Systematic Examination of Gene Expression and Proteomic Evidence Across Tissues Supports the Role of Mitochondrial Dysregulation in ME/CFS.
Int J Mol Sci.
2026 Feb 19;27(4). doi: 10.3390/ijms27041997. PubMed PMID:
41752134; PubMed Central PMCID:
PMC12940889.
Optimizing Control Definitions in Opioid Use Disorder Genetic Research Using Electronic Health Records.
Addict Biol.
2026 Jan;31(1):e70094. doi: 10.1111/adb.70094. PubMed PMID:
41549723; PubMed Central PMCID:
PMC12813555.
Trajectories of genetic risk across dimensions of alcohol use behaviors.
Addiction.
2026 May;121(5):1153-1165. doi: 10.1111/add.70292. Epub 2025 Dec 23. PubMed PMID:
41437533; PubMed Central PMCID:
PMC13088926.
Risk factors for spontaneous preterm birth are mediated through changes in cervical length.
Commun Med (Lond).
2025 Dec 16;6(1):52. doi: 10.1038/s43856-025-01309-4. PubMed PMID:
41398068; PubMed Central PMCID:
PMC12830857.
Mapping the genetic landscape across 14 psychiatric disorders.
Nature.
2026 Jan;649(8096):406-415. doi: 10.1038/s41586-025-09820-3. Epub 2025 Dec 10. PubMed PMID:
41372416; PubMed Central PMCID:
PMC12779569.
Identifying compounds to treat opiate use disorder by leveraging multi-omic data integration and multiple drug repurposing databases.
Transl Psychiatry.
2025 Nov 21;15(1):528. doi: 10.1038/s41398-025-03721-9. PubMed PMID:
41271629; PubMed Central PMCID:
PMC12711988.
Comprehensive multi-domain classification of Myalgic encephalomyelitis/chronic fatigue syndrome cases and controls in the UK Biobank increases heritability in contrast to single domain classification.
American Society of Human Genetics; 2025 October; Boston, MA, USA. c2025.
The genetic architecture of cervical length is shared with spontaneous preterm birth risk.
Commun Med (Lond).
2025 Aug 14;5(1):352. doi: 10.1038/s43856-025-01078-0. PubMed PMID:
40813921; PubMed Central PMCID:
PMC12354721.
Drinking motives and alcohol sensitivity mediate multidimensional genetic influences on alcohol use behaviors.
Alcohol Clin Exp Res (Hoboken).
2025 May;49(5):1001-1012. doi: 10.1111/acer.70045. Epub 2025 Mar 31. PubMed PMID:
40165496; PubMed Central PMCID:
PMC12098791.
Trans-ancestry Genome-Wide Analyses in UK Biobank Yield Novel Risk Loci for Major Depression.
medRxiv.
2025 Feb 24;. doi: 10.1101/2025.02.22.25322721. PubMed PMID:
40061314; PubMed Central PMCID:
PMC11888526.
Machine Learning Approaches to Predict Alcohol Consumption from Biomarkers in the UK Biobank.
medRxiv.
2024 Dec 24;. doi: 10.1101/2024.12.22.24319486. PubMed PMID:
39763569; PubMed Central PMCID:
PMC11703295.
Genetic architecture and comprehensive phenotypic assessment of alcohol use disorder and related outcomes in All of Us.
American Society of Human Genetics; 2024 November; Denver, CO, USA. c2024.
Alcohol Use Disorder-Associated DNA Methylation in the Nucleus Accumbens and Dorsolateral Prefrontal Cortex.
Biol Psychiatry Glob Open Sci.
2024 Nov;4(6):100375. doi: 10.1016/j.bpsgos.2024.100375. eCollection 2024 Nov. PubMed PMID:
39399155; PubMed Central PMCID:
PMC11470413.
Distinct genetic liability profiles define clinically relevant patient strata across common diseases.
Nat Commun.
2024 Jul 1;15(1):5534. doi: 10.1038/s41467-024-49338-2. PubMed PMID:
38951512; PubMed Central PMCID:
PMC11217418.
Associations between polygenic liability to psychopathology and non-suicidal versus suicidal self-injury.
Am J Med Genet B Neuropsychiatr Genet.
2024 Oct;195(7):e32982. doi: 10.1002/ajmg.b.32982. Epub 2024 Mar 29. PubMed PMID:
38551161; PubMed Central PMCID:
PMC11438949.
Naturalistic symptom trajectories of atypical anorexia nervosa, anorexia nervosa, and bulimia nervosa in a prospective cohort study of United States college students.
Int J Eat Disord.
2024 Apr;57(4):924-936. doi: 10.1002/eat.24152. Epub 2024 Feb 2. PubMed PMID:
38303677; PubMed Central PMCID:
PMC11018494.
Alcohol Use Disorder-Associated DNA Methylation in the Nucleus Accumbens and Dorsolateral Prefrontal Cortex.
medRxiv.
2024 Jan 17;. doi: 10.1101/2024.01.17.23300238. PubMed PMID:
38293028; PubMed Central PMCID:
PMC10827272.
Examining interactions between polygenic scores and interpersonal trauma exposure on alcohol consumption and use disorder in an ancestrally diverse college cohort.
Front Genet.
2023;14:1274381. doi: 10.3389/fgene.2023.1274381. eCollection 2023. PubMed PMID:
38361984; PubMed Central PMCID:
PMC10868390.
Improving the discovery of rare variants associated with alcohol problems by leveraging machine learning phenotype prediction and functional information.
bioRxiv.
2023 Sep 15;. doi: 10.1101/2023.09.11.557163. PubMed PMID:
37745400; PubMed Central PMCID:
PMC10515858.
Investigating genetically stratified subgroups to better understand the etiology of alcohol misuse.
Mol Psychiatry.
2023 Oct;28(10):4225-4233. doi: 10.1038/s41380-023-02174-0. Epub 2023 Jul 25. PubMed PMID:
37488169; PubMed Central PMCID:
PMC10827662.
Missingness adapted group informed clustered (MAGIC)-LASSO: a novel paradigm for phenotype prediction to improve power for genetic loci discovery.
Front Genet.
2023;14:1162690. doi: 10.3389/fgene.2023.1162690. eCollection 2023. PubMed PMID:
37547462; PubMed Central PMCID:
PMC10399453.
Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent NRXN1 and ABCB11 disruptions.
Cell Genom.
2023 Aug 9;3(8):100356. doi: 10.1016/j.xgen.2023.100356. eCollection 2023 Aug 9. PubMed PMID:
37601975; PubMed Central PMCID:
PMC10435376.
Relationship between polygenic risk scores and symptom dimensions of schizophrenia and schizotypy in multiplex families with schizophrenia.
Br J Psychiatry.
2023 Jul;223(1):301-308. doi: 10.1192/bjp.2022.179. PubMed PMID:
36503694; PubMed Central PMCID:
PMC10258219.
Polygenic risk prediction: why and when out-of-sample prediction R(2) can exceed SNP-based heritability.
Am J Hum Genet.
2023 Jul 6;110(7):1207-1215. doi: 10.1016/j.ajhg.2023.06.006. Epub 2023 Jun 27. PubMed PMID:
37379836; PubMed Central PMCID:
PMC10357496.
Case-only exome variation analysis of severe alcohol dependence using a multivariate hierarchical gene clustering approach.
PLoS One.
2023;18(4):e0283985. doi: 10.1371/journal.pone.0283985. eCollection 2023. PubMed PMID:
37098020; PubMed Central PMCID:
PMC10128939.
Multifaceted risk for non-suicidal self-injury only versus suicide attempt in a population-based cohort of adults.
J Affect Disord.
2023 Jul 15;333:474-481. doi: 10.1016/j.jad.2023.04.040. Epub 2023 Apr 20. PubMed PMID:
37084979.
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.
iScience.
2023 May 19;26(5):106701. doi: 10.1016/j.isci.2023.106701. eCollection 2023 May 19. PubMed PMID:
37207277; PubMed Central PMCID:
PMC10189495.
Examining the source of increased bipolar disorder and major depressive disorder common risk variation burden in multiplex schizophrenia families.
Schizophrenia (Heidelb).
2022 Nov 25;8(1):106. doi: 10.1038/s41537-022-00317-w. PubMed PMID:
36434002; PubMed Central PMCID:
PMC9700852.
Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond.
Sci Rep.
2022 Oct 7;12(1):16873. doi: 10.1038/s41598-022-21003-y. PubMed PMID:
36207451; PubMed Central PMCID:
PMC9546890.
Differences in genetic correlations between posttraumatic stress disorder and alcohol-related problems phenotypes compared to alcohol consumption-related phenotypes.
Psychol Med.
2023 Sep;53(12):5767-5777. doi: 10.1017/S0033291722002999. Epub 2022 Sep 30. PubMed PMID:
36177877; PubMed Central PMCID:
PMC10060434.
COVID-19-Induced Inequalities and Mental Health: Testing the Moderating Roles of Self-rated Health and Race/Ethnicity.
J Racial Ethn Health Disparities.
2023 Oct;10(5):2093-2103. doi: 10.1007/s40615-022-01389-1. Epub 2022 Aug 26. PubMed PMID:
36018451; PubMed Central PMCID:
PMC9415252.
Determining the stability of genome-wide factors in BMI between ages 40 to 69 years.
PLoS Genet.
2022 Aug;18(8):e1010303. doi: 10.1371/journal.pgen.1010303. eCollection 2022 Aug. PubMed PMID:
35951648; PubMed Central PMCID:
PMC9398001.
Evaluating the role of common risk variation in the recurrence risk of schizophrenia in multiplex schizophrenia families.
Transl Psychiatry.
2022 Jul 21;12(1):291. doi: 10.1038/s41398-022-02060-3. PubMed PMID:
35864105; PubMed Central PMCID:
PMC9304393.
Genome-wide analysis of schizophrenia and multiple sclerosis identifies shared genomic loci with mixed direction of effects.
Brain Behav Immun.
2022 Aug;104:183-190. doi: 10.1016/j.bbi.2022.06.007. Epub 2022 Jun 14. PubMed PMID:
35714915; NIHMSID:NIHMS1851392.
Identifying the Common Genetic Basis of Antidepressant Response.
Biol Psychiatry Glob Open Sci.
2022 Apr;2(2):115-126. doi: 10.1016/j.bpsgos.2021.07.008. PubMed PMID:
35712048; PubMed Central PMCID:
PMC9117153.
Mapping genomic loci implicates genes and synaptic biology in schizophrenia.
Nature.
2022 Apr;604(7906):502-508. doi: 10.1038/s41586-022-04434-5. Epub 2022 Apr 8. PubMed PMID:
35396580; PubMed Central PMCID:
PMC9392466.
Coffee and energy drink use patterns in college freshmen: associations with adverse health behaviors and risk factors.
BMC Public Health.
2022 Mar 26;22(1):594. doi: 10.1186/s12889-022-13012-3. PubMed PMID:
35346128; PubMed Central PMCID:
PMC8962474.
Case-only rare variant analysis of severe alcohol dependence (AD) using a multivariate hierarchical gene clustering approach. Biorxiv 2022.03.16.484608 [Preprint]. 2022 March. 2022.03.16.484608Available from: https://www.biorxiv.org/content/10.1101/2022.03.16.484608v1. doi: https://doi.org/10.1101/2022.03.16.484608.
Study protocol to quantify the genetic architecture of sonographic cervical length and its relationship to spontaneous preterm birth.
BMJ Open.
2022 Mar 17;12(3):e053631. doi: 10.1136/bmjopen-2021-053631. PubMed PMID:
35301205; PubMed Central PMCID:
PMC8932269.
Differences in Genetic Correlations between Posttraumatic Stress Disorder and Alcohol Use Disorder-Related Phenotypes Compared to Alcohol Consumption-Related Phenotypes. medRxiv 2022.03.02.22271415 [Preprint]. 2022 March. 2022.03.02.22271415v1Available from: https://www. org/content/10.1101/2022.03.02.22271415v1. doi: https://doi.org/10.1101/2022.03.02.22271415.
Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia.
JAMA Psychiatry.
2022 Mar 1;79(3):260-269. doi: 10.1001/jamapsychiatry.2021.3799. PubMed PMID:
35019943; PubMed Central PMCID:
PMC8756361.
The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study.
JAMA Psychiatry.
2021 Nov 1;78(11):1258-1269. doi: 10.1001/jamapsychiatry.2021.2099. PubMed PMID:
34586374; PubMed Central PMCID:
PMC8482304.
Stability of genetic influences on alcohol consumption and BMI across middle and late adulthood.
European Neuropsychopharmacology. 2021 World Congress of Psychiatric Genetics; 2021 October; c2021.
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors.
Biol Psychiatry.
2022 Feb 1;91(3):313-327. doi: 10.1016/j.biopsych.2021.05.029. Epub 2021 Sep 9. PubMed PMID:
34861974; PubMed Central PMCID:
PMC8851871.
DECO: a framework for jointly analyzing de novo and rare case/control variants, and biological pathways.
Brief Bioinform.
2021 Sep 2;22(5). doi: 10.1093/bib/bbab067. PubMed PMID:
33791774; PubMed Central PMCID:
PMC8425460.
Determining the stability of genome-wide factors in BMI between ages 40 to 69 years. Biorxiv 2021.07.28.454172 [Preprint]. 2021 August. 2021.07.28.45417Available from: https://www.biorxiv.org/content/10.1101/2021.07.28.454172v2. doi: https://doi.org/10.1101/2021.07.28.454172.
Potential causal effect of posttraumatic stress disorder on alcohol use disorder and alcohol consumption in individuals of European descent: A Mendelian Randomization Study.
Alcohol Clin Exp Res.
2021 Aug;45(8):1616-1623. doi: 10.1111/acer.14649. Epub 2021 Jun 24. PubMed PMID:
34120358; PubMed Central PMCID:
PMC8429238.
A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple Cohorts.
Biol Psychiatry.
2021 Nov 1;90(9):611-620. doi: 10.1016/j.biopsych.2021.04.018. Epub 2021 May 4. PubMed PMID:
34304866; PubMed Central PMCID:
PMC8500913.
Missingness Adapted Group Informed Clustered (MAGIC)-LASSO: A novel paradigm for prediction in data with widespread non-random missingness. Biorxiv 2021.04.29.442057 [Preprint]. 2021 April. Available from: https://www.biorxiv.org/content/10.1101/2021.04.29.442057v1. doi: https://doi.org/10.1101/2021.04.29.442057.
Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders.
Biol Psychiatry.
2022 Jan 1;91(1):102-117. doi: 10.1016/j.biopsych.2021.02.972. Epub 2021 Mar 23. PubMed PMID:
34099189; PubMed Central PMCID:
PMC8458480.
What would you like to do?