My Bibliography

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Lange AV, Glickman A, Wells K, Mee TC, Carey EP, Kavalieratos D, Bettcher BM, Kluger B, Bekelman DB. Does Cognitive Function Influence the Benefits of Multicomponent Team Interventions?. J Am Med Dir Assoc. 2026 Jan;27(1):105976. doi: 10.1016/j.jamda.2025.105976. Epub 2025 Nov 18. PubMed PMID: 41205997; PubMed Central PMCID: PMC12987410.

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Farro SA, Juarez-Colunga E, Patel C, Bettcher BM, Haynes CA, Huebschmann AG, Nowels D, Tietbohl CK, Shi J, Ritger C, Shanbhag P, Resman K, Sudore RL, Lum HD. Engaging English- and Spanish-speaking older adults with and without possible cognitive impairment in advance care planning group visits: protocol for the ENgaging in Advance Care Planning Talks (ENACT) randomized controlled trial. Trials. 2025 Sep 25;26(1):353. doi: 10.1186/s13063-025-08964-x. PubMed PMID: 40999430; PubMed Central PMCID: PMC12465542.

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Cavalier AN, Smith ME, McWilliams GT, McEntee CM, Bettcher BM, Coughlan C, LaRocca TJ. Epigenetic dysregulation of transposable elements in cognitive impairment and Alzheimer's disease. Geroscience. 2025 Dec;47(6):6731-6748. doi: 10.1007/s11357-025-01765-9. Epub 2025 Aug 8. PubMed PMID: 40779089; PubMed Central PMCID: PMC12638477.

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Bettcher BM, de Oliveira FF, Willette AA, Michalowska MM, Machado LS, Rajbanshi B, Borelli WV, Tansey MG, Rocha A, Suryadevara V, Hu WT. Analysis and interpretation of inflammatory fluid markers in Alzheimer's disease: a roadmap for standardization. J Neuroinflammation. 2025 Apr 15;22(1):105. doi: 10.1186/s12974-025-03432-4. Review. PubMed PMID: 40234920; PubMed Central PMCID: PMC11998147.

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Bettcher BM, Gunn-Sandell LB, Lopez-Esquibel N, Carlson NE, Krupa JR, Lum HD, Holden SK, Greher MR. Integrating home-based video teleneuropsychology into neurology clinical practice: Utility in patients with suspected typical or atypical Alzheimer's disease presentations. Clin Neuropsychol. 2025 Jul;39(5):1155-1177. doi: 10.1080/13854046.2025.2482083. Epub 2025 Mar 27. PubMed PMID: 40145568; PubMed Central PMCID: PMC12303580.

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Tanabe J, Lim MF, Dash S, Pattee J, Steach B, Pressman P, Bettcher BM, Honce JM, Potigailo VA, Colantoni W, Zander D, Thaker AA. Automated Volumetric Software in Dementia: Help or Hindrance to the Neuroradiologist?. AJNR Am J Neuroradiol. 2024 Nov 7;45(11):1737-1744. doi: 10.3174/ajnr.A8406. PubMed PMID: 39362700; PubMed Central PMCID: PMC11543079.

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Jensen AM, DeWitt P, Bettcher BM, Wrobel J, Kechris K, Ghosh D. Kernel machine tests of association using extrinsic and intrinsic cluster evaluation metrics. PLoS Comput Biol. 2024 Nov;20(11):e1012524. doi: 10.1371/journal.pcbi.1012524. eCollection 2024 Nov. PubMed PMID: 39527632; PubMed Central PMCID: PMC11581413.

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Bettcher BM, Lopez Paniagua D, Wang Y, McConnell BV, Coughlan C, Carlisle TC, Thaker AA, Lippitt W, Filley CM, Pelak VS, Shapiro ALB, Heffernan KS, Potter H, Solano A, Boyd J, Carlson NE. Synergistic effects of GFAP and Aβ42: Implications for white matter integrity and verbal memory across the cognitive spectrum. Brain Behav Immun Health. 2024 Oct;40:100834. doi: 10.1016/j.bbih.2024.100834. eCollection 2024 Oct. PubMed PMID: 39206431; PubMed Central PMCID: PMC11357780.

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Shapiro ALB, Coughlan C, Bettcher BM, Pauley ME, Kim J, Bjornstad P, Rajic B, Truong J, Bell C, Choi YJ, Walker KA, Potter H, Liese AD, Dabelea D, Whitlow CT. Biomarkers of Neurodegeneration and Alzheimer's Disease Neuropathology in Adolescents and Young Adults with Youth-Onset Type 1 or Type 2 Diabetes: A Proof-of-Concept Study. Endocrines. 2024 Jun;5(2):197-213. doi: 10.3390/endocrines5020014. Epub 2024 May 6. PubMed PMID: 38764894; PubMed Central PMCID: PMC11101213.

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Pelak VS, Krishnan V, Serva S, Pressman P, Mahmood A, Noteboom L, Bettcher BM, Sillau SH, Callen AL, Thaker AA. Lobar Microbleeds in the Posterior Cortical Atrophy Syndrome: A Comparison to Typical Alzheimer's Disease. Curr Neurol Neurosci Rep. 2024 Feb;24(2):27-33. doi: 10.1007/s11910-024-01330-5. Epub 2024 Jan 23. Review. PubMed PMID: 38261145.

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Pulver RL, Kronberg E, Medenblik LM, Kheyfets VO, Ramos AR, Holtzman DM, Morris JC, Toedebusch CD, Sillau SH, Bettcher BM, Lucey BP, McConnell BV. Mapping sleep's oscillatory events as a biomarker of Alzheimer's disease. Alzheimers Dement. 2024 Jan;20(1):301-315. doi: 10.1002/alz.13420. Epub 2023 Aug 23. PubMed PMID: 37610059; PubMed Central PMCID: PMC10840635.

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Thaker AA, McConnell BV, Rogers DM, Carlson NE, Coughlan C, Jensen AM, Lopez-Paniagua D, Holden SK, Pressman PS, Pelak VS, Filley CM, Potter H, Solano DA, Heffernan KS, Bettcher BM. Astrogliosis, neuritic microstructure, and sex effects: GFAP is an indicator of neuritic orientation in women. Brain Behav Immun. 2023 Oct;113:124-135. doi: 10.1016/j.bbi.2023.06.026. Epub 2023 Jun 30. PubMed PMID: 37394144; PubMed Central PMCID: PMC10584366.

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Walker KA, Le Page LM, Terrando N, Duggan MR, Heneka MT, Bettcher BM. The role of peripheral inflammatory insults in Alzheimer's disease: a review and research roadmap. Mol Neurodegener. 2023 Jun 5;18(1):37. doi: 10.1186/s13024-023-00627-2. Review. PubMed PMID: 37277738; PubMed Central PMCID: PMC10240487.

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Arce Rentería M, Mobley TM, Evangelista ND, Medina LD, Deters KD, Fox-Fuller JT, Minto LR, Avila-Rieger J, Bettcher BM. Representativeness of samples enrolled in Alzheimer's disease research centers. Alzheimers Dement (Amst). 2023 Apr-Jun;15(2):e12450. doi: 10.1002/dad2.12450. eCollection 2023 Apr-Jun. PubMed PMID: 37287650; PubMed Central PMCID: PMC10242202.

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Chiu SY, Wyman-Chick KA, Ferman TJ, Bayram E, Holden SK, Choudhury P, Armstrong MJ. Sex differences in dementia with Lewy bodies: Focused review of available evidence and future directions. Parkinsonism Relat Disord. 2023 Feb;107:105285. doi: 10.1016/j.parkreldis.2023.105285. Epub 2023 Jan 16. Review. PubMed PMID: 36682958; PubMed Central PMCID: PMC10024862.

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Daddato AE, Staton EW, Bettcher BM, Shanbhag P, Lum HD. Human-Centered Design of an Advance Care Planning Group Visit for Mild Cognitive Impairment. Gerontologist. 2022 Sep 7;62(8):1226-1237. doi: 10.1093/geront/gnab181. PubMed PMID: 34940855; PubMed Central PMCID: PMC9451012.

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McConnell BV, Kronberg E, Medenblik LM, Kheyfets VO, Ramos AR, Sillau SH, Pulver RL, Bettcher BM. The Rise and Fall of Slow Wave Tides: Vacillations in Coupled Slow Wave/Spindle Pairing Shift the Composition of Slow Wave Activity in Accordance With Depth of Sleep. Front Neurosci. 2022;16:915934. doi: 10.3389/fnins.2022.915934. eCollection 2022. PubMed PMID: 35812239; PubMed Central PMCID: PMC9260314.

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Holden SK, Pelak VS, Sooy T, Heffernan KS, McConnell BV, Pressman PS, Bettcher BM. Development of the Colorado posterior cortical questionnaire within an Alzheimer's disease study cohort. J Clin Exp Neuropsychol. 2022 Apr;44(3):226-236. doi: 10.1080/13803395.2022.2105820. Epub 2022 Aug 1. PubMed PMID: 35913095; PubMed Central PMCID: PMC9420807.

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McConnell BV, Kronberg E, Teale PD, Sillau SH, Fishback GM, Kaplan RI, Fought AJ, Dhanasekaran AR, Berman BD, Ramos AR, McClure RL, Bettcher BM. The aging slow wave: a shifting amalgam of distinct slow wave and spindle coupling subtypes define slow wave sleep across the human lifespan. Sleep. 2021 Oct 11;44(10). doi: 10.1093/sleep/zsab125. PubMed PMID: 33999194; PubMed Central PMCID: PMC8503831.

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Bettcher BM, Tansey MG, Dorothée G, Heneka MT. Peripheral and central immune system crosstalk in Alzheimer disease - a research prospectus. Nat Rev Neurol. 2021 Nov;17(11):689-701. doi: 10.1038/s41582-021-00549-x. Epub 2021 Sep 14. Review. PubMed PMID: 34522039; PubMed Central PMCID: PMC8439173.

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Grossberg AN, Bettcher BM, Gorgens KA, Ledreux A. Curiosity-Based Interventions Increase Everyday Functioning Score But Not Serum BDNF Levels in a Cohort of Healthy Older Adults. Front Aging. 2021;2:700838. doi: 10.3389/fragi.2021.700838. eCollection 2021. PubMed PMID: 35822037; PubMed Central PMCID: PMC9261453.

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Memel M, Staffaroni AM, Cobigo Y, Casaletto KB, Fonseca C, Bettcher BM, Yassa MA, Elahi FM, Wolf A, Rosen HJ, Kramer JH. APOE moderates the effect of hippocampal blood flow on memory pattern separation in clinically normal older adults. Hippocampus. 2021 Aug;31(8):845-857. doi: 10.1002/hipo.23327. Epub 2021 Apr 9. PubMed PMID: 33835624; PubMed Central PMCID: PMC8295213.

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Bettcher BM, Olson KE, Carlson NE, McConnell BV, Boyd T, Adame V, Solano DA, Anton P, Markham N, Thaker AA, Jensen AM, Dallmann EN, Potter H, Coughlan C. Astrogliosis and episodic memory in late life: higher GFAP is related to worse memory and white matter microstructure in healthy aging and Alzheimer's disease. Neurobiol Aging. 2021 Jul;103:68-77. doi: 10.1016/j.neurobiolaging.2021.02.012. Epub 2021 Feb 26. PubMed PMID: 33845398; PubMed Central PMCID: PMC8313091.

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Medina LD, Heffernan K, Holden S, Simpson A, Bettcher BM. Neural correlates of daily function: A pilot study of the white matter retrogenesis hypothesis and three separate performance-based functional assessments. Neuropsychology. 2021 Jan;35(1):103-110. doi: 10.1037/neu0000649. PubMed PMID: 33393804; PubMed Central PMCID: PMC8363027.

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Coughlan C, Bruce KD, Burgy O, Boyd TD, Michel CR, Garcia-Perez JE, Adame V, Anton P, Bettcher BM, Chial HJ, Königshoff M, Hsieh EWY, Graner M, Potter H. Exosome Isolation by Ultracentrifugation and Precipitation and Techniques for Downstream Analyses. Curr Protoc Cell Biol. 2020 Sep;88(1):e110. doi: 10.1002/cpcb.110. PubMed PMID: 32633898; PubMed Central PMCID: PMC8088761.

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Altendahl M, Cotter DL, Staffaroni AM, Wolf A, Mumford P, Cobigo Y, Casaletto K, Elahi F, Ruoff L, Javed S, Bettcher BM, Fox E, You M, Saloner R, Neylan TC, Kramer JH, Walsh CM. REM sleep is associated with white matter integrity in cognitively healthy, older adults. PLoS One. 2020;15(7):e0235395. doi: 10.1371/journal.pone.0235395. eCollection 2020. PubMed PMID: 32645032; PubMed Central PMCID: PMC7347149.

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Shdo SM, Ranasinghe KG, Sturm VE, Possin KL, Bettcher BM, Stephens ML, Foley JM, You SC, Rosen HJ, Miller BL, Kramer JH, Rankin KP. Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages. Front Neurol. 2020;11:446. doi: 10.3389/fneur.2020.00446. eCollection 2020. PubMed PMID: 32547476; PubMed Central PMCID: PMC7273507.

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Suemoto CK, Gibbons LE, Thacker EL, Jackson JD, Satizabal CL, Bettcher BM, Launer L, Phillips C, White LR, Power MC. Incident prolonged QT interval in midlife and late-life cognitive performance. PLoS One. 2020;15(2):e0229519. doi: 10.1371/journal.pone.0229519. eCollection 2020. PubMed PMID: 32097438; PubMed Central PMCID: PMC7041789.

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Holden SK, Bettcher BM, Pelak VS. Update on posterior cortical atrophy. Curr Opin Neurol. 2020 Feb;33(1):68-73. doi: 10.1097/WCO.0000000000000767. Review. PubMed PMID: 31688098; PubMed Central PMCID: PMC7310594.

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Bettcher BM, Gross AL, Gavett BE, Widaman KF, Fletcher E, Dowling NM, Buckley RF, Arenaza-Urquijo EM, Zahodne LB, Hohman TJ, Vonk JMJ, Rentz DM, Mungas D. Dynamic change of cognitive reserve: associations with changes in brain, cognition, and diagnosis. Neurobiol Aging. 2019 Nov;83:95-104. doi: 10.1016/j.neurobiolaging.2019.08.016. Epub 2019 Aug 21. PubMed PMID: 31585371; PubMed Central PMCID: PMC6977973.

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Munoz E, Filshtein T, Bettcher BM, McLaren D, Hedden T, Tommet D, Mungas D, Therneau T. Cognitive function and neuropathological outcomes: a forward-looking approach. J Neurol. 2019 Dec;266(12):2920-2928. doi: 10.1007/s00415-019-09516-5. Epub 2019 Aug 21. PubMed PMID: 31435771; PubMed Central PMCID: PMC6851487.

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Bateman JR, Filley CM, Kaplan RI, Heffernan KS, Bettcher BM. Lifetime surgical exposure, episodic memory, and forniceal microstructure in older adults. J Clin Exp Neuropsychol. 2019 Dec;41(10):1048-1059. doi: 10.1080/13803395.2019.1647151. Epub 2019 Aug 1. PubMed PMID: 31370773; PubMed Central PMCID: PMC6764849.

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Bateman JR, Filley CM, Ross ED, Bettcher BM, Hubbard HI, Babiak M, Pressman PS. Aprosodia and prosoplegia with right frontal neurodegeneration. Neurocase. 2019 Oct;25(5):187-194. doi: 10.1080/13554794.2019.1646291. Epub 2019 Jul 23. PubMed PMID: 31335278; PubMed Central PMCID: PMC7510567.

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Bettcher BM, Neuhaus J, Wynn MJ, Elahi FM, Casaletto KB, Saloner R, Fitch R, Karydas A, Kramer JH. Increases in a Pro-inflammatory Chemokine, MCP-1, Are Related to Decreases in Memory Over Time. Front Aging Neurosci. 2019;11:25. doi: 10.3389/fnagi.2019.00025. eCollection 2019. PubMed PMID: 30814948; PubMed Central PMCID: PMC6381047.

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Bettcher BM, Johnson SC, Fitch R, Casaletto KB, Heffernan KS, Asthana S, Zetterberg H, Blennow K, Carlsson CM, Neuhaus J, Bendlin BB, Kramer JH. Cerebrospinal Fluid and Plasma Levels of Inflammation Differentially Relate to CNS Markers of Alzheimer's Disease Pathology and Neuronal Damage. J Alzheimers Dis. 2018;62(1):385-397. doi: 10.3233/JAD-170602. PubMed PMID: 29439331; PubMed Central PMCID: PMC6007886.

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Casaletto KB, Staffaroni AM, Elahi F, Fox E, Crittenden PA, You M, Neuhaus J, Glymour M, Bettcher BM, Yaffe K, Kramer JH. Perceived Stress is Associated with Accelerated Monocyte/Macrophage Aging Trajectories in Clinically Normal Adults. Am J Geriatr Psychiatry. 2018 Sep;26(9):952-963. doi: 10.1016/j.jagp.2018.05.004. Epub 2018 Jun 18. PubMed PMID: 30017239; PubMed Central PMCID: PMC6108924.

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Casaletto KB, Elahi FM, Fitch R, Walters S, Fox E, Staffaroni AM, Bettcher BM, Zetterberg H, Karydas A, Rojas JC, Boxer AL, Kramer JH. A comparison of biofluid cytokine markers across platform technologies: Correspondence or divergence?. Cytokine. 2018 Nov;111:481-489. doi: 10.1016/j.cyto.2018.05.032. Epub 2018 Jun 14. PubMed PMID: 29908923; PubMed Central PMCID: PMC6289877.

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Bettcher BM, Ard MC, Reed BR, Benitez A, Simmons A, Larson EB, Sonnen JA, Montine TJ, Li G, Keene CD, Crane PK, Mungas D. Association between Cholesterol Exposure and Neuropathological Findings: The ACT Study. J Alzheimers Dis. 2017;59(4):1307-1315. doi: 10.3233/JAD-161224. PubMed PMID: 28731431; PubMed Central PMCID: PMC5604311.

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Casaletto KB, Elahi FM, Bettcher BM, Neuhaus J, Bendlin BB, Asthana S, Johnson SC, Yaffe K, Carlsson C, Blennow K, Zetterberg H, Kramer JH. Neurogranin, a synaptic protein, is associated with memory independent of Alzheimer biomarkers. Neurology. 2017 Oct 24;89(17):1782-1788. doi: 10.1212/WNL.0000000000004569. Epub 2017 Sep 22. PubMed PMID: 28939668; PubMed Central PMCID: PMC5664306.

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Hamlett ED, Ledreux A, Potter H, Chial HJ, Patterson D, Espinosa JM, Bettcher BM, Granholm AC. Exosomal biomarkers in Down syndrome and Alzheimer's disease. Free Radic Biol Med. 2018 Jan;114:110-121. doi: 10.1016/j.freeradbiomed.2017.08.028. Epub 2017 Sep 5. Review. PubMed PMID: 28882786; PubMed Central PMCID: PMC6135098.

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Parthasarathy V, Frazier DT, Bettcher BM, Jastrzab L, Chao L, Reed B, Mungas D, Weiner M, DeCarli C, Chui H, Kramer JH. Triglycerides are negatively correlated with cognitive function in nondemented aging adults. Neuropsychology. 2017 Sep;31(6):682-688. doi: 10.1037/neu0000335. Epub 2017 Jun 12. PubMed PMID: 28604016; PubMed Central PMCID: PMC5726405.

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Bott NT, Bettcher BM, Yokoyama JS, Frazier DT, Wynn M, Karydas A, Yaffe K, Kramer JH. Youthful Processing Speed in Older Adults: Genetic, Biological, and Behavioral Predictors of Cognitive Processing Speed Trajectories in Aging. Front Aging Neurosci. 2017;9:55. doi: 10.3389/fnagi.2017.00055. eCollection 2017. PubMed PMID: 28344553; PubMed Central PMCID: PMC5344896.

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Casaletto KB, Ward ME, Baker NS, Bettcher BM, Gelfand JM, Li Y, Chen R, Dutt S, Miller B, Kramer JH, Green AJ. Retinal thinning is uniquely associated with medial temporal lobe atrophy in neurologically normal older adults. Neurobiol Aging. 2017 Mar;51:141-147. doi: 10.1016/j.neurobiolaging.2016.12.011. Epub 2016 Dec 21. PubMed PMID: 28068565; PubMed Central PMCID: PMC5554591.

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Ranasinghe KG, Rankin KP, Pressman PS, Perry DC, Lobach IV, Seeley WW, Coppola G, Karydas AM, Grinberg LT, Shany-Ur T, Lee SE, Rabinovici GD, Rosen HJ, Gorno-Tempini ML, Boxer AL, Miller ZA, Chiong W, DeMay M, Kramer JH, Possin KL, Sturm VE, Bettcher BM, Neylan M, Zackey DD, Nguyen LA, Ketelle R, Block N, Wu TQ, Dallich A, Russek N, Caplan A, Geschwind DH, Vossel KA, Miller BL. Distinct Subtypes of Behavioral Variant Frontotemporal Dementia Based on Patterns of Network Degeneration. JAMA Neurol. 2016 Sep 1;73(9):1078-88. doi: 10.1001/jamaneurol.2016.2016. PubMed PMID: 27429218; PubMed Central PMCID: PMC5024785.

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Bettcher BM, Fitch R, Wynn MJ, Lalli MA, Elofson J, Jastrzab L, Mitic L, Miller ZA, Rabinovici GD, Miller BL, Kao AW, Kosik KS, Kramer JH. MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes. Alzheimers Dement (Amst). 2016;3:91-7. doi: 10.1016/j.dadm.2016.05.004. eCollection 2016. PubMed PMID: 27453930; PubMed Central PMCID: PMC4941041.

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Ossenkoppele R, Schonhaut DR, Schöll M, Lockhart SN, Ayakta N, Baker SL, O'Neil JP, Janabi M, Lazaris A, Cantwell A, Vogel J, Santos M, Miller ZA, Bettcher BM, Vossel KA, Kramer JH, Gorno-Tempini ML, Miller BL, Jagust WJ, Rabinovici GD. Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease. Brain. 2016 May;139(Pt 5):1551-67. doi: 10.1093/brain/aww027. Epub 2016 Mar 8. PubMed PMID: 26962052; PubMed Central PMCID: PMC5006248.

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Bettcher BM, Mungas D, Patel N, Elofson J, Dutt S, Wynn M, Watson CL, Stephens M, Walsh CM, Kramer JH. Neuroanatomical substrates of executive functions: Beyond prefrontal structures. Neuropsychologia. 2016 May;85:100-9. doi: 10.1016/j.neuropsychologia.2016.03.001. Epub 2016 Mar 3. PubMed PMID: 26948072; PubMed Central PMCID: PMC4853308.

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Ranasinghe KG, Rankin KP, Lobach IV, Kramer JH, Sturm VE, Bettcher BM, Possin K, Christine You S, Lamarre AK, Shany-Ur T, Stephens ML, Perry DC, Lee SE, Miller ZA, Gorno-Tempini ML, Rosen HJ, Boxer A, Seeley WW, Rabinovici GD, Vossel KA, Miller BL. Cognition and neuropsychiatry in behavioral variant frontotemporal dementia by disease stage. Neurology. 2016 Feb 16;86(7):600-10. doi: 10.1212/WNL.0000000000002373. Epub 2016 Jan 22. PubMed PMID: 26802093; PubMed Central PMCID: PMC4762418.

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Lalli MA, Bettcher BM, Arcila ML, Garcia G, Guzman C, Madrigal L, Ramirez L, Acosta-Uribe J, Baena A, Wojta KJ, Coppola G, Fitch R, de Both MD, Huentelman MJ, Reiman EM, Brunkow ME, Glusman G, Roach JC, Kao AW, Lopera F, Kosik KS. Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease. Mol Psychiatry. 2015 Nov;20(11):1294-300. doi: 10.1038/mp.2015.131. Epub 2015 Sep 1. PubMed PMID: 26324103; PubMed Central PMCID: PMC4759097.

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Frazier DT, Bettcher BM, Dutt S, Patel N, Mungas D, Miller J, Green R, Kramer JH. Relationship between Insulin-Resistance Processing Speed and Specific Executive Function Profiles in Neurologically Intact Older Adults. J Int Neuropsychol Soc. 2015 Sep;21(8):622-8. doi: 10.1017/S1355617715000624. Epub 2015 Aug 14. PubMed PMID: 26272269; PubMed Central PMCID: PMC4764989.