My Bibliography

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Michgehl S, Heusipp G, Greune L, Rüter C, Schmidt MA. Esp-independent functional integration of the translocated intimin receptor (Tir) of enteropathogenic Escherichia coli (EPEC) into host cell membranes. Cell Microbiol. 2006 Apr;8(4):625-33. doi: 10.1111/j.1462-5822.2005.00655.x. PubMed PMID: 16548888.

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Buss C, Müller D, Rüter C, Heusipp G, Schmidt MA. Identification and characterization of Ibe, a novel type III effector protein of A/E pathogens targeting human IQGAP1. Cell Microbiol. 2009 Apr;11(4):661-77. doi: 10.1111/j.1462-5822.2009.01284.x. Epub 2009 Jan 7. PubMed PMID: 19134119.

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Rüter C, Buss C, Scharnert J, Heusipp G, Schmidt MA. A newly identified bacterial cell-penetrating peptide that reduces the transcription of pro-inflammatory cytokines. J Cell Sci. 2010 Jul 1;123(Pt 13):2190-8. doi: 10.1242/jcs.063016. PubMed PMID: 20554895.

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Scharnert J, Greune L, Zeuschner D, Lubos ML, Alexander Schmidt M, Rüter C. Autonomous translocation and intracellular trafficking of the cell-penetrating and immune-suppressive effector protein YopM. Cell Mol Life Sci. 2013 Dec;70(24):4809-23. doi: 10.1007/s00018-013-1413-2. Epub 2013 Jul 9. PubMed PMID: 23835836; PubMed Central PMCID: PMC11113385.

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Rüter C, Hardwidge PR. 'Drugs from bugs': bacterial effector proteins as promising biological (immune-) therapeutics. FEMS Microbiol Lett. 2014 Feb;351(2):126-32. doi: 10.1111/1574-6968.12333. Epub 2013 Dec 11. Review. PubMed PMID: 24261744.

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Bielaszewska M, Rüter C, Kunsmann L, Greune L, Bauwens A, Zhang W, Kuczius T, Kim KS, Mellmann A, Schmidt MA, Karch H. Enterohemorrhagic Escherichia coli hemolysin employs outer membrane vesicles to target mitochondria and cause endothelial and epithelial apoptosis. PLoS Pathog. 2013;9(12):e1003797. doi: 10.1371/journal.ppat.1003797. Epub 2013 Dec 12. PubMed PMID: 24348251; PubMed Central PMCID: PMC3861543.

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Lubos M, Norkowski S, Stolle A, Langel Ü, Schmidt MA, Rüter C. Analysis of T3SS-independent Autonomous Internalization of the Bacterial Effector Protein SspH1 from Salmonella typhimurium. Inflammation and Cell Signaling. 2014; 1(6). doi: 10.14800/ics.423.

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Rüter C, Silva MR, Grabowski B, Lubos ML, Scharnert J, Poceva M, von Tils D, Flieger A, Heesemann J, Bliska JB, Schmidt MA. Rabbit monoclonal antibodies directed at the T3SS effector protein YopM identify human pathogenic Yersinia isolates. Int J Med Microbiol. 2014 May;304(3-4):444-51. doi: 10.1016/j.ijmm.2014.02.003. Epub 2014 Feb 18. PubMed PMID: 24636859.

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Cichon C, Sabharwal H, Rüter C, Schmidt MA. MicroRNAs regulate tight junction proteins and modulate epithelial/endothelial barrier functions. Tissue Barriers. 2014;2(4):e944446. doi: 10.4161/21688362.2014.944446. eCollection 2014. PubMed PMID: 25610754; PubMed Central PMCID: PMC4292042.

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Höfling S, Scharnert J, Cromme C, Bertrand J, Pap T, Schmidt MA, Rüter C. Manipulation of pro-inflammatory cytokine production by the bacterial cell-penetrating effector protein YopM is independent of its interaction with host cell kinases RSK1 and PRK2. Virulence. 2014;5(7):761-71. doi: 10.4161/viru.29062. PubMed PMID: 25513777; PubMed Central PMCID: PMC4189882.

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Höfling S, Grabowski B, Norkowski S, Schmidt MA, Rüter C. Current activities of the Yersinia effector protein YopM. Int J Med Microbiol. 2015 May;305(3):424-32. doi: 10.1016/j.ijmm.2015.03.009. Epub 2015 Apr 1. Review. PubMed PMID: 25865799.

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Kunsmann L, Rüter C, Bauwens A, Greune L, Glüder M, Kemper B, Fruth A, Wai SN, He X, Lloubes R, Schmidt MA, Dobrindt U, Mellmann A, Karch H, Bielaszewska M. Virulence from vesicles: Novel mechanisms of host cell injury by Escherichia coli O104:H4 outbreak strain. Sci Rep. 2015 Aug 18;5:13252. doi: 10.1038/srep13252. PubMed PMID: 26283502; PubMed Central PMCID: PMC4539607.

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Kossow A, Zhang W, Bielaszewska M, Rhode S, Hansen K, Fruth A, Rüter C, Karch H, Mellmann A. Molecular Characterization of Human Atypical Sorbitol-Fermenting Enteropathogenic Escherichia coli O157 Reveals High Diversity. J Clin Microbiol. 2016 May;54(5):1357-63. doi: 10.1128/JCM.02897-15. Epub 2016 Mar 16. PubMed PMID: 26984976; PubMed Central PMCID: PMC4844722.

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Gao X, Pham TH, Feuerbacher LA, Chen K, Hays MP, Singh G, Rueter C, Hurtado-Guerrero R, Hardwidge PR. Citrobacter rodentium NleB Protein Inhibits Tumor Necrosis Factor (TNF) Receptor-associated Factor 3 (TRAF3) Ubiquitination to Reduce Host Type I Interferon Production. J Biol Chem. 2016 Aug 26;291(35):18232-8. doi: 10.1074/jbc.M116.738278. Epub 2016 Jul 7. PubMed PMID: 27387501; PubMed Central PMCID: PMC5000071.

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Rüter C, Schmidt MA. Cell-Penetrating Bacterial Effector Proteins: Better Tools than Targets. Trends Biotechnol. 2017 Feb;35(2):109-120. doi: 10.1016/j.tibtech.2016.08.002. Epub 2016 Sep 1. Review. PubMed PMID: 27592802.

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Starost LJ, Karassek S, Sano Y, Kanda T, Kim KS, Dobrindt U, Rüter C, Schmidt MA. Pertussis Toxin Exploits Host Cell Signaling Pathways Induced by Meningitis-Causing E. coli K1-RS218 and Enhances Adherence of Monocytic THP-1 Cells to Human Cerebral Endothelial Cells. Toxins (Basel). 2016 Oct 13;8(10). doi: 10.3390/toxins8100291. PubMed PMID: 27754355; PubMed Central PMCID: PMC5086651.

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Bielaszewska M, Rüter C, Bauwens A, Greune L, Jarosch KA, Steil D, Zhang W, He X, Lloubes R, Fruth A, Kim KS, Schmidt MA, Dobrindt U, Mellmann A, Karch H. Host cell interactions of outer membrane vesicle-associated virulence factors of enterohemorrhagic Escherichia coli O157: Intracellular delivery, trafficking and mechanisms of cell injury. PLoS Pathog. 2017 Feb;13(2):e1006159. doi: 10.1371/journal.ppat.1006159. eCollection 2017 Feb. PubMed PMID: 28158302; PubMed Central PMCID: PMC5310930.

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Grabowski B, Schmidt MA, Rüter C. Immunomodulatory Yersinia outer proteins (Yops)-useful tools for bacteria and humans alike. Virulence. 2017 Oct 3;8(7):1124-1147. doi: 10.1080/21505594.2017.1303588. Epub 2017 Mar 15. Review. PubMed PMID: 28296562; PubMed Central PMCID: PMC5711447.

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Gomarasca M, F C Martins T, Greune L, Hardwidge PR, Schmidt MA, Rüter C. Bacterium-Derived Cell-Penetrating Peptides Deliver Gentamicin To Kill Intracellular Pathogens. Antimicrob Agents Chemother. 2017 Apr;61(4). doi: 10.1128/AAC.02545-16. Print 2017 Apr. PubMed PMID: 28096156; PubMed Central PMCID: PMC5365713.

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Stolle AS, Norkowski S, Körner B, Schmitz J, Lüken L, Frankenberg M, Rüter C, Schmidt MA. T3SS-Independent Uptake of the Short-Trip Toxin-Related Recombinant NleC Effector of Enteropathogenic Escherichia coli Leads to NF-κB p65 Cleavage. Front Cell Infect Microbiol. 2017;7:119. doi: 10.3389/fcimb.2017.00119. eCollection 2017. PubMed PMID: 28451521; PubMed Central PMCID: PMC5390045.

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Wang G, Geisbrecht BV, Rueter C, Hardwidge PR. Enterotoxigenic Escherichia coli Flagellin Inhibits TNF-Induced NF-κB Activation in Intestinal Epithelial Cells. Pathogens. 2017 May 17;6(2). doi: 10.3390/pathogens6020018. PubMed PMID: 28513540; PubMed Central PMCID: PMC5488652.

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El Qaidi S, Chen K, Halim A, Siukstaite L, Rueter C, Hurtado-Guerrero R, Clausen H, Hardwidge PR. NleB/SseK effectors from Citrobacter rodentium, Escherichia coli, and Salmonella enterica display distinct differences in host substrate specificity. J Biol Chem. 2017 Jul 7;292(27):11423-11430. doi: 10.1074/jbc.M117.790675. Epub 2017 May 18. PubMed PMID: 28522607; PubMed Central PMCID: PMC5500807.

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Norkowski S, Körner B, Greune L, Stolle AS, Lubos ML, Hardwidge PR, Schmidt MA, Rüter C. Bacterial LPX motif-harboring virulence factors constitute a species-spanning family of cell-penetrating effectors. Cell Mol Life Sci. 2018 Jun;75(12):2273-2289. doi: 10.1007/s00018-017-2733-4. Epub 2017 Dec 28. PubMed PMID: 29285573; PubMed Central PMCID: PMC11105228.

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Baumann D, Salia H, Greune L, Norkowski S, Körner B, Uckeley ZM, Frankel G, Guenot M, Rüter C, Schmidt MA. Multitalented EspB of enteropathogenic Escherichia coli (EPEC) enters cells autonomously and induces programmed cell death in human monocytic THP-1 cells. Int J Med Microbiol. 2018 Apr;308(3):387-404. doi: 10.1016/j.ijmm.2018.03.005. Epub 2018 Mar 12. PubMed PMID: 29550166.

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Rüter C, Lubos ML, Norkowski S, Schmidt MA. All in-Multiple parallel strategies for intracellular delivery by bacterial pathogens. Int J Med Microbiol. 2018 Oct;308(7):872-881. doi: 10.1016/j.ijmm.2018.06.007. Epub 2018 Jun 19. Review. PubMed PMID: 29936031.

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Norkowski S, Schmidt MA, Rüter C. The species-spanning family of LPX-motif harbouring effector proteins. Cell Microbiol. 2018 Nov;20(11):e12945. doi: 10.1111/cmi.12945. Epub 2018 Sep 17. Review. PubMed PMID: 30137651.

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Kuehnast T, Cakar F, Weinhäupl T, Pilz A, Selak S, Schmidt MA, Rüter C, Schild S. Comparative analyses of biofilm formation among different Cutibacterium acnes isolates. Int J Med Microbiol. 2018 Dec;308(8):1027-1035. doi: 10.1016/j.ijmm.2018.09.005. Epub 2018 Sep 22. PubMed PMID: 30268774.

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Rueter C, Bielaszewska M. Secretion and Delivery of Intestinal Pathogenic Escherichia coli Virulence Factors via Outer Membrane Vesicles. Front Cell Infect Microbiol. 2020;10:91. doi: 10.3389/fcimb.2020.00091. eCollection 2020. Review. PubMed PMID: 32211344; PubMed Central PMCID: PMC7068151.

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Chaoprasid P, Lukat P, Mühlen S, Heidler T, Gazdag EM, Dong S, Bi W, Rüter C, Kirchenwitz M, Steffen A, Jänsch L, Stradal TEB, Dersch P, Blankenfeldt W. Crystal structure of bacterial cytotoxic necrotizing factor CNF(Y) reveals molecular building blocks for intoxication. EMBO J. 2021 Feb 15;40(4):e105202. doi: 10.15252/embj.2020105202. Epub 2021 Jan 7. PubMed PMID: 33410511; PubMed Central PMCID: PMC7883292.

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Faust A, Bäumer N, Schlütermann A, Becht M, Greune L, Geyer C, Rüter C, Margeta R, Wittmann L, Dersch P, Lenz G, Berdel WE, Bäumer S. Tumor-Cell-Specific Targeting of Ibrutinib: Introducing Electrostatic Antibody-Inhibitor Conjugates (AiCs). Angew Chem Int Ed Engl. 2022 Jan 3;61(1):e202109769. doi: 10.1002/anie.202109769. Epub 2021 Nov 25. PubMed PMID: 34725904; PubMed Central PMCID: PMC9299256.

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Bielaszewska M, Greune L, Bauwens A, Dersch P, Mellmann A, Rüter C. Virulence Factor Cargo and Host Cell Interactions of Shiga Toxin-Producing Escherichia coli Outer Membrane Vesicles. Methods Mol Biol. 2021;2291:177-205. doi: 10.1007/978-1-0716-1339-9_8. PubMed PMID: 33704754.

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Bäumer N, Tiemann J, Scheller A, Meyer T, Wittmann L, Suburu MEG, Greune L, Peipp M, Kellmann N, Gumnior A, Brand C, Hartmann W, Rossig C, Müller-Tidow C, Neri D, Strassert CA, Rüter C, Dersch P, Lenz G, Koeffler HP, Berdel WE, Bäumer S. Targeted siRNA nanocarrier: a platform technology for cancer treatment. Oncogene. 2022 Apr;41(15):2210-2224. doi: 10.1038/s41388-022-02241-w. Epub 2022 Feb 26. PubMed PMID: 35220407; PubMed Central PMCID: PMC8993695.

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Bäumer N, Scheller A, Wittmann L, Faust A, Apel M, Nimmagadda SC, Geyer C, Grunert K, Kellmann N, Peipp M, Kailayangiri S, Gutierrez Suburu ME, Strassert CA, Schenk M, Greune L, Rüter C, Dersch P, Hartmann W, Rossig C, Neri D, Müller-Tidow C, Schwöppe C, Schliemann C, Khandanpour C, Lenz G, Berdel WE, Bäumer S. Electrostatic anti-CD33-antibody-protamine nanocarriers as platform for a targeted treatment of acute myeloid leukemia. J Hematol Oncol. 2022 Dec 1;15(1):171. doi: 10.1186/s13045-022-01390-5. PubMed PMID: 36457063; PubMed Central PMCID: PMC9716776.

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Rüter C. Delivery of Antibiotics by Cell-Penetrating Peptides to Kill Intracellular Pathogens. Methods Mol Biol. 2022;2383:335-345. doi: 10.1007/978-1-0716-1752-6_22. PubMed PMID: 34766300.