My Bibliography

select

Seshadri C, Uiso LO, Ostermann J, Diefenthal H, Shao HJ, Chu HY, Asmuth DM, Thielman NM, Bartlett JA, Crump JA. Low sensitivity of T-cell based detection of tuberculosis among HIV co-infected Tanzanian in-patients. East Afr Med J. 2008 Sep;85(9):442-9. doi: 10.4314/eamj.v85i9.117085. PubMed PMID: 19537417; PubMed Central PMCID: PMC3168735.

select

Ter Horst B, Seshadri C, Sweet L, Young DC, Feringa BL, Moody DB, Minnaard AJ. Asymmetric synthesis and structure elucidation of a glycerophospholipid from Mycobacterium tuberculosis. J Lipid Res. 2010 May;51(5):1017-22. doi: 10.1194/jlr.M001982. Epub 2009 Nov 5. PubMed PMID: 19965610; PubMed Central PMCID: PMC2853428.

select

ter Horst B, Seshadri C, Sweet L, Young D, Feringa B, Moody D, Minnaard A. Asymmetric synthesis and structure elucidation of a glycerophospholipid from Mycobacterium tuberculosis. Journal of Lipid Research. 2010 May; 51(5):1017-1022. doi: 10.1194/jlr.M001982.

select

Drage MG, Tsai HC, Pecora ND, Cheng TY, Arida AR, Shukla S, Rojas RE, Seshadri C, Moody DB, Boom WH, Sacchettini JC, Harding CV. Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2. Nat Struct Mol Biol. 2010 Sep;17(9):1088-95. doi: 10.1038/nsmb.1869. Epub 2010 Aug 8. PubMed PMID: 20694006; PubMed Central PMCID: PMC2933325.

select

Kasmar AG, van Rhijn I, Cheng TY, Turner M, Seshadri C, Schiefner A, Kalathur RC, Annand JW, de Jong A, Shires J, Leon L, Brenner M, Wilson IA, Altman JD, Moody DB. CD1b tetramers bind αβ T cell receptors to identify a mycobacterial glycolipid-reactive T cell repertoire in humans. J Exp Med. 2011 Aug 29;208(9):1741-7. doi: 10.1084/jem.20110665. Epub 2011 Aug 1. PubMed PMID: 21807869; PubMed Central PMCID: PMC3171094.

select

Kasmar A, van Rhijn I, Cheng T, Turner M, Seshadri C, Schiefner A, Kalathur R, Annand J, de Jong A, Shires J, Leon L, Brenner M, Wilson I, Altman J, Moody D. CD1b tetramers bind αβ T cell receptors to identify a mycobacterial glycolipid-reactive T cell repertoire in humans. Journal of Experimental Medicine. 2011 August; 208(9):1741-1747. doi: 10.1084/jem.20110665.

select

Seshadri C, Turner MT, Lewinsohn DM, Moody DB, Van Rhijn I. Lipoproteins are major targets of the polyclonal human T cell response to Mycobacterium tuberculosis. J Immunol. 2013 Jan 1;190(1):278-84. doi: 10.4049/jimmunol.1201667. Epub 2012 Nov 28. PubMed PMID: 23197260; PubMed Central PMCID: PMC3529834.

select

Seshadri C, Turner M, Lewinsohn D, Moody D, Van Rhijn I. Lipoproteins Are Major Targets of the Polyclonal Human T Cell Response to <i>Mycobacterium tuberculosis</i>. The Journal of Immunology. 2013 January; 190(1):278-284. doi: 10.4049/jimmunol.1201667.

select

Seshadri C, Shenoy M, Wells RD, Hensley-McBain T, Andersen-Nissen E, McElrath MJ, Cheng TY, Moody DB, Hawn TR. Human CD1a deficiency is common and genetically regulated. J Immunol. 2013 Aug 15;191(4):1586-93. doi: 10.4049/jimmunol.1300575. Epub 2013 Jul 15. PubMed PMID: 23858036; PubMed Central PMCID: PMC3748949.

select

Seshadri C, Shenoy M, Wells R, Hensley-McBain T, Andersen-Nissen E, McElrath M, Cheng T, Moody D, Hawn T. Human CD1a Deficiency Is Common and Genetically Regulated. The Journal of Immunology. 2013 August; 191(4):1586-1593. doi: 10.4049/jimmunol.1300575.

select

Seshadri C, Thuong NT, Yen NT, Bang ND, Chau TT, Thwaites GE, Dunstan SJ, Hawn TR. A polymorphism in human CD1A is associated with susceptibility to tuberculosis. Genes Immun. 2014 Apr-May;15(3):195-8. doi: 10.1038/gene.2014.5. Epub 2014 Feb 6. PubMed PMID: 24500401; PubMed Central PMCID: PMC3998877.

select

Seshadri C, Thuong N, Yen N, Bang N, Chau T, Thwaites G, Dunstan S, Hawn T. A polymorphism in human CD1A is associated with susceptibility to tuberculosis. Genes & Immunity. 2014 February; 15(3):195-198. doi: 10.1038/gene.2014.5.

select

Young D, Layre E, Pan S, Tapley A, Adamson J, Seshadri C, Wu Z, Buter J, Minnaard A, Coscolla M, Gagneux S, Copin R, Ernst J, Bishai W, Snider B, Moody D. In Vivo Biosynthesis of Terpene Nucleosides Provides Unique Chemical Markers of Mycobacterium tuberculosis Infection. Chemistry & Biology. 2015 April; 22(4):516-526. doi: 10.1016/j.chembiol.2015.03.015.

select

Lin L, Frelinger J, Jiang W, Finak G, Seshadri C, Bart PA, Pantaleo G, McElrath J, DeRosa S, Gottardo R. Identification and visualization of multidimensional antigen-specific T-cell populations in polychromatic cytometry data. Cytometry A. 2015 Jul;87(7):675-82. doi: 10.1002/cyto.a.22623. Epub 2015 Apr 23. PubMed PMID: 25908275; PubMed Central PMCID: PMC4482785.

select

Young DC, Layre E, Pan SJ, Tapley A, Adamson J, Seshadri C, Wu Z, Buter J, Minnaard AJ, Coscolla M, Gagneux S, Copin R, Ernst JD, Bishai WR, Snider BB, Moody DB. In vivo biosynthesis of terpene nucleosides provides unique chemical markers of Mycobacterium tuberculosis infection. Chem Biol. 2015 Apr 23;22(4):516-526. doi: 10.1016/j.chembiol.2015.03.015. PubMed PMID: 25910243; PubMed Central PMCID: PMC4432472.

select

Lin L, Finak G, Ushey K, Seshadri C, Hawn TR, Frahm N, Scriba TJ, Mahomed H, Hanekom W, Bart PA, Pantaleo G, Tomaras GD, Rerks-Ngarm S, Kaewkungwal J, Nitayaphan S, Pitisuttithum P, Michael NL, Kim JH, Robb ML, O'Connell RJ, Karasavvas N, Gilbert P, C De Rosa S, McElrath MJ, Gottardo R. COMPASS identifies T-cell subsets correlated with clinical outcomes. Nat Biotechnol. 2015 Jun;33(6):610-6. doi: 10.1038/nbt.3187. Epub 2015 May 25. PubMed PMID: 26006008; PubMed Central PMCID: PMC4569006.

select

Lin L, Finak G, Ushey K, Seshadri C, Hawn T, Frahm N, Scriba T, Mahomed H, Hanekom W, Bart P, Pantaleo G, Tomaras G, Rerks-Ngarm S, Kaewkungwal J, Nitayaphan S, Pitisuttithum P, Michael N, Kim J, Robb M, O'Connell R, Karasavvas N, Gilbert P, C De Rosa S, McElrath M, Gottardo R. COMPASS identifies T-cell subsets correlated with clinical outcomes. Nature Biotechnology. 2015-5-; 33(6):610-616. doi: 10.1038/nbt.3187.

select

Seshadri C, Lin L, Scriba TJ, Peterson G, Freidrich D, Frahm N, DeRosa SC, Moody DB, Prandi J, Gilleron M, Mahomed H, Jiang W, Finak G, Hanekom WA, Gottardo R, McElrath MJ, Hawn TR. T Cell Responses against Mycobacterial Lipids and Proteins Are Poorly Correlated in South African Adolescents. J Immunol. 2015 Nov 15;195(10):4595-603. doi: 10.4049/jimmunol.1501285. Epub 2015 Oct 14. PubMed PMID: 26466957; PubMed Central PMCID: PMC4637215.

select

Seshadri C, Lin L, Scriba T, Peterson G, Freidrich D, Frahm N, DeRosa S, Moody D, Prandi J, Gilleron M, Mahomed H, Jiang W, Finak G, Hanekom W, Gottardo R, McElrath M, Hawn T. T Cell Responses against Mycobacterial Lipids and Proteins Are Poorly Correlated in South African Adolescents. The Journal of Immunology. 2015 November; 195(10):4595-4603. doi: 10.4049/jimmunol.1501285.

select

Seshadri C, Thuong NT, Mai NT, Bang ND, Chau TT, Lewinsohn DM, Thwaites GE, Dunstan SJ, Hawn TR. A polymorphism in human MR1 is associated with mRNA expression and susceptibility to tuberculosis. Genes Immun. 2017 Jan;18(1):8-14. doi: 10.1038/gene.2016.41. Epub 2016 Nov 24. PubMed PMID: 27881839; PubMed Central PMCID: PMC5269436.

select

Seshadri C, Thuong N, Mai N, Bang N, Chau T, Lewinsohn D, Thwaites G, Dunstan S, Hawn T. A polymorphism in human MR1 is associated with mRNA expression and susceptibility to tuberculosis. Genes & Immunity. 2016 November; 18(1):8-14. doi: 10.1038/gene.2016.41.

select

Deep sequencing of T-cells specific for a mycobacterial glycolipid reveals shared T-cell receptor motifs with diagnostic potential in population-based studies. EUROPEAN JOURNAL OF IMMUNOLOGY. 2016.

select

DeWitt W, Quan K, Wilburn D, Sherwood A, Vignali M, De Rosa S, Day C, Scriba T, Robins H, Swanson W, Emerson R, Seshadri C. Unbiased definition of a shared T-cell receptor motif enables population-based studies of tuberculosis. [Preprint]. 2017 April. doi: 10.1101/123174.

select

Seshadri C, Sedaghat N, Campo M, Peterson G, Wells RD, Olson GS, Sherman DR, Stein CM, Mayanja-Kizza H, Shojaie A, Boom WH, Hawn TR, Tuberculosis Research Unit (TBRU). Transcriptional networks are associated with resistance to Mycobacterium tuberculosis infection. PLoS One. 2017;12(4):e0175844. doi: 10.1371/journal.pone.0175844. eCollection 2017. PubMed PMID: 28414762; PubMed Central PMCID: PMC5393882.

select

Seshadri C, Sedaghat N, Campo M, Peterson G, Wells R, Olson G, Sherman D, Stein C, Mayanja-Kizza H, Shojaie A, Boom W, Hawn T. Transcriptional networks are associated with resistance to Mycobacterium tuberculosis infection. PLOS ONE. 2017-4-; 12(4):e0175844-. doi: 10.1371/journal.pone.0175844.

select

James CA, Yu KKQ, Gilleron M, Prandi J, Yedulla VR, Moleda ZZ, Diamanti E, Khan M, Aggarwal VK, Reijneveld JF, Reinink P, Lenz S, Emerson RO, Scriba TJ, Souter MNT, Godfrey DI, Pellicci DG, Moody DB, Minnaard AJ, Seshadri C, Van Rhijn I. CD1b Tetramers Identify T Cells that Recognize Natural and Synthetic Diacylated Sulfoglycolipids from Mycobacterium tuberculosis. Cell Chem Biol. 2018 Apr 19;25(4):392-402.e14. doi: 10.1016/j.chembiol.2018.01.006. Epub 2018 Feb 1. PubMed PMID: 29398561; PubMed Central PMCID: PMC5910231.

select

James C, Yu K, Gilleron M, Prandi J, Yedulla V, Moleda Z, Diamanti E, Khan M, Aggarwal V, Reijneveld J, Reinink P, Lenz S, Emerson R, Scriba T, Souter M, Godfrey D, Pellicci D, Moody D, Minnaard A, Seshadri C, Van Rhijn I. CD1b Tetramers Identify T Cells that Recognize Natural and Synthetic Diacylated Sulfoglycolipids from Mycobacterium tuberculosis. Cell Chemical Biology. 2018 April; 25(4):392-402.e14. doi: 10.1016/j.chembiol.2018.01.006.

select

Layton ED, Yu KKQ, Smith MT, Scriba TJ, De Rosa SC, Seshadri C. Validation of a CD1b tetramer assay for studies of human mycobacterial infection or vaccination. J Immunol Methods. 2018 Jul;458:44-52. doi: 10.1016/j.jim.2018.04.004. Epub 2018 Apr 21. PubMed PMID: 29684428; PubMed Central PMCID: PMC5960426.

select

Simmons J, Stein C, Seshadri C, Campo M, Alter G, Fortune S, Schurr E, Wallis R, Churchyard G, Mayanja-Kizza H, Boom W, Hawn T. Immunological mechanisms of human resistance to persistent Mycobacterium tuberculosis infection. Nature Reviews Immunology. 2018 June; 18(9):575-589. doi: 10.1038/s41577-018-0025-3.

select

DeWitt WS, Yu KKQ, Wilburn DB, Sherwood A, Vignali M, Day CL, Scriba TJ, Robins HS, Swanson WJ, Emerson RO, Bradley PH, Seshadri C. A Diverse Lipid Antigen-Specific TCR Repertoire Is Clonally Expanded during Active Tuberculosis. J Immunol. 2018 Aug 1;201(3):888-896. doi: 10.4049/jimmunol.1800186. Epub 2018 Jun 18. PubMed PMID: 29914888; PubMed Central PMCID: PMC6057832.

select

Layton E, Yu K, Smith M, Scriba T, De Rosa S, Seshadri C. Validation of a CD1b tetramer assay for studies of human mycobacterial infection or vaccination. Journal of Immunological Methods. 2018 July; 458:44-52. doi: 10.1016/j.jim.2018.04.004.

select

DeWitt W, Yu K, Wilburn D, Sherwood A, Vignali M, Day C, Scriba T, Robins H, Swanson W, Emerson R, Bradley P, Seshadri C. A Diverse Lipid Antigen–Specific TCR Repertoire Is Clonally Expanded during Active Tuberculosis. The Journal of Immunology. 2018 August; 201(3):888-896. doi: 10.4049/jimmunol.1800186.

select

Simmons JD, Stein CM, Seshadri C, Campo M, Alter G, Fortune S, Schurr E, Wallis RS, Churchyard G, Mayanja-Kizza H, Boom WH, Hawn TR. Immunological mechanisms of human resistance to persistent Mycobacterium tuberculosis infection. Nat Rev Immunol. 2018 Sep;18(9):575-589. doi: 10.1038/s41577-018-0025-3. Review. PubMed PMID: 29895826; PubMed Central PMCID: PMC6278832.

select

Graustein AD, Misch EA, Musvosvi M, Shey M, Shah JA, Seshadri C, Ajuogu A, Bowman K, Mulenga H, Veldsman A, Hanekom WA, Hatherill M, Scriba TJ, Hawn TR. Toll-like receptor chaperone HSP90B1 and the immune response to Mycobacteria. PLoS One. 2018;13(12):e0208940. doi: 10.1371/journal.pone.0208940. eCollection 2018. PubMed PMID: 30550567; PubMed Central PMCID: PMC6294361.

select

Joosten SA, Ottenhoff THM, Lewinsohn DM, Hoft DF, Moody DB, Seshadri C, Collaboration for Tuberculosis Vaccine Discovery - Donor-Unrestricted T-cells Working Group, Bill and Melinda Gates Foundation. Harnessing donor unrestricted T-cells for new vaccines against tuberculosis. Vaccine. 2019 May 21;37(23):3022-3030. doi: 10.1016/j.vaccine.2019.04.050. Epub 2019 Apr 27. Review. PubMed PMID: 31040086; PubMed Central PMCID: PMC6525272.

select

Lu LL, Smith MT, Yu KKQ, Luedemann C, Suscovich TJ, Grace PS, Cain A, Yu WH, McKitrick TR, Lauffenburger D, Cummings RD, Mayanja-Kizza H, Hawn TR, Boom WH, Stein CM, Fortune SM, Seshadri C, Alter G. IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure. Nat Med. 2019 Jun;25(6):977-987. doi: 10.1038/s41591-019-0441-3. Epub 2019 May 20. PubMed PMID: 31110348; PubMed Central PMCID: PMC6559862.

select

Yu KKQ, Wilburn DB, Hackney JA, Darrah PA, Foulds KE, James CA, Smith MT, Jing L, Seder RA, Roederer M, Koelle DM, Swanson WJ, Seshadri C. Conservation of molecular and cellular phenotypes of invariant NKT cells between humans and non-human primates. Immunogenetics. 2019 Jul;71(7):465-478. doi: 10.1007/s00251-019-01118-9. Epub 2019 May 23. PubMed PMID: 31123763; PubMed Central PMCID: PMC6647187.

select

Yu K, Wilburn D, Hackney J, Darrah P, Foulds K, James C, Smith M, Jing L, Seder R, Roederer M, Koelle D, Swanson W, Seshadri C. Conservation of molecular and cellular phenotypes of invariant NKT cells between humans and non-human primates. Immunogenetics. 2019-5-; 71(7):465-478. doi: 10.1007/s00251-019-01118-9.

select

Lu LL, Smith MT, Yu KKQ, Luedemann C, Suscovich TJ, Grace PS, Cain A, Yu WH, McKitrick TR, Lauffenburger D, Cummings RD, Mayanja-Kizza H, Hawn TR, Boom WH, Stein CM, Fortune SM, Seshadri C, Alter G. Publisher Correction: IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure. Nat Med. 2019 Jul;25(7):1175. doi: 10.1038/s41591-019-0519-y. PubMed PMID: 31222179; PubMed Central PMCID: PMC7609258.

select

Lalvani A, Seshadri C. Understanding How BCG Vaccine Protects Against Mycobacterium tuberculosis Infection: Lessons From Household Contact Studies. The Journal of Infectious Diseases. 2019 July; :-. doi: 10.1093/infdis/jiz261.

select

Dropulic LK, Oestreich MC, Pietz HL, Laing KJ, Hunsberger S, Lumbard K, Garabedian D, Turk SP, Chen A, Hornung RL, Seshadri C, Smith MT, Hosken NA, Phogat S, Chang LJ, Koelle DM, Wang K, Cohen JI. A Randomized, Double-Blinded, Placebo-Controlled, Phase 1 Study of a Replication-Defective Herpes Simplex Virus (HSV) Type 2 Vaccine, HSV529, in Adults With or Without HSV Infection. J Infect Dis. 2019 Aug 9;220(6):990-1000. doi: 10.1093/infdis/jiz225. PubMed PMID: 31058977; PubMed Central PMCID: PMC6688060.

select

James CA, Seshadri C. T Cell Responses to Mycobacterial Glycolipids: On the Spectrum of "Innateness". Front Immunol. 2020;11:170. doi: 10.3389/fimmu.2020.00170. eCollection 2020. Review. PubMed PMID: 32117300; PubMed Central PMCID: PMC7026021.

select

Lalvani A, Seshadri C. Understanding How BCG Vaccine Protects Against Mycobacterium tuberculosis Infection: Lessons From Household Contact Studies. J Infect Dis. 2020 Mar 28;221(8):1229-1231. doi: 10.1093/infdis/jiz261. PubMed PMID: 31298279.

select

Berry S, Gower M, Su X, Seshadri C, Theberge A. A modular microscale granuloma model for immune-microenvironment signaling studies <i>in vitro</i>. [Preprint]. 2020 April. doi: 10.1101/2020.04.14.040048.

select

Berry SB, Gower MS, Su X, Seshadri C, Theberge AB. A Modular Microscale Granuloma Model for Immune-Microenvironment Signaling Studies in vitro. Front Bioeng Biotechnol. 2020;8:931. doi: 10.3389/fbioe.2020.00931. eCollection 2020. PubMed PMID: 32974300; PubMed Central PMCID: PMC7461927.

select

Berry S, Gower M, Su X, Seshadri C, Theberge A. A Modular Microscale Granuloma Model for Immune-Microenvironment Signaling Studies in vitro. Frontiers in Bioengineering and Biotechnology. 2020-8-; 8:-. doi: 10.3389/fbioe.2020.00931.

select

Yu KKQ, Fischinger S, Smith MT, Atyeo C, Cizmeci D, Wolf CR, Layton ED, Logue JK, Aguilar MS, Shuey K, Loos C, Yu J, Franko N, Choi RY, Wald A, Barouch DH, Koelle DM, Lauffenburger D, Chu HY, Alter G, Seshadri C. T cell and antibody functional correlates of severe COVID-19. medRxiv. 2020 Nov 30;. doi: 10.1101/2020.11.25.20235150. PubMed PMID: 33269369; PubMed Central PMCID: PMC7709190.

select

Layton ED, Barman S, Wilburn DB, Yu KKQ, Smith MT, Altman JD, Scriba TJ, Tahiri N, Minnaard AJ, Roederer M, Seder RA, Darrah PA, Seshadri C. T Cells Specific for a Mycobacterial Glycolipid Expand after Intravenous Bacillus Calmette-Guérin Vaccination. J Immunol. 2021 Mar 15;206(6):1240-1250. doi: 10.4049/jimmunol.2001065. Epub 2021 Feb 3. PubMed PMID: 33536255; PubMed Central PMCID: PMC7939042.

select

Layton E, Barman S, Wilburn D, Yu K, Smith M, Altman J, Scriba T, Tahiri N, Minnaard A, Roederer M, Seder R, Darrah P, Seshadri C. T Cells Specific for a Mycobacterial Glycolipid Expand after Intravenous Bacillus Calmette–Guérin Vaccination. The Journal of Immunology. 2021 March; 206(6):1240-1250. doi: 10.4049/jimmunol.2001065.

select

Yu KK, Fischinger S, Smith MT, Atyeo C, Cizmeci D, Wolf CR, Layton ED, Logue JK, Aguilar MS, Shuey K, Loos C, Yu J, Franko N, Choi RY, Wald A, Barouch DH, Koelle DM, Lauffenburger D, Chu HY, Alter G, Seshadri C. Comorbid illnesses are associated with altered adaptive immune responses to SARS-CoV-2. JCI Insight. 2021 Mar 22;6(6). doi: 10.1172/jci.insight.146242. PubMed PMID: 33621211; PubMed Central PMCID: PMC8026190.