Analyzing the FMN-heme interdomain docking interactions in neuronal and inducible NOS isoforms by pulsed EPR experiments and conformational distribution modeling.
J Biol Inorg Chem.
2024 Sep;29(6):611-623. doi: 10.1007/s00775-024-02068-8. Epub 2024 Aug 13. PubMed PMID:
39136772; PubMed Central PMCID:
PMC11390318.
Mapping the Intersubunit Interdomain FMN-Heme Interactions in Neuronal Nitric Oxide Synthase by Targeted Quantitative Cross-Linking Mass Spectrometry.
Biochemistry.
2024 Jun 4;63(11):1395-1411. doi: 10.1021/acs.biochem.4c00157. Epub 2024 May 15. PubMed PMID:
38747545.
Systemic immunological responses are dependent on sex and ovarian hormone presence following acute inhaled woodsmoke exposure.
Part Fibre Toxicol.
2024 May 27;21(1):27. doi: 10.1186/s12989-024-00587-5. PubMed PMID:
38797836; PubMed Central PMCID:
PMC11129474.
Probing calmodulin-NO synthase interactions via site-specific infrared spectroscopy: an introductory investigation.
J Biol Inorg Chem.
2024 Mar;29(2):243-250. doi: 10.1007/s00775-024-02046-0. Epub 2024 Apr 5. PubMed PMID:
38580821; PubMed Central PMCID:
PMC11181464.
Differential superoxide production in phosphorylated neuronal nitric oxide synthase mu and alpha variants.
J Inorg Biochem.
2024 Feb;251:112454. doi: 10.1016/j.jinorgbio.2023.112454. Epub 2023 Dec 11. PubMed PMID:
38100901; PubMed Central PMCID:
PMC10843652.
Probing Protein Dynamics in Neuronal Nitric Oxide Synthase by Quantitative Cross-Linking Mass Spectrometry.
Biochemistry.
2023 Aug 1;62(15):2232-2237. doi: 10.1021/acs.biochem.3c00245. Epub 2023 Jul 17. PubMed PMID:
37459398; PubMed Central PMCID:
PMC10529231.
Interdomain Interactions Modulate the Active Site Dynamics of Human Inducible Nitric Oxide Synthase.
J Phys Chem B.
2022 Sep 15;126(36):6811-6819. doi: 10.1021/acs.jpcb.2c04091. Epub 2022 Sep 3. PubMed PMID:
36056879; PubMed Central PMCID:
PMC10110350.
A dye-andrographolide assembly as a turn-on sensor for detection of phthalate in both cells and fish.
Anal Chim Acta.
2022 Feb 22;1195:339460. doi: 10.1016/j.aca.2022.339460. Epub 2022 Jan 10. PubMed PMID:
35090651.
Heat shock protein 90α increases superoxide generation from neuronal nitric oxide synthases.
J Inorg Biochem.
2021 Jan;214:111298. doi: 10.1016/j.jinorgbio.2020.111298. Epub 2020 Nov 4. PubMed PMID:
33181440; PubMed Central PMCID:
PMC7719093.
An isoform-specific pivot modulates the electron transfer between the flavin mononucleotide and heme centers in inducible nitric oxide synthase.
J Biol Inorg Chem.
2020 Dec;25(8):1097-1105. doi: 10.1007/s00775-020-01824-w. Epub 2020 Oct 14. PubMed PMID:
33057871; PubMed Central PMCID:
PMC7669679.
Heat shock protein 90 enhances the electron transfer between the FMN and heme cofactors in neuronal nitric oxide synthase.
FEBS Lett.
2020 Sep;594(17):2904-2913. doi: 10.1002/1873-3468.13870. Epub 2020 Jul 4. PubMed PMID:
32573772; PubMed Central PMCID:
PMC7722166.
Mitochondrial targeting nano-curcumin for attenuation on PKM2 and FASN.
Colloids Surf B Biointerfaces.
2019 Oct 1;182:110405. doi: 10.1016/j.colsurfb.2019.110405. Epub 2019 Jul 29. PubMed PMID:
31377611.
Positional Distributions of the Tethered Modules in Nitric Oxide Synthase: Monte Carlo Calculations and Pulsed EPR Measurements.
J Phys Chem A.
2019 Aug 15;123(32):7075-7086. doi: 10.1021/acs.jpca.9b05388. Epub 2019 Aug 2. PubMed PMID:
31310526; PubMed Central PMCID:
PMC7534783.
Effect of Macromolecular Crowding on the FMN-Heme Intraprotein Electron Transfer in Inducible NO Synthase.
Biochemistry.
2019 Jul 16;58(28):3087-3096. doi: 10.1021/acs.biochem.9b00193. Epub 2019 Jun 28. PubMed PMID:
31251033; PubMed Central PMCID:
PMC7534385.
Generation and characterization of functional phosphoserine-incorporated neuronal nitric oxide synthase holoenzyme.
J Biol Inorg Chem.
2019 Feb;24(1):1-9. doi: 10.1007/s00775-018-1621-1. Epub 2018 Oct 12. PubMed PMID:
30315355; PubMed Central PMCID:
PMC6384131.
Ground State Nuclear Magnetic Resonance Chemical Shifts Predict Charge-Separated Excited State Lifetimes.
Inorg Chem.
2018 Nov 5;57(21):13470-13476. doi: 10.1021/acs.inorgchem.8b02087. Epub 2018 Oct 9. PubMed PMID:
30299098.
A docked state conformational dynamics model to explain the ionic strength dependence of FMN - heme electron transfer in nitric oxide synthase.
J Inorg Biochem.
2018 Jul;184:146-155. doi: 10.1016/j.jinorgbio.2018.03.012. Epub 2018 Mar 26. PubMed PMID:
29751215; PubMed Central PMCID:
PMC5983377.
Role of an isoform-specific residue at the calmodulin-heme (NO synthase) interface in the FMN - heme electron transfer.
FEBS Lett.
2018 Jul;592(14):2425-2431. doi: 10.1002/1873-3468.13158. Epub 2018 Jun 29. PubMed PMID:
29904908; PubMed Central PMCID:
PMC6105432.
Deciphering mechanism of conformationally controlled electron transfer in nitric oxide synthases.
Front Biosci (Landmark Ed).
2018 Jun 1;23(10):1803-1821. doi: 10.2741/4674. Review. PubMed PMID:
29772530; PubMed Central PMCID:
PMC11167721.
Metastatic melanoma imaging using a novel Tc-99m-labeled lactam-cyclized alpha-MSH peptide.
Bioorg Med Chem Lett.
2017 Nov 15;27(22):4952-4955. doi: 10.1016/j.bmcl.2017.10.022. Epub 2017 Oct 12. PubMed PMID:
29054361; PubMed Central PMCID:
PMC5667642.
Evaluation of novel (111)In-labeled gonadotropin-releasing hormone peptides for human prostate cancer imaging.
Bioorg Med Chem Lett.
2017 Oct 15;27(20):4647-4651. doi: 10.1016/j.bmcl.2017.09.004. Epub 2017 Sep 7. PubMed PMID:
28917649; PubMed Central PMCID:
PMC5726392.
Exploring second coordination sphere effects in nitric oxide synthase.
J Biol Inorg Chem.
2016 Dec;21(8):997-1008. doi: 10.1007/s00775-016-1396-1. Epub 2016 Sep 29. PubMed PMID:
27686338; PubMed Central PMCID:
PMC5541774.
Role of a Conserved Tyrosine Residue in the FMN-Heme Interdomain Electron Transfer in Inducible Nitric Oxide Synthase.
J Phys Chem A.
2016 Oct 6;120(39):7610-7616. doi: 10.1021/acs.jpca.6b08207. Epub 2016 Sep 27. PubMed PMID:
27633182; PubMed Central PMCID:
PMC5526657.
Kinetics and thermodynamics of zinc(II) and arsenic(III) binding to XPA and PARP-1 zinc finger peptides.
J Inorg Biochem.
2016 Oct;163:45-52. doi: 10.1016/j.jinorgbio.2016.08.003. Epub 2016 Aug 2. PubMed PMID:
27521476; PubMed Central PMCID:
PMC5096954.
Imaging human melanoma using a novel Tc-99m-labeled lactam bridge-cyclized alpha-MSH peptide.
Bioorg Med Chem Lett.
2016 Oct 1;26(19):4724-4728. doi: 10.1016/j.bmcl.2016.08.042. Epub 2016 Aug 17. PubMed PMID:
27568083; PubMed Central PMCID:
PMC5018458.
A Mn(II) complex of boradiazaindacene (BODIPY) loaded graphene oxide as both LED light and H2O2 enhanced anticancer agent.
J Inorg Biochem.
2016 Jun;159:1-6. doi: 10.1016/j.jinorgbio.2016.02.007. Epub 2016 Feb 13. PubMed PMID:
26901626.
Insight into structural rearrangements and interdomain interactions related to electron transfer between flavin mononucleotide and heme in nitric oxide synthase: A molecular dynamics study.
J Inorg Biochem.
2015 Dec;153:186-196. doi: 10.1016/j.jinorgbio.2015.08.006. Epub 2015 Aug 7. PubMed PMID:
26277414; PubMed Central PMCID:
PMC4690761.
Solving Kinetic Equations for the Laser Flash Photolysis Experiment on Nitric Oxide Synthases: Effect of Conformational Dynamics on the Interdomain Electron Transfer.
J Phys Chem A.
2015 Nov 12;119(45):11066-75. doi: 10.1021/acs.jpca.5b08414. Epub 2015 Oct 30. PubMed PMID:
26477677; PubMed Central PMCID:
PMC5518706.
Probing the Hydrogen Bonding of the Ferrous-NO Heme Center of nNOS by Pulsed Electron Paramagnetic Resonance.
J Phys Chem A.
2015 Jun 25;119(25):6641-9. doi: 10.1021/acs.jpca.5b01804. Epub 2015 Jun 12. PubMed PMID:
26035438; PubMed Central PMCID:
PMC4533915.
Pulsed electron paramagnetic resonance study of domain docking in neuronal nitric oxide synthase: the calmodulin and output state perspective.
J Phys Chem A.
2014 Aug 28;118(34):6864-72. doi: 10.1021/jp503547w. Epub 2014 Jul 31. PubMed PMID:
25046446; PubMed Central PMCID:
PMC4148148.
Ligand control of donor-acceptor excited-state lifetimes.
Inorg Chem.
2014 May 19;53(10):4791-3. doi: 10.1021/ic500217y. Epub 2014 Apr 28. PubMed PMID:
24773363.
Introduction of D-phenylalanine enhanced the receptor binding affinities of gonadotropin-releasing hormone peptides.
Bioorg Med Chem Lett.
2014 Feb 1;24(3):725-30. doi: 10.1016/j.bmcl.2013.12.120. Epub 2014 Jan 6. PubMed PMID:
24418777; PubMed Central PMCID:
PMC3924789.
Linker modification reduced the renal uptake of technetium-99m-labeled Arg-Ala-Asp-conjugated alpha-melanocyte stimulating hormone peptide.
Bioorg Med Chem Lett.
2014 Jan 1;24(1):195-8. doi: 10.1016/j.bmcl.2013.11.042. Epub 2013 Nov 23. PubMed PMID:
24316121; PubMed Central PMCID:
PMC3889140.
Dissecting regulation mechanism of the FMN to heme interdomain electron transfer in nitric oxide synthases.
J Inorg Biochem.
2014 Jan;130:130-40. doi: 10.1016/j.jinorgbio.2013.09.005. Epub 2013 Sep 13. Review. PubMed PMID:
24084585; PubMed Central PMCID:
PMC3844001.
Differential calmodulin-modulatory and electron transfer properties of neuronal nitric oxide synthase mu compared to the alpha variant.
FEBS Lett.
2013 Dec 11;587(24):3973-8. doi: 10.1016/j.febslet.2013.10.032. Epub 2013 Nov 6. PubMed PMID:
24211446; PubMed Central PMCID:
PMC3897158.
Influences of hydrocarbon linkers on the receptor binding affinities of gonadotropin-releasing hormone peptides.
Bioorg Med Chem Lett.
2013 Oct 15;23(20):5484-7. doi: 10.1016/j.bmcl.2013.08.075. Epub 2013 Aug 23. PubMed PMID:
24018188; PubMed Central PMCID:
PMC3778074.
Regulatory role of Glu546 in flavin mononucleotide-heme electron transfer in human inducible nitric oxide synthase.
Inorg Chem.
2013 May 6;52(9):4795-801. doi: 10.1021/ic3020892. Epub 2013 Apr 9. PubMed PMID:
23570607; PubMed Central PMCID:
PMC3677850.
Pulsed ENDOR determination of the arginine location in the ferrous-NO form of neuronal NOS.
J Phys Chem A.
2012 Jun 28;116(25):6731-9. doi: 10.1021/jp302319c. Epub 2012 Jun 15. PubMed PMID:
22667467; PubMed Central PMCID:
PMC3386476.
Role of an isoform-specific serine residue in FMN-heme electron transfer in inducible nitric oxide synthase.
J Biol Inorg Chem.
2012 Jun;17(5):675-85. doi: 10.1007/s00775-012-0887-y. Epub 2012 Mar 10. PubMed PMID:
22407542; PubMed Central PMCID:
PMC3526944.
Mechanism of Nitric Oxide Synthase Regulation: Electron Transfer and Interdomain Interactions.
Coord Chem Rev.
2012 Feb 1;256(3-4):393-411. doi: 10.1016/j.ccr.2011.10.011. Epub 2011 Oct 17. PubMed PMID:
22523434; PubMed Central PMCID:
PMC3328867.
Comparing the temperature dependence of FMN to heme electron transfer in full length and truncated inducible nitric oxide synthase proteins.
FEBS Lett.
2012 Jan 20;586(2):159-62. doi: 10.1016/j.febslet.2011.12.009. Epub 2011 Dec 17. PubMed PMID:
22198200; PubMed Central PMCID:
PMC3259286.
Intraprotein electron transfer between the FMN and heme domains in endothelial nitric oxide synthase holoenzyme.
Biochim Biophys Acta.
2011 Dec;1814(12):1997-2002. doi: 10.1016/j.bbapap.2011.08.004. Epub 2011 Aug 16. PubMed PMID:
21864726; PubMed Central PMCID:
PMC3223294.
Pulsed ENDOR determination of relative orientation of g-frame and molecular frame of imidazole-coordinated heme center of iNOS.
J Phys Chem A.
2011 Sep 22;115(37):10345-52. doi: 10.1021/jp204969d. Epub 2011 Aug 26. PubMed PMID:
21834532; PubMed Central PMCID:
PMC3174316.
Effect of solution viscosity on intraprotein electron transfer between the FMN and heme domains in inducible nitric oxide synthase.
FEBS Lett.
2011 Aug 19;585(16):2622-6. doi: 10.1016/j.febslet.2011.07.022. Epub 2011 Jul 26. PubMed PMID:
21803041; PubMed Central PMCID:
PMC3163105.
Mutation in the flavin mononucleotide domain modulates magnetic circular dichroism spectra of the iNOS ferric cyano complex in a substrate-specific manner.
Inorg Chem.
2011 Aug 1;50(15):6859-61. doi: 10.1021/ic200952c. Epub 2011 Jun 30. PubMed PMID:
21718007; PubMed Central PMCID:
PMC3143224.
Role of an isoform-specific substrate access channel residue in CO ligand accessibilities of neuronal and inducible nitric oxide synthase isoforms.
Biochim Biophys Acta.
2011 Mar;1814(3):405-8. doi: 10.1016/j.bbapap.2010.11.007. Epub 2010 Dec 10. PubMed PMID:
21146639; PubMed Central PMCID:
PMC3039037.
Electron transfer in a human inducible nitric oxide synthase oxygenase/FMN construct co-expressed with the N-terminal globular domain of calmodulin.
FEBS Lett.
2010 Oct 22;584(20):4335-8. doi: 10.1016/j.febslet.2010.09.028. Epub 2010 Sep 23. PubMed PMID:
20868689; PubMed Central PMCID:
PMC2956772.
Pulsed EPR determination of the distance between heme iron and FMN centers in a human inducible nitric oxide synthase.
J Am Chem Soc.
2010 Sep 1;132(34):12059-67. doi: 10.1021/ja104461p. PubMed PMID:
20695464; PubMed Central PMCID:
PMC2931817.
Regulation of interdomain electron transfer in the NOS output state for NO production.
Dalton Trans.
2009 Sep 14;(34):6692-700. doi: 10.1039/b902884f. Epub 2009 Jun 17. PubMed PMID:
19690675; PubMed Central PMCID:
PMC2997718.
Mutations in the FMN domain modulate MCD spectra of the heme site in the oxygenase domain of inducible nitric oxide synthase.
J Am Chem Soc.
2009 May 27;131(20):6940-1. doi: 10.1021/ja902141v. PubMed PMID:
19405537; PubMed Central PMCID:
PMC2754207.
What would you like to do?