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Arunagiri A, Haataja L, Cunningham CN, Shrestha N, Tsai B, Qi L, Liu M, Arvan P. Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes. Ann N Y Acad Sci. 2018 Apr;1418(1):5-19. doi: 10.1111/nyas.13531. Epub 2018 Jan 28. Review. PubMed PMID: 29377149; PubMed Central PMCID: PMC5934315.
Arunagiri A, Haataja L, Pottekat A, Pamenan F, Kim S, Zeltser LM, Paton AW, Paton JC, Tsai B, Itkin-Ansari P, Kaufman RJ, Liu M, Arvan P. Proinsulin misfolding is an early event in the progression to type 2 diabetes. Elife. 2019 Jun 11;8. doi: 10.7554/eLife.44532. PubMed PMID: 31184302; PubMed Central PMCID: PMC6559786.
Bagchi P, Inoue T, Tsai B. EMC1-dependent stabilization drives membrane penetration of a partially destabilized non-enveloped virus. Elife. 2016 Dec 24;5. doi: 10.7554/eLife.21470. PubMed PMID: 28012275; PubMed Central PMCID: PMC5224922.
Bagchi P, Walczak CP, Tsai B. The endoplasmic reticulum membrane J protein C18 executes a distinct role in promoting simian virus 40 membrane penetration. J Virol. 2015 Apr;89(8):4058-68. doi: 10.1128/JVI.03574-14. Epub 2015 Jan 28. PubMed PMID: 25631089; PubMed Central PMCID: PMC4442405.
Bagchi P, Torres M, Qi L, Tsai B. Selective EMC subunits act as molecular tethers of intracellular organelles exploited during viral entry. Nat Commun. 2020 Feb 28;11(1):1127. doi: 10.1038/s41467-020-14967-w. PubMed PMID: 32111841; PubMed Central PMCID: PMC7048770.
Bagchi P, Liu X, Cho WJ, Tsai B. Lunapark-dependent formation of a virus-induced ER exit site contains multi-tubular ER junctions that promote viral ER-to-cytosol escape. Cell Rep. 2021 Dec 7;37(10):110077. doi: 10.1016/j.celrep.2021.110077. PubMed PMID: 34879280; PubMed Central PMCID: PMC8759150.
Bernardi KM, Williams JM, Inoue T, Schultz A, Tsai B. A deubiquitinase negatively regulates retro-translocation of nonubiquitinated substrates. Mol Biol Cell. 2013 Nov;24(22):3545-56. doi: 10.1091/mbc.E13-06-0332. Epub 2013 Sep 25. PubMed PMID: 24068323; PubMed Central PMCID: PMC3826992.
Bernardi KM, Forster ML, Lencer WI, Tsai B. Derlin-1 facilitates the retro-translocation of cholera toxin. Mol Biol Cell. 2008 Mar;19(3):877-84. doi: 10.1091/mbc.e07-08-0755. Epub 2007 Dec 19. PubMed PMID: 18094046; PubMed Central PMCID: PMC2262961.
Bernardi KM, Williams JM, Kikkert M, van Voorden S, Wiertz EJ, Ye Y, Tsai B. The E3 ubiquitin ligases Hrd1 and gp78 bind to and promote cholera toxin retro-translocation. Mol Biol Cell. 2010 Jan 1;21(1):140-51. doi: 10.1091/mbc.e09-07-0586. Epub 2009 Oct 28. PubMed PMID: 19864457; PubMed Central PMCID: PMC2801707.
Bhattacharya A, Sun S, Wang H, Liu M, Long Q, Yin L, Kersten S, Zhang K, Qi L. Hepatic Sel1L-Hrd1 ER-associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH. EMBO J. 2018 Nov 15;37(22). doi: 10.15252/embj.201899277. Epub 2018 Nov 2. PubMed PMID: 30389665; PubMed Central PMCID: PMC6236331.
Chen CW, Guan BJ, Alzahrani MR, Gao Z, Gao L, Bracey S, Wu J, Mbow CA, Jobava R, Haataja L, Zalavadia AH, Schaffer AE, Lee H, LaFramboise T, Bederman I, Arvan P, Mathews CE, Gerling IC, Kaestner KH, Tirosh B, Engin F, Hatzoglou M. Adaptation to chronic ER stress enforces pancreatic β-cell plasticity. Nat Commun. 2022 Aug 8;13(1):4621. doi: 10.1038/s41467-022-32425-7. PubMed PMID: 35941159; PubMed Central PMCID: PMC9360004.
Chen YJ, Liu X, Tsai B. SV40 Hijacks Cellular Transport, Membrane Penetration, and Disassembly Machineries to Promote Infection. Viruses. 2019 Oct 5;11(10). doi: 10.3390/v11100917. Review. PubMed PMID: 31590347; PubMed Central PMCID: PMC6832212.
Chen YJ, Williams JM, Arvan P, Tsai B. Reticulon protects the integrity of the ER membrane during ER escape of large macromolecular protein complexes. J Cell Biol. 2020 Feb 3;219(2). doi: 10.1083/jcb.201908182. PubMed PMID: 31895406; PubMed Central PMCID: PMC7041682.
Chen YJ, Bagchi P, Tsai B. ER functions are exploited by viruses to support distinct stages of their life cycle. Biochem Soc Trans. 2020 Oct 30;48(5):2173-2184. doi: 10.1042/BST20200395. Review. PubMed PMID: 33119046; PubMed Central PMCID: PMC7880721.
Chen YJ, Knupp J, Arunagiri A, Haataja L, Arvan P, Tsai B. PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones. Nat Commun. 2021 Oct 13;12(1):5991. doi: 10.1038/s41467-021-26225-8. PubMed PMID: 34645803; PubMed Central PMCID: PMC8514460.
Crite M, DiMaio D. Human Papillomavirus L2 Capsid Protein Stabilizes γ-Secretase during Viral Infection. Viruses. 2022 Apr 13;14(4). doi: 10.3390/v14040804. PubMed PMID: 35458534; PubMed Central PMCID: PMC9027364.
Cunningham CN, He K, Arunagiri A, Paton AW, Paton JC, Arvan P, Tsai B. Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in Parallel With Restoration of Wild-Type Insulin Secretion. Diabetes. 2017 Mar;66(3):741-753. doi: 10.2337/db16-1338. Epub 2016 Dec 27. PubMed PMID: 28028074; PubMed Central PMCID: PMC5319713.
Cunningham CN, Williams JM, Knupp J, Arunagiri A, Arvan P, Tsai B. Cells Deploy a Two-Pronged Strategy to Rectify Misfolded Proinsulin Aggregates. Mol Cell. 2019 Aug 8;75(3):442-456.e4. doi: 10.1016/j.molcel.2019.05.011. Epub 2019 Jun 5. PubMed PMID: 31176671; PubMed Central PMCID: PMC6688957.
DeVry CG, Tsai W, Clarke S. Structure of the human gene encoding the protein repair L-isoaspartyl (D-aspartyl) O-methyltransferase. Arch Biochem Biophys. 1996 Nov 15;335(2):321-32. doi: 10.1006/abbi.1996.0513. PubMed PMID: 8914929.
DiMaio D, Emu B, Goodman AL, Mothes W, Justice A. Cancer Microbiology. J Natl Cancer Inst. 2022 May 9;114(5):651-663. doi: 10.1093/jnci/djab212. PubMed PMID: 34850062; PubMed Central PMCID: PMC9086797.
Dupzyk A, Tsai B. How Polyomaviruses Exploit the ERAD Machinery to Cause Infection. Viruses. 2016 Aug 29;8(9). doi: 10.3390/v8090242. Review. PubMed PMID: 27589785; PubMed Central PMCID: PMC5035956.
Dupzyk A, Tsai B. Bag2 Is a Component of a Cytosolic Extraction Machinery That Promotes Membrane Penetration of a Nonenveloped Virus. J Virol. 2018 Aug 1;92(15). doi: 10.1128/JVI.00607-18. Print 2018 Aug 1. PubMed PMID: 29769335; PubMed Central PMCID: PMC6052292.
Dupzyk A, Williams JM, Bagchi P, Inoue T, Tsai B. SGTA-Dependent Regulation of Hsc70 Promotes Cytosol Entry of Simian Virus 40 from the Endoplasmic Reticulum. J Virol. 2017 Jun 15;91(12). doi: 10.1128/JVI.00232-17. Print 2017 Jun 15. PubMed PMID: 28356524; PubMed Central PMCID: PMC5446632.
Erickson KD, Garcea RL, Tsai B. Ganglioside GT1b is a putative host cell receptor for the Merkel cell polyomavirus. J Virol. 2009 Oct;83(19):10275-9. doi: 10.1128/JVI.00949-09. Epub 2009 Jul 15. PubMed PMID: 19605473; PubMed Central PMCID: PMC2748031.
Forster ML, Sivick K, Park YN, Arvan P, Lencer WI, Tsai B. Protein disulfide isomerase-like proteins play opposing roles during retrotranslocation. J Cell Biol. 2006 Jun 19;173(6):853-9. doi: 10.1083/jcb.200602046. PubMed PMID: 16785320; PubMed Central PMCID: PMC2063911.
Forster ML, Mahn JJ, Tsai B. Generating an unfoldase from thioredoxin-like domains. J Biol Chem. 2009 May 8;284(19):13045-56. doi: 10.1074/jbc.M808352200. Epub 2009 Mar 16. PubMed PMID: 19289469; PubMed Central PMCID: PMC2676037.
Fujinaga Y, Wolf AA, Rodighiero C, Wheeler H, Tsai B, Allen L, Jobling MG, Rapoport T, Holmes RK, Lencer WI. Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulm. Mol Biol Cell. 2003 Dec;14(12):4783-93. doi: 10.1091/mbc.e03-06-0354. Epub 2003 Sep 17. PubMed PMID: 13679513; PubMed Central PMCID: PMC284783.
Goodwin EC, Lipovsky A, Inoue T, Magaldi TG, Edwards AP, Van Goor KE, Paton AW, Paton JC, Atwood WJ, Tsai B, DiMaio D. BiP and multiple DNAJ molecular chaperones in the endoplasmic reticulum are required for efficient simian virus 40 infection. mBio. 2011;2(3):e00101-11. doi: 10.1128/mBio.00101-11. Print 2011. PubMed PMID: 21673190; PubMed Central PMCID: PMC3111607.
Guo H, Sun J, Li X, Xiong Y, Wang H, Shu H, Zhu R, Liu Q, Huang Y, Madley R, Wang Y, Cui J, Arvan P, Liu M. Positive charge in the n-region of the signal peptide contributes to efficient post-translational translocation of small secretory preproteins. J Biol Chem. 2018 Feb 9;293(6):1899-1907. doi: 10.1074/jbc.RA117.000922. Epub 2017 Dec 11. PubMed PMID: 29229776; PubMed Central PMCID: PMC5808753.
Haataja L, Manickam N, Soliman A, Tsai B, Liu M, Arvan P. Disulfide Mispairing During Proinsulin Folding in the Endoplasmic Reticulum. Diabetes. 2016 Apr;65(4):1050-60. doi: 10.2337/db15-1345. Epub 2016 Jan 28. PubMed PMID: 26822090; PubMed Central PMCID: PMC4806660.
Haataja L, Arunagiri A, Hassan A, Regan K, Tsai B, Dhayalan B, Weiss MA, Liu M, Arvan P. Distinct states of proinsulin misfolding in MIDY. Cell Mol Life Sci. 2021 Aug;78(16):6017-6031. doi: 10.1007/s00018-021-03871-1. Epub 2021 Jul 10. PubMed PMID: 34245311; PubMed Central PMCID: PMC8316239.
Harwood MC, Dupzyk AJ, Inoue T, DiMaio D, Tsai B. p120 catenin recruits HPV to γ-secretase to promote virus infection. PLoS Pathog. 2020 Oct;16(10):e1008946. doi: 10.1371/journal.ppat.1008946. eCollection 2020 Oct. PubMed PMID: 33085724; PubMed Central PMCID: PMC7577436.
Harwood MC, Woo TT, Takeo Y, DiMaio D, Tsai B. HPV is a cargo for the COPI sorting complex during virus entry. Sci Adv. 2023 Jan 20;9(3):eadc9830. doi: 10.1126/sciadv.adc9830. Epub 2023 Jan 20. PubMed PMID: 36662862; PubMed Central PMCID: PMC9858521.
He K, Ravindran MS, Tsai B. A bacterial toxin and a nonenveloped virus hijack ER-to-cytosol membrane translocation pathways to cause disease. Crit Rev Biochem Mol Biol. 2015;50(6):477-88. doi: 10.3109/10409238.2015.1085826. Epub 2015 Sep 11. Review. PubMed PMID: 26362261; PubMed Central PMCID: PMC4864032.
He K, Cunningham CN, Manickam N, Liu M, Arvan P, Tsai B. PDI reductase acts on Akita mutant proinsulin to initiate retrotranslocation along the Hrd1/Sel1L-p97 axis. Mol Biol Cell. 2015 Oct 1;26(19):3413-23. doi: 10.1091/mbc.E15-01-0034. Epub 2015 Aug 12. PubMed PMID: 26269577; PubMed Central PMCID: PMC4591687.
Huang Y, Xu X, Arvan P, Liu M. Deficient endoplasmic reticulum translocon-associated protein complex limits the biosynthesis of proinsulin and insulin. FASEB J. 2021 May;35(5):e21515. doi: 10.1096/fj.202002774R. PubMed PMID: 33811688; PubMed Central PMCID: PMC8106808.
Hwang J, Qi L. Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways. Trends Biochem Sci. 2018 Aug;43(8):593-605. doi: 10.1016/j.tibs.2018.06.005. Epub 2018 Jun 29. Review. PubMed PMID: 30056836; PubMed Central PMCID: PMC6327314.
Inoue T, Tsai B. A large and intact viral particle penetrates the endoplasmic reticulum membrane to reach the cytosol. PLoS Pathog. 2011 May;7(5):e1002037. doi: 10.1371/journal.ppat.1002037. Epub 2011 May 12. PubMed PMID: 21589906; PubMed Central PMCID: PMC3093372.
Inoue T, Tsai B. A nucleotide exchange factor promotes endoplasmic reticulum-to-cytosol membrane penetration of the nonenveloped virus simian virus 40. J Virol. 2015 Apr;89(8):4069-79. doi: 10.1128/JVI.03552-14. Epub 2015 Feb 4. PubMed PMID: 25653441; PubMed Central PMCID: PMC4442351.
Inoue T, Zhang P, Zhang W, Goodner-Bingham K, Dupzyk A, DiMaio D, Tsai B. γ-Secretase promotes membrane insertion of the human papillomavirus L2 capsid protein during virus infection. J Cell Biol. 2018 Oct 1;217(10):3545-3559. doi: 10.1083/jcb.201804171. Epub 2018 Jul 13. PubMed PMID: 30006461; PubMed Central PMCID: PMC6168257.
Inoue T, Dosey A, Herbstman JF, Ravindran MS, Skiniotis G, Tsai B. ERdj5 Reductase Cooperates with Protein Disulfide Isomerase To Promote Simian Virus 40 Endoplasmic Reticulum Membrane Translocation. J Virol. 2015 Sep;89(17):8897-908. doi: 10.1128/JVI.00941-15. Epub 2015 Jun 17. PubMed PMID: 26085143; PubMed Central PMCID: PMC4524074.
Inoue T, Moore P, Tsai B. How viruses and toxins disassemble to enter host cells. Annu Rev Microbiol. 2011;65:287-305. doi: 10.1146/annurev-micro-090110-102855. Review. PubMed PMID: 21682643.
Inoue T, Tsai B. Regulated Erlin-dependent release of the B12 transmembrane J-protein promotes ER membrane penetration of a non-enveloped virus. PLoS Pathog. 2017 Jun;13(6):e1006439. doi: 10.1371/journal.ppat.1006439. eCollection 2017 Jun. PubMed PMID: 28614383; PubMed Central PMCID: PMC5484543.
Inoue T, Tsai B. The Grp170 nucleotide exchange factor executes a key role during ERAD of cellular misfolded clients. Mol Biol Cell. 2016 May 15;27(10):1650-62. doi: 10.1091/mbc.E16-01-0033. Epub 2016 Mar 30. PubMed PMID: 27030672; PubMed Central PMCID: PMC4865321.
Inoue T, Tsai B. How viruses use the endoplasmic reticulum for entry, replication, and assembly. Cold Spring Harb Perspect Biol. 2013 Jan 1;5(1):a013250. doi: 10.1101/cshperspect.a013250. Review. PubMed PMID: 23284050; PubMed Central PMCID: PMC3579393.
Ji Y, Sun S, Shrestha N, Darragh LB, Shirakawa J, Xing Y, He Y, Carboneau BA, Kim H, An D, Ma M, Oberholzer J, Soleimanpour SA, Gannon M, Liu C, Naji A, Kulkarni RN, Wang Y, Kersten S, Qi L. Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity. Nat Immunol. 2019 Jun;20(6):677-686. doi: 10.1038/s41590-019-0396-z. Epub 2019 May 20. PubMed PMID: 31110312; PubMed Central PMCID: PMC6531334.
Jiang M, Abend JR, Tsai B, Imperiale MJ. Early events during BK virus entry and disassembly. J Virol. 2009 Feb;83(3):1350-8. doi: 10.1128/JVI.02169-08. Epub 2008 Nov 26. PubMed PMID: 19036822; PubMed Central PMCID: PMC2620883.
Kim GH, Shi G, Somlo DR, Haataja L, Song S, Long Q, Nillni EA, Low MJ, Arvan P, Myers MG Jr, Qi L. Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity. J Clin Invest. 2018 Mar 1;128(3):1125-1140. doi: 10.1172/JCI96420. Epub 2018 Feb 19. PubMed PMID: 29457782; PubMed Central PMCID: PMC5824855.
Knupp J, Chen YJ, Arunagiri A, Haataja L, Arvan P, Tsai B. The ER transmembrane protein PGRMC1 recruits misfolded proteins for reticulophagic clearance. Autophagy. 2022 Jan;18(1):228-230. doi: 10.1080/15548627.2021.1997062. Epub 2021 Nov 15. PubMed PMID: 34779709; PubMed Central PMCID: PMC8865224.
Lam AD, Tryoen-Toth P, Tsai B, Vitale N, Stuenkel EL. SNARE-catalyzed fusion events are regulated by Syntaxin1A-lipid interactions. Mol Biol Cell. 2008 Feb;19(2):485-97. doi: 10.1091/mbc.e07-02-0148. Epub 2007 Nov 14. PubMed PMID: 18003982; PubMed Central PMCID: PMC2230580.
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