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da Silva-Diz V, Cao B, Lancho O, Chiles E, Alasadi A, Aleksandrova M, Luo S, Singh A, Tao H, Augeri DJ, Minuzzo S, Indraccolo S, Khiabanian H, Su X, Jin S, Herranz D. A novel and highly effective mitochondrial uncoupling drug in T-cell leukemia. Blood. 2021 Apr 19;. doi: 10.1182/blood.2020008955. [Epub ahead of print] PubMed PMID: 33876224.
García-Cañaveras JC, Lancho O, Ducker GS, Ghergurovich JM, Xu X, da Silva-Diz V, Minuzzo S, Indraccolo S, Kim H, Herranz D, Rabinowitz JD. SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia. Leukemia. 2021 Feb;35(2):377-388. doi: 10.1038/s41375-020-0845-6. Epub 2020 May 7. PubMed PMID: 32382081; PubMed Central PMCID: PMC7647950.
Tottone L, Lancho O, Loh JW, Singh A, Kimura S, Roels J, Kuchmiy A, Strubbe S, Lawlor MA, da Silva-Diz V, Luo S, Gachet S, García-Prieto CA, Hagelaar R, Esteller M, Meijerink JPP, Soulier J, Taghon T, Van Vlierberghe P, Mullighan CG, Khiabanian H, Rocha PP, Herranz D. A Tumor Suppressor Enhancer of PTEN in T-cell development and leukemia. Blood Cancer Discov. 2021 Jan;2(1):92-109. doi: 10.1158/2643-3230.BCD-20-0201. Epub 2020 Nov 24. PubMed PMID: 33458694; PubMed Central PMCID: PMC7810363.
Xiong H, Mancini M, Gobert M, Shen S, Furtado GC, Lira SA, Parkhurst CN, Garambois V, Brengues M, Tadokoro CE, Trimarchi T, Gómez-López G, Singh A, Khiabanian H, Minuzzo S, Indraccolo S, Lobry C, Aifantis I, Herranz D, Lafaille JJ, Maraver A. Spleen plays a major role in DLL4-driven acute T-cell lymphoblastic leukemia. Theranostics. 2021;11(4):1594-1608. doi: 10.7150/thno.48067. eCollection 2021. PubMed PMID: 33408769; PubMed Central PMCID: PMC7778594.
Belver L, Yang AY, Albero R, Herranz D, Brundu FG, Quinn SA, Pérez-Durán P, Álvarez S, Gianni F, Rashkovan M, Gurung D, Rocha PP, Raviram R, Reglero C, Cortés JR, Cooke AJ, Wendorff AA, Cordó V, Meijerink JP, Rabadan R, Ferrando AA. GATA3-Controlled Nucleosome Eviction Drives MYC Enhancer Activity in T-cell Development and Leukemia. Cancer Discov. 2019 Dec;9(12):1774-1791. doi: 10.1158/2159-8290.CD-19-0471. Epub 2019 Sep 13. PubMed PMID: 31519704; PubMed Central PMCID: PMC6891196.
Lancho O, Herranz D. The MYC Enhancer-ome: Long-Range Transcriptional Regulation of MYC in Cancer. Trends Cancer. 2018 Dec;4(12):810-822. doi: 10.1016/j.trecan.2018.10.003. Epub 2018 Nov 2. Review. PubMed PMID: 30470303; PubMed Central PMCID: PMC6260942.
Costa-Machado LF, Martín-Hernández R, Sanchez-Luengo MÁ, Hess K, Vales-Villamarin C, Barradas M, Lynch C, de la Nava D, Diaz-Ruiz A, de Cabo R, Cañamero M, Martinez L, Sanchez-Carbayo M, Herranz D, Serrano M, Fernandez-Marcos PJ. Sirt1 protects from K-Ras-driven lung carcinogenesis. EMBO Rep. 2018 Sep;19(9). doi: 10.15252/embr.201643879. Epub 2018 Jul 18. PubMed PMID: 30021836; PubMed Central PMCID: PMC6123659.
Fabbri G, Holmes AB, Viganotti M, Scuoppo C, Belver L, Herranz D, Yan XJ, Kieso Y, Rossi D, Gaidano G, Chiorazzi N, Ferrando AA, Dalla-Favera R. Common nonmutational NOTCH1 activation in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2911-E2919. doi: 10.1073/pnas.1702564114. Epub 2017 Mar 17. PubMed PMID: 28314854; PubMed Central PMCID: PMC5389283.
Sanchez-Martin M, Ambesi-Impiombato A, Qin Y, Herranz D, Bansal M, Girardi T, Paietta E, Tallman MS, Rowe JM, De Keersmaecker K, Califano A, Ferrando AA. Synergistic antileukemic therapies in NOTCH1-induced T-ALL. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2006-2011. doi: 10.1073/pnas.1611831114. Epub 2017 Feb 7. PubMed PMID: 28174276; PubMed Central PMCID: PMC5338362.
Herranz D. Glutaminolysis gets the spotlight in cancer. Oncotarget. 2017 Feb 14;8(7):10761-10762. doi: 10.18632/oncotarget.14384. PubMed PMID: 28053289; PubMed Central PMCID: PMC5355212.
Herranz D, Ferrando AA. Targeting NOTCH1 in T-ALL: Starving the dragon. Cell Cycle. 2016;15(4):483-4. doi: 10.1080/15384101.2015.1128191. Epub 2016 Feb 11. PubMed PMID: 26864725; PubMed Central PMCID: PMC5056614.
Herranz D, Ambesi-Impiombato A, Sudderth J, Sánchez-Martín M, Belver L, Tosello V, Xu L, Wendorff AA, Castillo M, Haydu JE, Márquez J, Matés JM, Kung AL, Rayport S, Cordon-Cardo C, DeBerardinis RJ, Ferrando AA. Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia. Nat Med. 2015 Oct;21(10):1182-9. doi: 10.1038/nm.3955. Epub 2015 Sep 21. PubMed PMID: 26390244; PubMed Central PMCID: PMC4598309.
Herranz D, Ferrando AA. An oncogenic enhancer enemy (N-Me) in T-ALL. Cell Cycle. 2015;14(2):167-8. doi: 10.4161/15384101.2014.989129. PubMed PMID: 25584678; PubMed Central PMCID: PMC4615101.
Herranz D, Ambesi-Impiombato A, Palomero T, Schnell SA, Belver L, Wendorff AA, Xu L, Castillo-Martin M, Llobet-Navás D, Cordon-Cardo C, Clappier E, Soulier J, Ferrando AA. A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia. Nat Med. 2014 Oct;20(10):1130-7. doi: 10.1038/nm.3665. Epub 2014 Sep 7. PubMed PMID: 25194570; PubMed Central PMCID: PMC4192073.
Beiroa D, Imbernon M, Gallego R, Senra A, Herranz D, Villarroya F, Serrano M, Fernø J, Salvador J, Escalada J, Dieguez C, Lopez M, Frühbeck G, Nogueiras R. GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK. Diabetes. 2014 Oct;63(10):3346-58. doi: 10.2337/db14-0302. Epub 2014 Jun 10. PubMed PMID: 24917578.
García-Rodríguez JL, Barbier-Torres L, Fernández-Álvarez S, Gutiérrez-de Juan V, Monte MJ, Halilbasic E, Herranz D, Álvarez L, Aspichueta P, Marín JJ, Trauner M, Mato JM, Serrano M, Beraza N, Martínez-Chantar ML. SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling. Hepatology. 2014 May;59(5):1972-83. doi: 10.1002/hep.26971. Epub 2014 Mar 31. PubMed PMID: 24338587; PubMed Central PMCID: PMC3999184.
Piovan E, Yu J, Tosello V, Herranz D, Ambesi-Impiombato A, Da Silva AC, Sanchez-Martin M, Perez-Garcia A, Rigo I, Castillo M, Indraccolo S, Cross JR, de Stanchina E, Paietta E, Racevskis J, Rowe JM, Tallman MS, Basso G, Meijerink JP, Cordon-Cardo C, Califano A, Ferrando AA. Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia. Cancer Cell. 2013 Dec 9;24(6):766-76. doi: 10.1016/j.ccr.2013.10.022. Epub 2013 Nov 27. PubMed PMID: 24291004; PubMed Central PMCID: PMC3878658.
Herranz D, Maraver A, Cañamero M, Gómez-López G, Inglada-Pérez L, Robledo M, Castelblanco E, Matias-Guiu X, Serrano M. SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency. Oncogene. 2013 Aug 22;32(34):4052-6. doi: 10.1038/onc.2012.407. Epub 2012 Sep 17. PubMed PMID: 22986535.
Wauters E, Sanchez-Arévalo Lobo VJ, Pinho AV, Mawson A, Herranz D, Wu J, Cowley MJ, Colvin EK, Njicop EN, Sutherland RL, Liu T, Serrano M, Bouwens L, Real FX, Biankin AV, Rooman I. Sirtuin-1 regulates acinar-to-ductal metaplasia and supports cancer cell viability in pancreatic cancer. Cancer Res. 2013 Apr 1;73(7):2357-67. doi: 10.1158/0008-5472.CAN-12-3359. Epub 2013 Jan 31. PubMed PMID: 23370328.
Maraver A, Fernández-Marcos PJ, Herranz D, Muñoz-Martin M, Gomez-Lopez G, Cañamero M, Mulero F, Megías D, Sanchez-Carbayo M, Shen J, Sanchez-Cespedes M, Palomero T, Ferrando A, Serrano M. Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK. Cancer Cell. 2012 Aug 14;22(2):222-34. doi: 10.1016/j.ccr.2012.06.014. PubMed PMID: 22897852; PubMed Central PMCID: PMC3813920.
Muñoz-Fontela C, González D, Marcos-Villar L, Campagna M, Gallego P, González-Santamaría J, Herranz D, Gu W, Serrano M, Aaronson SA, Rivas C. Acetylation is indispensable for p53 antiviral activity. Cell Cycle. 2011 Nov 1;10(21):3701-5. doi: 10.4161/cc.10.21.17899. Epub 2011 Nov 1. PubMed PMID: 22033337; PubMed Central PMCID: PMC3685621.
Gambini J, Gomez-Cabrera MC, Borras C, Valles SL, Lopez-Grueso R, Martinez-Bello VE, Herranz D, Pallardo FV, Tresguerres JA, Serrano M, Viña J. Free [NADH]/[NAD(+)] regulates sirtuin expression. Arch Biochem Biophys. 2011 Aug 1;512(1):24-9. doi: 10.1016/j.abb.2011.04.020. Epub 2011 May 7. PubMed PMID: 21575591.
Herranz D, Iglesias G, Muñoz-Martín M, Serrano M. Limited role of Sirt1 in cancer protection by dietary restriction. Cell Cycle. 2011 Jul 1;10(13):2215-7. doi: 10.4161/cc.10.13.16185. Epub 2011 Jul 1. PubMed PMID: 21606675; PubMed Central PMCID: PMC3578182.
Campagna M, Herranz D, Garcia MA, Marcos-Villar L, González-Santamaría J, Gallego P, Gutierrez S, Collado M, Serrano M, Esteban M, Rivas C. SIRT1 stabilizes PML promoting its sumoylation. Cell Death Differ. 2011 Jan;18(1):72-9. doi: 10.1038/cdd.2010.77. Epub 2010 Jun 25. PubMed PMID: 20577263; PubMed Central PMCID: PMC3131875.
Palacios JA, Herranz D, De Bonis ML, Velasco S, Serrano M, Blasco MA. SIRT1 contributes to telomere maintenance and augments global homologous recombination. J Cell Biol. 2010 Dec 27;191(7):1299-313. doi: 10.1083/jcb.201005160. PubMed PMID: 21187328; PubMed Central PMCID: PMC3010065.
Herranz D, Serrano M. SIRT1: recent lessons from mouse models. Nat Rev Cancer. 2010 Dec;10(12):819-23. doi: 10.1038/nrc2962. Epub 2010 Nov 24. Review. PubMed PMID: 21102633; PubMed Central PMCID: PMC3672967.
Calvanese V, Lara E, Suárez-Alvarez B, Abu Dawud R, Vázquez-Chantada M, Martínez-Chantar ML, Embade N, López-Nieva P, Horrillo A, Hmadcha A, Soria B, Piazzolla D, Herranz D, Serrano M, Mato JM, Andrews PW, López-Larrea C, Esteller M, Fraga MF. Sirtuin 1 regulation of developmental genes during differentiation of stem cells. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13736-41. doi: 10.1073/pnas.1001399107. Epub 2010 Jul 14. PubMed PMID: 20631301; PubMed Central PMCID: PMC2922228.
Herranz D, Serrano M. Impact of Sirt1 on mammalian aging. Aging (Albany NY). 2010 Jun;2(6):315-6. doi: 10.18632/aging.100156. PubMed PMID: 20562473; PubMed Central PMCID: PMC2919245.
Herranz D, Muñoz-Martin M, Cañamero M, Mulero F, Martinez-Pastor B, Fernandez-Capetillo O, Serrano M. Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Nat Commun. 2010 Apr 12;1:3. doi: 10.1038/ncomms1001. PubMed PMID: 20975665; PubMed Central PMCID: PMC3641391.
Pfluger PT, Herranz D, Velasco-Miguel S, Serrano M, Tschöp MH. Sirt1 protects against high-fat diet-induced metabolic damage. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9793-8. doi: 10.1073/pnas.0802917105. Epub 2008 Jul 3. PubMed PMID: 18599449; PubMed Central PMCID: PMC2474520.
Efeyan A, Ortega-Molina A, Velasco-Miguel S, Herranz D, Vassilev LT, Serrano M. Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin. Cancer Res. 2007 Aug 1;67(15):7350-7. doi: 10.1158/0008-5472.CAN-07-0200. PubMed PMID: 17671205.
Efeyan A, Garcia-Cao I, Herranz D, Velasco-Miguel S, Serrano M. Tumour biology: Policing of oncogene activity by p53. Nature. 2006 Sep 14;443(7108):159. doi: 10.1038/443159a. PubMed PMID: 16971940.
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