My Bibliography

select

Ross D, Siegel D. The diverse functionality of NQO1 and its roles in redox control. Redox Biol. 2021 May;41:101950. doi: 10.1016/j.redox.2021.101950. Epub 2021 Mar 20. Review. PubMed PMID: 33774477; PubMed Central PMCID: PMC8027776.

select

Siegel D, Bersie S, Harris P, Di Francesco A, Armstrong M, Reisdorph N, Bernier M, de Cabo R, Fritz K, Ross D. A redox-mediated conformational change in NQO1 controls binding to microtubules and α-tubulin acetylation. Redox Biol. 2021 Feb;39:101840. doi: 10.1016/j.redox.2020.101840. Epub 2020 Dec 18. PubMed PMID: 33360352; PubMed Central PMCID: PMC7772575.

select

Di Francesco A, Choi Y, Bernier M, Zhang Y, Diaz-Ruiz A, Aon MA, Kalafut K, Ehrlich MR, Murt K, Ali A, Pearson KJ, Levan S, Preston JD, Martin-Montalvo A, Martindale JL, Abdelmohsen K, Michel CR, Willmes DM, Henke C, Navas P, Villalba JM, Siegel D, Gorospe M, Fritz K, Biswal S, Ross D, de Cabo R. NQO1 protects obese mice through improvements in glucose and lipid metabolism. NPJ Aging Mech Dis. 2020 Nov 19;6(1):13. doi: 10.1038/s41514-020-00051-6. PubMed PMID: 33298924; PubMed Central PMCID: PMC7678866.

select

Siegel D, Dehn DD, Bokatzian SS, Quinn K, Backos DS, Di Francesco A, Bernier M, Reisdorph N, de Cabo R, Ross D. Redox modulation of NQO1. PLoS One. 2018;13(1):e0190717. doi: 10.1371/journal.pone.0190717. eCollection 2018. PubMed PMID: 29298345; PubMed Central PMCID: PMC5752044.

select

Ross D, Siegel D. Functions of NQO1 in Cellular Protection and CoQ(10) Metabolism and its Potential Role as a Redox Sensitive Molecular Switch. Front Physiol. 2017;8:595. doi: 10.3389/fphys.2017.00595. eCollection 2017. Review. PubMed PMID: 28883796; PubMed Central PMCID: PMC5573868.

select

Xiong R, Zhou W, Siegel D, Kitson RR, Freed CR, Moody CJ, Ross D. A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity. Mol Pharmacol. 2015 Dec;88(6):1045-54. doi: 10.1124/mol.115.101451. Epub 2015 Sep 24. PubMed PMID: 26405178; PubMed Central PMCID: PMC4658594.

select

Blunt CE, Torcuk C, Liu Y, Lewis W, Siegel D, Ross D, Moody CJ. Synthesis and Intracellular Redox Cycling of Natural Quinones and Their Analogues and Identification of Indoleamine-2,3-dioxygenase (IDO) as Potential Target for Anticancer Activity. Angew Chem Int Ed Engl. 2015 Jul 20;54(30):8740-5. doi: 10.1002/anie.201503323. Epub 2015 Jun 10. PubMed PMID: 26096359.

select

Yan C, Liu D, Li L, Wempe MF, Guin S, Khanna M, Meier J, Hoffman B, Owens C, Wysoczynski CL, Nitz MD, Knabe WE, Ahmed M, Brautigan DL, Paschal BM, Schwartz MA, Jones DN, Ross D, Meroueh SO, Theodorescu D. Discovery and characterization of small molecules that target the GTPase Ral. Nature. 2014 Nov 20;515(7527):443-7. doi: 10.1038/nature13713. Epub 2014 Sep 14. PubMed PMID: 25219851; PubMed Central PMCID: PMC4351747.

select

Xiong R, Siegel D, Ross D. Quinone-induced protein handling changes: implications for major protein handling systems in quinone-mediated toxicity. Toxicol Appl Pharmacol. 2014 Oct 15;280(2):285-95. doi: 10.1016/j.taap.2014.08.014. Epub 2014 Aug 22. PubMed PMID: 25151970; PubMed Central PMCID: PMC4312139.

select

Inman M, Visconti A, Yan C, Siegel D, Ross D, Moody CJ. Antitumour indolequinones: synthesis and activity against human pancreatic cancer cells. Org Biomol Chem. 2014 Jul 21;12(27):4848-61. doi: 10.1039/c4ob00711e. PubMed PMID: 24848343; PubMed Central PMCID: PMC4495957.

select

Carvalho C, Siegel D, Inman M, Xiong R, Ross D, Moody CJ. Benzofuranquinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis and biological evaluation. Org Biomol Chem. 2014 May 7;12(17):2663-74. doi: 10.1039/c3ob42258e. PubMed PMID: 24608884.

select

Chang CH, Drechsel DA, Kitson RR, Siegel D, You Q, Backos DS, Ju C, Moody CJ, Ross D. 19-substituted benzoquinone ansamycin heat shock protein-90 inhibitors: biological activity and decreased off-target toxicity. Mol Pharmacol. 2014 Jun;85(6):849-57. doi: 10.1124/mol.113.090654. Epub 2014 Mar 28. PubMed PMID: 24682466; PubMed Central PMCID: PMC4014664.

select

Greim H, Kaden DA, Larson RA, Palermo CM, Rice JM, Ross D, Snyder R. The bone marrow niche, stem cells, and leukemia: impact of drugs, chemicals, and the environment. Ann N Y Acad Sci. 2014 Mar;1310(1):7-31. doi: 10.1111/nyas.12362. Epub 2014 Feb 4. PubMed PMID: 24495159; PubMed Central PMCID: PMC4002179.

select

Xiong R, Siegel D, Ross D. The activation sequence of cellular protein handling systems after proteasomal inhibition in dopaminergic cells. Chem Biol Interact. 2013 Jul 5;204(2):116-24. doi: 10.1016/j.cbi.2013.04.016. Epub 2013 May 14. PubMed PMID: 23684743; PubMed Central PMCID: PMC3784407.

select

Pasceri R, Siegel D, Ross D, Moody CJ. Aminophenoxazinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis of exfoliazone and chandrananimycin A. J Med Chem. 2013 Apr 25;56(8):3310-7. doi: 10.1021/jm400049z. Epub 2013 Apr 10. PubMed PMID: 23521768.

select

Kitson RR, Chang CH, Xiong R, Williams HE, Davis AL, Lewis W, Dehn DL, Siegel D, Roe SM, Prodromou C, Ross D, Moody CJ. Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90. Nat Chem. 2013 Apr;5(4):307-14. doi: 10.1038/nchem.1596. Epub 2013 Mar 10. PubMed PMID: 23511419; PubMed Central PMCID: PMC3839848.

select

Siegel D, Kepa JK, Ross D. NAD(P)H:quinone oxidoreductase 1 (NQO1) localizes to the mitotic spindle in human cells. PLoS One. 2012;7(9):e44861. doi: 10.1371/journal.pone.0044861. Epub 2012 Sep 11. PubMed PMID: 22984577; PubMed Central PMCID: PMC3439439.

select

Siew EL, Chan KM, Williams GT, Ross D, Inayat-Hussain SH. Protection of hydroquinone-induced apoptosis by downregulation of Fau is mediated by NQO1. Free Radic Biol Med. 2012 Oct 15;53(8):1616-24. doi: 10.1016/j.freeradbiomed.2012.05.046. Epub 2012 Jun 9. PubMed PMID: 22687461.

select

Siegel D, Yan C, Ross D. NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones. Biochem Pharmacol. 2012 Apr 15;83(8):1033-40. doi: 10.1016/j.bcp.2011.12.017. Epub 2011 Dec 24. Review. PubMed PMID: 22209713; PubMed Central PMCID: PMC3482497.

select

Yan C, Siegel D, Newsome J, Chilloux A, Moody CJ, Ross D. Antitumor indolequinones induced apoptosis in human pancreatic cancer cells via inhibition of thioredoxin reductase and activation of redox signaling. Mol Pharmacol. 2012 Mar;81(3):401-10. doi: 10.1124/mol.111.076091. Epub 2011 Dec 6. PubMed PMID: 22147753; PubMed Central PMCID: PMC3286294.

select

Yan C, Dufour M, Siegel D, Reigan P, Gomez J, Shieh B, Moody CJ, Ross D. Indolequinone inhibitors of NRH:quinone oxidoreductase 2. Characterization of the mechanism of inhibition in both cell-free and cellular systems. Biochemistry. 2011 Aug 9;50(31):6678-88. doi: 10.1021/bi2002967. Epub 2011 Jul 19. PubMed PMID: 21718050; PubMed Central PMCID: PMC3291479.

select

Dufour M, Yan C, Siegel D, Colucci MA, Jenner M, Oldham NJ, Gomez J, Reigan P, Li Y, De Matteis CI, Ross D, Moody CJ. Mechanism-based inhibition of quinone reductase 2 (NQO2): selectivity for NQO2 over NQO1 and structural basis for flavoprotein inhibition. Chembiochem. 2011 May 16;12(8):1203-8. doi: 10.1002/cbic.201100085. Epub 2011 Apr 19. PubMed PMID: 21506232; PubMed Central PMCID: PMC3880221.

select

Ross D. Quinone Reductases. In: Guengerich FP, editor. Comprehensive Toxicology 2nd ed. New York: Elsevier; 2010.

select

Ross D, Zhou H, Siegel D. Benzene toxicity: The role of the susceptibility factor NQO1 in bone marrow endothelial cell signaling and function. Chem Biol Interact. 2011 Jun 30;192(1-2):145-9. doi: 10.1016/j.cbi.2010.10.008. Epub 2010 Oct 21. PubMed PMID: 20970411; PubMed Central PMCID: PMC3155573.

select

Chan KM, Rajab NF, Siegel D, Din LB, Ross D, Inayat-Hussain SH. Goniothalamin induces coronary artery smooth muscle cells apoptosis: the p53-dependent caspase-2 activation pathway. Toxicol Sci. 2010 Aug;116(2):533-48. doi: 10.1093/toxsci/kfq151. Epub 2010 May 24. PubMed PMID: 20498002.

select

Zhou H, Dehn D, Kepa JK, Siegel D, Scott DE, Tan W, Ross D. NAD(P)H:quinone oxidoreductase 1-compromised human bone marrow endothelial cells exhibit decreased adhesion molecule expression and CD34+ hematopoietic cell adhesion. J Pharmacol Exp Ther. 2010 Jul;334(1):260-8. doi: 10.1124/jpet.110.167841. Epub 2010 Apr 8. PubMed PMID: 20378716; PubMed Central PMCID: PMC2912043.

select

Ross D, Reigan P, Siegel D. One and two electron mediated reduction of quinones. Enzymology and toxicolgical implications.. In: Elfarra A, editor. Advances in Bioactivation Research New York: Springer; 2009. p.169-198.

select

Inayat-Hussain SH, Ibrahim HA, Siew EL, Rajab NF, Chan KM, G T Williams, Ross D. Modulation of the benzene metabolite hydroquinone induced toxicity: evidence for an important role of fau. Chem Biol Interact. 2010 Mar 19;184(1-2):310-2. doi: 10.1016/j.cbi.2009.12.009. Epub 2009 Dec 16. PubMed PMID: 20025857.

select

Nolan KA, Doncaster JR, Dunstan MS, Scott KA, Frenkel AD, Siegel D, Ross D, Barnes J, Levy C, Leys D, Whitehead RC, Stratford IJ, Bryce RA. Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1). J Med Chem. 2009 Nov 26;52(22):7142-56. doi: 10.1021/jm9011609. PubMed PMID: 19877692.

select

Ross D, Zhou H. Relationships between metabolic and non-metabolic susceptibility factors in benzene toxicity. Chem Biol Interact. 2010 Mar 19;184(1-2):222-8. doi: 10.1016/j.cbi.2009.11.017. Epub 2009 Nov 24. PubMed PMID: 19941840; PubMed Central PMCID: PMC2846242.

select

Zhou H, Kepa JK, Siegel D, Miura S, Hiraki Y, Ross D. Benzene metabolite hydroquinone up-regulates chondromodulin-I and inhibits tube formation in human bone marrow endothelial cells. Mol Pharmacol. 2009 Sep;76(3):579-87. doi: 10.1124/mol.109.057323. Epub 2009 Jun 12. PubMed PMID: 19525446; PubMed Central PMCID: PMC2730389.

select

Yan C, Shieh B, Reigan P, Zhang Z, Colucci MA, Chilloux A, Newsome JJ, Siegel D, Chan D, Moody CJ, Ross D. Potent activity of indolequinones against human pancreatic cancer: identification of thioredoxin reductase as a potential target. Mol Pharmacol. 2009 Jul;76(1):163-72. doi: 10.1124/mol.109.055855. Epub 2009 Apr 13. PubMed PMID: 19364812; PubMed Central PMCID: PMC2701460.

select

Stagos D, Zhou H, Ross D, Vasiliou V. 4-HNE inhibits tube formation and up-regulates chondromodulin-I in human endothelial cells. Biochem Biophys Res Commun. 2009 Feb 13;379(3):654-8. doi: 10.1016/j.bbrc.2008.11.095. Epub 2008 Dec 3. PubMed PMID: 19056352; PubMed Central PMCID: PMC2757412.

select

Guo W, Siegel D, Ross D. Stability of the Hsp90 inhibitor 17AAG hydroquinone and prevention of metal-catalyzed oxidation. J Pharm Sci. 2008 Dec;97(12):5147-57. doi: 10.1002/jps.21394. PubMed PMID: 18393300; PubMed Central PMCID: PMC2580801.

select

Yan C, Kepa JK, Siegel D, Stratford IJ, Ross D. Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1). Mol Pharmacol. 2008 Dec;74(6):1657-65. doi: 10.1124/mol.108.050401. Epub 2008 Sep 15. PubMed PMID: 18794327; PubMed Central PMCID: PMC2612562.

select

Guo W, Reigan P, Siegel D, Ross D. Enzymatic reduction and glutathione conjugation of benzoquinone ansamycin heat shock protein 90 inhibitors: relevance for toxicity and mechanism of action. Drug Metab Dispos. 2008 Oct;36(10):2050-7. doi: 10.1124/dmd.108.022004. Epub 2008 Jul 17. PubMed PMID: 18635747; PubMed Central PMCID: PMC2574845.

select

Awadallah NS, Dehn D, Shah RJ, Russell Nash S, Chen YK, Ross D, Bentz JS, Shroyer KR. NQO1 expression in pancreatic cancer and its potential use as a biomarker. Appl Immunohistochem Mol Morphol. 2008 Jan;16(1):24-31. doi: 10.1097/PAI.0b013e31802e91d0. PubMed PMID: 18091324.

select

Zhu H, Jia Z, Mahaney JE, Ross D, Misra HP, Trush MA, Li Y. The highly expressed and inducible endogenous NAD(P)H:quinone oxidoreductase 1 in cardiovascular cells acts as a potential superoxide scavenger. Cardiovasc Toxicol. 2007;7(3):202-11. doi: 10.1007/s12012-007-9001-z. PubMed PMID: 17901563.

select

Siegel D, Kepa JK, Ross D. Biochemical and genetic analysis of NAD(P)H:quinone oxidoreductase 1 (NQO1). Curr Protoc Toxicol. 2007;Chapter 4:Unit4.22. doi: 10.1002/0471140856.tx0422s32. PubMed PMID: 23045144.

select

Nolan KA, Zhao H, Faulder PF, Frenkel AD, Timson DJ, Siegel D, Ross D, Burke TR Jr, Stratford IJ, Bryce RA. Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity. J Med Chem. 2007 Dec 13;50(25):6316-25. doi: 10.1021/jm070472p. Epub 2007 Nov 14. PubMed PMID: 17999461.

select

Colucci MA, Reigan P, Siegel D, Chilloux A, Ross D, Moody CJ. Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity. J Med Chem. 2007 Nov 15;50(23):5780-9. doi: 10.1021/jm070396q. Epub 2007 Oct 18. PubMed PMID: 17944451; PubMed Central PMCID: PMC2536657.

select

Zafar KS, Inayat-Hussain SH, Ross D. A comparative study of proteasomal inhibition and apoptosis induced in N27 mesencephalic cells by dopamine and MG132. J Neurochem. 2007 Aug;102(3):913-21. doi: 10.1111/j.1471-4159.2007.04637.x. Epub 2007 May 14. PubMed PMID: 17504267.

select

Reigan P, Colucci MA, Siegel D, Chilloux A, Moody CJ, Ross D. Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells. Biochemistry. 2007 May 22;46(20):5941-50. doi: 10.1021/bi700008y. Epub 2007 Apr 25. PubMed PMID: 17455910.

select

Fang L, Battisti RF, Cheng H, Reigan P, Xin Y, Shen J, Ross D, Chan KK, Martin EW Jr, Wang PG, Sun D. Enzyme specific activation of benzoquinone ansamycin prodrugs using HuCC49DeltaCH2-beta-galactosidase conjugates. J Med Chem. 2006 Oct 19;49(21):6290-7. doi: 10.1021/jm060647f. PubMed PMID: 17034135; PubMed Central PMCID: PMC2596603.

select

Zafar KS, Inayat-Hussain SH, Siegel D, Bao A, Shieh B, Ross D. Overexpression of NQO1 protects human SK-N-MC neuroblastoma cells against dopamine-induced cell death. Toxicol Lett. 2006 Oct 25;166(3):261-7. doi: 10.1016/j.toxlet.2006.07.340. Epub 2006 Aug 15. PubMed PMID: 16978807.

select

Guo W, Reigan P, Siegel D, Zirrolli J, Gustafson D, Ross D. The bioreduction of a series of benzoquinone ansamycins by NAD(P)H:quinone oxidoreductase 1 to more potent heat shock protein 90 inhibitors, the hydroquinone ansamycins. Mol Pharmacol. 2006 Oct;70(4):1194-203. doi: 10.1124/mol.106.025643. Epub 2006 Jul 6. PubMed PMID: 16825487.

select

Dehn DL, Siegel D, Zafar KS, Reigan P, Swann E, Moody CJ, Ross D. 5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo. Mol Cancer Ther. 2006 Jul;5(7):1702-9. doi: 10.1158/1535-7163.MCT-06-0105. PubMed PMID: 16891456.

select

Zafar KS, Siegel D, Ross D. A potential role for cyclized quinones derived from dopamine, DOPA, and 3,4-dihydroxyphenylacetic acid in proteasomal inhibition. Mol Pharmacol. 2006 Sep;70(3):1079-86. doi: 10.1124/mol.106.024703. Epub 2006 Jun 21. PubMed PMID: 16790533.

select

Zhu H, Zhang L, Itoh K, Yamamoto M, Ross D, Trush MA, Zweier JL, Li Y. Nrf2 controls bone marrow stromal cell susceptibility to oxidative and electrophilic stress. Free Radic Biol Med. 2006 Jul 1;41(1):132-43. doi: 10.1016/j.freeradbiomed.2006.03.020. Epub 2006 Apr 1. PubMed PMID: 16781461.

select

Vasiliou V, Ross D, Nebert DW. Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family. Hum Genomics. 2006 Mar;2(5):329-35. doi: 10.1186/1479-7364-2-5-329. Review. PubMed PMID: 16595077; PubMed Central PMCID: PMC3500182.