Skip to main page content
Accesskeys
  1. Nelson HH, Christensen B, Karagas MR. The XPC poly-AT polymorphism in non-melanoma skin cancer. Cancer Lett. 2005 May 26;222(2):205-9. doi: 10.1016/j.canlet.2004.11.032. Epub 2005 Jan 7. PubMed PMID: 15863269.
  2. Marsit CJ, Houseman EA, Christensen BC, Eddy K, Bueno R, Sugarbaker DJ, Nelson HH, Karagas MR, Kelsey KT. Examination of a CpG island methylator phenotype and implications of methylation profiles in solid tumors. Cancer Res. 2006 Nov 1;66(21):10621-9. doi: 10.1158/0008-5472.CAN-06-1687. PubMed PMID: 17079487.
  3. Christensen BC, Godleski JJ, Roelofs CR, Longacker JL, Bueno R, Sugarbaker DJ, Marsit CJ, Nelson HH, Kelsey KT. Asbestos burden predicts survival in pleural mesothelioma. Environ Health Perspect. 2008 Jun;116(6):723-6. doi: 10.1289/ehp.11151. PubMed PMID: 18560526; PubMed Central PMCID: PMC2430226.
  4. Christensen BC, Godleski JJ, Marsit CJ, Houseman EA, Lopez-Fagundo CY, Longacker JL, Bueno R, Sugarbaker DJ, Nelson HH, Kelsey KT. Asbestos exposure predicts cell cycle control gene promoter methylation in pleural mesothelioma. Carcinogenesis. 2008 Aug;29(8):1555-9. doi: 10.1093/carcin/bgn059. Epub 2008 Feb 28. PubMed PMID: 18310086; PubMed Central PMCID: PMC2516493.
  5. Houseman EA, Christensen BC, Yeh RF, Marsit CJ, Karagas MR, Wrensch M, Nelson HH, Wiemels J, Zheng S, Wiencke JK, Kelsey KT. Model-based clustering of DNA methylation array data: a recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions. BMC Bioinformatics. 2008 Sep 9;9:365. doi: 10.1186/1471-2105-9-365. PubMed PMID: 18782434; PubMed Central PMCID: PMC2553421.
  6. Christensen BC, Houseman EA, Godleski JJ, Marsit CJ, Longacker JL, Roelofs CR, Karagas MR, Wrensch MR, Yeh RF, Nelson HH, Wiemels JL, Zheng S, Wiencke JK, Bueno R, Sugarbaker DJ, Kelsey KT. Epigenetic profiles distinguish pleural mesothelioma from normal pleura and predict lung asbestos burden and clinical outcome. Cancer Res. 2009 Jan 1;69(1):227-34. doi: 10.1158/0008-5472.CAN-08-2586. PubMed PMID: 19118007; PubMed Central PMCID: PMC2744125.
  7. Marsit CJ, Christensen BC, Houseman EA, Karagas MR, Wrensch MR, Yeh RF, Nelson HH, Wiemels JL, Zheng S, Posner MR, McClean MD, Wiencke JK, Kelsey KT. Epigenetic profiling reveals etiologically distinct patterns of DNA methylation in head and neck squamous cell carcinoma. Carcinogenesis. 2009 Mar;30(3):416-22. doi: 10.1093/carcin/bgp006. Epub 2009 Jan 6. PubMed PMID: 19126652; PubMed Central PMCID: PMC2650795.
  8. Avissar M, Christensen BC, Kelsey KT, Marsit CJ. MicroRNA expression ratio is predictive of head and neck squamous cell carcinoma. Clin Cancer Res. 2009 Apr 15;15(8):2850-5. doi: 10.1158/1078-0432.CCR-08-3131. Epub 2009 Apr 7. PubMed PMID: 19351747; PubMed Central PMCID: PMC2669849.
  9. Chen AA, Marsit CJ, Christensen BC, Houseman EA, McClean MD, Smith JF, Bryan JT, Posner MR, Nelson HH, Kelsey KT. Genetic variation in the vitamin C transporter, SLC23A2, modifies the risk of HPV16-associated head and neck cancer. Carcinogenesis. 2009 Jun;30(6):977-81. doi: 10.1093/carcin/bgp076. Epub 2009 Apr 3. PubMed PMID: 19346260; PubMed Central PMCID: PMC2691140.
  10. Christensen BC, Moyer BJ, Avissar M, Ouellet LG, Plaza SL, McClean MD, Marsit CJ, Kelsey KT. A let-7 microRNA-binding site polymorphism in the KRAS 3' UTR is associated with reduced survival in oral cancers. Carcinogenesis. 2009 Jun;30(6):1003-7. doi: 10.1093/carcin/bgp099. Epub 2009 Apr 20. PubMed PMID: 19380522; PubMed Central PMCID: PMC2691138.
  11. Applebaum KM, McClean MD, Nelson HH, Marsit CJ, Christensen BC, Kelsey KT. Smoking modifies the relationship between XRCC1 haplotypes and HPV16-negative head and neck squamous cell carcinoma. Int J Cancer. 2009 Jun 1;124(11):2690-6. doi: 10.1002/ijc.24256. PubMed PMID: 19230024; PubMed Central PMCID: PMC2746567.
  12. Liang C, McClean MD, Marsit C, Christensen B, Peters E, Nelson HH, Kelsey KT. A population-based case-control study of marijuana use and head and neck squamous cell carcinoma. Cancer Prev Res (Phila). 2009 Aug;2(8):759-68. doi: 10.1158/1940-6207.CAPR-09-0048. Epub 2009 Jul 28. PubMed PMID: 19638490; PubMed Central PMCID: PMC2812803.
  13. Christensen BC, Marsit CJ, Houseman EA, Godleski JJ, Longacker JL, Zheng S, Yeh RF, Wrensch MR, Wiemels JL, Karagas MR, Bueno R, Sugarbaker DJ, Nelson HH, Wiencke JK, Kelsey KT. Differentiation of lung adenocarcinoma, pleural mesothelioma, and nonmalignant pulmonary tissues using DNA methylation profiles. Cancer Res. 2009 Aug 1;69(15):6315-21. doi: 10.1158/0008-5472.CAN-09-1073. Epub 2009 Jul 28. PubMed PMID: 19638575; PubMed Central PMCID: PMC2755616.
  14. Christensen BC, Houseman EA, Marsit CJ, Zheng S, Wrensch MR, Wiemels JL, Nelson HH, Karagas MR, Padbury JF, Bueno R, Sugarbaker DJ, Yeh RF, Wiencke JK, Kelsey KT. Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet. 2009 Aug;5(8):e1000602. doi: 10.1371/journal.pgen.1000602. Epub 2009 Aug 14. PubMed PMID: 19680444; PubMed Central PMCID: PMC2718614.
  15. Houseman EA, Christensen BC, Karagas MR, Wrensch MR, Nelson HH, Wiemels JL, Zheng S, Wiencke JK, Kelsey KT, Marsit CJ. Copy number variation has little impact on bead-array-based measures of DNA methylation. Bioinformatics. 2009 Aug 15;25(16):1999-2005. doi: 10.1093/bioinformatics/btp364. Epub 2009 Jun 19. PubMed PMID: 19542153; PubMed Central PMCID: PMC2723008.
  16. Poage GM, Christensen BC, Houseman EA, McClean MD, Wiencke JK, Posner MR, Clark JR, Nelson HH, Marsit CJ, Kelsey KT. Genetic and epigenetic somatic alterations in head and neck squamous cell carcinomas are globally coordinated but not locally targeted. PLoS One. 2010 Mar 11;5(3):e9651. doi: 10.1371/journal.pone.0009651. PubMed PMID: 20300172; PubMed Central PMCID: PMC2836370.
  17. Nelson HH, Christensen BC, Plaza SL, Wiencke JK, Marsit CJ, Kelsey KT. KRAS mutation, KRAS-LCS6 polymorphism, and non-small cell lung cancer. Lung Cancer. 2010 Jul;69(1):51-3. doi: 10.1016/j.lungcan.2009.09.008. Epub 2009 Oct 24. PubMed PMID: 19854534; PubMed Central PMCID: PMC2879467.
  18. Christensen BC, Avissar-Whiting M, Ouellet LG, Butler RA, Nelson HH, McClean MD, Marsit CJ, Kelsey KT. Mature microRNA sequence polymorphism in MIR196A2 is associated with risk and prognosis of head and neck cancer. Clin Cancer Res. 2010 Jul 15;16(14):3713-20. doi: 10.1158/1078-0432.CCR-10-0657. Epub 2010 May 25. PubMed PMID: 20501619; PubMed Central PMCID: PMC2914465.
  19. Christensen BC, Houseman EA, Poage GM, Godleski JJ, Bueno R, Sugarbaker DJ, Wiencke JK, Nelson HH, Marsit CJ, Kelsey KT. Integrated profiling reveals a global correlation between epigenetic and genetic alterations in mesothelioma. Cancer Res. 2010 Jul 15;70(14):5686-94. doi: 10.1158/0008-5472.CAN-10-0190. Epub 2010 Jun 29. PubMed PMID: 20587528; PubMed Central PMCID: PMC2905466.
  20. Christensen BC, Kelsey KT, Zheng S, Houseman EA, Marsit CJ, Wrensch MR, Wiemels JL, Nelson HH, Karagas MR, Kushi LH, Kwan ML, Wiencke JK. Breast cancer DNA methylation profiles are associated with tumor size and alcohol and folate intake. PLoS Genet. 2010 Jul 29;6(7):e1001043. doi: 10.1371/journal.pgen.1001043. PubMed PMID: 20686660; PubMed Central PMCID: PMC2912395.
  21. Marsit CJ, Houseman EA, Christensen BC, Gagne L, Wrensch MR, Nelson HH, Wiemels J, Zheng S, Wiencke JK, Andrew AS, Schned AR, Karagas MR, Kelsey KT. Identification of methylated genes associated with aggressive bladder cancer. PLoS One. 2010 Aug 23;5(8):e12334. doi: 10.1371/journal.pone.0012334. PubMed PMID: 20808801; PubMed Central PMCID: PMC2925945.
  22. Gee GV, Stanifer ML, Christensen BC, Atwood WJ, Ugolini D, Bonassi S, Resnick MB, Nelson HH, Marsit CJ, Kelsey KT. SV40 associated miRNAs are not detectable in mesotheliomas. Br J Cancer. 2010 Sep 7;103(6):885-8. doi: 10.1038/sj.bjc.6605848. Epub 2010 Aug 17. PubMed PMID: 20717113; PubMed Central PMCID: PMC2966630.
  23. Koestler DC, Marsit CJ, Christensen BC, Karagas MR, Bueno R, Sugarbaker DJ, Kelsey KT, Houseman EA. Semi-supervised recursively partitioned mixture models for identifying cancer subtypes. Bioinformatics. 2010 Oct 15;26(20):2578-85. doi: 10.1093/bioinformatics/btq470. Epub 2010 Aug 16. PubMed PMID: 20834038; PubMed Central PMCID: PMC2951086.
  24. Wilhelm-Benartzi CS, Koestler DC, Houseman EA, Christensen BC, Wiencke JK, Schned AR, Karagas MR, Kelsey KT, Marsit CJ. DNA methylation profiles delineate etiologic heterogeneity and clinically important subgroups of bladder cancer. Carcinogenesis. 2010 Nov;31(11):1972-6. doi: 10.1093/carcin/bgq178. Epub 2010 Aug 28. PubMed PMID: 20802236; PubMed Central PMCID: PMC2966555.
  25. Gee GV, Koestler DC, Christensen BC, Sugarbaker DJ, Ugolini D, Ivaldi GP, Resnick MB, Houseman EA, Kelsey KT, Marsit CJ. Downregulated microRNAs in the differential diagnosis of malignant pleural mesothelioma. Int J Cancer. 2010 Dec 15;127(12):2859-69. doi: 10.1002/ijc.25285. PubMed PMID: 21351265; PubMed Central PMCID: PMC2911512.
  26. Christensen BC, Smith AA, Zheng S, Koestler DC, Houseman EA, Marsit CJ, Wiemels JL, Nelson HH, Karagas MR, Wrensch MR, Kelsey KT, Wiencke JK. DNA methylation, isocitrate dehydrogenase mutation, and survival in glioma. J Natl Cancer Inst. 2011 Jan 19;103(2):143-53. doi: 10.1093/jnci/djq497. Epub 2010 Dec 16. PubMed PMID: 21163902; PubMed Central PMCID: PMC3022619.
  27. Zheng S, Houseman EA, Morrison Z, Wrensch MR, Patoka JS, Ramos C, Haas-Kogan DA, McBride S, Marsit CJ, Christensen BC, Nelson HH, Stokoe D, Wiemels JL, Chang SM, Prados MD, Tihan T, Vandenberg SR, Kelsey KT, Berger MS, Wiencke JK. DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expression. Neuro Oncol. 2011 Mar;13(3):280-9. doi: 10.1093/neuonc/noq190. PubMed PMID: 21339190; PubMed Central PMCID: PMC3064601.
  28. Almquist LM, Karagas MR, Christensen BC, Welsh MM, Perry AE, Storm CA, Nelson HH. The role of TP53 and MDM2 polymorphisms in TP53 mutagenesis and risk of non-melanoma skin cancer. Carcinogenesis. 2011 Mar;32(3):327-30. doi: 10.1093/carcin/bgq256. Epub 2010 Dec 1. PubMed PMID: 21123835; PubMed Central PMCID: PMC3105583.
  29. Marsit CJ, Koestler DC, Christensen BC, Karagas MR, Houseman EA, Kelsey KT. DNA methylation array analysis identifies profiles of blood-derived DNA methylation associated with bladder cancer. J Clin Oncol. 2011 Mar 20;29(9):1133-9. doi: 10.1200/JCO.2010.31.3577. Epub 2011 Feb 22. PubMed PMID: 21343564; PubMed Central PMCID: PMC3083868.
  30. Chen D, Truong T, Gaborieau V, Byrnes G, Chabrier A, Chuang SC, Olshan AF, Weissler MC, Luo J, Romkes M, Buch S, Nukui T, Franceschi S, Herrero R, Talamini R, Kelsey KT, Christensen B, McClean MD, Lacko M, Manni JJ, Peters WH, Lubiński J, Trubicka J, Lener M, Muscat JE, Lazarus P, Wei Q, Sturgis EM, Zhang ZF, Chang SC, Wang R, Schwartz SM, Chen C, Benhamou S, Lagiou P, Holcátová I, Richiardi L, Kjaerheim K, Agudo A, Castellsagué X, Macfarlane TV, Barzan L, Canova C, Thakker NS, Conway DI, Znaor A, Healy CM, Ahrens W, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Fabianova E, Bucur A, Bencko V, Foretova L, Janout V, Curado MP, Koifman S, Menezes A, Wünsch-Filho V, Eluf-Neto J, Fernandez L, Boccia S, Hashibe M, Hayes RB, Boffetta P, Brennan P, McKay JD. A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers. Cancer Epidemiol Biomarkers Prev. 2011 Apr;20(4):658-64. doi: 10.1158/1055-9965.EPI-10-1008. Epub 2011 Feb 18. PubMed PMID: 21335511; PubMed Central PMCID: PMC3070066.
  31. Avissar-Whiting M, Koestler DC, Houseman EA, Christensen BC, Kelsey KT, Marsit CJ. Polycomb group genes are targets of aberrant DNA methylation in renal cell carcinoma. Epigenetics. 2011 Jun;6(6):703-9. doi: 10.4161/epi.6.6.16158. Epub 2011 Jun 1. PubMed PMID: 21610323; PubMed Central PMCID: PMC3230543.
  32. Poage GM, Houseman EA, Christensen BC, Butler RA, Avissar-Whiting M, McClean MD, Waterboer T, Pawlita M, Marsit CJ, Kelsey KT. Global hypomethylation identifies Loci targeted for hypermethylation in head and neck cancer. Clin Cancer Res. 2011 Jun 1;17(11):3579-89. doi: 10.1158/1078-0432.CCR-11-0044. Epub 2011 Apr 19. PubMed PMID: 21505061; PubMed Central PMCID: PMC3107873.
  33. Pacheco SE, Houseman EA, Christensen BC, Marsit CJ, Kelsey KT, Sigman M, Boekelheide K. Integrative DNA methylation and gene expression analyses identify DNA packaging and epigenetic regulatory genes associated with low motility sperm. PLoS One. 2011;6(6):e20280. doi: 10.1371/journal.pone.0020280. Epub 2011 Jun 2. PubMed PMID: 21674046; PubMed Central PMCID: PMC3107223.
  34. Langevin SM, Houseman EA, Christensen BC, Wiencke JK, Nelson HH, Karagas MR, Marsit CJ, Kelsey KT. The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood. Epigenetics. 2011 Jul;6(7):908-19. doi: 10.4161/epi.6.7.16431. Epub 2011 Jul 1. PubMed PMID: 21617368; PubMed Central PMCID: PMC3154431.
  35. Wilhelm-Benartzi CS, Christensen BC, Koestler DC, Houseman EA, Schned AR, Karagas MR, Kelsey KT, Marsit CJ. Association of secondhand smoke exposures with DNA methylation in bladder carcinomas. Cancer Causes Control. 2011 Aug;22(8):1205-13. doi: 10.1007/s10552-011-9788-6. Epub 2011 Jun 10. PubMed PMID: 21660454; PubMed Central PMCID: PMC3140591.
  36. Torti DC, Christensen BC, Storm CA, Fortuny J, Perry AE, Zens MS, Stukel T, Spencer SK, Nelson HH, Karagas MR. Analgesic and nonsteroidal anti-inflammatory use in relation to nonmelanoma skin cancer: a population-based case-control study. J Am Acad Dermatol. 2011 Aug;65(2):304-312. doi: 10.1016/j.jaad.2010.05.042. Epub 2011 May 6. PubMed PMID: 21529996; PubMed Central PMCID: PMC3140678.
  37. Nelson HH, Almquist LM, LaRocca JL, Plaza SL, Lambert-Messerlian GM, Sugarbaker DJ, Bueno R, Godleski JJ, Marsit CJ, Christensen BC, Kelsey KT. The relationship between tumor MSLN methylation and serum mesothelin (SMRP) in mesothelioma. Epigenetics. 2011 Aug;6(8):1029-34. doi: 10.4161/epi.6.8.16074. Epub 2011 Aug 1. PubMed PMID: 21775819; PubMed Central PMCID: PMC3219084.
  38. Christensen BC, Marsit CJ. Epigenomics in environmental health. Front Genet. 2011;2:84. doi: 10.3389/fgene.2011.00084. eCollection 2011. PubMed PMID: 22303378; PubMed Central PMCID: PMC3268636.
  39. Vasconcelos GM, Christensen BC, Houseman EA, Xiao J, Marsit CJ, Wiencke JK, Zheng S, Karagas MR, Nelson HH, Wrensch MR, Kelsey KT, Pombo-de-Oliveira MS, Wiemels JL. History of Parvovirus B19 infection is associated with a DNA methylation signature in childhood acute lymphoblastic leukemia. Epigenetics. 2011 Dec;6(12):1436-43. doi: 10.4161/epi.6.12.18464. PubMed PMID: 22139573; PubMed Central PMCID: PMC3256332.
  40. Langevin SM, Koestler DC, Christensen BC, Butler RA, Wiencke JK, Nelson HH, Houseman EA, Marsit CJ, Kelsey KT. Peripheral blood DNA methylation profiles are indicative of head and neck squamous cell carcinoma: an epigenome-wide association study. Epigenetics. 2012 Mar;7(3):291-9. doi: 10.4161/epi.7.3.19134. PubMed PMID: 22430805; PubMed Central PMCID: PMC3335952.
  41. Houseman EA, Accomando WP, Koestler DC, Christensen BC, Marsit CJ, Nelson HH, Wiencke JK, Kelsey KT. DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics. 2012 May 8;13:86. doi: 10.1186/1471-2105-13-86. PubMed PMID: 22568884; PubMed Central PMCID: PMC3532182.
  42. Nelson HH, Marsit CJ, Christensen BC, Houseman EA, Kontic M, Wiemels JL, Karagas MR, Wrensch MR, Zheng S, Wiencke JK, Kelsey KT. Key epigenetic changes associated with lung cancer development: results from dense methylation array profiling. Epigenetics. 2012 Jun 1;7(6):559-66. doi: 10.4161/epi.20219. Epub 2012 Jun 1. PubMed PMID: 22522909; PubMed Central PMCID: PMC3398985.
  43. Poage GM, Butler RA, Houseman EA, McClean MD, Nelson HH, Christensen BC, Marsit CJ, Kelsey KT. Identification of an epigenetic profile classifier that is associated with survival in head and neck cancer. Cancer Res. 2012 Jun 1;72(11):2728-37. doi: 10.1158/0008-5472.CAN-11-4121-T. Epub 2012 Apr 16. PubMed PMID: 22507853; PubMed Central PMCID: PMC3650639.
  44. Michaud DS, Langevin SM, Eliot M, Nelson HH, McClean MD, Christensen BC, Marsit CJ, Kelsey KT. Allergies and risk of head and neck cancer. Cancer Causes Control. 2012 Aug;23(8):1317-22. doi: 10.1007/s10552-012-0009-8. Epub 2012 Jun 19. PubMed PMID: 22710748; PubMed Central PMCID: PMC3598569.
  45. Koestler DC, Marsit CJ, Christensen BC, Accomando W, Langevin SM, Houseman EA, Nelson HH, Karagas MR, Wiencke JK, Kelsey KT. Peripheral blood immune cell methylation profiles are associated with nonhematopoietic cancers. Cancer Epidemiol Biomarkers Prev. 2012 Aug;21(8):1293-302. doi: 10.1158/1055-9965.EPI-12-0361. Epub 2012 Jun 19. PubMed PMID: 22714737; PubMed Central PMCID: PMC3415587.
  46. Liang C, Marsit CJ, McClean MD, Nelson HH, Christensen BC, Haddad RI, Clark JR, Wein RO, Grillone GA, Houseman EA, Halec G, Waterboer T, Pawlita M, Krane JF, Kelsey KT. Biomarkers of HPV in head and neck squamous cell carcinoma. Cancer Res. 2012 Oct 1;72(19):5004-13. doi: 10.1158/0008-5472.CAN-11-3277. Epub 2012 Sep 18. PubMed PMID: 22991304; PubMed Central PMCID: PMC3463756.
  47. Wiencke JK, Accomando WP, Zheng S, Patoka J, Dou X, Phillips JJ, Hsuang G, Christensen BC, Houseman EA, Koestler DC, Bracci P, Wiemels JL, Wrensch M, Nelson HH, Kelsey KT. Epigenetic biomarkers of T-cells in human glioma. Epigenetics. 2012 Dec 1;7(12):1391-402. doi: 10.4161/epi.22675. Epub 2012 Oct 29. PubMed PMID: 23108258; PubMed Central PMCID: PMC3528694.
  48. Biswal BK, Beyrouthy MJ, Hever-Jardine MP, Armstrong D, Tomlinson CR, Christensen BC, Marsit CJ, Spinella MJ. Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27. PubMed PMID: 23300844; PubMed Central PMCID: PMC3531428.
  49. Koestler DC, Christensen BC, Marsit CJ, Kelsey KT, Houseman EA. Recursively partitioned mixture model clustering of DNA methylation data using biologically informed correlation structures. Stat Appl Genet Mol Biol. 2013 Mar 5;12(2):225-40. doi: 10.1515/sagmb-2012-0068. PubMed PMID: 23468465; PubMed Central PMCID: PMC4007267.
  50. Langevin SM, Michaud DS, Marsit CJ, Nelson HH, Birnbaum AE, Eliot M, Christensen BC, McClean MD, Kelsey KT. Gastric reflux is an independent risk factor for laryngopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev. 2013 Jun;22(6):1061-8. doi: 10.1158/1055-9965.EPI-13-0183. Epub 2013 May 23. PubMed PMID: 23703970; PubMed Central PMCID: PMC3681904.