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Diaz JD. TNF-a and IL-1b Do Not Induce Langerhans Cell Migration by Inhibiting TGFb Activation. JID innovations. Forthcoming.
Nguyen BA, Ho J, De La Cruz Diaz JS, Nishimura S, Kaplan DH. TGFβ activating integrins β6 and β8 are dysregulated in inflammatory skin disease and cutaneous melanoma. J Dermatol Sci. 2022 Apr;106(1):2-11. doi: 10.1016/j.jdermsci.2022.01.008. Epub 2022 Jan 31. PubMed PMID: 35277328; PubMed Central PMCID: PMC9124681.
Zhang S, Edwards TN, Chaudhri VK, Wu J, Cohen JA, Hirai T, Rittenhouse N, Schmitz EG, Zhou PY, McNeil BD, Yang Y, Koerber HR, Sumpter TL, Poholek AC, Davis BM, Albers KM, Singh H, Kaplan DH. Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis. Cell. 2021 Apr 15;184(8):2151-2166.e16. doi: 10.1016/j.cell.2021.03.002. Epub 2021 Mar 24. PubMed PMID: 33765440; PubMed Central PMCID: PMC8052305.
Najjar SA, Ejoh LL, Loeza-Alcocer E, Edwards BS, Smith-Edwards KM, Epouhe AY, Gold MS, Davis BM, Albers KM. Optogenetic inhibition of the colon epithelium reduces hypersensitivity in a mouse model of inflammatory bowel disease. Pain. 2021 Apr 1;162(4):1126-1134. doi: 10.1097/j.pain.0000000000002110. PubMed PMID: 33048854; PubMed Central PMCID: PMC7969374.
Elmets CA, Korman NJ, Prater EF, Wong EB, Rupani RN, Kivelevitch D, Armstrong AW, Connor C, Cordoro KM, Davis DMR, Elewski BE, Gelfand JM, Gordon KB, Gottlieb AB, Kaplan DH, Kavanaugh A, Kiselica M, Kroshinsky D, Lebwohl M, Leonardi CL, Lichten J, Lim HW, Mehta NN, Paller AS, Parra SL, Pathy AL, Siegel M, Stoff B, Strober B, Wu JJ, Hariharan V, Menter A. Joint AAD-NPF Guidelines of care for the management and treatment of psoriasis with topical therapy and alternative medicine modalities for psoriasis severity measures. J Am Acad Dermatol. 2021 Feb;84(2):432-470. doi: 10.1016/j.jaad.2020.07.087. Epub 2020 Jul 30. PubMed PMID: 32738429.
Hirai T, Yang Y, Zenke Y, Li H, Chaudhri VK, De La Cruz Diaz JS, Zhou PY, Nguyen BA, Bartholin L, Workman CJ, Griggs DW, Vignali DAA, Singh H, Masopust D, Kaplan DH. Competition for Active TGFβ Cytokine Allows for Selective Retention of Antigen-Specific Tissue- Resident Memory T Cells in the Epidermal Niche. Immunity. 2021 Jan 12;54(1):84-98.e5. doi: 10.1016/j.immuni.2020.10.022. Epub 2020 Nov 18. PubMed PMID: 33212014; PubMed Central PMCID: PMC7856016.
Zhou C, Monin L, Gordon R, Aggor FEY, Bechara R, Edwards TN, Kaplan DH, Gingras S, Gaffen SL. An IL-17F.S65L Knock-In Mouse Reveals Similarities and Differences in IL-17F Function in Oral Candidiasis: A New Tool to Understand IL-17F. J Immunol. 2020 Aug 1;205(3):720-730. doi: 10.4049/jimmunol.2000394. Epub 2020 Jun 29. PubMed PMID: 32601099; PubMed Central PMCID: PMC7369233.
Aggor FEY, Break TJ, Trevejo-Nuñez G, Whibley N, Coleman BM, Bailey RD, Kaplan DH, Naglik JR, Shan W, Shetty AC, McCracken C, Durum SK, Biswas PS, Bruno VM, Kolls JK, Lionakis MS, Gaffen SL. Oral epithelial IL-22/STAT3 signaling licenses IL-17-mediated immunity to oral mucosal candidiasis. Sci Immunol. 2020 Jun 5;5(48). doi: 10.1126/sciimmunol.aba0570. PubMed PMID: 32503875; PubMed Central PMCID: PMC7340112.
Menter A, Gelfand JM, Connor C, Armstrong AW, Cordoro KM, Davis DMR, Elewski BE, Gordon KB, Gottlieb AB, Kaplan DH, Kavanaugh A, Kiselica M, Kivelevitch D, Korman NJ, Kroshinsky D, Lebwohl M, Leonardi CL, Lichten J, Lim HW, Mehta NN, Paller AS, Parra SL, Pathy AL, Prater EF, Rahimi RS, Rupani RN, Siegel M, Stoff B, Strober BE, Tapper EB, Wong EB, Wu JJ, Hariharan V, Elmets CA. Joint American Academy of Dermatology-National Psoriasis Foundation guidelines of care for the management of psoriasis with systemic nonbiologic therapies. J Am Acad Dermatol. 2020 Jun;82(6):1445-1486. doi: 10.1016/j.jaad.2020.02.044. Epub 2020 Feb 28. PubMed PMID: 32119894.
Hirai T, Whitley SK, Kaplan DH. Migration and Function of Memory CD8+ T Cells in Skin. J Invest Dermatol. 2020 Apr;140(4):748-755. doi: 10.1016/j.jid.2019.09.014. Epub 2019 Dec 4. Review. PubMed PMID: 31812277; PubMed Central PMCID: PMC7573784.
Cohen JA, Wu J, Kaplan DH. Neuronal Regulation of Cutaneous Immunity. J Immunol. 2020 Jan 15;204(2):264-270. doi: 10.4049/jimmunol.1901109. Review. PubMed PMID: 31907268; PubMed Central PMCID: PMC7583491.
Menter A, Cordoro KM, Davis DMR, Kroshinsky D, Paller AS, Armstrong AW, Connor C, Elewski BE, Gelfand JM, Gordon KB, Gottlieb AB, Kaplan DH, Kavanaugh A, Kiselica M, Kivelevitch D, Korman NJ, Lebwohl M, Leonardi CL, Lichten J, Lim HW, Mehta NN, Parra SL, Pathy AL, Farley Prater EA, Rupani RN, Siegel M, Stoff B, Strober BE, Wong EB, Wu JJ, Hariharan V, Elmets CA. Joint American Academy of Dermatology-National Psoriasis Foundation guidelines of care for the management and treatment of psoriasis in pediatric patients. J Am Acad Dermatol. 2020 Jan;82(1):161-201. doi: 10.1016/j.jaad.2019.08.049. Epub 2019 Nov 5. PubMed PMID: 31703821.
De La Cruz Diaz JS, Kaplan DH. Langerhans Cells Spy on Keratinocytes. J Invest Dermatol. 2019 Nov;139(11):2260-2262. doi: 10.1016/j.jid.2019.06.120. PubMed PMID: 31648687; PubMed Central PMCID: PMC6818751.
Nelson DS, Marano RL, Joo Y, Tian SY, Patel B, Kaplan DH, Shlomchik MJ, Stevenson K, Bronson RT, Rollins BJ. BRAF V600E and Pten deletion in mice produces a histiocytic disorder with features of Langerhans cell histiocytosis. PLoS One. 2019;14(9):e0222400. doi: 10.1371/journal.pone.0222400. eCollection 2019. PubMed PMID: 31527903; PubMed Central PMCID: PMC6748438.
Yang Y, Zenke Y, Shaik JA, Hirai T, Kaplan DH. Corrigendum to "Keratinocyte-derived TGFβ is not required to maintain skin immune homeostasis" [J. Dermatol. Sci. 94 (2) (2019) 290-297]. J Dermatol Sci. 2019 Sep;95(3):134. doi: 10.1016/j.jdermsci.2019.08.001. Epub 2019 Aug 9. PubMed PMID: 31405538; PubMed Central PMCID: PMC6764846.
Elmets CA, Lim HW, Stoff B, Connor C, Cordoro KM, Lebwohl M, Armstrong AW, Davis DMR, Elewski BE, Gelfand JM, Gordon KB, Gottlieb AB, Kaplan DH, Kavanaugh A, Kiselica M, Kivelevitch D, Korman NJ, Kroshinsky D, Leonardi CL, Lichten J, Mehta NN, Paller AS, Parra SL, Pathy AL, Farley Prater EA, Rupani RN, Siegel M, Strober BE, Wong EB, Wu JJ, Hariharan V, Menter A. Joint American Academy of Dermatology-National Psoriasis Foundation guidelines of care for the management and treatment of psoriasis with phototherapy. J Am Acad Dermatol. 2019 Sep;81(3):775-804. doi: 10.1016/j.jaad.2019.04.042. Epub 2019 Jul 25. PubMed PMID: 31351884.
Amezcua Vesely MC, Pallis P, Bielecki P, Low JS, Zhao J, Harman CCD, Kroehling L, Jackson R, Bailis W, Licona-Limón P, Xu H, Iijima N, Pillai PS, Kaplan DH, Weaver CT, Kluger Y, Kowalczyk MS, Iwasaki A, Pereira JP, Esplugues E, Gagliani N, Flavell RA. Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection. Cell. 2019 Aug 22;178(5):1176-1188.e15. doi: 10.1016/j.cell.2019.07.032. PubMed PMID: 31442406; PubMed Central PMCID: PMC7057720.
Cohen JA, Edwards TN, Liu AW, Hirai T, Jones MR, Wu J, Li Y, Zhang S, Ho J, Davis BM, Albers KM, Kaplan DH. Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity. Cell. 2019 Aug 8;178(4):919-932.e14. doi: 10.1016/j.cell.2019.06.022. Epub 2019 Jul 25. PubMed PMID: 31353219; PubMed Central PMCID: PMC6788801.
Hirai T, Zenke Y, Yang Y, Bartholin L, Beura LK, Masopust D, Kaplan DH. Keratinocyte-Mediated Activation of the Cytokine TGF-β Maintains Skin Recirculating Memory CD8+ T Cells. Immunity. 2019 May 21;50(5):1249-1261.e5. doi: 10.1016/j.immuni.2019.03.002. Epub 2019 Apr 2. PubMed PMID: 30952606; PubMed Central PMCID: PMC6531326.
van Dalen R, De La Cruz Diaz JS, Rumpret M, Fuchsberger FF, van Teijlingen NH, Hanske J, Rademacher C, Geijtenbeek TBH, van Strijp JAG, Weidenmaier C, Peschel A, Kaplan DH, van Sorge NM. Langerhans Cells Sense Staphylococcus aureus Wall Teichoic Acid through Langerin To Induce Inflammatory Responses. mBio. 2019 May 14;10(3). doi: 10.1128/mBio.00330-19. PubMed PMID: 31088921; PubMed Central PMCID: PMC6520447.
Yang Y, Zenke Y, Hirai T, Kaplan DH. Keratinocyte-derived TGFβ is not required to maintain skin immune homeostasis. J Dermatol Sci. 2019 May;94(2):290-297. doi: 10.1016/j.jdermsci.2019.04.008. Epub 2019 May 7. PubMed PMID: 31118160; PubMed Central PMCID: PMC6602918.
Kim Y, Flamm A, ElSohly MA, Kaplan DH, Hage RJ Jr, Hamann CP, Marks JG Jr. Poison Ivy, Oak, and Sumac Dermatitis: What Is Known and What Is New?. Dermatitis. 2019 May/Jun;30(3):183-190. doi: 10.1097/DER.0000000000000472. PubMed PMID: 31045932.
Elmets CA, Leonardi CL, Davis DMR, Gelfand JM, Lichten J, Mehta NN, Armstrong AW, Connor C, Cordoro KM, Elewski BE, Gordon KB, Gottlieb AB, Kaplan DH, Kavanaugh A, Kivelevitch D, Kiselica M, Korman NJ, Kroshinsky D, Lebwohl M, Lim HW, Paller AS, Parra SL, Pathy AL, Prater EF, Rupani R, Siegel M, Stoff B, Strober BE, Wong EB, Wu JJ, Hariharan V, Menter A. Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with awareness and attention to comorbidities. J Am Acad Dermatol. 2019 Apr;80(4):1073-1113. doi: 10.1016/j.jaad.2018.11.058. Epub 2019 Feb 13. Review. PubMed PMID: 30772097.
Menter A, Strober BE, Kaplan DH, Kivelevitch D, Prater EF, Stoff B, Armstrong AW, Connor C, Cordoro KM, Davis DMR, Elewski BE, Gelfand JM, Gordon KB, Gottlieb AB, Kavanaugh A, Kiselica M, Korman NJ, Kroshinsky D, Lebwohl M, Leonardi CL, Lichten J, Lim HW, Mehta NN, Paller AS, Parra SL, Pathy AL, Rupani RN, Siegel M, Wong EB, Wu JJ, Hariharan V, Elmets CA. Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics. J Am Acad Dermatol. 2019 Apr;80(4):1029-1072. doi: 10.1016/j.jaad.2018.11.057. Epub 2019 Feb 13. Review. PubMed PMID: 30772098.
Sumpter TL, Balmert SC, Kaplan DH. Cutaneous immune responses mediated by dendritic cells and mast cells. JCI Insight. 2019 Jan 10;4(1). doi: 10.1172/jci.insight.123947. Review. PubMed PMID: 30626752; PubMed Central PMCID: PMC6485911.
Johndrow CT, Goldberg MF, Johnson AJ, Ng TW, Kunnath-Velayudhan S, Lauvau G, Kaplan DH, Gossel GH, Kadolsky UD, Yates AJ, Chan J, Jacobs WR Jr, Porcelli SA. Suppression of Th1 Priming by TLR2 Agonists during Cutaneous Immunization Is Mediated by Recruited CCR2+ Monocytes. J Immunol. 2018 Dec 15;201(12):3604-3616. doi: 10.4049/jimmunol.1801185. Epub 2018 Nov 19. PubMed PMID: 30455402; PubMed Central PMCID: PMC6487659.
Dainichi T, Kitoh A, Otsuka A, Nakajima S, Nomura T, Kaplan DH, Kabashima K. The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis. Nat Immunol. 2018 Dec;19(12):1286-1298. doi: 10.1038/s41590-018-0256-2. Epub 2018 Nov 16. Review. PubMed PMID: 30446754.
Snyder LM, Chiang MC, Loeza-Alcocer E, Omori Y, Hachisuka J, Sheahan TD, Gale JR, Adelman PC, Sypek EI, Fulton SA, Friedman RL, Wright MC, Duque MG, Lee YS, Hu Z, Huang H, Cai X, Meerschaert KA, Nagarajan V, Hirai T, Scherrer G, Kaplan DH, Porreca F, Davis BM, Gold MS, Koerber HR, Ross SE. Kappa Opioid Receptor Distribution and Function in Primary Afferents. Neuron. 2018 Sep 19;99(6):1274-1288.e6. doi: 10.1016/j.neuron.2018.08.044. PubMed PMID: 30236284; PubMed Central PMCID: PMC6300132.
Shipman WD, Chyou S, Ramanathan A, Izmirly PM, Sharma S, Pannellini T, Dasoveanu DC, Qing X, Magro CM, Granstein RD, Lowes MA, Pamer EG, Kaplan DH, Salmon JE, Mehrara BJ, Young JW, Clancy RM, Blobel CP, Lu TT. A protective Langerhans cell-keratinocyte axis that is dysfunctional in photosensitivity. Sci Transl Med. 2018 Aug 15;10(454). doi: 10.1126/scitranslmed.aap9527. PubMed PMID: 30111646; PubMed Central PMCID: PMC6365282.
Yao C, Kaplan DH. Langerhans Cells Transfer Targeted Antigen to Dermal Dendritic Cells and Acquire Major Histocompatibility Complex II In Vivo. J Invest Dermatol. 2018 Jul;138(7):1665-1668. doi: 10.1016/j.jid.2018.02.005. Epub 2018 Feb 21. PubMed PMID: 29474944; PubMed Central PMCID: PMC6019560.
Tolar J, Bauer JW, Kaplan DH, Leachman SA, McGrath JA, Paller AS, Griffith-Bauer KA, Stemwedel CE, Kulesz-Martin MF. Montagna Symposium 2017-Precision Dermatology: Next Generation Prevention, Diagnosis, and Treatment. J Invest Dermatol. 2018 Jun;138(6):1243-1248. doi: 10.1016/j.jid.2018.02.039. Epub 2018 May 2. PubMed PMID: 29550416; PubMed Central PMCID: PMC5970097.
Kashem SW, Kaplan DH. Isolation of Murine Skin Resident and Migratory Dendritic Cells via Enzymatic Digestion. Curr Protoc Immunol. 2018 Apr;121(1):e45. doi: 10.1002/cpim.45. PubMed PMID: 30040218; PubMed Central PMCID: PMC6060630.
Santos E Sousa P, Ciré S, Conlan T, Jardine L, Tkacz C, Ferrer IR, Lomas C, Ward S, West H, Dertschnig S, Blobner S, Means TK, Henderson S, Kaplan DH, Collin M, Plagnol V, Bennett CL, Chakraverty R. Peripheral tissues reprogram CD8+ T cells for pathogenicity during graft-versus-host disease. JCI Insight. 2018 Mar 8;3(5). doi: 10.1172/jci.insight.97011. PubMed PMID: 29515032; PubMed Central PMCID: PMC5922296.
Kitashima DY, Kobayashi T, Woodring T, Idouchi K, Doebel T, Voisin B, Adachi T, Ouchi T, Takahashi H, Nishifuji K, Kaplan DH, Clausen BE, Amagai M, Nagao K. Langerhans Cells Prevent Autoimmunity via Expansion of Keratinocyte Antigen-Specific Regulatory T Cells. EBioMedicine. 2018 Jan;27:293-303. doi: 10.1016/j.ebiom.2017.12.022. Epub 2017 Dec 20. PubMed PMID: 29307572; PubMed Central PMCID: PMC5828466.
Kaplan DH. Ontogeny and function of murine epidermal Langerhans cells. Nat Immunol. 2017 Sep 19;18(10):1068-1075. doi: 10.1038/ni.3815. Review. PubMed PMID: 28926543; PubMed Central PMCID: PMC6422157.
Strandt H, Pinheiro DF, Kaplan DH, Wirth D, Gratz IK, Hammerl P, Thalhamer J, Stoecklinger A. Neoantigen Expression in Steady-State Langerhans Cells Induces CTL Tolerance. J Immunol. 2017 Sep 1;199(5):1626-1634. doi: 10.4049/jimmunol.1602098. Epub 2017 Jul 24. PubMed PMID: 28739880; PubMed Central PMCID: PMC5563165.
Kashem SW, Haniffa M, Kaplan DH. Antigen-Presenting Cells in the Skin. Annu Rev Immunol. 2017 Apr 26;35:469-499. doi: 10.1146/annurev-immunol-051116-052215. Epub 2017 Feb 6. Review. PubMed PMID: 28226228.
Huang H, Kuzirian MS, Cai X, Snyder LM, Cohen J, Kaplan DH, Ross SE. Generation of a NK1R-CreER knockin mouse strain to study cells involved in Neurokinin 1 Receptor signaling. Genesis. 2016 Nov;54(11):593-601. doi: 10.1002/dvg.22985. Epub 2016 Oct 31. PubMed PMID: 27712014; PubMed Central PMCID: PMC5241089.
Kumamoto Y, Hirai T, Wong PW, Kaplan DH, Iwasaki A. CD301b+ dendritic cells suppress T follicular helper cells and antibody responses to protein antigens. Elife. 2016 Sep 22;5. doi: 10.7554/eLife.17979. PubMed PMID: 27657168; PubMed Central PMCID: PMC5033605.
Bittner-Eddy PD, Fischer LA, Kaplan DH, Thieu K, Costalonga M. Mucosal Langerhans Cells Promote Differentiation of Th17 Cells in a Murine Model of Periodontitis but Are Not Required for Porphyromonas gingivalis-Driven Alveolar Bone Destruction. J Immunol. 2016 Aug 15;197(4):1435-46. doi: 10.4049/jimmunol.1502693. Epub 2016 Jul 11. PubMed PMID: 27402698; PubMed Central PMCID: PMC4974489.
Kashem SW, Kaplan DH. Skin Immunity to Candida albicans. Trends Immunol. 2016 Jul;37(7):440-450. doi: 10.1016/j.it.2016.04.007. Epub 2016 May 10. Review. PubMed PMID: 27178391; PubMed Central PMCID: PMC4931795.
Mohammed J, Beura LK, Bobr A, Astry B, Chicoine B, Kashem SW, Welty NE, Igyártó BZ, Wijeyesinghe S, Thompson EA, Matte C, Bartholin L, Kaplan A, Sheppard D, Bridges AG, Shlomchik WD, Masopust D, Kaplan DH. Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β. Nat Immunol. 2016 Apr;17(4):414-21. doi: 10.1038/ni.3396. Epub 2016 Feb 22. PubMed PMID: 26901152; PubMed Central PMCID: PMC5135085.
Drummond RA, Dambuza IM, Vautier S, Taylor JA, Reid DM, Bain CC, Underhill DM, Masopust D, Kaplan DH, Brown GD. CD4(+) T-cell survival in the GI tract requires dectin-1 during fungal infection. Mucosal Immunol. 2016 Mar;9(2):492-502. doi: 10.1038/mi.2015.79. Epub 2015 Sep 9. PubMed PMID: 26349660; PubMed Central PMCID: PMC4677461.
Yang J, Hu S, Zhao L, Kaplan DH, Perdew GH, Xiong N. Selective programming of CCR10(+) innate lymphoid cells in skin-draining lymph nodes for cutaneous homeostatic regulation. Nat Immunol. 2016 Jan;17(1):48-56. doi: 10.1038/ni.3312. Epub 2015 Nov 2. PubMed PMID: 26523865; PubMed Central PMCID: PMC4838393.
Scholz F, Naik S, Sutterwala FS, Kaplan DH. Correction: Langerhans Cells Suppress CD49a+ NK Cell-Mediated Skin Inflammation. J Immunol. 2015 Dec 15;195(12):5837-8. doi: 10.4049/jimmunol.1502162. PubMed PMID: 26637662.
Yao C, Zurawski SM, Jarrett ES, Chicoine B, Crabtree J, Peterson EJ, Zurawski G, Kaplan DH, Igyártó BZ. Skin dendritic cells induce follicular helper T cells and protective humoral immune responses. J Allergy Clin Immunol. 2015 Nov;136(5):1387-97.e1-7. doi: 10.1016/j.jaci.2015.04.001. Epub 2015 May 9. PubMed PMID: 25962902; PubMed Central PMCID: PMC4639468.
Linehan JL, Dileepan T, Kashem SW, Kaplan DH, Cleary P, Jenkins MK. Generation of Th17 cells in response to intranasal infection requires TGF-β1 from dendritic cells and IL-6 from CD301b+ dendritic cells. Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12782-7. doi: 10.1073/pnas.1513532112. Epub 2015 Sep 28. PubMed PMID: 26417101; PubMed Central PMCID: PMC4611596.
Kashem SW, Riedl MS, Yao C, Honda CN, Vulchanova L, Kaplan DH. Nociceptive Sensory Fibers Drive Interleukin-23 Production from CD301b+ Dermal Dendritic Cells and Drive Protective Cutaneous Immunity. Immunity. 2015 Sep 15;43(3):515-26. doi: 10.1016/j.immuni.2015.08.016. PubMed PMID: 26377898; PubMed Central PMCID: PMC4607048.
Scholz F, Naik S, Sutterwala FS, Kaplan DH. Langerhans Cells Suppress CD49a+ NK Cell-Mediated Skin Inflammation. J Immunol. 2015 Sep 1;195(5):2335-42. doi: 10.4049/jimmunol.1500935. Epub 2015 Jul 24. PubMed PMID: 26209621; PubMed Central PMCID: PMC4546924.
Kobayashi T, Glatz M, Horiuchi K, Kawasaki H, Akiyama H, Kaplan DH, Kong HH, Amagai M, Nagao K. Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis. Immunity. 2015 Apr 21;42(4):756-66. doi: 10.1016/j.immuni.2015.03.014. PubMed PMID: 25902485; PubMed Central PMCID: PMC4407815.
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