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Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells. Cell. . NIHMSID: NIHMS1057065.
A biomaterial-based vaccine eliciting durable tumour-specific responses against acute myeloid leukaemia. Nature biomedical engineering. . NIHMSID: NIHMS1545031.
E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates. Science immunology. . NIHMSID: NIHMS1703952.
Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression. Science translational medicine. . NIHMSID: NIHMS1704106.
Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression. Science translational medicine. . NIHMSID: NIHMS1705195.
E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates. Science immunology. . NIHMSID: NIHMS1716986.
Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors. Stem cell reports. . NIHMSID: NIHMS631217.doi: 10.1016/j.stemcr.2014.08.011.
Improved hematopoietic stem cell transplantation upon inhibition of natural killer cell-derived interferon-gamma. Stem cell reports. . NIHMSID: NIHMS1723423.
Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis. Cell metabolism. . NIHMSID: NIHMS1827524.
Groopman JE, Scadden DT. Interferon therapy for Kaposi sarcoma associated with the acquired immunodeficiency syndrome (AIDS). Ann Intern Med. 1989 Mar 1;110(5):335-7. doi: 10.7326/0003-4819-110-5-335. Review. PubMed PMID: 2644884.
Molina JM, Scadden DT, Byrn R, Dinarello CA, Groopman JE. Production of tumor necrosis factor alpha and interleukin 1 beta by monocytic cells infected with human immunodeficiency virus. J Clin Invest. 1989 Sep;84(3):733-7. doi: 10.1172/JCI114230. PubMed PMID: 2474573; PubMed Central PMCID: PMC329713.
Scadden DT, Zon LI, Groopman JE. Pathophysiology and management of HIV-associated hematologic disorders. Blood. 1989 Oct;74(5):1455-63. Review. PubMed PMID: 2676010.
Groopman JE, Molina JM, Scadden DT. Hematopoietic growth factors. Biology and clinical applications. N Engl J Med. 1989 Nov 23;321(21):1449-59. doi: 10.1056/NEJM198911233212106. Review. PubMed PMID: 2682244.
Scadden DT. Granulocyte macrophage colony stimulating factor (GM-CSF) in AIDS. Prog Clin Biol Res. 1990;338:163-76. Review. PubMed PMID: 2189138.
Scadden DT, Fuller B, Cunningham JM. Human cells infected with retrovirus vectors acquire an endogenous murine provirus. J Virol. 1990 Jan;64(1):424-7. doi: 10.1128/JVI.64.1.424-427.1990. PubMed PMID: 2152828; PubMed Central PMCID: PMC249120.
Molina JM, Scadden DT, Amirault C, Woon A, Vannier E, Dinarello CA, Groopman JE. Human immunodeficiency virus does not induce interleukin-1, interleukin-6, or tumor necrosis factor in mononuclear cells. J Virol. 1990 Jun;64(6):2901-6. doi: 10.1128/JVI.64.6.2901-2906.1990. PubMed PMID: 2335821; PubMed Central PMCID: PMC249473.
Scadden DT, Zeira M, Woon A, Wang Z, Schieve L, Ikeuchi K, Lim B, Groopman JE. Human immunodeficiency virus infection of human bone marrow stromal fibroblasts. Blood. 1990 Jul 15;76(2):317-22. PubMed PMID: 1695109.
Mietus-Snyder M, Charmley P, Korf B, Ladias JA, Gatti RA, Karathanasis SK. Genetic linkage of the human apolipoprotein AI-CIII-AIV gene cluster and the neural cell adhesion molecule (NCAM) gene. Genomics. 1990 Aug;7(4):633-7. doi: 10.1016/0888-7543(90)90211-c. PubMed PMID: 1974882.
Molina JM, Scadden DT, Sakaguchi M, Fuller B, Woon A, Groopman JE. Lack of evidence for infection of or effect on growth of hematopoietic progenitor cells after in vivo or in vitro exposure to human immunodeficiency virus. Blood. 1990 Dec 15;76(12):2476-82. PubMed PMID: 2265244.
Scadden DT, Bering HA, Levine JD, Bresnahan J, Evans L, Epstein C, Groopman JE. GM-CSF as an alternative to dose modification of the combination zidovudine and interferon-alpha in the treatment of AIDS-associated Kaposi's sarcoma. Am J Clin Oncol. 1991;14 Suppl 1:S40-4. doi: 10.1097/00000421-199112001-00008. PubMed PMID: 2048563.
Scadden DT, Bering HA, Levine JD, Bresnahan J, Evans L, Epstein C, Groopman JE. Granulocyte-macrophage colony-stimulating factor mitigates the neutropenia of combined interferon alfa and zidovudine treatment of acquired immune deficiency syndrome-associated Kaposi's sarcoma. J Clin Oncol. 1991 May;9(5):802-8. doi: 10.1200/JCO.1991.9.5.802. PubMed PMID: 2016623.
Scadden DT, Feder D, Groopman JE. Scratching the surface. Curr Biol. 1991 Oct;1(5):301-3. doi: 10.1016/0960-9822(91)90091-a. PubMed PMID: 15336104.
Scadden DT. The use of GM-CSF in AIDS. Infection. 1992;20 Suppl 2:S103-6. doi: 10.1007/bf01705027. Review. PubMed PMID: 1283604.
Scadden DT, Wang Z, Groopman JE. Quantitation of plasma human immunodeficiency virus type 1 RNA by competitive polymerase chain reaction. J Infect Dis. 1992 Jun;165(6):1119-23. doi: 10.1093/infdis/165.6.1119. PubMed PMID: 1583331.
Scadden DT. The clinical applications of colony-stimulating factors in acquired immunodeficiency syndrome. Semin Hematol. 1992 Oct;29(4 Suppl 3):33-7. Review. PubMed PMID: 1492232.
Avraham H, Scadden DT, Chi S, Broudy VC, Zsebo KM, Groopman JE. Interaction of human bone marrow fibroblasts with megakaryocytes: role of the c-kit ligand. Blood. 1992 Oct 1;80(7):1679-84. PubMed PMID: 1382698.
Scadden DT, Agosti J. No antibodies to granulocyte macrophage colony-stimulating factor with prolonged use in AIDS. AIDS. 1993 Mar;7(3):438. doi: 10.1097/00002030-199303000-00024. PubMed PMID: 8471211.
Wang Z, Goldberg MA, Scadden DT. HIV-1 suppresses erythropoietin production in vitro. Exp Hematol. 1993 May;21(5):683-8. PubMed PMID: 8390370.
Freedman AR, Scadden DT. Viral activity in early HIV disease. Curr Opin Hematol. 1994 Jan;1(1):19-23. Review. PubMed PMID: 9371255.
Lee J, Wang Z, Luoh SM, Wood WI, Scadden DT. Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene. Gene. 1994 Jan 28;138(1-2):247-51. doi: 10.1016/0378-1119(94)90817-6. PubMed PMID: 7510261.
Scadden DT, Wang A, Zsebo KM, Groopman JE. In vitro effects of stem-cell factor or interleukin-3 on myelosuppression associated with AIDS. AIDS. 1994 Feb;8(2):193-6. doi: 10.1097/00002030-199402000-00006. PubMed PMID: 7519020.
Mark MR, Scadden DT, Wang Z, Gu Q, Goddard A, Godowski PJ. rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain. J Biol Chem. 1994 Apr 8;269(14):10720-8. PubMed PMID: 7511603.
Avraham H, Banu N, Scadden DT, Abraham J, Groopman JE. Modulation of megakaryocytopoiesis by human basic fibroblast growth factor. Blood. 1994 Apr 15;83(8):2126-32. PubMed PMID: 8161781.
Bennett BD, Wang Z, Kuang WJ, Wang A, Groopman JE, Goeddel DV, Scadden DT. Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily. J Biol Chem. 1994 May 13;269(19):14211-8. PubMed PMID: 8188704.
Gallo KA, Mark MR, Scadden DT, Wang Z, Gu Q, Godowski PJ. Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity. J Biol Chem. 1994 May 27;269(21):15092-100. PubMed PMID: 8195146.
Price P, Johnson RP, Scadden DT, Jassoy C, Rosenthal T, Kalams S, Walker BD. Cytotoxic CD8+ T lymphocytes reactive with human immunodeficiency virus-1 produce granulocyte/macrophage colony-stimulating factor and variable amounts of interleukins 2, 3, and 4 following stimulation with the cognate epitope. Clin Immunol Immunopathol. 1995 Jan;74(1):100-6. doi: 10.1006/clin.1995.1014. PubMed PMID: 7527747.
Berardi AC, Wang A, Levine JD, Lopez P, Scadden DT. Functional isolation and characterization of human hematopoietic stem cells. Science. 1995 Jan 6;267(5194):104-8. doi: 10.1126/science.7528940. PubMed PMID: 7528940.
Scadden DT, Levine JD, Bresnahan J, Gere J, McGrath J, Wang Z, Resta DJ, Young D, Hammer SM. In vivo effects of interleukin 3 in HIV type 1-infected patients with cytopenia. AIDS Res Hum Retroviruses. 1995 Jun;11(6):731-40. doi: 10.1089/aid.1995.11.731. PubMed PMID: 7576933.
Masood R, Zhang Y, Bond MW, Scadden DT, Moudgil T, Law RE, Kaplan MH, Jung B, Espina BM, Lunardi-Iskandar Y. Interleukin-10 is an autocrine growth factor for acquired immunodeficiency syndrome-related B-cell lymphoma. Blood. 1995 Jun 15;85(12):3423-30. PubMed PMID: 7780129.
Columbyova L, Loda M, Scadden DT. Thrombopoietin receptor expression in human cancer cell lines and primary tissues. Cancer Res. 1995 Aug 15;55(16):3509-12. PubMed PMID: 7627956.
Freedman AR, Zhu H, Levine JD, Kalams S, Scadden DT. Generation of human T lymphocytes from bone marrow CD34+ cells in vitro. Nat Med. 1996 Jan;2(1):46-51. doi: 10.1038/nm0196-46. PubMed PMID: 8564838.
Rosenzweig M, Marks DF, Zhu H, Hempel D, Mansfield KG, Sehgal PK, Kalams S, Scadden DT, Johnson RP. In vitro T lymphopoiesis of human and rhesus CD34+ progenitor cells. Blood. 1996 May 15;87(10):4040-8. PubMed PMID: 8639759.
Gill PS, Wernz J, Scadden DT, Cohen P, Mukwaya GM, von Roenn JH, Jacobs M, Kempin S, Silverberg I, Gonzales G, Rarick MU, Myers AM, Shepherd F, Sawka C, Pike MC, Ross ME. Randomized phase III trial of liposomal daunorubicin versus doxorubicin, bleomycin, and vincristine in AIDS-related Kaposi's sarcoma. J Clin Oncol. 1996 Aug;14(8):2353-64. doi: 10.1200/JCO.1996.14.8.2353. PubMed PMID: 8708728.
Scadden DT, Pickus O, Hammer SM, Stretcher B, Bresnahan J, Gere J, McGrath J, Agosti JM. Lack of in vivo effect of granulocyte-macrophage colony-stimulating factor on human immunodeficiency virus type 1. AIDS Res Hum Retroviruses. 1996 Aug 10;12(12):1151-9. doi: 10.1089/aid.1996.12.1151. PubMed PMID: 8844019.
Scadden DT. Hematologic disorders and growth factor support in HIV infection. Hematol Oncol Clin North Am. 1996 Oct;10(5):1149-61. doi: 10.1016/s0889-8588(05)70390-7. Review. PubMed PMID: 8880202.
Cheng T, Shen H, Giokas D, Gere J, Tenen DG, Scadden DT. Temporal mapping of gene expression levels during the differentiation of individual primary hematopoietic cells. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13158-63. doi: 10.1073/pnas.93.23.13158. PubMed PMID: 8917561; PubMed Central PMCID: PMC24063.
Franken M, Estabrooks A, Cavacini L, Sherburne B, Wang F, Scadden DT. Epstein-Barr virus-driven gene therapy for EBV-related lymphomas. Nat Med. 1996 Dec;2(12):1379-82. doi: 10.1038/nm1296-1379. PubMed PMID: 8946840.
Scadden DT. Cytokine use in the management of HIV disease. J Acquir Immune Defic Syndr Hum Retrovirol. 1997;16 Suppl 1:S23-9. doi: 10.1097/00042560-199701001-00004. Review. PubMed PMID: 9389312.
Levine AM, Tulpule A, Tessman D, Kaplan L, Giles F, Luskey BD, Scadden DT, Northfelt DW, Silverberg I, Wernz J, Espina B, Von Hoff D. Mitoguazone therapy in patients with refractory or relapsed AIDS-related lymphoma: results from a multicenter phase II trial. J Clin Oncol. 1997 Mar;15(3):1094-103. doi: 10.1200/JCO.1997.15.3.1094. PubMed PMID: 9060550.
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