My Bibliography

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Faccidomo S, Hoffman JL, Lee J, Whindleton CM, Kim M, Taylor SM, Kim A, Richter C, Seiters HL, Bryant JM, Chang A, Smith EN, Agoglia AE, Tomita S, Herman MA, Hodge CW. Transmembrane AMPA receptor regulatory protein TARP ɣ-8 is a target of ethanol that regulates self-administration and relapse in mice. Psychopharmacology (Berl). 2026 May;243(5):1131-1149. doi: 10.1007/s00213-025-06848-1. Epub 2025 Jul 18. PubMed PMID: 40679606; PubMed Central PMCID: PMC13363265.

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Faccidomo S, Hoffman JL, Lee J, Whindleton CM, Kim M, Taylor SM, Kim A, Richter C, Seiters HL, Bryant JM, Chang A, Smith EN, Agoglia AE, Tomita S, Herman MA, Hodge CW. TARP ɣ-8 is a target of ethanol that regulates self-administration and relapse in mice. bioRxiv. 2025 Apr 1;. doi: 10.1101/2025.03.27.645788. PubMed PMID: 40236160; PubMed Central PMCID: PMC11996309.

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Faccidomo S, Eastman VR, Santanam TS, Swaim KS, Taylor SM, Hodge CW. Distinct sex differences in ethanol consumption and operant self-administration in C57BL/6J mice with uniform regulation by glutamate AMPAR activity. Front Behav Neurosci. 2024;18:1498201. doi: 10.3389/fnbeh.2024.1498201. eCollection 2024. PubMed PMID: 39911242; PubMed Central PMCID: PMC11794300.

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Faccidomo S, Saunders BL, May AM, Eastman VR, Kim M, Taylor SM, Hoffman JL, McElligott ZA, Hodge CW. Ethanol self-administration targets GluA2-containing AMPA receptor expression and synaptic activity in the nucleus accumbens in a manner that drives the positive reinforcing properties of the drug. Psychopharmacology (Berl). 2025 Jun;242(6):1437-1452. doi: 10.1007/s00213-024-06740-4. Epub 2024 Dec 23. PubMed PMID: 39714485; PubMed Central PMCID: PMC12084143.

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Effinger DP, Hoffman JL, Mott SE, Magee SN, Quadir SG, Rollison CS, Toedt D, Echeveste Sanchez M, High MW, Hodge CW, Herman MA. Increased reactivity of the paraventricular nucleus of the hypothalamus and decreased threat responding in male rats following psilocin administration. Nat Commun. 2024 Jun 22;15(1):5321. doi: 10.1038/s41467-024-49741-9. PubMed PMID: 38909051; PubMed Central PMCID: PMC11193716.

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Hoffman JL, Faccidomo SP, Taylor SM, DeMiceli KG, May AM, Smith EN, Whindleton CM, Hodge CW. Negative modulation of AMPA receptors bound to transmembrane AMPA receptor regulatory protein γ-8 blunts the positive reinforcing properties of alcohol and sucrose in a brain region-dependent manner in male mice. Psychopharmacology (Berl). 2023 Jun;240(6):1261-1273. doi: 10.1007/s00213-023-06365-z. Epub 2023 Apr 13. PubMed PMID: 37055596; PubMed Central PMCID: PMC10698495.

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Echeveste Sanchez M, Quadir SG, Whindleton CM, Hoffman JL, Faccidomo SP, Guhr Lee TN, Esther CR Jr, Hodge CW, Herman MA. The effects of electronic nicotine vapor on voluntary alcohol consumption in female and male C57BL/6 J mice. Drug Alcohol Depend. 2022 Dec 1;241:109676. doi: 10.1016/j.drugalcdep.2022.109676. Epub 2022 Oct 26. PubMed PMID: 36343590; PubMed Central PMCID: PMC9979979.

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Hoffman JL, Faccidomo S, Saunders BL, Taylor SM, Kim M, Hodge CW. Inhibition of AMPA receptors (AMPARs) containing transmembrane AMPAR regulatory protein γ-8 with JNJ-55511118 shows preclinical efficacy in reducing chronic repetitive alcohol self-administration. Alcohol Clin Exp Res. 2021 Jul;45(7):1424-1435. doi: 10.1111/acer.14639. Epub 2021 Jun 22. PubMed PMID: 34086361; PubMed Central PMCID: PMC8336716.

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Agoglia AE, Zhu M, Quadir SG, Bluitt MN, Douglass E, Hanback T, Tella J, Ying R, Hodge CW, Herman MA. Sex-specific plasticity in CRF regulation of inhibitory control in central amygdala CRF1 neurons after chronic voluntary alcohol drinking. Addict Biol. 2022 Jan;27(1):e13067. doi: 10.1111/adb.13067. Epub 2021 Jun 2. PubMed PMID: 34075665; PubMed Central PMCID: PMC8636550.

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Faccidomo S, Cogan ES, Hon OJ, Hoffman JL, Saunders BL, Eastman VR, Kim M, Taylor SM, McElligott ZA, Hodge CW. Calcium-permeable AMPA receptor activity and GluA1 trafficking in the basolateral amygdala regulate operant alcohol self-administration. Addict Biol. 2021 Sep;26(5):e13049. doi: 10.1111/adb.13049. Epub 2021 May 5. PubMed PMID: 33955100; PubMed Central PMCID: PMC8376775.

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Faccidomo S, Holstein SE, Santanam TS, Saunders BL, Swaim KS, Reid GT, O'Neill C, Eastman VR, Hodge CW. Pharmacological inhibition of glycogen synthase kinase 3 increases operant alcohol self-administration in a manner associated with altered pGSK-3β, protein interacting with C kinase and GluA2 protein expression in the reward pathway of male C57BL/6J mice. Behav Pharmacol. 2020 Feb;31(1):15-26. doi: 10.1097/FBP.0000000000000501. PubMed PMID: 31503067; PubMed Central PMCID: PMC6954298.

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Torruella-Suárez ML, Vandenberg JR, Cogan ES, Tipton GJ, Teklezghi A, Dange K, Patel GK, McHenry JA, Hardaway JA, Kantak PA, Crowley NA, DiBerto JF, Faccidomo SP, Hodge CW, Stuber GD, McElligott ZA. Manipulations of Central Amygdala Neurotensin Neurons Alter the Consumption of Ethanol and Sweet Fluids in Mice. J Neurosci. 2020 Jan 15;40(3):632-647. doi: 10.1523/JNEUROSCI.1466-19.2019. Epub 2019 Nov 19. PubMed PMID: 31744862; PubMed Central PMCID: PMC6961987.

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Hoffman JL, Faccidomo S, Kim M, Taylor SM, Agoglia AE, May AM, Smith EN, Wong LC, Hodge CW. Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease. Int Rev Neurobiol. 2019;148:169-230. doi: 10.1016/bs.irn.2019.10.017. Epub 2019 Oct 23. Review. PubMed PMID: 31733664; PubMed Central PMCID: PMC6939615.

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Stevenson RA, Hoffman JL, Maldonado-Devincci AM, Faccidomo S, Hodge CW. MGluR5 activity is required for the induction of ethanol behavioral sensitization and associated changes in ERK MAP kinase phosphorylation in the nucleus accumbens shell and lateral habenula. Behav Brain Res. 2019 Jul 23;367:19-27. doi: 10.1016/j.bbr.2019.03.038. Epub 2019 Mar 23. PubMed PMID: 30914307; PubMed Central PMCID: PMC6476635.

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Faccidomo S, Swaim KS, Saunders BL, Santanam TS, Taylor SM, Kim M, Reid GT, Eastman VR, Hodge CW. Mining the nucleus accumbens proteome for novel targets of alcohol self-administration in male C57BL/6J mice. Psychopharmacology (Berl). 2018 Jun;235(6):1681-1696. doi: 10.1007/s00213-018-4870-3. Epub 2018 Mar 3. PubMed PMID: 29502276; PubMed Central PMCID: PMC5949261.

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Salling MC, Hodge CJ, Psilos KE, Eastman VR, Faccidomo SP, Hodge CW. Cue-induced reinstatement of alcohol-seeking behavior is associated with increased CaMKII T286 phosphorylation in the reward pathway of mice. Pharmacol Biochem Behav. 2017 Dec;163:20-29. doi: 10.1016/j.pbb.2017.10.011. Epub 2017 Oct 31. PubMed PMID: 29100991; PubMed Central PMCID: PMC5779622.

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Agoglia AE, Holstein SE, Small AT, Spanos M, Burrus BM, Hodge CW. Comparison of the adolescent and adult mouse prefrontal cortex proteome. PLoS One. 2017;12(6):e0178391. doi: 10.1371/journal.pone.0178391. eCollection 2017. PubMed PMID: 28570644; PubMed Central PMCID: PMC5453624.

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Agoglia AE, Holstein SE, Eastman VR, Hodge CW. Cannabinoid CB1 receptor inhibition blunts adolescent-typical increased binge alcohol and sucrose consumption in male C57BL/6J mice. Pharmacol Biochem Behav. 2016 Apr;143:11-7. doi: 10.1016/j.pbb.2016.01.009. Epub 2016 Jan 19. PubMed PMID: 26800788; PubMed Central PMCID: PMC4905821.

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Cannady R, Fisher KR, Graham C, Crayle J, Besheer J, Hodge CW. Potentiation of amygdala AMPA receptor activity selectively promotes escalated alcohol self-administration in a CaMKII-dependent manner. Addict Biol. 2017 May;22(3):652-664. doi: 10.1111/adb.12357. Epub 2016 Jan 6. PubMed PMID: 26742808; PubMed Central PMCID: PMC4935658.

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Faccidomo S, Reid GT, Agoglia AE, Ademola SA, Hodge CW. CaMKII inhibition in the prefrontal cortex specifically increases the positive reinforcing effects of sweetened alcohol in C57BL/6J mice. Behav Brain Res. 2016 Feb 1;298(Pt B):286-90. doi: 10.1016/j.bbr.2015.11.018. Epub 2015 Nov 19. PubMed PMID: 26608538; PubMed Central PMCID: PMC4688209.

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Agoglia AE, Holstein SE, Reid G, Hodge CW. CaMKIIα-GluA1 Activity Underlies Vulnerability to Adolescent Binge Alcohol Drinking. Alcohol Clin Exp Res. 2015 Sep;39(9):1680-90. doi: 10.1111/acer.12819. Epub 2015 Aug 6. PubMed PMID: 26247621; PubMed Central PMCID: PMC4558330.

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Faccidomo S, Salling MC, Galunas C, Hodge CW. Operant ethanol self-administration increases extracellular-signal regulated protein kinase (ERK) phosphorylation in reward-related brain regions: selective regulation of positive reinforcement in the prefrontal cortex of C57BL/6J mice. Psychopharmacology (Berl). 2015 Sep;232(18):3417-30. doi: 10.1007/s00213-015-3993-z. Epub 2015 Jun 28. PubMed PMID: 26123321; PubMed Central PMCID: PMC4537834.

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Agoglia AE, Sharko AC, Psilos KE, Holstein SE, Reid GT, Hodge CW. Alcohol alters the activation of ERK1/2, a functional regulator of binge alcohol drinking in adult C57BL/6J mice. Alcohol Clin Exp Res. 2015 Mar;39(3):463-75. doi: 10.1111/acer.12645. Epub 2015 Feb 19. PubMed PMID: 25703719; PubMed Central PMCID: PMC4348173.

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Salling MC, Faccidomo SP, Li C, Psilos K, Galunas C, Spanos M, Agoglia AE, Kash TL, Hodge CW. Moderate Alcohol Drinking and the Amygdala Proteome: Identification and Validation of Calcium/Calmodulin Dependent Kinase II and AMPA Receptor Activity as Novel Molecular Mechanisms of the Positive Reinforcing Effects of Alcohol. Biol Psychiatry. 2016 Mar 15;79(6):430-42. doi: 10.1016/j.biopsych.2014.10.020. Epub 2014 Oct 31. PubMed PMID: 25579851; PubMed Central PMCID: PMC4417085.

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Cook JB, Werner DF, Maldonado-Devincci AM, Leonard MN, Fisher KR, O'Buckley TK, Porcu P, McCown TJ, Besheer J, Hodge CW, Morrow AL. Overexpression of the steroidogenic enzyme cytochrome P450 side chain cleavage in the ventral tegmental area increases 3α,5α-THP and reduces long-term operant ethanol self-administration. J Neurosci. 2014 Apr 23;34(17):5824-34. doi: 10.1523/JNEUROSCI.4733-13.2014. PubMed PMID: 24760842; PubMed Central PMCID: PMC3996211.

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Hay RA, Jennings JH, Zitzman DL, Hodge CW, Robinson DL. Specific and nonspecific effects of naltrexone on goal-directed and habitual models of alcohol seeking and drinking. Alcohol Clin Exp Res. 2013 Jul;37(7):1100-10. doi: 10.1111/acer.12081. Epub 2013 Feb 7. PubMed PMID: 23398292; PubMed Central PMCID: PMC3655078.

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Robinson JE, Chen M, Stamatakis AM, Krouse MC, Howard EC, Faccidomo S, Hodge CW, Fish EW, Malanga CJ. Levetiracetam has opposite effects on alcohol- and cocaine-related behaviors in C57BL/6J mice. Neuropsychopharmacology. 2013 Jun;38(7):1322-33. doi: 10.1038/npp.2013.30. Epub 2013 Jan 25. PubMed PMID: 23353709; PubMed Central PMCID: PMC3656375.

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Riday TT, Dankoski EC, Krouse MC, Fish EW, Walsh PL, Han JE, Hodge CW, Wightman RM, Philpot BD, Malanga CJ. Pathway-specific dopaminergic deficits in a mouse model of Angelman syndrome. J Clin Invest. 2012 Dec;122(12):4544-54. doi: 10.1172/JCI61888. Epub 2012 Nov 12. PubMed PMID: 23143301; PubMed Central PMCID: PMC3533533.

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Cannady R, Fisher KR, Durant B, Besheer J, Hodge CW. Enhanced AMPA receptor activity increases operant alcohol self-administration and cue-induced reinstatement. Addict Biol. 2013 Jan;18(1):54-65. doi: 10.1111/adb.12000. Epub 2012 Nov 6. PubMed PMID: 23126443; PubMed Central PMCID: PMC3535558.

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Cox ET, Hodge CW, Sheikh MJ, Abramowitz AC, Jones GF, Jamieson-Drake AW, Makam PR, Zeskind PS, Johns JM. Delayed developmental changes in neonatal vocalizations correlates with variations in ventral medial hypothalamus and central amygdala development in the rodent infant: effects of prenatal cocaine. Behav Brain Res. 2012 Dec 1;235(2):166-75. doi: 10.1016/j.bbr.2012.07.035. Epub 2012 Aug 4. PubMed PMID: 22867871; PubMed Central PMCID: PMC3461834.

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Spanos M, Besheer J, Hodge CW. Increased sensitivity to alcohol induced changes in ERK Map kinase phosphorylation and memory disruption in adolescent as compared to adult C57BL/6J mice. Behav Brain Res. 2012 Apr 21;230(1):158-66. doi: 10.1016/j.bbr.2012.02.010. Epub 2012 Feb 13. PubMed PMID: 22348893; PubMed Central PMCID: PMC3310330.

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Besheer J, Fisher KR, Cannady R, Grondin JJ, Hodge CW. Intra-amygdala inhibition of ERK(1/2) potentiates the discriminative stimulus effects of alcohol. Behav Brain Res. 2012 Mar 17;228(2):398-405. doi: 10.1016/j.bbr.2011.12.023. Epub 2011 Dec 23. PubMed PMID: 22209853; PubMed Central PMCID: PMC3268949.

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Besheer J, Fisher KR, Grondin JJ, Cannady R, Hodge CW. The effects of repeated corticosterone exposure on the interoceptive effects of alcohol in rats. Psychopharmacology (Berl). 2012 Apr;220(4):809-22. doi: 10.1007/s00213-011-2533-8. Epub 2011 Oct 21. PubMed PMID: 22016195; PubMed Central PMCID: PMC3422726.

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Fish EW, Robinson JE, Krouse MC, Hodge CW, Reed C, Phillips TJ, Malanga CJ. Intracranial self-stimulation in FAST and SLOW mice: effects of alcohol and cocaine. Psychopharmacology (Berl). 2012 Apr;220(4):719-30. doi: 10.1007/s00213-011-2523-x. Epub 2011 Oct 7. PubMed PMID: 21983918; PubMed Central PMCID: PMC3289728.

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Cannady R, Grondin JJ, Fisher KR, Hodge CW, Besheer J. Activation of group II metabotropic glutamate receptors inhibits the discriminative stimulus effects of alcohol via selective activity within the amygdala. Neuropsychopharmacology. 2011 Oct;36(11):2328-38. doi: 10.1038/npp.2011.121. Epub 2011 Jul 6. PubMed PMID: 21734651; PubMed Central PMCID: PMC3176569.

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Holstein SE, Spanos M, Hodge CW. Adolescent C57BL/6J mice show elevated alcohol intake, but reduced taste aversion, as compared to adult mice: a potential behavioral mechanism for binge drinking. Alcohol Clin Exp Res. 2011 Oct;35(10):1842-51. doi: 10.1111/j.1530-0277.2011.01528.x. Epub 2011 May 16. PubMed PMID: 21575017; PubMed Central PMCID: PMC3158303.

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Besheer J, Lindsay TG, O'Buckley TK, Hodge CW, Morrow AL. Pregnenolone and ganaxolone reduce operant ethanol self-administration in alcohol-preferring p rats. Alcohol Clin Exp Res. 2010 Dec;34(12):2044-52. doi: 10.1111/j.1530-0277.2010.01300.x. Epub 2010 Oct 14. PubMed PMID: 20946297; PubMed Central PMCID: PMC2988984.

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Lowery EG, Spanos M, Navarro M, Lyons AM, Hodge CW, Thiele TE. CRF-1 antagonist and CRF-2 agonist decrease binge-like ethanol drinking in C57BL/6J mice independent of the HPA axis. Neuropsychopharmacology. 2010 May;35(6):1241-52. doi: 10.1038/npp.2009.209. Epub 2010 Feb 3. PubMed PMID: 20130533; PubMed Central PMCID: PMC2927867.

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Besheer J, Grondin JJ, Cannady R, Sharko AC, Faccidomo S, Hodge CW. Metabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intake. Biol Psychiatry. 2010 May 1;67(9):812-22. doi: 10.1016/j.biopsych.2009.09.016. Epub 2009 Nov 7. PubMed PMID: 19897175; PubMed Central PMCID: PMC2854174.

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Fish EW, Riday TT, McGuigan MM, Faccidomo S, Hodge CW, Malanga CJ. Alcohol, cocaine, and brain stimulation-reward in C57Bl6/J and DBA2/J mice. Alcohol Clin Exp Res. 2010 Jan;34(1):81-9. doi: 10.1111/j.1530-0277.2009.01069.x. Epub 2009 Oct 23. PubMed PMID: 19860803; PubMed Central PMCID: PMC5744672.

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Arolfo MP, Overstreet DH, Yao L, Fan P, Lawrence AJ, Tao G, Keung WM, Vallee BL, Olive MF, Gass JT, Rubin E, Anni H, Hodge CW, Besheer J, Zablocki J, Leung K, Blackburn BK, Lange LG, Diamond I. Suppression of heavy drinking and alcohol seeking by a selective ALDH-2 inhibitor. Alcohol Clin Exp Res. 2009 Nov;33(11):1935-44. doi: 10.1111/j.1530-0277.2009.01031.x. Epub 2009 Aug 10. PubMed PMID: 19673742; PubMed Central PMCID: PMC8212937.

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Besheer J, Lepoutre V, Hodge CW. Preclinical evaluation of riluzole: assessments of ethanol self-administration and ethanol withdrawal symptoms. Alcohol Clin Exp Res. 2009 Aug;33(8):1460-8. doi: 10.1111/j.1530-0277.2009.00976.x. PubMed PMID: 19426166; PubMed Central PMCID: PMC2845177.

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Besheer J, Grondin JJ, Salling MC, Spanos M, Stevenson RA, Hodge CW. Interoceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbens. J Neurosci. 2009 Jul 29;29(30):9582-91. doi: 10.1523/JNEUROSCI.2366-09.2009. PubMed PMID: 19641121; PubMed Central PMCID: PMC2845172.

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Faccidomo S, Besheer J, Stanford PC, Hodge CW. Increased operant responding for ethanol in male C57BL/6J mice: specific regulation by the ERK1/2, but not JNK, MAP kinase pathway. Psychopharmacology (Berl). 2009 May;204(1):135-47. doi: 10.1007/s00213-008-1444-9. Epub 2009 Jan 6. PubMed PMID: 19125235; PubMed Central PMCID: PMC2845162.

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Besheer J, Schroeder JP, Stevenson RA, Hodge CW. Ethanol-induced alterations of c-Fos immunoreactivity in specific limbic brain regions following ethanol discrimination training. Brain Res. 2008 Sep 26;1232:124-31. doi: 10.1016/j.brainres.2008.07.061. Epub 2008 Jul 26. PubMed PMID: 18692030; PubMed Central PMCID: PMC2575425.

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Schroeder JP, Spanos M, Stevenson JR, Besheer J, Salling M, Hodge CW. Cue-induced reinstatement of alcohol-seeking behavior is associated with increased ERK1/2 phosphorylation in specific limbic brain regions: blockade by the mGluR5 antagonist MPEP. Neuropharmacology. 2008 Sep;55(4):546-54. doi: 10.1016/j.neuropharm.2008.06.057. Epub 2008 Jul 4. PubMed PMID: 18619984; PubMed Central PMCID: PMC2613007.

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Stevenson JR, Schroeder JP, Nixon K, Besheer J, Crews FT, Hodge CW. Abstinence following alcohol drinking produces depression-like behavior and reduced hippocampal neurogenesis in mice. Neuropsychopharmacology. 2009 Apr;34(5):1209-22. doi: 10.1038/npp.2008.90. Epub 2008 Jun 18. PubMed PMID: 18563059; PubMed Central PMCID: PMC2844649.

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Salling MC, Faccidomo S, Hodge CW. Nonselective suppression of operant ethanol and sucrose self-administration by the mGluR7 positive allosteric modulator AMN082. Pharmacol Biochem Behav. 2008 Nov;91(1):14-20. doi: 10.1016/j.pbb.2008.06.006. Epub 2008 Jun 14. PubMed PMID: 18593591; PubMed Central PMCID: PMC2562464.

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Besheer J, Faccidomo S, Grondin JJ, Hodge CW. Effects of mGlu1-receptor blockade on ethanol self-administration in inbred alcohol-preferring rats. Alcohol. 2008 Feb;42(1):13-20. doi: 10.1016/j.alcohol.2007.11.001. PubMed PMID: 18164577; PubMed Central PMCID: PMC2350187.

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Stevenson RA, Besheer J, Hodge CW. Comparison of ethanol locomotor sensitization in adolescent and adult DBA/2J mice. Psychopharmacology (Berl). 2008 Apr;197(3):361-70. doi: 10.1007/s00213-007-1038-y. Epub 2007 Dec 22. PubMed PMID: 18157521; PubMed Central PMCID: PMC2531208.