My Bibliography

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Azzi A, Atkinson J, Ozer NK, Manor D, Wallert M, Galli F. Vitamin E discussion forum position paper on the revision of the nomenclature of vitamin E. Free Radic Biol Med. 2023 Oct;207:178-180. doi: 10.1016/j.freeradbiomed.2023.06.029. Epub 2023 Jul 16. Review. PubMed PMID: 37463635; PubMed Central PMCID: PMC10681751.

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Ulatowski L, Ghelfi M, West R, Atkinson J, Finno CJ, Manor D. The tocopherol transfer protein mediates vitamin E trafficking between cerebellar astrocytes and neurons. J Biol Chem. 2022 Mar;298(3):101712. doi: 10.1016/j.jbc.2022.101712. Epub 2022 Feb 9. PubMed PMID: 35150738; PubMed Central PMCID: PMC8913317.

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Volovetz J, Berezovsky AD, Alban T, Chen Y, Lauko A, Aranjuez GF, Burtscher A, Shibuya K, Silver DJ, Peterson J, Manor D, McDonald JA, Lathia JD. Identifying conserved molecular targets required for cell migration of glioblastoma cancer stem cells. Cell Death Dis. 2020 Feb 26;11(2):152. doi: 10.1038/s41419-020-2342-2. PubMed PMID: 32102991; PubMed Central PMCID: PMC7044427.

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Violet PC, Ebenuwa IC, Wang Y, Niyyati M, Padayatty SJ, Head B, Wilkins K, Chung S, Thakur V, Ulatowski L, Atkinson J, Ghelfi M, Smith S, Tu H, Bobe G, Liu CY, Herion DW, Shamburek RD, Manor D, Traber MG, Levine M. Vitamin E sequestration by liver fat in humans. JCI Insight. 2020 Jan 16;5(1). doi: 10.1172/jci.insight.133309. PubMed PMID: 31821172; PubMed Central PMCID: PMC7030816.

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Cao S, Chung S, Kim S, Li Z, Manor D, Buck M. K-Ras G-domain binding with signaling lipid phosphatidylinositol (4,5)-phosphate (PIP2): membrane association, protein orientation, and function. J Biol Chem. 2019 Apr 26;294(17):7068-7084. doi: 10.1074/jbc.RA118.004021. Epub 2019 Feb 21. PubMed PMID: 30792310; PubMed Central PMCID: PMC6497929.

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Cianciola NL, Chung S, Manor D, Carlin CR. Adenovirus Modulates Toll-Like Receptor 4 Signaling by Reprogramming ORP1L-VAP Protein Contacts for Cholesterol Transport from Endosomes to the Endoplasmic Reticulum. J Virol. 2017 Mar 15;91(6). doi: 10.1128/JVI.01904-16. Print 2017 Mar 15. PubMed PMID: 28077646; PubMed Central PMCID: PMC5331795.

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Chung S, Ghelfi M, Atkinson J, Parker R, Qian J, Carlin C, Manor D. Vitamin E and Phosphoinositides Regulate the Intracellular Localization of the Hepatic α-Tocopherol Transfer Protein. J Biol Chem. 2016 Aug 12;291(33):17028-39. doi: 10.1074/jbc.M116.734210. Epub 2016 Jun 15. PubMed PMID: 27307040; PubMed Central PMCID: PMC5016108.

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Gupta M, Qi X, Thakur V, Manor D. Tyrosine phosphorylation of Dbl regulates GTPase signaling. J Biol Chem. 2014 Jun 13;289(24):17195-202. doi: 10.1074/jbc.M114.573782. Epub 2014 Apr 28. PubMed PMID: 24778185; PubMed Central PMCID: PMC4059160.

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Ulatowski L, Parker R, Warrier G, Sultana R, Butterfield DA, Manor D. Vitamin E is essential for Purkinje neuron integrity. Neuroscience. 2014 Feb 28;260:120-9. doi: 10.1016/j.neuroscience.2013.12.001. Epub 2013 Dec 14. PubMed PMID: 24342566; PubMed Central PMCID: PMC3943241.

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Gupta M, Kamynina E, Morley S, Chung S, Muakkassa N, Wang H, Brathwaite S, Sharma G, Manor D. Plekhg4 is a novel Dbl family guanine nucleotide exchange factor protein for rho family GTPases. J Biol Chem. 2013 May 17;288(20):14522-14530. doi: 10.1074/jbc.M112.430371. Epub 2013 Apr 9. PubMed PMID: 23572525; PubMed Central PMCID: PMC3656306.

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Ulatowski L, Manor D. Vitamin E trafficking in neurologic health and disease. Annu Rev Nutr. 2013;33:87-103. doi: 10.1146/annurev-nutr-071812-161252. Epub 2013 Apr 29. Review. PubMed PMID: 23642196; PubMed Central PMCID: PMC9719402.

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Ulatowski L, Dreussi C, Noy N, Barnholtz-Sloan J, Klein E, Manor D. Expression of the α-tocopherol transfer protein gene is regulated by oxidative stress and common single-nucleotide polymorphisms. Free Radic Biol Med. 2012 Dec 15;53(12):2318-26. doi: 10.1016/j.freeradbiomed.2012.10.528. Epub 2012 Oct 16. PubMed PMID: 23079030; PubMed Central PMCID: PMC3612136.

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Miller GW, Ulatowski L, Labut EM, Lebold KM, Manor D, Atkinson J, Barton CL, Tanguay RL, Traber MG. The α-tocopherol transfer protein is essential for vertebrate embryogenesis. PLoS One. 2012;7(10):e47402. doi: 10.1371/journal.pone.0047402. Epub 2012 Oct 15. PubMed PMID: 23077608; PubMed Central PMCID: PMC3471827.

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Bardowell SA, Duan F, Manor D, Swanson JE, Parker RS. Disruption of mouse cytochrome p450 4f14 (Cyp4f14 gene) causes severe perturbations in vitamin E metabolism. J Biol Chem. 2012 Jul 27;287(31):26077-86. doi: 10.1074/jbc.M112.373597. Epub 2012 Jun 4. PubMed PMID: 22665481; PubMed Central PMCID: PMC3406691.

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Traber MG, Manor D. Vitamin E. Adv Nutr. 2012 May 1;3(3):330-1. doi: 10.3945/an.112.002139. PubMed PMID: 22585906; PubMed Central PMCID: PMC3649464.

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Ulatowski L, Parker R, Davidson C, Yanjanin N, Kelley TJ, Corey D, Atkinson J, Porter F, Arai H, Walkley SU, Manor D. Altered vitamin E status in Niemann-Pick type C disease. J Lipid Res. 2011 Jul;52(7):1400-10. doi: 10.1194/jlr.M015560. Epub 2011 May 5. PubMed PMID: 21550990; PubMed Central PMCID: PMC3122910.

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Zhang WX, Thakur V, Lomize A, Pogozheva I, Panagabko C, Cecchini M, Baptist M, Morley S, Manor D, Atkinson J. The contribution of surface residues to membrane binding and ligand transfer by the α-tocopherol transfer protein (α-TTP). J Mol Biol. 2011 Jan 28;405(4):972-88. doi: 10.1016/j.jmb.2010.11.028. Epub 2010 Nov 24. PubMed PMID: 21110980; PubMed Central PMCID: PMC3038628.

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Morley S, Thakur V, Danielpour D, Parker R, Arai H, Atkinson J, Barnholtz-Sloan J, Klein E, Manor D. Tocopherol transfer protein sensitizes prostate cancer cells to vitamin E. J Biol Chem. 2010 Nov 12;285(46):35578-89. doi: 10.1074/jbc.M110.169664. Epub 2010 Sep 8. PubMed PMID: 20826775; PubMed Central PMCID: PMC2975182.

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Thakur V, Morley S, Manor D. Hepatic α-tocopherol transfer protein: ligand-induced protection from proteasomal degradation. Biochemistry. 2010 Nov 2;49(43):9339-44. doi: 10.1021/bi100960b. PubMed PMID: 20828164; PubMed Central PMCID: PMC2964440.

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Bardowell SA, Stec DE, Parker RS. Common variants of cytochrome P450 4F2 exhibit altered vitamin E-{omega}-hydroxylase specific activity. J Nutr. 2010 Nov;140(11):1901-6. doi: 10.3945/jn.110.128579. Epub 2010 Sep 22. PubMed PMID: 20861217; PubMed Central PMCID: PMC2955872.

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West R, Panagabko C, Atkinson J. Synthesis and characterization of BODIPY-alpha-tocopherol: a fluorescent form of vitamin E. J Org Chem. 2010 May 7;75(9):2883-92. doi: 10.1021/jo100095n. PubMed PMID: 20387845; PubMed Central PMCID: PMC2891523.

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Zhang WX, Frahm G, Morley S, Manor D, Atkinson J. Effect of bilayer phospholipid composition and curvature on ligand transfer by the alpha-tocopherol transfer protein. Lipids. 2009 Jul;44(7):631-41. doi: 10.1007/s11745-009-3310-x. Epub 2009 May 21. PubMed PMID: 19458973; PubMed Central PMCID: PMC9784539.

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Ohnmacht S, Nava P, West R, Parker R, Atkinson J. Inhibition of oxidative metabolism of tocopherols with omega-N-heterocyclic derivatives of vitamin E. Bioorg Med Chem. 2008 Aug 15;16(16):7631-8. doi: 10.1016/j.bmc.2008.07.020. Epub 2008 Jul 13. PubMed PMID: 18656365; PubMed Central PMCID: PMC2610486.

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Morley S, Cecchini M, Zhang W, Virgulti A, Noy N, Atkinson J, Manor D. Mechanisms of ligand transfer by the hepatic tocopherol transfer protein. J Biol Chem. 2008 Jun 27;283(26):17797-804. doi: 10.1074/jbc.M800121200. Epub 2008 May 5. PubMed PMID: 18458085; PubMed Central PMCID: PMC2440614.

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Valastyan S, Thakur V, Johnson A, Kumar K, Manor D. Novel transcriptional activities of vitamin E: inhibition of cholesterol biosynthesis. Biochemistry. 2008 Jan 15;47(2):744-52. doi: 10.1021/bi701432q. Epub 2007 Dec 21. PubMed PMID: 18095660; PubMed Central PMCID: PMC2531211.

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Kamynina E, Kauppinen K, Duan F, Muakkassa N, Manor D. Regulation of proto-oncogenic dbl by chaperone-controlled, ubiquitin-mediated degradation. Mol Cell Biol. 2007 Mar;27(5):1809-22. doi: 10.1128/MCB.01051-06. Epub 2006 Dec 18. PubMed PMID: 17178836; PubMed Central PMCID: PMC1820456.

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Manor D, Morley S. The alpha-tocopherol transfer protein. Vitam Horm. 2007;76:45-65. doi: 10.1016/S0083-6729(07)76003-X. Review. PubMed PMID: 17628171.

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Morley S, Wagner J, Kauppinen K, Sherman M, Manor D. Requirement for Akt-mediated survival in cell transformation by the dbl oncogene. Cell Signal. 2007 Jan;19(1):211-8. doi: 10.1016/j.cellsig.2006.06.005. Epub 2006 Aug 17. PubMed PMID: 16916597.

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Qian J, Atkinson J, Manor D. Biochemical consequences of heritable mutations in the alpha-tocopherol transfer protein. Biochemistry. 2006 Jul 11;45(27):8236-42. doi: 10.1021/bi060522c. PubMed PMID: 16819822.

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Nava P, Cecchini M, Chirico S, Gordon H, Morley S, Manor D, Atkinson J. Preparation of fluorescent tocopherols for use in protein binding and localization with the alpha-tocopherol transfer protein. Bioorg Med Chem. 2006 Jun 1;14(11):3721-36. doi: 10.1016/j.bmc.2006.01.053. Epub 2006 Feb 14. PubMed PMID: 16481173.

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Morley S, Cross V, Cecchini M, Nava P, Atkinson J, Manor D. Utility of a fluorescent vitamin E analogue as a probe for tocopherol transfer protein activity. Biochemistry. 2006 Jan 31;45(4):1075-81. doi: 10.1021/bi052271y. PubMed PMID: 16430203; PubMed Central PMCID: PMC2515562.

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Qian J, Morley S, Wilson K, Nava P, Atkinson J, Manor D. Intracellular trafficking of vitamin E in hepatocytes: the role of tocopherol transfer protein. J Lipid Res. 2005 Oct;46(10):2072-82. doi: 10.1194/jlr.M500143-JLR200. Epub 2005 Jul 16. PubMed PMID: 16024914.

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Kauppinen KP, Duan F, Wels JI, Manor D. Regulation of the Dbl proto-oncogene by heat shock cognate protein 70 (Hsc70). J Biol Chem. 2005 Jun 3;280(22):21638-44. doi: 10.1074/jbc.M413984200. Epub 2005 Mar 31. PubMed PMID: 15802271.

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Morley S, Panagabko C, Stocker A, Atkinson J, Manor D. Structure-function relationship in the tocopherol transfer protein. Ann N Y Acad Sci. 2004 Dec;1031:332-3. doi: 10.1196/annals.1331.035. PubMed PMID: 15753161.

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Johnson A, Manor D. The transcriptional signature of vitamin E. Ann N Y Acad Sci. 2004 Dec;1031:337-8. doi: 10.1196/annals.1331.037. PubMed PMID: 15753163.

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Qian J, Wilson K, Nava P, Morley S, Atkinson J, Manor D. Intracellular localization of alpha-tocopherol transfer protein and alpha-tocopherol. Ann N Y Acad Sci. 2004 Dec;1031:330-1. doi: 10.1196/annals.1331.034. PubMed PMID: 15753160.

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Atkinson JK, Nava P, Frahm G, Curtis V, Manor D. Fluorescent tocopherols as probes of inter-vesicular transfer catalyzed by the alpha-tocopherol transfer protein. Ann N Y Acad Sci. 2004 Dec;1031:324-7. doi: 10.1196/annals.1331.032. PubMed PMID: 15753158.

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Morley S, Panagabko C, Shineman D, Mani B, Stocker A, Atkinson J, Manor D. Molecular determinants of heritable vitamin E deficiency. Biochemistry. 2004 Apr 13;43(14):4143-9. doi: 10.1021/bi0363073. PubMed PMID: 15065857.

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Manor D, Shmidt EN, Budhu A, Flesken-Nikitin A, Zgola M, Page R, Nikitin AY, Noy N. Mammary carcinoma suppression by cellular retinoic acid binding protein-II. Cancer Res. 2003 Aug 1;63(15):4426-33. PubMed PMID: 12907615.

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Manor D, Atkinson J. Is tocopherol associated protein a misnomer?. J Nutr Biochem. 2003 Jul;14(7):421-2; author reply 423. doi: 10.1016/s0955-2863(03)00073-1. PubMed PMID: 12915224.

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Panagabko C, Morley S, Hernandez M, Cassolato P, Gordon H, Parsons R, Manor D, Atkinson J. Ligand specificity in the CRAL-TRIO protein family. Biochemistry. 2003 Jun 3;42(21):6467-74. doi: 10.1021/bi034086v. PubMed PMID: 12767229.

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Panagabko C, Morley S, Neely S, Lei H, Manor D, Atkinson J. Expression and refolding of recombinant human alpha-tocopherol transfer protein capable of specific alpha-tocopherol binding. Protein Expr Purif. 2002 Apr;24(3):395-403. doi: 10.1006/prep.2001.1576. PubMed PMID: 11922755.

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Manor D. Measurement of GTPase.effector affinities. Methods Enzymol. 2000;325:139-49. doi: 10.1016/s0076-6879(00)25438-4. PubMed PMID: 11036599.

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Lin R, Cerione RA, Manor D. Specific contributions of the small GTPases Rho, Rac, and Cdc42 to Dbl transformation. J Biol Chem. 1999 Aug 13;274(33):23633-41. doi: 10.1074/jbc.274.33.23633. PubMed PMID: 10438546.

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Nassar N, Hoffman GR, Manor D, Clardy JC, Cerione RA. Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP. Nat Struct Biol. 1998 Dec;5(12):1047-52. doi: 10.1038/4156. PubMed PMID: 9846874.

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Wu WJ, Lin R, Cerione RA, Manor D. Transformation activity of Cdc42 requires a region unique to Rho-related proteins. J Biol Chem. 1998 Jul 3;273(27):16655-8. doi: 10.1074/jbc.273.27.16655. PubMed PMID: 9642217.

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Leonard DA, Lin R, Cerione RA, Manor D. Biochemical studies of the mechanism of action of the Cdc42-GTPase-activating protein. J Biol Chem. 1998 Jun 26;273(26):16210-5. doi: 10.1074/jbc.273.26.16210. PubMed PMID: 9632678.

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Wu WJ, Leonard DA, A-Cerione R, Manor D. Interaction between Cdc42Hs and RhoGDI is mediated through the Rho insert region. J Biol Chem. 1997 Oct 17;272(42):26153-8. doi: 10.1074/jbc.272.42.26153. PubMed PMID: 9334181.

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Lin R, Bagrodia S, Cerione R, Manor D. A novel Cdc42Hs mutant induces cellular transformation. Curr Biol. 1997 Oct 1;7(10):794-7. doi: 10.1016/s0960-9822(06)00338-1. PubMed PMID: 9368762.

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Feltham JL, Dötsch V, Raza S, Manor D, Cerione RA, Sutcliffe MJ, Wagner G, Oswald RE. Definition of the switch surface in the solution structure of Cdc42Hs. Biochemistry. 1997 Jul 22;36(29):8755-66. doi: 10.1021/bi970694x. PubMed PMID: 9220962.