My Bibliography

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Horvath CM, Williams MA, Lamb RA. Eukaryotic coupled translation of tandem cistrons: identification of the influenza B virus BM2 polypeptide. EMBO J. 1990 Aug;9(8):2639-47. doi: 10.1002/j.1460-2075.1990.tb07446.x. PubMed PMID: 2114979; PubMed Central PMCID: PMC552297.

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Lamb RA, Horvath CM. Diversity of coding strategies in influenza viruses. Trends Genet. 1991 Aug;7(8):261-6. doi: 10.1016/0168-9525(91)90326-L. Review. PubMed PMID: 1771674; PubMed Central PMCID: PMC7173306.

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Horvath CM, Lamb RA. Studies on the fusion peptide of a paramyxovirus fusion glycoprotein: roles of conserved residues in cell fusion. J Virol. 1992 Apr;66(4):2443-55. doi: 10.1128/JVI.66.4.2443-2455.1992. PubMed PMID: 1548771; PubMed Central PMCID: PMC289040.

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Horvath CM, Paterson RG, Shaughnessy MA, Wood R, Lamb RA. Biological activity of paramyxovirus fusion proteins: factors influencing formation of syncytia. J Virol. 1992 Jul;66(7):4564-9. doi: 10.1128/JVI.66.7.4564-4569.1992. PubMed PMID: 1602561; PubMed Central PMCID: PMC241269.

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Horvath CM, Wolven A, Machadeo D, Huber J, Boter L, Benedetti M, Hempstead B, Chao MV. Analysis of the trk NGF receptor tyrosine kinase using recombinant fusion proteins. J Cell Sci Suppl. 1993;17:223-8. doi: 10.1242/jcs.1993.supplement_17.31. PubMed PMID: 8144701.

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Shuai K, Horvath CM, Huang LH, Qureshi SA, Cowburn D, Darnell JE Jr. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell. 1994 Mar 11;76(5):821-8. doi: 10.1016/0092-8674(94)90357-3. PubMed PMID: 7510216.

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Improta T, Schindler C, Horvath CM, Kerr IM, Stark GR, Darnell JE Jr. Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4776-80. doi: 10.1073/pnas.91.11.4776. PubMed PMID: 8197134; PubMed Central PMCID: PMC43871.

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Horvath CM, Wen Z, Darnell JE Jr. A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes Dev. 1995 Apr 15;9(8):984-94. doi: 10.1101/gad.9.8.984. PubMed PMID: 7774815.

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Horvath CM, Darnell JE Jr. The antiviral state induced by alpha interferon and gamma interferon requires transcriptionally active Stat1 protein. J Virol. 1996 Jan;70(1):647-50. doi: 10.1128/JVI.70.1.647-650.1996. PubMed PMID: 8523587; PubMed Central PMCID: PMC189860.

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Bromberg JF, Horvath CM, Wen Z, Schreiber RD, Darnell JE Jr. Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma. Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7673-8. doi: 10.1073/pnas.93.15.7673. PubMed PMID: 8755534; PubMed Central PMCID: PMC38805.

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Vaisse C, Halaas JL, Horvath CM, Darnell JE Jr, Stoffel M, Friedman JM. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat Genet. 1996 Sep;14(1):95-7. doi: 10.1038/ng0996-95. PubMed PMID: 8782827.

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Horvath CM, Stark GR, Kerr IM, Darnell JE Jr. Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex. Mol Cell Biol. 1996 Dec;16(12):6957-64. doi: 10.1128/MCB.16.12.6957. PubMed PMID: 8943351; PubMed Central PMCID: PMC231699.

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Zhang JJ, Vinkemeier U, Gu W, Chakravarti D, Horvath CM, Darnell JE Jr. Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling. Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15092-6. doi: 10.1073/pnas.93.26.15092. PubMed PMID: 8986769; PubMed Central PMCID: PMC26361.

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Horvath CM, Darnell JE. The state of the STATs: recent developments in the study of signal transduction to the nucleus. Curr Opin Cell Biol. 1997 Apr;9(2):233-9. doi: 10.1016/s0955-0674(97)80067-1. Review. PubMed PMID: 9069254.

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Ceresa BP, Horvath CM, Pessin JE. Signal transducer and activator of transcription-3 serine phosphorylation by insulin is mediated by a Ras/Raf/MEK-dependent pathway. Endocrinology. 1997 Oct;138(10):4131-7. doi: 10.1210/endo.138.10.5266. PubMed PMID: 9322921.

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Kumar A, Commane M, Flickinger TW, Horvath CM, Stark GR. Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases. Science. 1997 Nov 28;278(5343):1630-2. doi: 10.1126/science.278.5343.1630. PubMed PMID: 9374464.

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Bromberg JF, Horvath CM, Besser D, Lathem WW, Darnell JE Jr. Stat3 activation is required for cellular transformation by v-src. Mol Cell Biol. 1998 May;18(5):2553-8. doi: 10.1128/MCB.18.5.2553. PubMed PMID: 9566875; PubMed Central PMCID: PMC110635.

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Zhang X, Wrzeszczynska MH, Horvath CM, Darnell JE Jr. Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation. Mol Cell Biol. 1999 Oct;19(10):7138-46. doi: 10.1128/MCB.19.10.7138. PubMed PMID: 10490649; PubMed Central PMCID: PMC84707.

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Ram PT, Horvath CM, Iyengar R. Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Galphao protein. Science. 2000 Jan 7;287(5450):142-4. doi: 10.1126/science.287.5450.142. PubMed PMID: 10615050.

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Ouchi T, Lee SW, Ouchi M, Aaronson SA, Horvath CM. Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5208-13. doi: 10.1073/pnas.080469697. PubMed PMID: 10792030; PubMed Central PMCID: PMC25807.

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Huang Y, Horvath CM, Waxman S. Regrowth of 5-fluorouracil-treated human colon cancer cells is prevented by the combination of interferon gamma, indomethacin, and phenylbutyrate. Cancer Res. 2000 Jun 15;60(12):3200-6. PubMed PMID: 10866311.

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Lau JF, Parisien JP, Horvath CM. Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7278-83. doi: 10.1073/pnas.97.13.7278. PubMed PMID: 10860992; PubMed Central PMCID: PMC16536.

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Talon J, Horvath CM, Polley R, Basler CF, Muster T, Palese P, García-Sastre A. Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein. J Virol. 2000 Sep;74(17):7989-96. doi: 10.1128/jvi.74.17.7989-7996.2000. PubMed PMID: 10933707; PubMed Central PMCID: PMC112330.

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Horvath CM. STAT proteins and transcriptional responses to extracellular signals. Trends Biochem Sci. 2000 Oct;25(10):496-502. doi: 10.1016/s0968-0004(00)01624-8. Review. PubMed PMID: 11050435.

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Ivanov VN, Bhoumik A, Krasilnikov M, Raz R, Owen-Schaub LB, Levy D, Horvath CM, Ronai Z. Cooperation between STAT3 and c-jun suppresses Fas transcription. Mol Cell. 2001 Mar;7(3):517-28. doi: 10.1016/s1097-2765(01)00199-x. PubMed PMID: 11463377.

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Ehret GB, Reichenbach P, Schindler U, Horvath CM, Fritz S, Nabholz M, Bucher P. DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites. J Biol Chem. 2001 Mar 2;276(9):6675-88. doi: 10.1074/jbc.M001748200. Epub 2000 Oct 26. PubMed PMID: 11053426.

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Parisien JP, Lau JF, Rodriguez JJ, Sullivan BM, Moscona A, Parks GD, Lamb RA, Horvath CM. The V protein of human parainfluenza virus 2 antagonizes type I interferon responses by destabilizing signal transducer and activator of transcription 2. Virology. 2001 May 10;283(2):230-9. doi: 10.1006/viro.2001.0856. PubMed PMID: 11336548.

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Myers MP, Andersen JN, Cheng A, Tremblay ML, Horvath CM, Parisien JP, Salmeen A, Barford D, Tonks NK. TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B. J Biol Chem. 2001 Dec 21;276(51):47771-4. doi: 10.1074/jbc.C100583200. Epub 2001 Nov 1. PubMed PMID: 11694501.

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Salvatore M, Basler CF, Parisien JP, Horvath CM, Bourmakina S, Zheng H, Muster T, Palese P, García-Sastre A. Effects of influenza A virus NS1 protein on protein expression: the NS1 protein enhances translation and is not required for shutoff of host protein synthesis. J Virol. 2002 Feb;76(3):1206-12. doi: 10.1128/jvi.76.3.1206-1212.2002. PubMed PMID: 11773396; PubMed Central PMCID: PMC135795.

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Lau JF, Horvath CM. Mechanisms of Type I interferon cell signaling and STAT-mediated transcriptional responses. Mt Sinai J Med. 2002 May;69(3):156-68. Review. PubMed PMID: 12035075.

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Parisien JP, Lau JF, Rodriguez JJ, Ulane CM, Horvath CM. Selective STAT protein degradation induced by paramyxoviruses requires both STAT1 and STAT2 but is independent of alpha/beta interferon signal transduction. J Virol. 2002 May;76(9):4190-8. doi: 10.1128/jvi.76.9.4190-4198.2002. PubMed PMID: 11932384; PubMed Central PMCID: PMC155111.

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Aaronson DS, Horvath CM. A road map for those who don't know JAK-STAT. Science. 2002 May 31;296(5573):1653-5. doi: 10.1126/science.1071545. Review. PubMed PMID: 12040185.

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Parisien JP, Lau JF, Horvath CM. STAT2 acts as a host range determinant for species-specific paramyxovirus interferon antagonism and simian virus 5 replication. J Virol. 2002 Jul;76(13):6435-41. doi: 10.1128/jvi.76.13.6435-6441.2002. PubMed PMID: 12050355; PubMed Central PMCID: PMC136248.

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Rodriguez JJ, Parisien JP, Horvath CM. Nipah virus V protein evades alpha and gamma interferons by preventing STAT1 and STAT2 activation and nuclear accumulation. J Virol. 2002 Nov;76(22):11476-83. doi: 10.1128/jvi.76.22.11476-11483.2002. PubMed PMID: 12388709; PubMed Central PMCID: PMC136769.

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Ulane CM, Horvath CM. Paramyxoviruses SV5 and HPIV2 assemble STAT protein ubiquitin ligase complexes from cellular components. Virology. 2002 Dec 20;304(2):160-6. doi: 10.1006/viro.2002.1773. PubMed PMID: 12504558.

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Lau JF, Nusinzon I, Burakov D, Freedman LP, Horvath CM. Role of metazoan mediator proteins in interferon-responsive transcription. Mol Cell Biol. 2003 Jan;23(2):620-8. doi: 10.1128/MCB.23.2.620-628.2003. PubMed PMID: 12509459; PubMed Central PMCID: PMC151539.

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Kraus TA, Lau JF, Parisien JP, Horvath CM. A hybrid IRF9-STAT2 protein recapitulates interferon-stimulated gene expression and antiviral response. J Biol Chem. 2003 Apr 11;278(15):13033-8. doi: 10.1074/jbc.M212972200. Epub 2003 Feb 5. PubMed PMID: 12574168.

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Ulane CM, Rodriguez JJ, Parisien JP, Horvath CM. STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling. J Virol. 2003 Jun;77(11):6385-93. doi: 10.1128/jvi.77.11.6385-6393.2003. PubMed PMID: 12743296; PubMed Central PMCID: PMC155014.

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Palosaari H, Parisien JP, Rodriguez JJ, Ulane CM, Horvath CM. STAT protein interference and suppression of cytokine signal transduction by measles virus V protein. J Virol. 2003 Jul;77(13):7635-44. doi: 10.1128/jvi.77.13.7635-7644.2003. PubMed PMID: 12805463; PubMed Central PMCID: PMC164804.

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Rogers RS, Horvath CM, Matunis MJ. SUMO modification of STAT1 and its role in PIAS-mediated inhibition of gene activation. J Biol Chem. 2003 Aug 8;278(32):30091-7. doi: 10.1074/jbc.M301344200. Epub 2003 May 22. PubMed PMID: 12764129.

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Rodriguez JJ, Wang LF, Horvath CM. Hendra virus V protein inhibits interferon signaling by preventing STAT1 and STAT2 nuclear accumulation. J Virol. 2003 Nov;77(21):11842-5. doi: 10.1128/jvi.77.21.11842-11845.2003. PubMed PMID: 14557668; PubMed Central PMCID: PMC229371.

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Nusinzon I, Horvath CM. Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14742-7. doi: 10.1073/pnas.2433987100. Epub 2003 Nov 25. PubMed PMID: 14645718; PubMed Central PMCID: PMC299790.

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Rodriguez JJ, Horvath CM. Host evasion by emerging paramyxoviruses: Hendra virus and Nipah virus v proteins inhibit interferon signaling. Viral Immunol. 2004;17(2):210-9. doi: 10.1089/0882824041310568. Review. PubMed PMID: 15279700.

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Horvath CM. Silencing STATs: lessons from paramyxovirus interferon evasion. Cytokine Growth Factor Rev. 2004 Apr-Jun;15(2-3):117-27. doi: 10.1016/j.cytogfr.2004.02.003. Review. PubMed PMID: 15110796.

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Rodriguez JJ, Cruz CD, Horvath CM. Identification of the nuclear export signal and STAT-binding domains of the Nipah virus V protein reveals mechanisms underlying interferon evasion. J Virol. 2004 May;78(10):5358-67. doi: 10.1128/jvi.78.10.5358-5367.2004. PubMed PMID: 15113915; PubMed Central PMCID: PMC400366.

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Horvath CM. The Jak-STAT pathway stimulated by interleukin 6. Sci STKE. 2004 Nov 23;2004(260):tr9. doi: 10.1126/stke.2602004tr9. PubMed PMID: 15561981.

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Horvath CM. The Jak-STAT pathway stimulated by interferon gamma. Sci STKE. 2004 Nov 23;2004(260):tr8. doi: 10.1126/stke.2602004tr8. PubMed PMID: 15561980.

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Horvath CM. The Jak-STAT pathway stimulated by interferon alpha or interferon beta. Sci STKE. 2004 Nov 23;2004(260):tr10. doi: 10.1126/stke.2602004tr10. PubMed PMID: 15561979.

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Horvath CM. Weapons of STAT destruction. Interferon evasion by paramyxovirus V protein. Eur J Biochem. 2004 Dec;271(23-24):4621-8. doi: 10.1111/j.1432-1033.2004.04425.x. Review. PubMed PMID: 15606749.

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Ulane CM, Kentsis A, Cruz CD, Parisien JP, Schneider KL, Horvath CM. Composition and assembly of STAT-targeting ubiquitin ligase complexes: paramyxovirus V protein carboxyl terminus is an oligomerization domain. J Virol. 2005 Aug;79(16):10180-9. doi: 10.1128/JVI.79.16.10180-10189.2005. PubMed PMID: 16051811; PubMed Central PMCID: PMC1182666.