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Bizub D, Weber IT, Cameron CE, Leis JP, Skalka AM. A range of catalytic efficiencies with avian retroviral protease subunits genetically linked to form single polypeptide chains. J Biol Chem. 1991 Mar 15;266(8):4951-8. PubMed PMID: 1848230.
Grinde B, Cameron CE, Leis J, Weber IT, Wlodawer A, Burstein H, Skalka AM. Analysis of substrate interactions of the Rous sarcoma virus wild type and mutant proteases and human immunodeficiency virus-1 protease using a set of systematically altered peptide substrates. J Biol Chem. 1992 May 15;267(14):9491-8. PubMed PMID: 1315756.
Grinde B, Cameron CE, Leis J, Weber IT, Wlodawer A, Burstein H, Bizub D, Skalka AM. Mutations that alter the activity of the Rous sarcoma virus protease. J Biol Chem. 1992 May 15;267(14):9481-90. PubMed PMID: 1315755.
Cameron CE, Grinde B, Jentoft J, Leis J, Weber IT, Copeland TD, Wlodawer A. Mechanism of inhibition of the retroviral protease by a Rous sarcoma virus peptide substrate representing the cleavage site between the gag p2 and p10 proteins. J Biol Chem. 1992 Nov 25;267(33):23735-41. PubMed PMID: 1331099.
Cameron CE, Grinde B, Jacques P, Jentoft J, Leis J, Wlodawer A, Weber IT. Comparison of the substrate-binding pockets of the Rous sarcoma virus and human immunodeficiency virus type 1 proteases. J Biol Chem. 1993 Jun 5;268(16):11711-20. PubMed PMID: 8389361.
Cameron CE, Ridky TW, Shulenin S, Leis J, Weber IT, Copeland T, Wlodawer A, Burstein H, Bizub-Bender D, Skalka AM. Mutational analysis of the substrate binding pockets of the Rous sarcoma virus and human immunodeficiency virus-1 proteases. J Biol Chem. 1994 Apr 15;269(15):11170-7. PubMed PMID: 8157644; NIHMSID:NIHMS92042.
Leis JP, Cameron CE. Engineering proteases with altered specificity. Curr Opin Biotechnol. 1994 Aug;5(4):403-8. doi: 10.1016/0958-1669(94)90049-3. PubMed PMID: 7765173.
Wills JW, Cameron CE, Wilson CB, Xiang Y, Bennett RP, Leis J. An assembly domain of the Rous sarcoma virus Gag protein required late in budding. J Virol. 1994 Oct;68(10):6605-18. doi: 10.1128/JVI.68.10.6605-6618.1994. PubMed PMID: 8083996; PubMed Central PMCID: PMC237081.
Le Grice SF, Cameron CE, Benkovic SJ. Purification and characterization of human immunodeficiency virus type 1 reverse transcriptase. Methods Enzymol. 1995;262:130-44. doi: 10.1016/0076-6879(95)62015-x. PubMed PMID: 8594344.
Benkovic SJ, Cameron CE. Kinetic analysis of nucleotide incorporation and misincorporation by Klenow fragment of Escherichia coli DNA polymerase I. Methods Enzymol. 1995;262:257-69. doi: 10.1016/0076-6879(95)62022-2. PubMed PMID: 8594352.
Cameron CE, Burstein H, Bizub-Bender D, Ridky T, Weber IT, Wlodawer A, Skalka AM, Leis J. Identification of amino acid residues of the retroviral aspartic proteinases important for substrate specificity and catalytic efficiency. Adv Exp Med Biol. 1995;362:399-406. doi: 10.1007/978-1-4615-1871-6_52. PubMed PMID: 8540349.
Ghosh M, Howard KJ, Cameron CE, Benkovic SJ, Hughes SH, Le Grice SF. Truncating alpha-helix E' of p66 human immunodeficiency virus reverse transcriptase modulates RNase H function and impairs DNA strand transfer. J Biol Chem. 1995 Mar 31;270(13):7068-76. doi: 10.1074/jbc.270.13.7068. PubMed PMID: 7535765.
Cirino NM, Cameron CE, Smith JS, Rausch JW, Roth MJ, Benkovic SJ, Le Grice SF. Divalent cation modulation of the ribonuclease functions of human immunodeficiency virus reverse transcriptase. Biochemistry. 1995 Aug 8;34(31):9936-43. doi: 10.1021/bi00031a016. PubMed PMID: 7543283.
Ridky TW, Cameron CE, Cameron J, Leis J, Copeland T, Wlodawer A, Weber IT, Harrison RW. Human immunodeficiency virus, type 1 protease substrate specificity is limited by interactions between substrate amino acids bound in adjacent enzyme subsites. J Biol Chem. 1996 Mar 1;271(9):4709-17. doi: 10.1074/jbc.271.9.4709. PubMed PMID: 8617736.
Ridky TW, Bizub-Bender D, Cameron CE, Weber IT, Wlodawer A, Copeland T, Skalka AM, Leis J. Programming the Rous sarcoma virus protease to cleave new substrate sequences. J Biol Chem. 1996 May 3;271(18):10538-44. doi: 10.1074/jbc.271.18.10538. PubMed PMID: 8631853.
Xiang Y, Cameron CE, Wills JW, Leis J. Fine mapping and characterization of the Rous sarcoma virus Pr76gag late assembly domain. J Virol. 1996 Aug;70(8):5695-700. doi: 10.1128/JVI.70.8.5695-5700.1996. PubMed PMID: 8764091; PubMed Central PMCID: PMC190537.
Cameron CE, Ghosh M, Le Grice SF, Benkovic SJ. Mutations in HIV reverse transcriptase which alter RNase H activity and decrease strand transfer efficiency are suppressed by HIV nucleocapsid protein. Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6700-5. doi: 10.1073/pnas.94.13.6700. PubMed PMID: 9192628; PubMed Central PMCID: PMC21221.
Cameron CE, Benkovic SJ. Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant. Biochemistry. 1997 Dec 16;36(50):15792-800. doi: 10.1021/bi9716231. PubMed PMID: 9398309.
Arnold JJ, Cameron CE. Poliovirus RNA-dependent RNA polymerase (3Dpol) is sufficient for template switching in vitro. J Biol Chem. 1999 Jan 29;274(5):2706-16. doi: 10.1074/jbc.274.5.2706. PubMed PMID: 9915801.
Arnold JJ, Ghosh SK, Bevilacqua PC, Cameron CE. Single-nucleotide resolution of RNA strands in the presence of their RNA complements. Biotechniques. 1999 Sep;27(3):450-2, 454, 456. doi: 10.2144/99273bm11. PubMed PMID: 10489603.
Gohara DW, Ha CS, Kumar S, Ghosh B, Arnold JJ, Wisniewski TJ, Cameron CE. Production of "authentic" poliovirus RNA-dependent RNA polymerase (3D(pol)) by ubiquitin-protease-mediated cleavage in Escherichia coli. Protein Expr Purif. 1999 Oct;17(1):128-38. doi: 10.1006/prep.1999.1100. PubMed PMID: 10497078.
Arnold JJ, Ghosh SK, Cameron CE. Poliovirus RNA-dependent RNA polymerase (3D(pol)). Divalent cation modulation of primer, template, and nucleotide selection. J Biol Chem. 1999 Dec 24;274(52):37060-9. doi: 10.1074/jbc.274.52.37060. PubMed PMID: 10601264.
Arnold JJ, Cameron CE. Poliovirus RNA-dependent RNA polymerase (3D(pol)). Assembly of stable, elongation-competent complexes by using a symmetrical primer-template substrate (sym/sub). J Biol Chem. 2000 Feb 25;275(8):5329-36. doi: 10.1074/jbc.275.8.5329. PubMed PMID: 10681506.
Gohara DW, Crotty S, Arnold JJ, Yoder JD, Andino R, Cameron CE. Poliovirus RNA-dependent RNA polymerase (3Dpol): structural, biochemical, and biological analysis of conserved structural motifs A and B. J Biol Chem. 2000 Aug 18;275(33):25523-32. doi: 10.1074/jbc.M002671200. PubMed PMID: 10827187.
Zhong W, Ferrari E, Lesburg CA, Maag D, Ghosh SK, Cameron CE, Lau JY, Hong Z. Template/primer requirements and single nucleotide incorporation by hepatitis C virus nonstructural protein 5B polymerase. J Virol. 2000 Oct;74(19):9134-43. doi: 10.1128/jvi.74.19.9134-9143.2000. PubMed PMID: 10982360; PubMed Central PMCID: PMC102112.
Crotty S, Maag D, Arnold JJ, Zhong W, Lau JY, Hong Z, Andino R, Cameron CE. The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nat Med. 2000 Dec;6(12):1375-9. doi: 10.1038/82191. PubMed PMID: 11100123.
Tackett AJ, Wei L, Cameron CE, Raney KD. Unwinding of nucleic acids by HCV NS3 helicase is sensitive to the structure of the duplex. Nucleic Acids Res. 2001 Jan 15;29(2):565-72. doi: 10.1093/nar/29.2.565. PubMed PMID: 11139627; PubMed Central PMCID: PMC29657.
Wei L, Huhn JS, Mory A, Pathak HB, Sosnovtsev SV, Green KY, Cameron CE. Proteinase-polymerase precursor as the active form of feline calicivirus RNA-dependent RNA polymerase. J Virol. 2001 Feb;75(3):1211-9. doi: 10.1128/JVI.75.3.1211-1219.2001. PubMed PMID: 11152494; PubMed Central PMCID: PMC114027.
Crotty S, Cameron CE, Andino R. RNA virus error catastrophe: direct molecular test by using ribavirin. Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6895-900. doi: 10.1073/pnas.111085598. Epub 2001 May 22. PubMed PMID: 11371613; PubMed Central PMCID: PMC34449.
Hong Z, Cameron CE, Walker MP, Castro C, Yao N, Lau JY, Zhong W. A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase. Virology. 2001 Jun 20;285(1):6-11. doi: 10.1006/viro.2001.0948. PubMed PMID: 11414800.
Cameron CE, Castro C. The mechanism of action of ribavirin: lethal mutagenesis of RNA virus genomes mediated by the viral RNA-dependent RNA polymerase. Curr Opin Infect Dis. 2001 Dec;14(6):757-64. doi: 10.1097/00001432-200112000-00015. Review. PubMed PMID: 11964896.
Maag D, Castro C, Hong Z, Cameron CE. Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin. J Biol Chem. 2001 Dec 7;276(49):46094-8. doi: 10.1074/jbc.C100349200. Epub 2001 Oct 15. PubMed PMID: 11602568.
Hong Z, Cameron CE. Pleiotropic mechanisms of ribavirin antiviral activities. Prog Drug Res. 2002;59:41-69. doi: 10.1007/978-3-0348-8171-5_2. Review. PubMed PMID: 12458963.
Morris PD, Byrd AK, Tackett AJ, Cameron CE, Tanega P, Ott R, Fanning E, Raney KD. Hepatitis C virus NS3 and simian virus 40 T antigen helicases displace streptavidin from 5'-biotinylated oligonucleotides but not from 3'-biotinylated oligonucleotides: evidence for directional bias in translocation on single-stranded DNA. Biochemistry. 2002 Feb 19;41(7):2372-8. doi: 10.1021/bi012058b. PubMed PMID: 11841230.
Graci JD, Cameron CE. Quasispecies, error catastrophe, and the antiviral activity of ribavirin. Virology. 2002 Jul 5;298(2):175-80. doi: 10.1006/viro.2002.1487. Review. PubMed PMID: 12127780.
Harki DA, Graci JD, Korneeva VS, Ghosh SK, Hong Z, Cameron CE, Peterson BR. Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-beta-D-Ribofuranosyl-3-nitropyrrole. Biochemistry. 2002 Jul 23;41(29):9026-33. doi: 10.1021/bi026120w. PubMed PMID: 12119016.
Pathak HB, Ghosh SK, Roberts AW, Sharma SD, Yoder JD, Arnold JJ, Gohara DW, Barton DJ, Paul AV, Cameron CE. Structure-function relationships of the RNA-dependent RNA polymerase from poliovirus (3Dpol). A surface of the primary oligomerization domain functions in capsid precursor processing and VPg uridylylation. J Biol Chem. 2002 Aug 30;277(35):31551-62. doi: 10.1074/jbc.M204408200. Epub 2002 Jun 19. PubMed PMID: 12077141.
Green KY, Mory A, Fogg MH, Weisberg A, Belliot G, Wagner M, Mitra T, Ehrenfeld E, Cameron CE, Sosnovtsev SV. Isolation of enzymatically active replication complexes from feline calicivirus-infected cells. J Virol. 2002 Sep;76(17):8582-95. doi: 10.1128/jvi.76.17.8582-8595.2002. PubMed PMID: 12163578; PubMed Central PMCID: PMC136418.
Gorbalenya AE, Pringle FM, Zeddam JL, Luke BT, Cameron CE, Kalmakoff J, Hanzlik TN, Gordon KH, Ward VK. The palm subdomain-based active site is internally permuted in viral RNA-dependent RNA polymerases of an ancient lineage. J Mol Biol. 2002 Nov 15;324(1):47-62. doi: 10.1016/s0022-2836(02)01033-1. PubMed PMID: 12421558; PubMed Central PMCID: PMC7127740.
Crotty S, Gohara D, Gilligan DK, Karelsky S, Cameron CE, Andino R. Manganese-dependent polioviruses caused by mutations within the viral polymerase. J Virol. 2003 May;77(9):5378-88. doi: 10.1128/jvi.77.9.5378-5388.2003. PubMed PMID: 12692240; PubMed Central PMCID: PMC153957.
Graci JD, Cameron CE. Challenges for the development of ribonucleoside analogues as inducers of error catastrophe. Antivir Chem Chemother. 2004 Jan;15(1):1-13. doi: 10.1177/095632020401500101. Review. PubMed PMID: 15074710.
Freistadt MS, Meades GD, Cameron CE. Lethal mutagens: broad-spectrum antivirals with limited potential for development of resistance?. Drug Resist Updat. 2004 Feb;7(1):19-24. doi: 10.1016/j.drup.2003.12.003. Review. PubMed PMID: 15072768.
Gohara DW, Arnold JJ, Cameron CE. Poliovirus RNA-dependent RNA polymerase (3Dpol): kinetic, thermodynamic, and structural analysis of ribonucleotide selection. Biochemistry. 2004 May 11;43(18):5149-58. doi: 10.1021/bi035429s. PubMed PMID: 15122880; PubMed Central PMCID: PMC2426919.
Arnold JJ, Cameron CE. Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mg2+. Biochemistry. 2004 May 11;43(18):5126-37. doi: 10.1021/bi035212y. PubMed PMID: 15122878; PubMed Central PMCID: PMC2426923.
Arnold JJ, Gohara DW, Cameron CE. Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mn2+. Biochemistry. 2004 May 11;43(18):5138-48. doi: 10.1021/bi035213q. PubMed PMID: 15122879; PubMed Central PMCID: PMC2426922.
de Miranda JR, Drebot M, Tyler S, Shen M, Cameron CE, Stoltz DB, Camazine SM. Complete nucleotide sequence of Kashmir bee virus and comparison with acute bee paralysis virus. J Gen Virol. 2004 Aug;85(Pt 8):2263-2270. doi: 10.1099/vir.0.79990-0. PubMed PMID: 15269367.
Huang L, Sineva EV, Hargittai MR, Sharma SD, Suthar M, Raney KD, Cameron CE. Purification and characterization of hepatitis C virus non-structural protein 5A expressed in Escherichia coli. Protein Expr Purif. 2004 Sep;37(1):144-53. doi: 10.1016/j.pep.2004.05.005. PubMed PMID: 15294292.
Castro C, Arnold JJ, Cameron CE. Incorporation fidelity of the viral RNA-dependent RNA polymerase: a kinetic, thermodynamic and structural perspective. Virus Res. 2005 Feb;107(2):141-9. doi: 10.1016/j.virusres.2004.11.004. Review. PubMed PMID: 15649560; PubMed Central PMCID: PMC7125856.
Belliot G, Sosnovtsev SV, Chang KO, Babu V, Uche U, Arnold JJ, Cameron CE, Green KY. Norovirus proteinase-polymerase and polymerase are both active forms of RNA-dependent RNA polymerase. J Virol. 2005 Feb;79(4):2393-403. doi: 10.1128/JVI.79.4.2393-2403.2005. PubMed PMID: 15681440; PubMed Central PMCID: PMC546540.
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