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Kim J, Zimmerman MA, Shin WY, Boettcher BT, Lee JS, Park JI, Ali M, Yang M, Mishra J, Hagen CE, McGraw JE, Mathison A, Woehlck HJ, Lomberk G, Camara AKS, Urrutia RA, Stowe DF, Hong JC. Effects of Subnormothermic Regulated Hepatic Reperfusion on Mitochondrial and Transcriptomic Profiles in a Porcine Model. Ann Surg. 2023 Feb 1;277(2):e366-e375. doi: 10.1097/SLA.0000000000005156. Epub 2023 Jan 10. PubMed PMID: 34387201; PubMed Central PMCID: PMC8840998.
Malas KM, Lambert DS, Heisner JS, Camara AKS, Stowe DF. Time and charge/pH-dependent activation of K(+) channel-mediated K(+) influx and K(+)/H(+) exchange in guinea pig heart isolated mitochondria; role in bioenergetic stability. Biochim Biophys Acta Bioenerg. 2022 Nov 1;1863(8):148908. doi: 10.1016/j.bbabio.2022.148908. Epub 2022 Aug 9. PubMed PMID: 35961396.
Sun J, Mishra J, Yang M, Stowe DF, Heisner JS, An J, Kwok WM, Camara AKS. Hypothermia Prevents Cardiac Dysfunction during Acute Ischemia Reperfusion by Maintaining Mitochondrial Bioenergetics and by Promoting Hexokinase II Binding to Mitochondria. Oxid Med Cell Longev. 2022;2022:4476448. doi: 10.1155/2022/4476448. eCollection 2022. PubMed PMID: 35873800; PubMed Central PMCID: PMC9301761.
Gerdes HJ, Yang M, Heisner JS, Camara AKS, Stowe DF. Modulation of peroxynitrite produced via mitochondrial nitric oxide synthesis during Ca(2+) and succinate-induced oxidative stress in cardiac isolated mitochondria. Biochim Biophys Acta Bioenerg. 2020 Dec 1;1861(12):148290. doi: 10.1016/j.bbabio.2020.148290. Epub 2020 Aug 20. PubMed PMID: 32828729; PubMed Central PMCID: PMC7560995.
Natarajan GK, Glait L, Mishra J, Stowe DF, Camara AKS, Kwok WM. Total Matrix Ca(2+) Modulates Ca(2+) Efflux via the Ca(2+)/H(+) Exchanger in Cardiac Mitochondria. Front Physiol. 2020;11:510600. doi: 10.3389/fphys.2020.510600. eCollection 2020. PubMed PMID: 33041851; PubMed Central PMCID: PMC7526510.
Yang M, Sun J, Stowe DF, Tajkhorshid E, Kwok WM, Camara AKS. Knockout of VDAC1 in H9c2 Cells Promotes Oxidative Stress-Induced Cell Apoptosis through Decreased Mitochondrial Hexokinase II Binding and Enhanced Glycolytic Stress. Cell Physiol Biochem. 2020 Sep 9;54(5):853-874. doi: 10.33594/000000274. PubMed PMID: 32901466; PubMed Central PMCID: PMC7898235.
Riess ML, Elorbany R, Weihrauch D, Stowe DF, Camara AKS. PPARγ-Independent Side Effects of Thiazolidinediones on Mitochondrial Redox State in Rat Isolated Hearts. Cells. 2020 Jan 20;9(1). doi: 10.3390/cells9010252. PubMed PMID: 31968546; PubMed Central PMCID: PMC7017211.
Mishra J, Davani AJ, Natarajan GK, Kwok WM, Stowe DF, Camara AKS. Cyclosporin A Increases Mitochondrial Buffering of Calcium: An Additional Mechanism in Delaying Mitochondrial Permeability Transition Pore Opening. Cells. 2019 Sep 7;8(9). doi: 10.3390/cells8091052. PubMed PMID: 31500337; PubMed Central PMCID: PMC6770067.
Camara AKS, Stowe DF, O-Uchi J, Bazil JN. Editorial: Genetic Modification of Cardiac Tissue. Front Cardiovasc Med. 2019;6:93. doi: 10.3389/fcvm.2019.00093. eCollection 2019. PubMed PMID: 31380395; PubMed Central PMCID: PMC6646414.
Haumann J, Camara AKS, Gadicherla AK, Navarro CD, Boelens AD, Blomeyer CA, Dash RK, Boswell MR, Kwok WM, Stowe DF. Slow Ca(2+) Efflux by Ca(2+)/H(+) Exchange in Cardiac Mitochondria Is Modulated by Ca(2+) Re-uptake via MCU, Extra-Mitochondrial pH, and H(+) Pumping by F(O)F(1)-ATPase. Front Physiol. 2018;9:1914. doi: 10.3389/fphys.2018.01914. eCollection 2018. PubMed PMID: 30804812; PubMed Central PMCID: PMC6378946.
Stowe DF, Yang M, Heisner JS, Camara AKS. Endogenous and Agonist-induced Opening of Mitochondrial Big Versus Small Ca2+-sensitive K+ Channels on Cardiac Cell and Mitochondrial Protection. J Cardiovasc Pharmacol. 2017 Nov;70(5):314-328. doi: 10.1097/FJC.0000000000000524. PubMed PMID: 28777255; PubMed Central PMCID: PMC5726766.
Yang M, Camara AKS, Aldakkak M, Kwok WM, Stowe DF. Identity and function of a cardiac mitochondrial small conductance Ca(2+)-activated K(+) channel splice variant. Biochim Biophys Acta Bioenerg. 2017 Jun;1858(6):442-458. doi: 10.1016/j.bbabio.2017.03.005. Epub 2017 Mar 22. PubMed PMID: 28342809; PubMed Central PMCID: PMC5749404.
Heerdt PM, Stowe DF. Single-lung ventilation and oxidative stress: a different perspective on a common practice. Curr Opin Anaesthesiol. 2017 Feb;30(1):42-49. doi: 10.1097/ACO.0000000000000410. Review. PubMed PMID: 27783023.
Rhodes SS, Camara AK, Aldakkak M, Heisner JS, Stowe DF. Stretch-induced increase in cardiac contractility is independent of myocyte Ca2+ while block of stretch channels by streptomycin improves contractility after ischemic stunning. Physiol Rep. 2015 Aug;3(8). doi: 10.14814/phy2.12486. PubMed PMID: 26290532; PubMed Central PMCID: PMC4562572.
Abdoli A, Dulikravich GS, Bajaj CL, Stowe DF, Jahania SM. Human heart preservation analyses using convective cooling. International Journal of Numerical Methods for Heat and Fluid Flow. 2015 June; 25(6):1426-1443. doi: 10.1172/JC179984.
Lindsay DP, Camara AK, Stowe DF, Lubbe R, Aldakkak M. Differential effects of buffer pH on Ca(2+)-induced ROS emission with inhibited mitochondrial complexes I and III. Front Physiol. 2015;6:58. doi: 10.3389/fphys.2015.00058. eCollection 2015. PubMed PMID: 25805998; PubMed Central PMCID: PMC4354303.
Yang M, Stowe DF, Udoh KB, Heisner JS, Camara AK. Reversible blockade of complex I or inhibition of PKCβ reduces activation and mitochondria translocation of p66Shc to preserve cardiac function after ischemia. PLoS One. 2014;9(12):e113534. doi: 10.1371/journal.pone.0113534. eCollection 2014. PubMed PMID: 25436907; PubMed Central PMCID: PMC4250075.
Abdoli A, Dulikravich GS, Bajaj C, Stowe DF, Jahania MS. Human heart conjugate cooling simulation: unsteady thermo-fluid-stress analysis. Int J Numer Method Biomed Eng. 2014 Nov;30(11):1372-86. doi: 10.1002/cnm.2662. Epub 2014 Aug 4. PubMed PMID: 25045006; PubMed Central PMCID: PMC4351112.
Agarwal B, Stowe DF, Dash RK, Bosnjak ZJ, Camara AK. Mitochondrial targets for volatile anesthetics against cardiac ischemia-reperfusion injury. Front Physiol. 2014;5:341. doi: 10.3389/fphys.2014.00341. eCollection 2014. Review. PubMed PMID: 25278902; PubMed Central PMCID: PMC4165278.
Tewari SG, Camara AK, Stowe DF, Dash RK. Computational analysis of Ca2+ dynamics in isolated cardiac mitochondria predicts two distinct modes of Ca2+ uptake. J Physiol. 2014 May 1;592(9):1917-30. doi: 10.1113/jphysiol.2013.268847. Epub 2014 Mar 3. PubMed PMID: 24591571; PubMed Central PMCID: PMC4230769.
Nabbi R, Gadicherla AK, Kersten JR, Stowe DF, Lazar J, Riess ML. Genetically determined mitochondrial preservation and cardioprotection against myocardial ischemia-reperfusion injury in a consomic rat model. Physiol Genomics. 2014 Mar 1;46(5):169-76. doi: 10.1152/physiolgenomics.00118.2013. Epub 2013 Dec 31. PubMed PMID: 24380873; PubMed Central PMCID: PMC3949105.
Agarwal B, Dash RK, Stowe DF, Bosnjak ZJ, Camara AK. Isoflurane modulates cardiac mitochondrial bioenergetics by selectively attenuating respiratory complexes. Biochim Biophys Acta. 2014 Mar;1837(3):354-65. doi: 10.1016/j.bbabio.2013.11.006. Epub 2013 Dec 17. PubMed PMID: 24355434; PubMed Central PMCID: PMC4084852.
Blomeyer CA, Bazil JN, Stowe DF, Pradhan RK, Dash RK, Camara AK. Dynamic buffering of mitochondrial Ca2+ during Ca2+ uptake and Na+-induced Ca2+ release. J Bioenerg Biomembr. 2013 Jun;45(3):189-202. doi: 10.1007/s10863-012-9483-7. Epub 2012 Dec 7. PubMed PMID: 23225099; PubMed Central PMCID: PMC4065551.
Boelens AD, Pradhan RK, Blomeyer CA, Camara AK, Dash RK, Stowe DF. Extra-matrix Mg2+ limits Ca2+ uptake and modulates Ca2+ uptake-independent respiration and redox state in cardiac isolated mitochondria. J Bioenerg Biomembr. 2013 Jun;45(3):203-18. doi: 10.1007/s10863-013-9500-5. Epub 2013 Mar 3. PubMed PMID: 23456198; PubMed Central PMCID: PMC3670670.
Aldakkak M, Stowe DF, Dash RK, Camara AK. Mitochondrial handling of excess Ca2+ is substrate-dependent with implications for reactive oxygen species generation. Free Radic Biol Med. 2013 Mar;56:193-203. doi: 10.1016/j.freeradbiomed.2012.09.020. Epub 2012 Sep 23. PubMed PMID: 23010495; PubMed Central PMCID: PMC3542420.
Stowe DF, Gadicherla AK, Zhou Y, Aldakkak M, Cheng Q, Kwok WM, Jiang MT, Heisner JS, Yang M, Camara AK. Protection against cardiac injury by small Ca(2+)-sensitive K(+) channels identified in guinea pig cardiac inner mitochondrial membrane. Biochim Biophys Acta. 2013 Feb;1828(2):427-42. doi: 10.1016/j.bbamem.2012.08.031. Epub 2012 Sep 8. PubMed PMID: 22982251; PubMed Central PMCID: PMC3534888.
Aldakkak M, Stowe DF, Camara AK. Safety and Efficacy of Ranolazine for the Treatment of Chronic Angina Pectoris. Clin Med Insights Ther. 2013 Jan 15;2013(5):1-14. doi: 10.4137/CMT.S7824. PubMed PMID: 24574825; PubMed Central PMCID: PMC3932785.
Yang M, Camara AK, Wakim BT, Zhou Y, Gadicherla AK, Kwok WM, Stowe DF. Tyrosine nitration of voltage-dependent anion channels in cardiac ischemia-reperfusion: reduction by peroxynitrite scavenging. Biochim Biophys Acta. 2012 Nov;1817(11):2049-59. doi: 10.1016/j.bbabio.2012.06.004. Epub 2012 Jun 15. PubMed PMID: 22709907; PubMed Central PMCID: PMC3985433.
Gadicherla AK, Stowe DF, Antholine WE, Yang M, Camara AK. Damage to mitochondrial complex I during cardiac ischemia reperfusion injury is reduced indirectly by anti-anginal drug ranolazine. Biochim Biophys Acta. 2012 Mar;1817(3):419-29. doi: 10.1016/j.bbabio.2011.11.021. Epub 2011 Dec 8. PubMed PMID: 22178605; PubMed Central PMCID: PMC3269517.
Aldakkak M, Stowe DF, Heisner JS, Riess ML, Camara AK. Adding ROS quenchers to cold K+ cardioplegia reduces superoxide emission during 2-hour global cold cardiac ischemia. J Cardiovasc Pharmacol Ther. 2012 Mar;17(1):93-101. doi: 10.1177/1074248410389815. Epub 2011 Jan 31. PubMed PMID: 21282477; PubMed Central PMCID: PMC3226871.
Aldakkak M, Camara AK, Heisner JS, Yang M, Stowe DF. Ranolazine reduces Ca2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts. Pharmacol Res. 2011 Oct;64(4):381-92. doi: 10.1016/j.phrs.2011.06.018. Epub 2011 Jun 29. PubMed PMID: 21741479; PubMed Central PMCID: PMC3233383.
Haumann J, Dash RK, Stowe DF, Boelens AD, Beard DA, Camara AK. Mitochondrial free [Ca2+] increases during ATP/ADP antiport and ADP phosphorylation: exploration of mechanisms. Biophys J. 2010 Aug 9;99(4):997-1006. doi: 10.1016/j.bpj.2010.04.069. PubMed PMID: 20712982; PubMed Central PMCID: PMC2920628.
Camara AK, Lesnefsky EJ, Stowe DF. Potential therapeutic benefits of strategies directed to mitochondria. Antioxid Redox Signal. 2010 Aug 1;13(3):279-347. doi: 10.1089/ars.2009.2788. Review. PubMed PMID: 20001744; PubMed Central PMCID: PMC2936955.
Aldakkak M, Stowe DF, Cheng Q, Kwok WM, Camara AK. Mitochondrial matrix K+ flux independent of large-conductance Ca2+-activated K+ channel opening. Am J Physiol Cell Physiol. 2010 Mar;298(3):C530-41. doi: 10.1152/ajpcell.00468.2009. Epub 2010 Jan 6. PubMed PMID: 20053924; PubMed Central PMCID: PMC2838564.
Riess ML, Rhodes SS, Stowe DF, Aldakkak M, Camara AK. Comparison of cumulative planimetry versus manual dissection to assess experimental infarct size in isolated hearts. J Pharmacol Toxicol Methods. 2009 Nov-Dec;60(3):275-80. doi: 10.1016/j.vascn.2009.05.012. Epub 2009 Sep 3. PubMed PMID: 19732842; PubMed Central PMCID: PMC3786703.
Aldakkak M, Stowe DF, Lesnefsky EJ, Heisner JS, Chen Q, Camara AK. Modulation of mitochondrial bioenergetics in the isolated Guinea pig beating heart by potassium and lidocaine cardioplegia: implications for cardioprotection. J Cardiovasc Pharmacol. 2009 Oct;54(4):298-309. doi: 10.1097/FJC.0b013e3181b2b842. PubMed PMID: 19620879; PubMed Central PMCID: PMC2774837.
Stowe DF, Camara AK. Mitochondrial reactive oxygen species production in excitable cells: modulators of mitochondrial and cell function. Antioxid Redox Signal. 2009 Jun;11(6):1373-414. doi: 10.1089/ars.2008.2331. Review. PubMed PMID: 19187004; PubMed Central PMCID: PMC2842133.
Stowe DF, Camara AK, Heisner JS, Aldakkak M, Harder DR. Low-flow perfusion of guinea pig isolated hearts with 26 degrees C air-saturated Lifor solution for 20 hours preserves function and metabolism. J Heart Lung Transplant. 2008 Sep;27(9):1008-15. doi: 10.1016/j.healun.2008.05.028. Epub 2008 Jul 26. PubMed PMID: 18765194; PubMed Central PMCID: PMC2720038.
Aldakkak M, Stowe DF, Heisner JS, Spence M, Camara AK. Enhanced Na+/H+ exchange during ischemia and reperfusion impairs mitochondrial bioenergetics and myocardial function. J Cardiovasc Pharmacol. 2008 Sep;52(3):236-44. doi: 10.1097/FJC.0b013e3181831337. PubMed PMID: 18806604; PubMed Central PMCID: PMC2659015.
Riess ML, Camara AK, Heinen A, Eells JT, Henry MM, Stowe DF. KATP channel openers have opposite effects on mitochondrial respiration under different energetic conditions. J Cardiovasc Pharmacol. 2008 May;51(5):483-91. doi: 10.1097/FJC.0b013e31816bf4a4. PubMed PMID: 18437094; PubMed Central PMCID: PMC3010203.
Riess ML, Costa AD, Carlson R Jr, Garlid KD, Heinen A, Stowe DF. Differential increase of mitochondrial matrix volume by sevoflurane in isolated cardiac mitochondria. Anesth Analg. 2008 Apr;106(4):1049-55, table of contents. doi: 10.1213/ane.0b013e318167875e. PubMed PMID: 18349172.
Aldakkak M, Stowe DF, Chen Q, Lesnefsky EJ, Camara AK. Inhibited mitochondrial respiration by amobarbital during cardiac ischaemia improves redox state and reduces matrix Ca2+ overload and ROS release. Cardiovasc Res. 2008 Jan 15;77(2):406-15. doi: 10.1016/j.cardiores.2007.08.008. PubMed PMID: 17900548.
Jiang MT, Nakae Y, Ljubkovic M, Kwok WM, Stowe DF, Bosnjak ZJ. Isoflurane activates human cardiac mitochondrial adenosine triphosphate-sensitive K+ channels reconstituted in lipid bilayers. Anesth Analg. 2007 Oct;105(4):926-32, table of contents. doi: 10.1213/01.ane.0000278640.81206.92. PubMed PMID: 17898367.
Heinen A, Aldakkak M, Stowe DF, Rhodes SS, Riess ML, Varadarajan SG, Camara AK. Reverse electron flow-induced ROS production is attenuated by activation of mitochondrial Ca2+-sensitive K+ channels. Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1400-7. doi: 10.1152/ajpheart.00198.2007. Epub 2007 May 18. PubMed PMID: 17513497.
Huang M, Camara AK, Stowe DF, Qi F, Beard DA. Mitochondrial inner membrane electrophysiology assessed by rhodamine-123 transport and fluorescence. Ann Biomed Eng. 2007 Jul;35(7):1276-85. doi: 10.1007/s10439-007-9265-2. Epub 2007 Mar 20. PubMed PMID: 17372838; PubMed Central PMCID: PMC3508792.
Stowe DF, Camara AK, Heisner JS, Aldakkak M, Harder DR. Ten-hour preservation of guinea pig isolated hearts perfused at low flow with air-saturated Lifor solution at 26{degrees}C: comparison to ViaSpan solution. Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H895-901. doi: 10.1152/ajpheart.00149.2007. Epub 2007 Apr 13. PubMed PMID: 17434975.
Camara AK, Aldakkak M, Heisner JS, Rhodes SS, Riess ML, An J, Heinen A, Stowe DF. ROS scavenging before 27 degrees C ischemia protects hearts and reduces mitochondrial ROS, Ca2+ overload, and changes in redox state. Am J Physiol Cell Physiol. 2007 Jun;292(6):C2021-31. doi: 10.1152/ajpcell.00231.2006. Epub 2007 Feb 7. PubMed PMID: 17287367.
Riess ML, Stowe DF. beta-Blockade abolishes anesthetic preconditioning: impact on clinical applicability. Anesthesiology. 2007 May;106(5):1061-2; author reply 1062. doi: 10.1097/01.anes.0000265172.44877.25. PubMed PMID: 17457142.
Heinen A, Camara AK, Aldakkak M, Rhodes SS, Riess ML, Stowe DF. Mitochondrial Ca2+-induced K+ influx increases respiration and enhances ROS production while maintaining membrane potential. Am J Physiol Cell Physiol. 2007 Jan;292(1):C148-56. doi: 10.1152/ajpcell.00215.2006. Epub 2006 Jul 26. PubMed PMID: 16870831.
Chen Q, Camara AK, Stowe DF, Hoppel CL, Lesnefsky EJ. Modulation of electron transport protects cardiac mitochondria and decreases myocardial injury during ischemia and reperfusion. Am J Physiol Cell Physiol. 2007 Jan;292(1):C137-47. doi: 10.1152/ajpcell.00270.2006. Epub 2006 Sep 13. Review. PubMed PMID: 16971498.
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