My Bibliography

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Agyemang-Dua C, Chung CS, Espinosa-Diez C. Heartbreakers and healers: RNA rebels in cardio-oncology. Semin Cancer Biol. 2026 Feb;119:1-11. doi: 10.1016/j.semcancer.2025.12.008. Epub 2025 Dec 23. Review. PubMed PMID: 41448375; PubMed Central PMCID: PMC12861466.

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Qiu Q, Komnenov D, Hali M, Chung CS, Mueller PJ, Rossi NF, Kuhn DM, Mateika JH. Systolic and diastolic dysfunction is exacerbated by age and spinal cord injury in male and female mice with central nervous system serotonin deficiency. J Physiol. 2025 Mar;603(6):1375-1397. doi: 10.1113/JP287067. Epub 2025 Feb 19. PubMed PMID: 39968856; PubMed Central PMCID: PMC11908478.

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Babakr AA, Angoa-Perez M, Chung CS. Is HFpEF a chicken or an egg? Utility of models for a clinical syndrome. Am J Physiol Heart Circ Physiol. 2025 Jan 1;328(1):H159-H160. doi: 10.1152/ajpheart.00812.2024. Epub 2024 Dec 10. PubMed PMID: 39656508; PubMed Central PMCID: PMC12168293.

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Tanner BCW, Palmer BM, Chung CS. Strain rate of stretch affects crossbridge detachment during relaxation of intact cardiac trabeculae. PLoS One. 2024;19(3):e0297212. doi: 10.1371/journal.pone.0297212. eCollection 2024. PubMed PMID: 38437198; PubMed Central PMCID: PMC10911597.

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Pittman LA, Whittaker P, Milne ML, Chung CS. Collagenase treatment reduces the anisotropy of ultrasonic backscatter in rat myocardium by reducing collagen crosslinks. Physiol Rep. 2023 Nov;11(21):e15849. doi: 10.14814/phy2.15849. PubMed PMID: 37960992; PubMed Central PMCID: PMC10643982.

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Bukowski MJ, Cavanaugh B, Abbo A, Chung CS. Mechanical Control of Relaxation using Intact Cardiac Trabeculae. J Vis Exp. 2023 Feb 17;(192). doi: 10.3791/64879. PubMed PMID: 36876939; PubMed Central PMCID: PMC10690804.

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Chung CS. Pressing physiology to move our understanding of cytosolic calcium dynamics. J Appl Physiol (1985). 2022 Sep 1;133(3):661-662. doi: 10.1152/japplphysiol.00453.2022. Epub 2022 Aug 18. PubMed PMID: 35981731; PubMed Central PMCID: PMC9448333.

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Levanovich PE, Chung CS, Komnenov D, Rossi NF. Fructose plus High-Salt Diet in Early Life Results in Salt-Sensitive Cardiovascular Changes in Mature Male Sprague Dawley Rats. Nutrients. 2021 Sep 8;13(9). doi: 10.3390/nu13093129. PubMed PMID: 34579006; PubMed Central PMCID: PMC8465679.

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Schick BM, Dlugas H, Czeiszperger TL, Matus AR, Bukowski MJ, Chung CS. Reduced preload increases Mechanical Control (strain-rate dependence) of Relaxation by modifying myosin kinetics. Arch Biochem Biophys. 2021 Aug 15;707:108909. doi: 10.1016/j.abb.2021.108909. Epub 2021 May 18. PubMed PMID: 34015323; PubMed Central PMCID: PMC8635462.

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Komnenov D, Levanovich PE, Perecki N, Chung CS, Rossi NF. Aortic Stiffness and Diastolic Dysfunction in Sprague Dawley Rats Consuming Short-Term Fructose Plus High Salt Diet. Integr Blood Press Control. 2020;13:111-124. doi: 10.2147/IBPC.S257205. eCollection 2020. PubMed PMID: 33061560; PubMed Central PMCID: PMC7532309.

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van der Pijl RJ, Hudson B, Granzier-Nakajima T, Li F, Knottnerus AM, Smith J, Chung CS, Gotthardt M, Granzier HL, Ottenheijm CAC. Deleting Titin's C-Terminal PEVK Exons Increases Passive Stiffness, Alters Splicing, and Induces Cross-Sectional and Longitudinal Hypertrophy in Skeletal Muscle. Front Physiol. 2020;11:494. doi: 10.3389/fphys.2020.00494. eCollection 2020. PubMed PMID: 32547410; PubMed Central PMCID: PMC7274174.

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Mannozzi J, Kaur J, Spranger MD, Al-Hassan MH, Lessanework B, Alvarez A, Chung CS, O'Leary DS. Muscle metaboreflex-induced increases in effective arterial elastance: effect of heart failure. Am J Physiol Regul Integr Comp Physiol. 2020 Jul 1;319(1):R1-R10. doi: 10.1152/ajpregu.00040.2020. Epub 2020 Apr 29. PubMed PMID: 32348680; PubMed Central PMCID: PMC7468796.

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Ai L, Perez E, Asimes A, Kampaengsri T, Heroux M, Zlobin A, Hiske MA, Chung CS, Pak TR, Kirk JA. Binge Alcohol Exposure in Adolescence Impairs Normal Heart Growth. J Am Heart Assoc. 2020 May 5;9(9):e015611. doi: 10.1161/JAHA.119.015611. Epub 2020 Apr 22. PubMed PMID: 32319345; PubMed Central PMCID: PMC7428579.

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Chung CS. Move quickly to detach: Strain rate-dependent myosin detachment and cardiac relaxation. J Gen Physiol. 2020 Apr 6;152(4). doi: 10.1085/jgp.202012588. PubMed PMID: 32197272; PubMed Central PMCID: PMC7141589.

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Chung CS, Hiske MA, Chadha A, Mueller PJ. Compliant Titin Isoform Content Is Reduced in Left Ventricles of Sedentary Versus Active Rats. Front Physiol. 2020;11:15. doi: 10.3389/fphys.2020.00015. eCollection 2020. PubMed PMID: 32116740; PubMed Central PMCID: PMC7025574.

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Czeiszperger TL, Wang MP, Chung CS. Membrane stabilizer Poloxamer 188 improves yield of primary isolated rat cardiomyocytes without impairing function. Physiol Rep. 2020 Feb;8(4):e14382. doi: 10.14814/phy2.14382. PubMed PMID: 32109347; PubMed Central PMCID: PMC7048379.

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Zhang X, Liu ZQ, Singh D, Powell DK, Chung CS, Campbell KS, Wenk JF. Differential Effects of Isoproterenol on Regional Myocardial Mechanics in Rat Using Three-Dimensional Cine DENSE Cardiovascular Magnetic Resonance. J Biomech Eng. 2019 Jun 1;141(6):0609041-9. doi: 10.1115/1.4041042. PubMed PMID: 30098173; PubMed Central PMCID: PMC7580659.

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Milne ML, Schick BM, Alkhazal T, Chung CS. Myocardial Fiber Mapping of Rat Hearts, Using Apparent Backscatter, with Histologic Validation. Ultrasound Med Biol. 2019 Aug;45(8):2075-2085. doi: 10.1016/j.ultrasmedbio.2019.05.002. Epub 2019 May 30. PubMed PMID: 31155403; PubMed Central PMCID: PMC6615029.

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Chung CS. How myofilament strain and strain rate lead the dance of the cardiac cycle. Arch Biochem Biophys. 2019 Mar 30;664:62-67. doi: 10.1016/j.abb.2019.01.034. Epub 2019 Jan 30. Review. PubMed PMID: 30710504; PubMed Central PMCID: PMC6589344.

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Munkanatta Godage DNP, VanHecke GC, Samarasinghe KTG, Feng HZ, Hiske M, Holcomb J, Yang Z, Jin JP, Chung CS, Ahn YH. SMYD2 glutathionylation contributes to degradation of sarcomeric proteins. Nat Commun. 2018 Oct 18;9(1):4341. doi: 10.1038/s41467-018-06786-x. PubMed PMID: 30337525; PubMed Central PMCID: PMC6194001.

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Lalande S, Mueller PJ, Chung CS. The link between exercise and titin passive stiffness. Exp Physiol. 2017 Sep 1;102(9):1055-1066. doi: 10.1113/EP086275. Epub 2017 Jul 31. Review. PubMed PMID: 28762234; PubMed Central PMCID: PMC5578882.

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Chung CS, Hoopes CW, Campbell KS. Myocardial relaxation is accelerated by fast stretch, not reduced afterload. J Mol Cell Cardiol. 2017 Feb;103:65-73. doi: 10.1016/j.yjmcc.2017.01.004. Epub 2017 Jan 11. PubMed PMID: 28087265; PubMed Central PMCID: PMC5347980.

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Blair CA, Haynes P, Campbell SG, Chung C, Mitov MI, Dennis D, Bonnell MR, Hoopes CW, Guglin M, Campbell KS. A Protocol for Collecting Human Cardiac Tissue for Research. VAD J. 2016;2(1). doi: 10.13023/VAD.2016.12. Epub 2016 Jun 3. PubMed PMID: 28042604; PubMed Central PMCID: PMC5199025.

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Chung CS, Afonso L. Heart Rate Is an Important Consideration for Cardiac Imaging of Diastolic Function. JACC Cardiovasc Imaging. 2016 Jun;9(6):756-8. doi: 10.1016/j.jcmg.2015.10.021. Epub 2016 Feb 17. PubMed PMID: 26897673.

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Chung CS, Shmuylovich L, Kovács SJ. What global diastolic function is, what it is not, and how to measure it. Am J Physiol Heart Circ Physiol. 2015 Nov;309(9):H1392-406. doi: 10.1152/ajpheart.00436.2015. Epub 2015 Aug 28. Review. PubMed PMID: 26320035.

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Chung CS, Shmuylovich L, Kovács SJ. Early detection of abnormal left ventricular relaxation in acute myocardial ischemia with a quadratic model. Med Eng Phys 2014;36(September (9)):1101-5 by Morimont et al. Med Eng Phys. 2015 Aug;37(8):826. doi: 10.1016/j.medengphy.2015.05.002. Epub 2015 Jun 3. PubMed PMID: 26050201.

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Chung CS, Mechas C, Campbell KS. Myocyte contractility can be maintained by storing cells with the myosin ATPase inhibitor 2,3 butanedione monoxime. Physiol Rep. 2015 Jun;3(6). doi: 10.14814/phy2.12445. PubMed PMID: 26116551; PubMed Central PMCID: PMC4522161.

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Hutchinson KR, Saripalli C, Chung CS, Granzier H. Increased myocardial stiffness due to cardiac titin isoform switching in a mouse model of volume overload limits eccentric remodeling. J Mol Cell Cardiol. 2015 Feb;79:104-14. doi: 10.1016/j.yjmcc.2014.10.020. Epub 2014 Nov 8. PubMed PMID: 25450617; PubMed Central PMCID: PMC4302034.

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Haynes P, Nava KE, Lawson BA, Chung CS, Mitov MI, Campbell SG, Stromberg AJ, Sadayappan S, Bonnell MR, Hoopes CW, Campbell KS. Transmural heterogeneity of cellular level power output is reduced in human heart failure. J Mol Cell Cardiol. 2014 Jul;72:1-8. doi: 10.1016/j.yjmcc.2014.02.008. Epub 2014 Feb 20. PubMed PMID: 24560668; PubMed Central PMCID: PMC4037376.

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Buck D, Smith JE 3rd, Chung CS, Ono Y, Sorimachi H, Labeit S, Granzier HL. Removal of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy. J Gen Physiol. 2014 Feb;143(2):215-30. doi: 10.1085/jgp.201311129. PubMed PMID: 24470489; PubMed Central PMCID: PMC4001778.

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Chung CS, Campbell KS. Temperature and transmural region influence functional measurements in unloaded left ventricular cardiomyocytes. Physiol Rep. 2013 Nov;1(6):e00158. doi: 10.1002/phy2.158. Epub 2013 Nov 14. PubMed PMID: 24400159; PubMed Central PMCID: PMC3871472.

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Chung CS, Mitov MI, Callahan LA, Campbell KS. Increased myocardial short-range forces in a rodent model of diabetes reflect elevated content of β myosin heavy chain. Arch Biochem Biophys. 2014 Jun 15;552-553:92-9. doi: 10.1016/j.abb.2013.08.013. Epub 2013 Sep 4. PubMed PMID: 24012810; PubMed Central PMCID: PMC3942377.

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Chung CS, Hutchinson KR, Methawasin M, Saripalli C, Smith JE 3rd, Hidalgo CG, Luo X, Labeit S, Guo C, Granzier HL. Shortening of the elastic tandem immunoglobulin segment of titin leads to diastolic dysfunction. Circulation. 2013 Jul 2;128(1):19-28. doi: 10.1161/CIRCULATIONAHA.112.001268. Epub 2013 May 24. PubMed PMID: 23709671; PubMed Central PMCID: PMC3822017.

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Hidalgo CG, Chung CS, Saripalli C, Methawasin M, Hutchinson KR, Tsaprailis G, Labeit S, Mattiazzi A, Granzier HL. The multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin's spring elements. J Mol Cell Cardiol. 2013 Jan;54:90-7. doi: 10.1016/j.yjmcc.2012.11.012. Epub 2012 Dec 5. PubMed PMID: 23220127; PubMed Central PMCID: PMC3535572.

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Sheikh F, Ouyang K, Campbell SG, Lyon RC, Chuang J, Fitzsimons D, Tangney J, Hidalgo CG, Chung CS, Cheng H, Dalton ND, Gu Y, Kasahara H, Ghassemian M, Omens JH, Peterson KL, Granzier HL, Moss RL, McCulloch AD, Chen J. Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease. J Clin Invest. 2012 Apr;122(4):1209-21. doi: 10.1172/JCI61134. Epub 2012 Mar 19. PubMed PMID: 22426213; PubMed Central PMCID: PMC3314469.

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Chung CS, Bogomolovas J, Gasch A, Hidalgo CG, Labeit S, Granzier HL. Titin-actin interaction: PEVK-actin-based viscosity in a large animal. J Biomed Biotechnol. 2011;2011:310791. doi: 10.1155/2011/310791. Epub 2011 Nov 15. PubMed PMID: 22162634; PubMed Central PMCID: PMC3227466.

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Chung CS, Methawasin M, Nelson OL, Radke MH, Hidalgo CG, Gotthardt M, Granzier HL. Titin based viscosity in ventricular physiology: an integrative investigation of PEVK-actin interactions. J Mol Cell Cardiol. 2011 Sep;51(3):428-34. doi: 10.1016/j.yjmcc.2011.06.006. Epub 2011 Jun 16. PubMed PMID: 21708170; PubMed Central PMCID: PMC3150406.

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Chung CS, Granzier HL. Contribution of titin and extracellular matrix to passive pressure and measurement of sarcomere length in the mouse left ventricle. J Mol Cell Cardiol. 2011 Apr;50(4):731-9. doi: 10.1016/j.yjmcc.2011.01.005. Epub 2011 Jan 19. PubMed PMID: 21255582; PubMed Central PMCID: PMC3057392.

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King NM, Methawasin M, Nedrud J, Harrell N, Chung CS, Helmes M, Granzier H. Mouse intact cardiac myocyte mechanics: cross-bridge and titin-based stress in unactivated cells. J Gen Physiol. 2011 Jan;137(1):81-91. doi: 10.1085/jgp.201010499. PubMed PMID: 21187335; PubMed Central PMCID: PMC3010058.

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Shmuylovich L, Chung CS, Kovács SJ. Last word on point: Counterpoint: Left ventricular volume during diastasis is the physiological in vivo equilibrium volume and is related to diastolic suction. J Appl Physiol (1985). 2010 Aug;109(2):615. doi: 10.1152/japplphysiol.00619.2010. PubMed PMID: 20697138.

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Fukushima H, Chung CS, Granzier H. Titin-isoform dependence of titin-actin interaction and its regulation by S100A1/Ca2+ in skinned myocardium. J Biomed Biotechnol. 2010;2010:727239. doi: 10.1155/2010/727239. Epub 2010 Apr 14. PubMed PMID: 20414336; PubMed Central PMCID: PMC2855102.

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Shmuylovich L, Chung CS, Kovács SJ. Point: Left ventricular volume during diastasis is the physiological in vivo equilibrium volume and is related to diastolic suction. J Appl Physiol (1985). 2010 Aug;109(2):606-8. doi: 10.1152/japplphysiol.01399.2009. Epub 2009 Dec 24. PubMed PMID: 20035061; PubMed Central PMCID: PMC2928590.

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Chung CS, Kovács SJ. Physical determinants of left ventricular isovolumic pressure decline: model prediction with in vivo validation. Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1589-96. doi: 10.1152/ajpheart.00990.2007. Epub 2008 Jan 25. PubMed PMID: 18223192.

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Chung CS, Kovács SJ. Pressure phase-plane based determination of the onset of left ventricular relaxation. Cardiovasc Eng. 2007 Dec;7(4):162-71. doi: 10.1007/s10558-007-9036-6. PubMed PMID: 18026836.

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Zhang W, Chung CS, Shmuylovich L, Kovács SJ. Is left ventricular volume during diastasis the real equilibrium volume, and what is its relationship to diastolic suction?. J Appl Physiol (1985). 2008 Sep;105(3):1012-4. doi: 10.1152/japplphysiol.00799.2007. Epub 2007 Sep 27. PubMed PMID: 17901239.

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Zhang W, Chung CS, Riordan MM, Wu Y, Shmuylovich L, Kovács SJ. The kinematic filling efficiency index of the left ventricle: contrasting normal vs. diabetic physiology. Ultrasound Med Biol. 2007 Jun;33(6):842-50. doi: 10.1016/j.ultrasmedbio.2006.11.003. Epub 2007 May 3. PubMed PMID: 17478033; PubMed Central PMCID: PMC1995600.

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Zhang W, Chung CS, Kovács SJ. Derivation and left ventricular pressure phase plane based validation of a time dependent isometric crossbridge attachment model. Cardiovasc Eng. 2006 Dec;6(4):132-44. doi: 10.1007/s10558-006-9020-6. PubMed PMID: 17111228.

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Chung CS, Strunc A, Oliver R, Kovács SJ. Diastolic ventricular-vascular stiffness and relaxation relation: elucidation of coupling via pressure phase plane-derived indexes. Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2415-23. doi: 10.1152/ajpheart.00257.2006. Epub 2006 May 26. PubMed PMID: 16731647.

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Riordan MM, Chung CS, Kovács SJ. Diabetes and diastolic function: stiffness and relaxation from transmitral flow. Ultrasound Med Biol. 2005 Dec;31(12):1589-96. doi: 10.1016/j.ultrasmedbio.2005.07.015. PubMed PMID: 16344121.

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Chung CS, Kovács SJ. Consequences of increasing heart rate on deceleration time, the velocity-time integral, and E/A. Am J Cardiol. 2006 Jan 1;97(1):130-6. doi: 10.1016/j.amjcard.2005.07.116. Epub 2005 Nov 15. PubMed PMID: 16377298.