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Lindsell CE, Shawber CJ, Boulter J, Weinmaster G. Jagged: a mammalian ligand that activates Notch1. Cell. 1995 Mar 24;80(6):909-17. doi: 10.1016/0092-8674(95)90294-5. PubMed PMID: 7697721.
Shawber C, Boulter J, Lindsell CE, Weinmaster G. Jagged2: a serrate-like gene expressed during rat embryogenesis. Dev Biol. 1996 Nov 25;180(1):370-6. doi: 10.1006/dbio.1996.0310. PubMed PMID: 8948600.
Shawber C, Nofziger D, Hsieh JJ, Lindsell C, Bögler O, Hayward D, Weinmaster G. Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway. Development. 1996 Dec;122(12):3765-73. PubMed PMID: 9012498.
Lan Y, Jiang R, Shawber C, Weinmaster G, Gridley T. The Jagged2 gene maps to chromosome 12 and is a candidate for the lgl and sm mutations. Mamm Genome. 1997;8(11):875-6. doi: 10.1007/s003359900642. PubMed PMID: 9341252.
Jiang R, Lan Y, Chapman HD, Shawber C, Norton CR, Serreze DV, Weinmaster G, Gridley T. Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice. Genes Dev. 1998 Apr 1;12(7):1046-57. doi: 10.1101/gad.12.7.1046. PubMed PMID: 9531541; PubMed Central PMCID: PMC316673.
Haritunians T, Boulter J, Hicks C, Buhrman J, DiSibio G, Shawber C, Weinmaster G, Nofziger D, Schanen C. CADASIL Notch3 mutant proteins localize to the cell surface and bind ligand. Circ Res. 2002 Mar 22;90(5):506-8. doi: 10.1161/01.res.0000013796.73742.c8. PubMed PMID: 11909813; PubMed Central PMCID: PMC3690627.
Shawber CJ, Das I, Francisco E, Kitajewski J. Notch signaling in primary endothelial cells. Ann N Y Acad Sci. 2003 May;995:162-70. doi: 10.1111/j.1749-6632.2003.tb03219.x. PubMed PMID: 12814948.
Shawber CJ, Kitajewski J. Notch function in the vasculature: insights from zebrafish, mouse and man. Bioessays. 2004 Mar;26(3):225-34. doi: 10.1002/bies.20004. Review. PubMed PMID: 14988924.
Masckauchán TN, Shawber CJ, Funahashi Y, Li CM, Kitajewski J. Wnt/beta-catenin signaling induces proliferation, survival and interleukin-8 in human endothelial cells. Angiogenesis. 2005;8(1):43-51. doi: 10.1007/s10456-005-5612-9. PubMed PMID: 16132617.
Vorontchikhina MA, Zimmermann RC, Shawber CJ, Tang H, Kitajewski J. Unique patterns of Notch1, Notch4 and Jagged1 expression in ovarian vessels during folliculogenesis and corpus luteum formation. Gene Expr Patterns. 2005 Jun;5(5):701-9. doi: 10.1016/j.modgep.2005.02.001. Epub 2005 Apr 13. PubMed PMID: 15939383.
Cheng YW, Shawber C, Notterman D, Paty P, Barany F. Multiplexed profiling of candidate genes for CpG island methylation status using a flexible PCR/LDR/Universal Array assay. Genome Res. 2006 Feb;16(2):282-9. doi: 10.1101/gr.4181406. Epub 2005 Dec 20. PubMed PMID: 16369045; PubMed Central PMCID: PMC1361724.
Lee A, Frischer J, Serur A, Huang J, Bae JO, Kornfield ZN, Eljuga L, Shawber CJ, Feirt N, Mansukhani M, Stempak D, Baruchel S, Glade Bender J, Kandel JJ, Yamashiro DJ. Inhibition of cyclooxygenase-2 disrupts tumor vascular mural cell recruitment and survival signaling. Cancer Res. 2006 Apr 15;66(8):4378-84. doi: 10.1158/0008-5472.CAN-05-3810. PubMed PMID: 16618763.
Kitamura T, Kitamura YI, Funahashi Y, Shawber CJ, Castrillon DH, Kollipara R, DePinho RA, Kitajewski J, Accili D. A Foxo/Notch pathway controls myogenic differentiation and fiber type specification. J Clin Invest. 2007 Sep;117(9):2477-85. doi: 10.1172/JCI32054. PubMed PMID: 17717603; PubMed Central PMCID: PMC1950461.
Shawber CJ, Funahashi Y, Francisco E, Vorontchikhina M, Kitamura Y, Stowell SA, Borisenko V, Feirt N, Podgrabinska S, Shiraishi K, Chawengsaksophak K, Rossant J, Accili D, Skobe M, Kitajewski J. Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. J Clin Invest. 2007 Nov;117(11):3369-82. doi: 10.1172/JCI24311. PubMed PMID: 17948123; PubMed Central PMCID: PMC2030453.
Shawber CJ, Kitajewski J. Arterial regulators taken up by lymphatics. Lymphat Res Biol. 2008;6(3-4):139-43. doi: 10.1089/lrb.2008.1024. Review. PubMed PMID: 19093785; PubMed Central PMCID: PMC2940254.
Funahashi Y, Hernandez SL, Das I, Ahn A, Huang J, Vorontchikhina M, Sharma A, Kanamaru E, Borisenko V, Desilva DM, Suzuki A, Wang X, Shawber CJ, Kandel JJ, Yamashiro DJ, Kitajewski J. A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis. Cancer Res. 2008 Jun 15;68(12):4727-35. doi: 10.1158/0008-5472.CAN-07-6499. PubMed PMID: 18559519; PubMed Central PMCID: PMC3690602.
Funahashi Y, Shawber CJ, Vorontchikhina M, Sharma A, Outtz HH, Kitajewski J. Notch regulates the angiogenic response via induction of VEGFR-1. J Angiogenes Res. 2010 Jan 26;2(1):3. doi: 10.1186/2040-2384-2-3. PubMed PMID: 20298529; PubMed Central PMCID: PMC2828996.
Butler JM, Nolan DJ, Vertes EL, Varnum-Finney B, Kobayashi H, Hooper AT, Seandel M, Shido K, White IA, Kobayashi M, Witte L, May C, Shawber C, Kimura Y, Kitajewski J, Rosenwaks Z, Bernstein ID, Rafii S. Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. Cell Stem Cell. 2010 Mar 5;6(3):251-64. doi: 10.1016/j.stem.2010.02.001. PubMed PMID: 20207228; PubMed Central PMCID: PMC2866527.
Nichol D, Shawber C, Fitch MJ, Bambino K, Sharma A, Kitajewski J, Stuhlmann H. Impaired angiogenesis and altered Notch signaling in mice overexpressing endothelial Egfl7. Blood. 2010 Dec 23;116(26):6133-43. doi: 10.1182/blood-2010-03-274860. Epub 2010 Oct 14. PubMed PMID: 20947685; PubMed Central PMCID: PMC3031397.
Funahashi Y, Shawber CJ, Sharma A, Kanamaru E, Choi YK, Kitajewski J. Notch modulates VEGF action in endothelial cells by inducing Matrix Metalloprotease activity. Vasc Cell. 2011 Jan 18;3(1):2. doi: 10.1186/2045-824X-3-2. PubMed PMID: 21349159; PubMed Central PMCID: PMC3039832.
Pajvani UB, Shawber CJ, Samuel VT, Birkenfeld AL, Shulman GI, Kitajewski J, Accili D. Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner. Nat Med. 2011 Jul 31;17(8):961-7. doi: 10.1038/nm.2378. PubMed PMID: 21804540; PubMed Central PMCID: PMC3387563.
Kofler NM, Shawber CJ, Kangsamaksin T, Reed HO, Galatioto J, Kitajewski J. Notch signaling in developmental and tumor angiogenesis. Genes Cancer. 2011 Dec;2(12):1106-16. doi: 10.1177/1947601911423030. PubMed PMID: 22866202; PubMed Central PMCID: PMC3411124.
Quante M, Bhagat G, Abrams JA, Marache F, Good P, Lee MD, Lee Y, Friedman R, Asfaha S, Dubeykovskaya Z, Mahmood U, Figueiredo JL, Kitajewski J, Shawber C, Lightdale CJ, Rustgi AK, Wang TC. Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia. Cancer Cell. 2012 Jan 17;21(1):36-51. doi: 10.1016/j.ccr.2011.12.004. PubMed PMID: 22264787; PubMed Central PMCID: PMC3266546.
Wong A, Hardy KL, Kitajewski AM, Shawber CJ, Kitajewski JK, Wu JK. Propranolol accelerates adipogenesis in hemangioma stem cells and causes apoptosis of hemangioma endothelial cells. Plast Reconstr Surg. 2012 Nov;130(5):1012-1021. doi: 10.1097/PRS.0b013e318267d3db. PubMed PMID: 23096601; PubMed Central PMCID: PMC3668332.
Shah MM, Zerlin M, Li BY, Herzog TJ, Kitajewski JK, Wright JD. The role of Notch and gamma-secretase inhibition in an ovarian cancer model. Anticancer Res. 2013 Mar;33(3):801-8. PubMed PMID: 23482747; PubMed Central PMCID: PMC3893696.
Jovanovic VP, Sauer CM, Shawber CJ, Gomez R, Wang X, Sauer MV, Kitajewski J, Zimmermann RC. Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4). Reprod Biol Endocrinol. 2013 May 15;11:43. doi: 10.1186/1477-7827-11-43. PubMed PMID: 23675950; PubMed Central PMCID: PMC3662615.
Murtomaki A, Uh MK, Choi YK, Kitajewski C, Borisenko V, Kitajewski J, Shawber CJ. Notch1 functions as a negative regulator of lymphatic endothelial cell differentiation in the venous endothelium. Development. 2013 Jun;140(11):2365-76. doi: 10.1242/dev.083865. Epub 2013 Apr 24. PubMed PMID: 23615281; PubMed Central PMCID: PMC3653558.
Kitajewski J, Shawber CJ, Simons M. Lymphatics in health and disease: a new thematic series in vascular cell. Vasc Cell. 2013 Jul 25;5(1):14. doi: 10.1186/2045-824X-5-14. PubMed PMID: 23885747; PubMed Central PMCID: PMC3734013.
Galic V, Shawber CJ, Reeves C, Shah M, Murtomaki A, Wright J, Herzog T, Tong GX, Kitajewski J. NOTCH2 expression is decreased in epithelial ovarian cancer and is related to the tumor histological subtype. Pathol Discov. 2013 Aug 16;1:4. doi: 10.7243/2052-7896-1-4. PubMed PMID: 24707357; PubMed Central PMCID: PMC3975618.
Hernandez SL, Banerjee D, Garcia A, Kangsamaksin T, Cheng WY, Anastassiou D, Funahashi Y, Kadenhe-Chiweshe A, Shawber CJ, Kitajewski JK, Kandel JJ, Yamashiro DJ. Notch and VEGF pathways play distinct but complementary roles in tumor angiogenesis. Vasc Cell. 2013 Sep 25;5(1):17. doi: 10.1186/2045-824X-5-17. PubMed PMID: 24066611; PubMed Central PMCID: PMC3849070.
Valenti L, Mendoza RM, Rametta R, Maggioni M, Kitajewski C, Shawber CJ, Pajvani UB. Hepatic notch signaling correlates with insulin resistance and nonalcoholic fatty liver disease. Diabetes. 2013 Dec;62(12):4052-62. doi: 10.2337/db13-0769. Epub 2013 Aug 29. PubMed PMID: 23990360; PubMed Central PMCID: PMC3837035.
Murtomaki A, Uh MK, Kitajewski C, Zhao J, Nagasaki T, Shawber CJ, Kitajewski J. Notch signaling functions in lymphatic valve formation. Development. 2014 Jun;141(12):2446-51. doi: 10.1242/dev.101188. PubMed PMID: 24917500; PubMed Central PMCID: PMC4050693.
Douglas NC, Zimmermann RC, Tan QK, Sullivan-Pyke CS, Sauer MV, Kitajewski JK, Shawber CJ. VEGFR-1 blockade disrupts peri-implantation decidual angiogenesis and macrophage recruitment. Vasc Cell. 2014;6:16. doi: 10.1186/2045-824X-6-16. eCollection 2014. PubMed PMID: 25101167; PubMed Central PMCID: PMC4122670.
England RW, Hardy KL, Kitajewski AM, Wong A, Kitajewski JK, Shawber CJ, Wu JK. Propranolol promotes accelerated and dysregulated adipogenesis in hemangioma stem cells. Ann Plast Surg. 2014 Sep;73 Suppl 1:S119-24. doi: 10.1097/SAP.0000000000000272. PubMed PMID: 25115372; PubMed Central PMCID: PMC4134106.
Kangsamaksin T, Murtomaki A, Kofler NM, Cuervo H, Chaudhri RA, Tattersall IW, Rosenstiel PE, Shawber CJ, Kitajewski J. NOTCH decoys that selectively block DLL/NOTCH or JAG/NOTCH disrupt angiogenesis by unique mechanisms to inhibit tumor growth. Cancer Discov. 2015 Feb;5(2):182-97. doi: 10.1158/2159-8290.CD-14-0650. Epub 2014 Nov 11. PubMed PMID: 25387766; PubMed Central PMCID: PMC4423829.
Wu JK, Kitajewski C, Reiley M, Keung CH, Monteagudo J, Andrews JP, Liou P, Thirumoorthi A, Wong A, Kandel JJ, Shawber CJ. Aberrant lymphatic endothelial progenitors in lymphatic malformation development. PLoS One. 2015;10(2):e0117352. doi: 10.1371/journal.pone.0117352. eCollection 2015. PubMed PMID: 25719418; PubMed Central PMCID: PMC4342011.
Banerjee D, Hernandez SL, Garcia A, Kangsamaksin T, Sbiroli E, Andrews J, Forrester LA, Wei N, Kadenhe-Chiweshe A, Shawber CJ, Kitajewski JK, Kandel JJ, Yamashiro DJ. Notch suppresses angiogenesis and progression of hepatic metastases. Cancer Res. 2015 Apr 15;75(8):1592-602. doi: 10.1158/0008-5472.CAN-14-1493. Epub 2015 Mar 5. PubMed PMID: 25744722; PubMed Central PMCID: PMC4401639.
Munabi NC, Tan QK, Garzon MC, Behr GG, Shawber CJ, Wu JK. Growth Hormone Induces Recurrence of Infantile Hemangiomas After Apparent Involution: Evidence of Growth Hormone Receptors in Infantile Hemangioma. Pediatr Dermatol. 2015 Jul-Aug;32(4):539-43. doi: 10.1111/pde.12530. Epub 2015 Feb 18. PubMed PMID: 25690955; PubMed Central PMCID: PMC5433863.
Shawber CJ, Lin L, Gnarra M, Sauer MV, Papaioannou VE, Kitajewski JK, Douglas NC. Vascular Notch proteins and Notch signaling in the peri-implantation mouse uterus. Vasc Cell. 2015;7:9. doi: 10.1186/s13221-015-0034-y. eCollection 2015. PubMed PMID: 26629328; PubMed Central PMCID: PMC4666149.
Munabi NC, England RW, Edwards AK, Kitajewski AA, Tan QK, Weinstein A, Kung JE, Wilcox M, Kitajewski JK, Shawber CJ, Wu JK. Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation. Stem Cells Transl Med. 2016 Jan;5(1):45-55. doi: 10.5966/sctm.2015-0076. Epub 2015 Nov 16. PubMed PMID: 26574555; PubMed Central PMCID: PMC4704871.
Gnarra M, Behr G, Kitajewski A, Wu JK, Anupindi SA, Shawber CJ, Zavras N, Schizas D, Salakos C, Economopoulos KP. History of the infantile hepatic hemangioma: From imaging to generating a differential diagnosis. World J Clin Pediatr. 2016 Aug 8;5(3):273-80. doi: 10.5409/wjcp.v5.i3.273. eCollection 2016 Aug 8. Review. PubMed PMID: 27610342; PubMed Central PMCID: PMC4978619.
Wu JK, Hooper ED, Laifer-Narin SL, Simpson LL, Kandel J, Shawber CJ. Initial Experience With Propranolol Treatment of Lymphatic Anomalies: A Case Series. Pediatrics. 2016 Sep;138(3). doi: 10.1542/peds.2015-4545. Epub 2016 Aug 25. PubMed PMID: 27561730; PubMed Central PMCID: PMC5005016.
Vink JY, Qin S, Brock CO, Zork NM, Feltovich HM, Chen X, Urie P, Myers KM, Hall TJ, Wapner R, Kitajewski JK, Shawber CJ, Gallos G. A new paradigm for the role of smooth muscle cells in the human cervix. Am J Obstet Gynecol. 2016 Oct;215(4):478.e1-478.e11. doi: 10.1016/j.ajog.2016.04.053. Epub 2016 May 7. PubMed PMID: 27166013.
Werth M, Schmidt-Ott KM, Leete T, Qiu A, Hinze C, Viltard M, Paragas N, Shawber CJ, Yu W, Lee P, Chen X, Sarkar A, Mu W, Rittenberg A, Lin CS, Kitajewski J, Al-Awqati Q, Barasch J. Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts. Elife. 2017 Jun 3;6. doi: 10.7554/eLife.24265. PubMed PMID: 28577314; PubMed Central PMCID: PMC5484618.
Levin HI, Sullivan-Pyke CS, Papaioannou VE, Wapner RJ, Kitajewski JK, Shawber CJ, Douglas NC. Dynamic maternal and fetal Notch activity and expression in placentation. Placenta. 2017 Jul;55:5-12. doi: 10.1016/j.placenta.2017.04.014. Epub 2017 Apr 21. PubMed PMID: 28623973; PubMed Central PMCID: PMC5754215.
Muley A, Odaka Y, Lewkowich IP, Vemaraju S, Yamaguchi TP, Shawber C, Dickie BH, Lang RA. Myeloid Wnt ligands are required for normal development of dermal lymphatic vasculature. PLoS One. 2017;12(8):e0181549. doi: 10.1371/journal.pone.0181549. eCollection 2017. PubMed PMID: 28846685; PubMed Central PMCID: PMC5573294.
Edwards AK, Glithero K, Grzesik P, Kitajewski AA, Munabi NC, Hardy K, Tan QK, Schonning M, Kangsamaksin T, Kitajewski JK, Shawber CJ, Wu JK. NOTCH3 regulates stem-to-mural cell differentiation in infantile hemangioma. JCI Insight. 2017 Nov 2;2(21). doi: 10.1172/jci.insight.93764. PubMed PMID: 29093274; PubMed Central PMCID: PMC5752265.
Nathan J, Ruscitto A, Pylawka S, Sohraby A, Shawber CJ, Embree MC. Fibrocartilage Stem Cells Engraft and Self-Organize into Vascularized Bone. J Dent Res. 2018 Mar;97(3):329-337. doi: 10.1177/0022034517735094. Epub 2017 Oct 11. PubMed PMID: 29020504; PubMed Central PMCID: PMC5833184.
Sones JL, Merriam AA, Seffens A, Brown-Grant DA, Butler SD, Zhao AM, Xu X, Shawber CJ, Grenier JK, Douglas NC. Angiogenic factor imbalance precedes complement deposition in placentae of the BPH/5 model of preeclampsia. FASEB J. 2018 May;32(5):2574-2586. doi: 10.1096/fj.201701008R. Epub 2018 Jan 8. PubMed PMID: 29279353; PubMed Central PMCID: PMC5901389.
Davis RB, Pahl K, Datto NC, Smith SV, Shawber C, Caron KM, Blatt J. Notch signaling pathway is a potential therapeutic target for extracranial vascular malformations. Sci Rep. 2018 Dec 20;8(1):17987. doi: 10.1038/s41598-018-36628-1. PubMed PMID: 30573741; PubMed Central PMCID: PMC6302123.
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