-based method for the identification of ob mutant mice. Obesity (Silver Spring). 2009 Feb;17(2):402-4. doi: 10.1038/oby.2008.443. Epub 2008 Oct 23. PubMed PMID: 18948969.

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Zhang XK, Moussa O, LaRue A, Bradshaw S, Molano I, Spyropoulos DD, Gilkeson GS, Watson DK. The transcription factor Fli-1 modulates marginal zone and follicular B cell development in mice. J Immunol. 2008 Aug 1;181(3):1644-54. doi: 10.4049/jimmunol.181.3.1644. PubMed PMID: 18641300; PubMed Central PMCID: PMC2504761.

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McCabe CD, Spyropoulos DD, Martin D, Moreno CS. Genome-wide analysis of the homeobox C6 transcriptional network in prostate cancer. Cancer Res. 2008 Mar 15;68(6):1988-96. doi: 10.1158/0008-5472.CAN-07-5843. PubMed PMID: 18339881; PubMed Central PMCID: PMC2584783.

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Higuchi T, Bartel FO, Masuya M, Deguchi T, Henderson KW, Li R, Muise-Helmericks RC, Kern MJ, Watson DK, Spyropoulos DD. Thymomegaly, microsplenia, and defective homeostatic proliferation of peripheral lymphocytes in p51-Ets1 isoform-specific null mice. Mol Cell Biol. 2007 May;27(9):3353-66. doi: 10.1128/MCB.01871-06. Epub 2007 Mar 5. PubMed PMID: 17339335; PubMed Central PMCID: PMC1899970.

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Schweinfest CW, Spyropoulos DD, Henderson KW, Kim JH, Chapman JM, Barone S, Worrell RT, Wang Z, Soleimani M. slc26a3 (dra)-deficient mice display chloride-losing diarrhea, enhanced colonic proliferation, and distinct up-regulation of ion transporters in the colon. J Biol Chem. 2006 Dec 8;281(49):37962-71. doi: 10.1074/jbc.M607527200. Epub 2006 Sep 25. PubMed PMID: 17001077.

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Smith BT, Mussell JC, Fleming PA, Barth JL, Spyropoulos DD, Cooley MA, Drake CJ, Argraves WS. Targeted disruption of cubilin reveals essential developmental roles in the structure and function of endoderm and in somite formation. BMC Dev Biol. 2006 Jun 20;6:30. doi: 10.1186/1471-213X-6-30. PubMed PMID: 16787536; PubMed Central PMCID: PMC1533814.

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Burger AM, Leyland-Jones B, Banerjee K, Spyropoulos DD, Seth AK. Essential roles of IGFBP-3 and IGFBP-rP1 in breast cancer. Eur J Cancer. 2005 Jul;41(11):1515-27. doi: 10.1016/j.ejca.2005.04.023. Review. PubMed PMID: 15979304.

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Mitas M, Almeida JS, Mikhitarian K, Gillanders WE, Lewin DN, Spyropoulos DD, Hoover L, Graham A, Glenn T, King P, Cole DJ, Hawes R, Reed CE, Hoffman BJ. Accurate discrimination of Barrett's esophagus and esophageal adenocarcinoma using a quantitative three-tiered algorithm and multimarker real-time reverse transcription-PCR. Clin Cancer Res. 2005 Mar 15;11(6):2205-14. doi: 10.1158/1078-0432.CCR-04-1091. PubMed PMID: 15788668.

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Grund EM, Spyropoulos DD, Watson DK, Muise-Helmericks RC. Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells. J Biol Chem. 2005 Feb 11;280(6):4772-8. doi: 10.1074/jbc.M408356200. Epub 2004 Nov 23. PubMed PMID: 15563472.

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Zhang XK, Gallant S, Molano I, Moussa OM, Ruiz P, Spyropoulos DD, Watson DK, Gilkeson G. Decreased expression of the Ets family transcription factor Fli-1 markedly prolongs survival and significantly reduces renal disease in MRL/lpr mice. J Immunol. 2004 Nov 15;173(10):6481-9. doi: 10.4049/jimmunol.173.10.6481. PubMed PMID: 15528390.

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Masuya M, Moussa O, Abe T, Deguchi T, Higuchi T, Ebihara Y, Spyropoulos DD, Watson DK, Ogawa M. Dysregulation of granulocyte, erythrocyte, and NK cell lineages in Fli-1 gene-targeted mice. Blood. 2005 Jan 1;105(1):95-102. doi: 10.1182/blood-2003-12-4345. Epub 2004 Sep 14. PubMed PMID: 15367440.

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Maroulakou IG, Spyropoulos DD. The study of HOX gene function in hematopoietic, breast and lung carcinogenesis. Anticancer Res. 2003 May-Jun;23(3A):2101-10. Review. PubMed PMID: 12894584.

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Spyropoulos DD, Bartel FO, Higuchi T, Deguchi T, Ogawa M, Watson DK. Marker-assisted study of genetic background and gene-targeted locus modifiers in lymphopoietic phenotypes. Anticancer Res. 2003 May-Jun;23(3A):2015-26. Review. PubMed PMID: 12894574.

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Kawada H, Ito T, Pharr PN, Spyropoulos DD, Watson DK, Ogawa M. Defective megakaryopoiesis and abnormal erythroid development in Fli-1 gene-targeted mice. Int J Hematol. 2001 Jun;73(4):463-468. doi: 10.1007/BF02994008. PubMed PMID: 11503960.

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Bartel FO, Higuchi T, Spyropoulos DD. Mouse models in the study of the Ets family of transcription factors. Oncogene. 2000 Dec 18;19(55):6443-54. doi: 10.1038/sj.onc.1204038. Review. PubMed PMID: 11175360.

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Garcia-Gasca A, Spyropoulos DD. Differential mammary morphogenesis along the anteroposterior axis in Hoxc6 gene targeted mice. Dev Dyn. 2000 Oct;219(2):261-76. doi: 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1048>3.0.CO;2-3. PubMed PMID: 11002345.

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Spyropoulos DD, Pharr PN, Lavenburg KR, Jackers P, Papas TS, Ogawa M, Watson DK. Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the Fli1 transcription factor. Mol Cell Biol. 2000 Aug;20(15):5643-52. doi: 10.1128/MCB.20.15.5643-5652.2000. PubMed PMID: 10891501; PubMed Central PMCID: PMC86032.

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Rogner UC, Spyropoulos DD, Le Novère N, Changeux JP, Avner P. Control of neurulation by the nucleosome assembly protein-1-like 2. Nat Genet. 2000 Aug;25(4):431-5. doi: 10.1038/78124. PubMed PMID: 10932189.

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de la Cruz CC, Der-Avakian A, Spyropoulos DD, Tieu DD, Carpenter EM. Targeted disruption of Hoxd9 and Hoxd10 alters locomotor behavior, vertebral identity, and peripheral nervous system development. Dev Biol. 1999 Dec 15;216(2):595-610. doi: 10.1006/dbio.1999.9528. PubMed PMID: 10642795.

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Papas TS, Bhat NK, Spyropoulos DD, Mjaatvedt AE, Vournakis J, Seth A, Watson DK. Functional relationships among ETS gene family members. Leukemia. 1997 Apr;11 Suppl 3:557-66. Review. PubMed PMID: 9209455.

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Spyropoulos DD, Capecchi MR. Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus. Genes Dev. 1994 Aug 15;8(16):1949-61. doi: 10.1101/gad.8.16.1949. PubMed PMID: 7958869.