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Gerdes HJ, Yang M, Heisner JS, Camara AKS, Stowe DF. Modulation of peroxynitrite produced via mitochondrial nitric oxide synthesis during Ca2+ and succinate-induced oxidative stress in cardiac isolated mitochondria. Biochim Biophys Acta Bioenerg. 2020 Dec 1;1861(12):148290. doi: 10.1016/j.bbabio.2020.148290. Epub 2020 Aug 20. PubMed PMID: 32828729; PubMed Central PMCID: PMC7560995.
Natarajan GK, Glait L, Mishra J, Stowe DF, Camara AKS, Kwok WM. Total Matrix Ca2+ Modulates Ca2+ Efflux via the Ca2+/H+ Exchanger in Cardiac Mitochondria. Front Physiol. 2020;11:510600. doi: 10.3389/fphys.2020.510600. eCollection 2020. PubMed PMID: 33041851; PubMed Central PMCID: PMC7526510.
Yang M, Sun J, Stowe DF, Tajkhorshid E, Kwok WM, Camara AKS. Knockout of VDAC1 in H9c2 Cells Promotes Oxidative Stress-Induced Cell Apoptosis through Decreased Mitochondrial Hexokinase II Binding and Enhanced Glycolytic Stress. Cell Physiol Biochem. 2020 Sep 9;54(5):853-874. doi: 10.33594/000000274. PubMed PMID: 32901466; PubMed Central PMCID: PMC7898235.
Riess ML, Elorbany R, Weihrauch D, Stowe DF, Camara AKS. PPARγ-Independent Side Effects of Thiazolidinediones on Mitochondrial Redox State in Rat Isolated Hearts. Cells. 2020 Jan 20;9(1). doi: 10.3390/cells9010252. PubMed PMID: 31968546; PubMed Central PMCID: PMC7017211.
Mishra J, Davani AJ, Natarajan GK, Kwok WM, Stowe DF, Camara AKS. Cyclosporin A Increases Mitochondrial Buffering of Calcium: An Additional Mechanism in Delaying Mitochondrial Permeability Transition Pore Opening. Cells. 2019 Sep 7;8(9). doi: 10.3390/cells8091052. PubMed PMID: 31500337; PubMed Central PMCID: PMC6770067.
Camara AKS, Stowe DF, O-Uchi J, Bazil JN. Editorial: Genetic Modification of Cardiac Tissue. Front Cardiovasc Med. 2019;6:93. doi: 10.3389/fcvm.2019.00093. eCollection 2019. PubMed PMID: 31380395; PubMed Central PMCID: PMC6646414.
Haumann J, Camara AKS, Gadicherla AK, Navarro CD, Boelens AD, Blomeyer CA, Dash RK, Boswell MR, Kwok WM, Stowe DF. Slow Ca2+ Efflux by Ca2+/H+ Exchange in Cardiac Mitochondria Is Modulated by Ca2+ Re-uptake via MCU, Extra-Mitochondrial pH, and H+ Pumping by FOF1-ATPase. Front Physiol. 2018;9:1914. doi: 10.3389/fphys.2018.01914. eCollection 2018. PubMed PMID: 30804812; PubMed Central PMCID: PMC6378946.
Stowe DF, Yang M, Heisner JS, Camara AKS. Endogenous and Agonist-induced Opening of Mitochondrial Big Versus Small Ca2+-sensitive K+ Channels on Cardiac Cell and Mitochondrial Protection. J Cardiovasc Pharmacol. 2017 Nov;70(5):314-328. doi: 10.1097/FJC.0000000000000524. PubMed PMID: 28777255; PubMed Central PMCID: PMC5726766.
Yang M, Camara AKS, Aldakkak M, Kwok WM, Stowe DF. Identity and function of a cardiac mitochondrial small conductance Ca2+-activated K+ channel splice variant. Biochim Biophys Acta Bioenerg. 2017 Jun;1858(6):442-458. doi: 10.1016/j.bbabio.2017.03.005. Epub 2017 Mar 22. PubMed PMID: 28342809; PubMed Central PMCID: PMC5749404.
Heerdt PM, Stowe DF. Single-lung ventilation and oxidative stress: a different perspective on a common practice. Curr Opin Anaesthesiol. 2017 Feb;30(1):42-49. doi: 10.1097/ACO.0000000000000410. Review. PubMed PMID: 27783023.
Rhodes SS, Camara AK, Aldakkak M, Heisner JS, Stowe DF. Stretch-induced increase in cardiac contractility is independent of myocyte Ca2+ while block of stretch channels by streptomycin improves contractility after ischemic stunning. Physiol Rep. 2015 Aug;3(8). doi: 10.14814/phy2.12486. PubMed PMID: 26290532; PubMed Central PMCID: PMC4562572.
Abdoli A, Dulikravich GS, Bajaj CL, Stowe DF, Jahania SM. Human heart preservation analyses using convective cooling. International Journal of Numerical Methods for Heat and Fluid Flow. 2015 June; 25(6):1426-1443. doi: 10.1172/JC179984.
Lindsay DP, Camara AK, Stowe DF, Lubbe R, Aldakkak M. Differential effects of buffer pH on Ca(2+)-induced ROS emission with inhibited mitochondrial complexes I and III. Front Physiol. 2015;6:58. doi: 10.3389/fphys.2015.00058. eCollection 2015. PubMed PMID: 25805998; PubMed Central PMCID: PMC4354303.
Yang M, Stowe DF, Udoh KB, Heisner JS, Camara AK. Reversible blockade of complex I or inhibition of PKCβ reduces activation and mitochondria translocation of p66Shc to preserve cardiac function after ischemia. PLoS One. 2014;9(12):e113534. doi: 10.1371/journal.pone.0113534. eCollection 2014. PubMed PMID: 25436907; PubMed Central PMCID: PMC4250075.
Abdoli A, Dulikravich GS, Bajaj C, Stowe DF, Jahania MS. Human heart conjugate cooling simulation: unsteady thermo-fluid-stress analysis. Int J Numer Method Biomed Eng. 2014 Nov;30(11):1372-86. doi: 10.1002/cnm.2662. Epub 2014 Aug 4. PubMed PMID: 25045006; PubMed Central PMCID: PMC4351112.
Agarwal B, Stowe DF, Dash RK, Bosnjak ZJ, Camara AK. Mitochondrial targets for volatile anesthetics against cardiac ischemia-reperfusion injury. Front Physiol. 2014;5:341. doi: 10.3389/fphys.2014.00341. eCollection 2014. Review. PubMed PMID: 25278902; PubMed Central PMCID: PMC4165278.
Tewari SG, Camara AK, Stowe DF, Dash RK. Computational analysis of Ca2+ dynamics in isolated cardiac mitochondria predicts two distinct modes of Ca2+ uptake. J Physiol. 2014 May 1;592(9):1917-30. doi: 10.1113/jphysiol.2013.268847. Epub 2014 Mar 3. PubMed PMID: 24591571; PubMed Central PMCID: PMC4230769.
Nabbi R, Gadicherla AK, Kersten JR, Stowe DF, Lazar J, Riess ML. Genetically determined mitochondrial preservation and cardioprotection against myocardial ischemia-reperfusion injury in a consomic rat model. Physiol Genomics. 2014 Mar 1;46(5):169-76. doi: 10.1152/physiolgenomics.00118.2013. Epub 2013 Dec 31. PubMed PMID: 24380873; PubMed Central PMCID: PMC3949105.
Agarwal B, Dash RK, Stowe DF, Bosnjak ZJ, Camara AK. Isoflurane modulates cardiac mitochondrial bioenergetics by selectively attenuating respiratory complexes. Biochim Biophys Acta. 2014 Mar;1837(3):354-65. doi: 10.1016/j.bbabio.2013.11.006. Epub 2013 Dec 17. PubMed PMID: 24355434; PubMed Central PMCID: PMC4084852.
Blomeyer CA, Bazil JN, Stowe DF, Pradhan RK, Dash RK, Camara AK. Dynamic buffering of mitochondrial Ca2+ during Ca2+ uptake and Na+-induced Ca2+ release. J Bioenerg Biomembr. 2013 Jun;45(3):189-202. doi: 10.1007/s10863-012-9483-7. Epub 2012 Dec 7. PubMed PMID: 23225099; PubMed Central PMCID: PMC4065551.
Boelens AD, Pradhan RK, Blomeyer CA, Camara AK, Dash RK, Stowe DF. Extra-matrix Mg2+ limits Ca2+ uptake and modulates Ca2+ uptake-independent respiration and redox state in cardiac isolated mitochondria. J Bioenerg Biomembr. 2013 Jun;45(3):203-18. doi: 10.1007/s10863-013-9500-5. Epub 2013 Mar 3. PubMed PMID: 23456198; PubMed Central PMCID: PMC3670670.
Aldakkak M, Stowe DF, Dash RK, Camara AK. Mitochondrial handling of excess Ca2+ is substrate-dependent with implications for reactive oxygen species generation. Free Radic Biol Med. 2013 Mar;56:193-203. doi: 10.1016/j.freeradbiomed.2012.09.020. Epub 2012 Sep 23. PubMed PMID: 23010495; PubMed Central PMCID: PMC3542420.
Stowe DF, Gadicherla AK, Zhou Y, Aldakkak M, Cheng Q, Kwok WM, Jiang MT, Heisner JS, Yang M, Camara AK. Protection against cardiac injury by small Ca(2+)-sensitive K(+) channels identified in guinea pig cardiac inner mitochondrial membrane. Biochim Biophys Acta. 2013 Feb;1828(2):427-42. doi: 10.1016/j.bbamem.2012.08.031. Epub 2012 Sep 8. PubMed PMID: 22982251; PubMed Central PMCID: PMC3534888.
Aldakkak M, Stowe DF, Camara AK. Safety and Efficacy of Ranolazine for the Treatment of Chronic Angina Pectoris. Clin Med Insights Ther. 2013 Jan 15;2013(5):1-14. doi: 10.4137/CMT.S7824. PubMed PMID: 24574825; PubMed Central PMCID: PMC3932785.
Yang M, Camara AK, Wakim BT, Zhou Y, Gadicherla AK, Kwok WM, Stowe DF. Tyrosine nitration of voltage-dependent anion channels in cardiac ischemia-reperfusion: reduction by peroxynitrite scavenging. Biochim Biophys Acta. 2012 Nov;1817(11):2049-59. doi: 10.1016/j.bbabio.2012.06.004. Epub 2012 Jun 15. PubMed PMID: 22709907; PubMed Central PMCID: PMC3985433.
Gadicherla AK, Stowe DF, Antholine WE, Yang M, Camara AK. Damage to mitochondrial complex I during cardiac ischemia reperfusion injury is reduced indirectly by anti-anginal drug ranolazine. Biochim Biophys Acta. 2012 Mar;1817(3):419-29. doi: 10.1016/j.bbabio.2011.11.021. Epub 2011 Dec 8. PubMed PMID: 22178605; PubMed Central PMCID: PMC3269517.
Aldakkak M, Stowe DF, Heisner JS, Riess ML, Camara AK. Adding ROS quenchers to cold K+ cardioplegia reduces superoxide emission during 2-hour global cold cardiac ischemia. J Cardiovasc Pharmacol Ther. 2012 Mar;17(1):93-101. doi: 10.1177/1074248410389815. Epub 2011 Jan 31. PubMed PMID: 21282477; PubMed Central PMCID: PMC3226871.
Aldakkak M, Camara AK, Heisner JS, Yang M, Stowe DF. Ranolazine reduces Ca2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts. Pharmacol Res. 2011 Oct;64(4):381-92. doi: 10.1016/j.phrs.2011.06.018. Epub 2011 Jun 29. PubMed PMID: 21741479; PubMed Central PMCID: PMC3233383.
Haumann J, Dash RK, Stowe DF, Boelens AD, Beard DA, Camara AK. Mitochondrial free [Ca2+] increases during ATP/ADP antiport and ADP phosphorylation: exploration of mechanisms. Biophys J. 2010 Aug 9;99(4):997-1006. doi: 10.1016/j.bpj.2010.04.069. PubMed PMID: 20712982; PubMed Central PMCID: PMC2920628.
Camara AK, Lesnefsky EJ, Stowe DF. Potential therapeutic benefits of strategies directed to mitochondria. Antioxid Redox Signal. 2010 Aug 1;13(3):279-347. doi: 10.1089/ars.2009.2788. Review. PubMed PMID: 20001744; PubMed Central PMCID: PMC2936955.
Aldakkak M, Stowe DF, Cheng Q, Kwok WM, Camara AK. Mitochondrial matrix K+ flux independent of large-conductance Ca2+-activated K+ channel opening. Am J Physiol Cell Physiol. 2010 Mar;298(3):C530-41. doi: 10.1152/ajpcell.00468.2009. Epub 2010 Jan 6. PubMed PMID: 20053924; PubMed Central PMCID: PMC2838564.
Riess ML, Rhodes SS, Stowe DF, Aldakkak M, Camara AK. Comparison of cumulative planimetry versus manual dissection to assess experimental infarct size in isolated hearts. J Pharmacol Toxicol Methods. 2009 Nov-Dec;60(3):275-80. doi: 10.1016/j.vascn.2009.05.012. Epub 2009 Sep 3. PubMed PMID: 19732842; PubMed Central PMCID: PMC3786703.
Aldakkak M, Stowe DF, Lesnefsky EJ, Heisner JS, Chen Q, Camara AK. Modulation of mitochondrial bioenergetics in the isolated Guinea pig beating heart by potassium and lidocaine cardioplegia: implications for cardioprotection. J Cardiovasc Pharmacol. 2009 Oct;54(4):298-309. doi: 10.1097/FJC.0b013e3181b2b842. PubMed PMID: 19620879; PubMed Central PMCID: PMC2774837.
Stowe DF, Camara AK. Mitochondrial reactive oxygen species production in excitable cells: modulators of mitochondrial and cell function. Antioxid Redox Signal. 2009 Jun;11(6):1373-414. doi: 10.1089/ars.2008.2331. Review. PubMed PMID: 19187004; PubMed Central PMCID: PMC2842133.
Stowe DF, Camara AK, Heisner JS, Aldakkak M, Harder DR. Low-flow perfusion of guinea pig isolated hearts with 26 degrees C air-saturated Lifor solution for 20 hours preserves function and metabolism. J Heart Lung Transplant. 2008 Sep;27(9):1008-15. doi: 10.1016/j.healun.2008.05.028. Epub 2008 Jul 26. PubMed PMID: 18765194; PubMed Central PMCID: PMC2720038.
Aldakkak M, Stowe DF, Heisner JS, Spence M, Camara AK. Enhanced Na+/H+ exchange during ischemia and reperfusion impairs mitochondrial bioenergetics and myocardial function. J Cardiovasc Pharmacol. 2008 Sep;52(3):236-44. doi: 10.1097/FJC.0b013e3181831337. PubMed PMID: 18806604; PubMed Central PMCID: PMC2659015.
Riess ML, Camara AK, Heinen A, Eells JT, Henry MM, Stowe DF. KATP channel openers have opposite effects on mitochondrial respiration under different energetic conditions. J Cardiovasc Pharmacol. 2008 May;51(5):483-91. doi: 10.1097/FJC.0b013e31816bf4a4. PubMed PMID: 18437094; PubMed Central PMCID: PMC3010203.
Riess ML, Costa AD, Carlson R Jr, Garlid KD, Heinen A, Stowe DF. Differential increase of mitochondrial matrix volume by sevoflurane in isolated cardiac mitochondria. Anesth Analg. 2008 Apr;106(4):1049-55, table of contents. doi: 10.1213/ane.0b013e318167875e. PubMed PMID: 18349172.
Aldakkak M, Stowe DF, Chen Q, Lesnefsky EJ, Camara AK. Inhibited mitochondrial respiration by amobarbital during cardiac ischaemia improves redox state and reduces matrix Ca2+ overload and ROS release. Cardiovasc Res. 2008 Jan 15;77(2):406-15. doi: 10.1016/j.cardiores.2007.08.008. PubMed PMID: 17900548.
Jiang MT, Nakae Y, Ljubkovic M, Kwok WM, Stowe DF, Bosnjak ZJ. Isoflurane activates human cardiac mitochondrial adenosine triphosphate-sensitive K+ channels reconstituted in lipid bilayers. Anesth Analg. 2007 Oct;105(4):926-32, table of contents. doi: 10.1213/01.ane.0000278640.81206.92. PubMed PMID: 17898367.
Heinen A, Aldakkak M, Stowe DF, Rhodes SS, Riess ML, Varadarajan SG, Camara AK. Reverse electron flow-induced ROS production is attenuated by activation of mitochondrial Ca2+-sensitive K+ channels. Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1400-7. doi: 10.1152/ajpheart.00198.2007. Epub 2007 May 18. PubMed PMID: 17513497.
Huang M, Camara AK, Stowe DF, Qi F, Beard DA. Mitochondrial inner membrane electrophysiology assessed by rhodamine-123 transport and fluorescence. Ann Biomed Eng. 2007 Jul;35(7):1276-85. doi: 10.1007/s10439-007-9265-2. Epub 2007 Mar 20. PubMed PMID: 17372838; PubMed Central PMCID: PMC3508792.
Stowe DF, Camara AK, Heisner JS, Aldakkak M, Harder DR. Ten-hour preservation of guinea pig isolated hearts perfused at low flow with air-saturated Lifor solution at 26{degrees}C: comparison to ViaSpan solution. Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H895-901. doi: 10.1152/ajpheart.00149.2007. Epub 2007 Apr 13. PubMed PMID: 17434975.
Camara AK, Aldakkak M, Heisner JS, Rhodes SS, Riess ML, An J, Heinen A, Stowe DF. ROS scavenging before 27 degrees C ischemia protects hearts and reduces mitochondrial ROS, Ca2+ overload, and changes in redox state. Am J Physiol Cell Physiol. 2007 Jun;292(6):C2021-31. doi: 10.1152/ajpcell.00231.2006. Epub 2007 Feb 7. PubMed PMID: 17287367.
Riess ML, Stowe DF. beta-Blockade abolishes anesthetic preconditioning: impact on clinical applicability. Anesthesiology. 2007 May;106(5):1061-2; author reply 1062. doi: 10.1097/01.anes.0000265172.44877.25. PubMed PMID: 17457142.
Heinen A, Camara AK, Aldakkak M, Rhodes SS, Riess ML, Stowe DF. Mitochondrial Ca2+-induced K+ influx increases respiration and enhances ROS production while maintaining membrane potential. Am J Physiol Cell Physiol. 2007 Jan;292(1):C148-56. doi: 10.1152/ajpcell.00215.2006. Epub 2006 Jul 26. PubMed PMID: 16870831.
Chen Q, Camara AK, Stowe DF, Hoppel CL, Lesnefsky EJ. Modulation of electron transport protects cardiac mitochondria and decreases myocardial injury during ischemia and reperfusion. Am J Physiol Cell Physiol. 2007 Jan;292(1):C137-47. doi: 10.1152/ajpcell.00270.2006. Epub 2006 Sep 13. Review. PubMed PMID: 16971498.
An J, Rhodes SS, Jiang MT, Bosnjak ZJ, Tian M, Stowe DF. Anesthetic preconditioning enhances Ca2+ handling and mechanical and metabolic function elicited by Na+-Ca2+ exchange inhibition in isolated hearts. Anesthesiology. 2006 Sep;105(3):541-9. doi: 10.1097/00000542-200609000-00018. PubMed PMID: 16931987.
Zausig YA, Stowe DF, Zink W, Grube C, Martin E, Graf BM. A comparison of three phosphodiesterase type III inhibitors on mechanical and metabolic function in guinea pig isolated hearts. Anesth Analg. 2006 Jun;102(6):1646-52. doi: 10.1213/01.ane.0000216290.74626.27. PubMed PMID: 16717301.
Jiang MT, Ljubkovic M, Nakae Y, Shi Y, Kwok WM, Stowe DF, Bosnjak ZJ. Characterization of human cardiac mitochondrial ATP-sensitive potassium channel and its regulation by phorbol ester in vitro. Am J Physiol Heart Circ Physiol. 2006 May;290(5):H1770-6. doi: 10.1152/ajpheart.01084.2005. Epub 2005 Dec 16. PubMed PMID: 16361367.
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