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Bagchi P, Liu X, Cho WJ, Tsai B. Lunapark-dependent formation of a virus-induced ER exit site contains multi-tubular ER junctions that promote viral ER-to-cytosol escape. Cell Rep. 2021 Dec 7;37(10):110077. doi: 10.1016/j.celrep.2021.110077. PubMed PMID: 34879280; NIHMSID:NIHMS1762844.
Haataja L, Arunagiri A, Hassan A, Regan K, Tsai B, Dhayalan B, Weiss MA, Liu M, Arvan P. Distinct states of proinsulin misfolding in MIDY. Cell Mol Life Sci. 2021 Aug;78(16):6017-6031. doi: 10.1007/s00018-021-03871-1. Epub 2021 Jul 10. PubMed PMID: 34245311; PubMed Central PMCID: PMC8316239.
Xie J, Zhang P, Crite M, Lindsay CV, DiMaio D. Retromer stabilizes transient membrane insertion of L2 capsid protein during retrograde entry of human papillomavirus. Sci Adv. 2021 Jul;7(27). doi: 10.1126/sciadv.abh4276. Print 2021 Jul. PubMed PMID: 34193420.
Speckhart K, Williams JM, Tsai B. How DNA and RNA Viruses Exploit Host Chaperones to Promote Infection. Viruses. 2021 May 21;13(6). doi: 10.3390/v13060958. Review. PubMed PMID: 34064125; PubMed Central PMCID: PMC8224278.
Huang Y, Xu X, Arvan P, Liu M. Deficient endoplasmic reticulum translocon-associated protein complex limits the biosynthesis of proinsulin and insulin. FASEB J. 2021 May;35(5):e21515. doi: 10.1096/fj.202002774R. PubMed PMID: 33811688; PubMed Central PMCID: PMC8106808.
Sui L, Xin Y, Du Q, Georgieva D, Diedenhofen G, Haataja L, Su Q, Zuccaro MV, Kim J, Fu J, Xing Y, He Y, Baum D, Goland RS, Wang Y, Oberholzer J, Barbetti F, Arvan P, Kleiner S, Egli D. Reduced replication fork speed promotes pancreatic endocrine differentiation and controls graft size. JCI Insight. 2021 Mar 8;6(5). doi: 10.1172/jci.insight.141553. PubMed PMID: 33529174; PubMed Central PMCID: PMC8022502.
Xie J, DiMaio D. Traptamer screening: a new functional genomics approach to study virus entry and other cellular processes. FEBS J. 2021 Feb 18;. doi: 10.1111/febs.15775. [Epub ahead of print] Review. PubMed PMID: 33604985; PubMed Central PMCID: PMC8371075.
Liu M, Huang Y, Xu X, Li X, Alam M, Arunagiri A, Haataja L, Ding L, Wang S, Itkin-Ansari P, Kaufman RJ, Tsai B, Qi L, Arvan P. Normal and defective pathways in biogenesis and maintenance of the insulin storage pool. J Clin Invest. 2021 Jan 19;131(2). doi: 10.1172/JCI142240. Review. PubMed PMID: 33463547; PubMed Central PMCID: PMC7810482.
Wu SA, Kersten S, Qi L. Lipoprotein Lipase and Its Regulators: An Unfolding Story. Trends Endocrinol Metab. 2021 Jan;32(1):48-61. doi: 10.1016/j.tem.2020.11.005. Epub 2020 Dec 1. Review. PubMed PMID: 33277156; PubMed Central PMCID: PMC8627828.
Chen YJ, Bagchi P, Tsai B. ER functions are exploited by viruses to support distinct stages of their life cycle. Biochem Soc Trans. 2020 Oct 30;48(5):2173-2184. doi: 10.1042/BST20200395. Review. PubMed PMID: 33119046; PubMed Central PMCID: PMC7880721.
Harwood MC, Dupzyk AJ, Inoue T, DiMaio D, Tsai B. p120 catenin recruits HPV to γ-secretase to promote virus infection. PLoS Pathog. 2020 Oct;16(10):e1008946. doi: 10.1371/journal.ppat.1008946. eCollection 2020 Oct. PubMed PMID: 33085724; PubMed Central PMCID: PMC7577436.
Shrestha N, Liu T, Ji Y, Reinert RB, Torres M, Li X, Zhang M, Tang CA, Hu CA, Liu C, Naji A, Liu M, Lin JD, Kersten S, Arvan P, Qi L. Sel1L-Hrd1 ER-associated degradation maintains β cell identity via TGF-β signaling. J Clin Invest. 2020 Jul 1;130(7):3499-3510. doi: 10.1172/JCI134874. PubMed PMID: 32182217; PubMed Central PMCID: PMC7324191.
Shrestha N, Reinert RB, Qi L. Endoplasmic Reticulum Protein Quality Control in β Cells. Semin Cell Dev Biol. 2020 Jul;103:59-67. doi: 10.1016/j.semcdb.2020.04.006. Epub 2020 May 8. Review. PubMed PMID: 32402517; PubMed Central PMCID: PMC7321887.
Liu X, Tsai B. Ubqln4 Facilitates Endoplasmic Reticulum-to-Cytosol Escape of a Nonenveloped Virus during Infection. J Virol. 2020 May 18;94(11). doi: 10.1128/JVI.00103-20. Print 2020 May 18. PubMed PMID: 32161173; PubMed Central PMCID: PMC7269444.
Spriggs CC, Badieyan S, Verhey KJ, Cianfrocco MA, Tsai B. Golgi-associated BICD adaptors couple ER membrane penetration and disassembly of a viral cargo. J Cell Biol. 2020 May 4;219(5). doi: 10.1083/jcb.201908099. PubMed PMID: 32259203; PubMed Central PMCID: PMC7199864.
Bagchi P, Torres M, Qi L, Tsai B. Selective EMC subunits act as molecular tethers of intracellular organelles exploited during viral entry. Nat Commun. 2020 Feb 28;11(1):1127. doi: 10.1038/s41467-020-14967-w. PubMed PMID: 32111841; PubMed Central PMCID: PMC7048770.
Chen YJ, Williams JM, Arvan P, Tsai B. Reticulon protects the integrity of the ER membrane during ER escape of large macromolecular protein complexes. J Cell Biol. 2020 Feb 3;219(2). doi: 10.1083/jcb.201908182. PubMed PMID: 31895406; PubMed Central PMCID: PMC7041682.
Chen YJ, Liu X, Tsai B. SV40 Hijacks Cellular Transport, Membrane Penetration, and Disassembly Machineries to Promote Infection. Viruses. 2019 Oct 5;11(10). doi: 10.3390/v11100917. Review. PubMed PMID: 31590347; PubMed Central PMCID: PMC6832212.
Cunningham CN, Williams JM, Knupp J, Arunagiri A, Arvan P, Tsai B. Cells Deploy a Two-Pronged Strategy to Rectify Misfolded Proinsulin Aggregates. Mol Cell. 2019 Aug 8;75(3):442-456.e4. doi: 10.1016/j.molcel.2019.05.011. Epub 2019 Jun 5. PubMed PMID: 31176671; PubMed Central PMCID: PMC6688957.
Spriggs CC, Harwood MC, Tsai B. How non-enveloped viruses hijack host machineries to cause infection. Adv Virus Res. 2019;104:97-122. doi: 10.1016/bs.aivir.2019.05.002. Epub 2019 Jul 2. PubMed PMID: 31439154; PubMed Central PMCID: PMC6923802.
Arunagiri A, Haataja L, Pottekat A, Pamenan F, Kim S, Zeltser LM, Paton AW, Paton JC, Tsai B, Itkin-Ansari P, Kaufman RJ, Liu M, Arvan P. Proinsulin misfolding is an early event in the progression to type 2 diabetes. Elife. 2019 Jun 11;8. doi: 10.7554/eLife.44532. PubMed PMID: 31184302; PubMed Central PMCID: PMC6559786.
Ji Y, Sun S, Shrestha N, Darragh LB, Shirakawa J, Xing Y, He Y, Carboneau BA, Kim H, An D, Ma M, Oberholzer J, Soleimanpour SA, Gannon M, Liu C, Naji A, Kulkarni RN, Wang Y, Kersten S, Qi L. Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity. Nat Immunol. 2019 Jun;20(6):677-686. doi: 10.1038/s41590-019-0396-z. Epub 2019 May 20. PubMed PMID: 31110312; PubMed Central PMCID: PMC6531334.
Lin DL, Inoue T, Chen YJ, Chang A, Tsai B, Tai AW. The ER Membrane Protein Complex Promotes Biogenesis of Dengue and Zika Virus Non-structural Multi-pass Transmembrane Proteins to Support Infection. Cell Rep. 2019 May 7;27(6):1666-1674.e4. doi: 10.1016/j.celrep.2019.04.051. PubMed PMID: 31067454; PubMed Central PMCID: PMC6521869.
Bhattacharya A, Sun S, Wang H, Liu M, Long Q, Yin L, Kersten S, Zhang K, Qi L. Hepatic Sel1L-Hrd1 ER-associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH. EMBO J. 2018 Nov 15;37(22). doi: 10.15252/embj.201899277. Epub 2018 Nov 2. PubMed PMID: 30389665; PubMed Central PMCID: PMC6236331.
Inoue T, Zhang P, Zhang W, Goodner-Bingham K, Dupzyk A, DiMaio D, Tsai B. γ-Secretase promotes membrane insertion of the human papillomavirus L2 capsid protein during virus infection. J Cell Biol. 2018 Oct 1;217(10):3545-3559. doi: 10.1083/jcb.201804171. Epub 2018 Jul 13. PubMed PMID: 30006461; PubMed Central PMCID: PMC6168257.
Liu M, Weiss MA, Arunagiri A, Yong J, Rege N, Sun J, Haataja L, Kaufman RJ, Arvan P. Biosynthesis, structure, and folding of the insulin precursor protein. Diabetes Obes Metab. 2018 Sep;20 Suppl 2:28-50. doi: 10.1111/dom.13378. Review. PubMed PMID: 30230185; PubMed Central PMCID: PMC6463291.
Dupzyk A, Tsai B. Bag2 Is a Component of a Cytosolic Extraction Machinery That Promotes Membrane Penetration of a Nonenveloped Virus. J Virol. 2018 Aug 1;92(15). doi: 10.1128/JVI.00607-18. Print 2018 Aug 1. PubMed PMID: 29769335; PubMed Central PMCID: PMC6052292.
Hwang J, Qi L. Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways. Trends Biochem Sci. 2018 Aug;43(8):593-605. doi: 10.1016/j.tibs.2018.06.005. Epub 2018 Jun 29. Review. PubMed PMID: 30056836; PubMed Central PMCID: PMC6327314.
Ravindran MS, Spriggs CC, Verhey KJ, Tsai B. Dynein Engages and Disassembles Cytosol-Localized Simian Virus 40 To Promote Infection. J Virol. 2018 Jun 15;92(12). doi: 10.1128/JVI.00353-18. Print 2018 Jun 15. PubMed PMID: 29593037; PubMed Central PMCID: PMC5974495.
Arunagiri A, Haataja L, Cunningham CN, Shrestha N, Tsai B, Qi L, Liu M, Arvan P. Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes. Ann N Y Acad Sci. 2018 Apr;1418(1):5-19. doi: 10.1111/nyas.13531. Epub 2018 Jan 28. Review. PubMed PMID: 29377149; PubMed Central PMCID: PMC5934315.
Kim GH, Shi G, Somlo DR, Haataja L, Song S, Long Q, Nillni EA, Low MJ, Arvan P, Myers MG Jr, Qi L. Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity. J Clin Invest. 2018 Mar 1;128(3):1125-1140. doi: 10.1172/JCI96420. Epub 2018 Feb 19. PubMed PMID: 29457782; PubMed Central PMCID: PMC5824855.
Guo H, Sun J, Li X, Xiong Y, Wang H, Shu H, Zhu R, Liu Q, Huang Y, Madley R, Wang Y, Cui J, Arvan P, Liu M. Positive charge in the n-region of the signal peptide contributes to efficient post-translational translocation of small secretory preproteins. J Biol Chem. 2018 Feb 9;293(6):1899-1907. doi: 10.1074/jbc.RA117.000922. Epub 2017 Dec 11. PubMed PMID: 29229776; PubMed Central PMCID: PMC5808753.
Shi G, Somlo DRM, Kim GH, Prescianotto-Baschong C, Sun S, Beuret N, Long Q, Rutishauser J, Arvan P, Spiess M, Qi L. ER-associated degradation is required for vasopressin prohormone processing and systemic water homeostasis. J Clin Invest. 2017 Oct 2;127(10):3897-3912. doi: 10.1172/JCI94771. Epub 2017 Sep 18. PubMed PMID: 28920920; PubMed Central PMCID: PMC5617659.
Dupzyk A, Williams JM, Bagchi P, Inoue T, Tsai B. SGTA-Dependent Regulation of Hsc70 Promotes Cytosol Entry of Simian Virus 40 from the Endoplasmic Reticulum. J Virol. 2017 Jun 15;91(12). doi: 10.1128/JVI.00232-17. Print 2017 Jun 15. PubMed PMID: 28356524; PubMed Central PMCID: PMC5446632.
Inoue T, Tsai B. Regulated Erlin-dependent release of the B12 transmembrane J-protein promotes ER membrane penetration of a non-enveloped virus. PLoS Pathog. 2017 Jun;13(6):e1006439. doi: 10.1371/journal.ppat.1006439. eCollection 2017 Jun. PubMed PMID: 28614383; PubMed Central PMCID: PMC5484543.
Qi L, Tsai B, Arvan P. New Insights into the Physiological Role of Endoplasmic Reticulum-Associated Degradation. Trends Cell Biol. 2017 Jun;27(6):430-440. doi: 10.1016/j.tcb.2016.12.002. Epub 2017 Feb 9. Review. PubMed PMID: 28131647; PubMed Central PMCID: PMC5440201.
Ravindran MS, Engelke MF, Verhey KJ, Tsai B. Exploiting the kinesin-1 molecular motor to generate a virus membrane penetration site. Nat Commun. 2017 May 24;8:15496. doi: 10.1038/ncomms15496. PubMed PMID: 28537258; PubMed Central PMCID: PMC5458101.
Cunningham CN, He K, Arunagiri A, Paton AW, Paton JC, Arvan P, Tsai B. Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in Parallel With Restoration of Wild-Type Insulin Secretion. Diabetes. 2017 Mar;66(3):741-753. doi: 10.2337/db16-1338. Epub 2016 Dec 27. PubMed PMID: 28028074; PubMed Central PMCID: PMC5319713.
Bagchi P, Inoue T, Tsai B. EMC1-dependent stabilization drives membrane penetration of a partially destabilized non-enveloped virus. Elife. 2016 Dec 24;5. doi: 10.7554/eLife.21470. PubMed PMID: 28012275; PubMed Central PMCID: PMC5224922.
Dupzyk A, Tsai B. How Polyomaviruses Exploit the ERAD Machinery to Cause Infection. Viruses. 2016 Aug 29;8(9). doi: 10.3390/v8090242. Review. PubMed PMID: 27589785; PubMed Central PMCID: PMC5035956.
Williams JM, Tsai B. Intracellular trafficking of bacterial toxins. Curr Opin Cell Biol. 2016 Aug;41:51-6. doi: 10.1016/j.ceb.2016.03.019. Epub 2016 Apr 13. Review. PubMed PMID: 27084982; PubMed Central PMCID: PMC4983527.
Ravindran MS, Bagchi P, Cunningham CN, Tsai B. Opportunistic intruders: how viruses orchestrate ER functions to infect cells. Nat Rev Microbiol. 2016 Jul;14(7):407-420. doi: 10.1038/nrmicro.2016.60. Epub 2016 Jun 6. Review. PubMed PMID: 27265768; PubMed Central PMCID: PMC5272919.
Ravindran MS, Tsai B. Correction: Viruses Utilize Cellular Cues in Distinct Combination to Undergo Systematic Priming and Uncoating. PLoS Pathog. 2016 Jun;12(6):e1005712. doi: 10.1371/journal.ppat.1005712. eCollection 2016 Jun. PubMed PMID: 27281031; PubMed Central PMCID: PMC4900604.
Inoue T, Tsai B. The Grp170 nucleotide exchange factor executes a key role during ERAD of cellular misfolded clients. Mol Biol Cell. 2016 May 15;27(10):1650-62. doi: 10.1091/mbc.E16-01-0033. Epub 2016 Mar 30. PubMed PMID: 27030672; PubMed Central PMCID: PMC4865321.
Ravindran MS, Tsai B. Viruses Utilize Cellular Cues in Distinct Combination to Undergo Systematic Priming and Uncoating. PLoS Pathog. 2016 Apr;12(4):e1005467. doi: 10.1371/journal.ppat.1005467. eCollection 2016 Apr. Review. PubMed PMID: 27055025; PubMed Central PMCID: PMC4824415.
Haataja L, Manickam N, Soliman A, Tsai B, Liu M, Arvan P. Disulfide Mispairing During Proinsulin Folding in the Endoplasmic Reticulum. Diabetes. 2016 Apr;65(4):1050-60. doi: 10.2337/db15-1345. Epub 2016 Jan 28. PubMed PMID: 26822090; PubMed Central PMCID: PMC4806660.
Sun S, Shi G, Sha H, Ji Y, Han X, Shu X, Ma H, Inoue T, Gao B, Kim H, Bu P, Guber RD, Shen X, Lee AH, Iwawaki T, Paton AW, Paton JC, Fang D, Tsai B, Yates JR 3rd, Wu H, Kersten S, Long Q, Duhamel GE, Simpson KW, Qi L. IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation. Nat Cell Biol. 2015 Dec;17(12):1546-55. doi: 10.1038/ncb3266. Epub 2015 Nov 9. PubMed PMID: 26551274; PubMed Central PMCID: PMC4670240.
He K, Cunningham CN, Manickam N, Liu M, Arvan P, Tsai B. PDI reductase acts on Akita mutant proinsulin to initiate retrotranslocation along the Hrd1/Sel1L-p97 axis. Mol Biol Cell. 2015 Oct 1;26(19):3413-23. doi: 10.1091/mbc.E15-01-0034. Epub 2015 Aug 12. PubMed PMID: 26269577; PubMed Central PMCID: PMC4591687.
He K, Ravindran MS, Tsai B. A bacterial toxin and a nonenveloped virus hijack ER-to-cytosol membrane translocation pathways to cause disease. Crit Rev Biochem Mol Biol. 2015;50(6):477-88. doi: 10.3109/10409238.2015.1085826. Epub 2015 Sep 11. Review. PubMed PMID: 26362261; PubMed Central PMCID: PMC4864032.
Inoue T, Dosey A, Herbstman JF, Ravindran MS, Skiniotis G, Tsai B. ERdj5 Reductase Cooperates with Protein Disulfide Isomerase To Promote Simian Virus 40 Endoplasmic Reticulum Membrane Translocation. J Virol. 2015 Sep;89(17):8897-908. doi: 10.1128/JVI.00941-15. Epub 2015 Jun 17. PubMed PMID: 26085143; PubMed Central PMCID: PMC4524074.
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