My Bibliography

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Messier SP, Mihalko S, Loeser RF, Legault C, Jolla J, Pfruender J, Prosser B, Adrian A, Williamson JD. Glucosamine/chondroitin combined with exercise for the treatment of knee osteoarthritis: a preliminary study. Osteoarthritis Cartilage. 2007 Nov;15(11):1256-66. doi: 10.1016/j.joca.2007.04.016. Epub 2007 Jun 11. PubMed PMID: 17561418.

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Prosser B, Wright N, Hernãndez-Ochoa E, Varney K, Liu Y, Olojo R, Zimmer D, Weber D, Schneider M. S100A1 Binds to the Calmodulin-binding Site of Ryanodine Receptor and Modulates Skeletal Muscle Excitation-Contraction Coupling. Journal of Biological Chemistry. 2008 February; 283(8):5046-5057. doi: 10.1074/jbc.M709231200.

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Wright NT, Prosser BL, Varney KM, Zimmer DB, Schneider MF, Weber DJ. S100A1 and calmodulin compete for the same binding site on ryanodine receptor. J Biol Chem. 2008 Sep 26;283(39):26676-83. doi: 10.1074/jbc.M804432200. Epub 2008 Jul 23. PubMed PMID: 18650434; PubMed Central PMCID: PMC2546546.

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Prosser BL, Hernández-Ochoa EO, Zimmer DB, Schneider MF. The Qgamma component of intra-membrane charge movement is present in mammalian muscle fibres, but suppressed in the absence of S100A1. J Physiol. 2009 Sep 15;587(Pt 18):4523-41. doi: 10.1113/jphysiol.2009.177238. Epub 2009 Aug 3. PubMed PMID: 19651767; PubMed Central PMCID: PMC2766655.

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Prosser B, Hernández‐Ochoa E, Zimmer D, Schneider M. Simultaneous recording of intramembrane charge movement components and calcium release in wild‐type and S100A1 <sup>−/−</sup> muscle fibres. The Journal of Physiology. 2009 September; 587(18):4543-4559. doi: 10.1113/jphysiol.2009.177246.

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Hernández-Ochoa E, Prosser B, Wright N, Contreras M, Weber D, Schneider M. Augmentation of Ca <sub>v</sub> 1 channel current and action potential duration after uptake of S100A1 in sympathetic ganglion neurons. American Journal of Physiology-Cell Physiology. 2009 October; 297(4):C955-C970. doi: 10.1152/ajpcell.00140.2009.

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Prosser B, Ward C, Lederer W. Subcellular Ca2+ signaling in the heart: the role of ryanodine receptor sensitivity. Journal of General Physiology. 2010 August; 136(2):135-142. doi: 10.1085/jgp.201010406.

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Prosser B, Hernández-Ochoa E, Lovering R, Andronache Z, Zimmer D, Melzer W, Schneider M. S100A1 promotes action potential-initiated calcium release flux and force production in skeletal muscle. American Journal of Physiology-Cell Physiology. 2010 November; 299(5):C891-C902. doi: 10.1152/ajpcell.00180.2010.

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Yamaguchi N, Prosser BL, Ghassemi F, Xu L, Pasek DA, Eu JP, Hernández-Ochoa EO, Cannon BR, Wilder PT, Lovering RM, Weber D, Melzer W, Schneider MF, Meissner G. Modulation of sarcoplasmic reticulum Ca2+ release in skeletal muscle expressing ryanodine receptor impaired in regulation by calmodulin and S100A1. Am J Physiol Cell Physiol. 2011 May;300(5):C998-C1012. doi: 10.1152/ajpcell.00370.2010. Epub 2011 Feb 2. PubMed PMID: 21289290; PubMed Central PMCID: PMC3093939.

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Lovering R, O'Neill A, Muriel J, Prosser B, Strong J, Bloch R. Physiology, structure, and susceptibility to injury of skeletal muscle in mice lacking keratin 19-based and desmin-based intermediate filaments. American Journal of Physiology-Cell Physiology. 2011 April; 300(4):C803-C813. doi: 10.1152/ajpcell.00394.2010.

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Prosser BL, Ward CW, Lederer WJ. X-ROS signaling: rapid mechano-chemo transduction in heart. Science. 2011 Sep 9;333(6048):1440-5. doi: 10.1126/science.1202768. PubMed PMID: 21903813.

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Prosser B, Hernández-Ochoa E, Schneider M. S100A1 and calmodulin regulation of ryanodine receptor in striated muscle. Cell Calcium. 2011 October; 50(4):323-331. doi: 10.1016/j.ceca.2011.06.001.

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Khairallah R, Shi G, Sbrana F, Prosser B, Borroto C, Mazaitis M, Hoffman E, Mahurkar A, Sachs F, Sun Y, Chen Y, Raiteri R, Lederer W, Dorsey S, Ward C. Microtubules Underlie Dysfunction in Duchenne Muscular Dystrophy. Science Signaling. 2012 August; 5(236):-. doi: 10.1126/scisignal.2002829.

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Prosser BL, Khairallah RJ, Ziman AP, Ward CW, Lederer WJ. X-ROS signaling in the heart and skeletal muscle: stretch-dependent local ROS regulates [Ca²⁺]i. J Mol Cell Cardiol. 2013 May;58:172-81. doi: 10.1016/j.yjmcc.2012.11.011. Epub 2012 Dec 6. Review. PubMed PMID: 23220288; PubMed Central PMCID: PMC3951390.

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Prosser BL, Ward CW, Lederer WJ. X-ROS signalling is enhanced and graded by cyclic cardiomyocyte stretch. Cardiovasc Res. 2013 May 1;98(2):307-14. doi: 10.1093/cvr/cvt066. Epub 2013 Mar 21. PubMed PMID: 23524301; PubMed Central PMCID: PMC3633162.

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Hohl M, Ardehali H, Azuaje FJ, Breckenridge RA, Doehner W, Eaton P, Ehret GB, Fujita T, Gaetani R, Giacca M, Hasenfuß G, Heymans S, Leite-Moreira AF, Linke WA, Linz D, Lyon A, Mamas MA, Orešič M, Papp Z, Pedrazzini T, Piepoli M, Prosser B, Rizzuto R, Tarone G, Tian R, van Craenenbroeck E, van Rooij E, Wai T, Weiss G, Maack C. Meeting highlights from the 2013 European Society of Cardiology Heart Failure Association Winter Meeting on Translational Heart Failure Research. Eur J Heart Fail. 2014 Jan;16(1):6-14. doi: 10.1002/ejhf.10. Epub 2013 Dec 14. Review. PubMed PMID: 24453095.

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Ward CW, Prosser BL, Lederer WJ. Mechanical stretch-induced activation of ROS/RNS signaling in striated muscle. Antioxid Redox Signal. 2014 Feb 20;20(6):929-36. doi: 10.1089/ars.2013.5517. Epub 2014 Jan 3. Review. PubMed PMID: 23971496; PubMed Central PMCID: PMC3924793.

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Prosser BL, Ward CW. Mechano-chemo transduction tunes the heartstrings. Sci Signal. 2014 Mar 18;7(317):pe7. doi: 10.1126/scisignal.2005214. PubMed PMID: 24643798; PubMed Central PMCID: PMC4372051.

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Zhang M, Prosser B, Bamboye M, Gondim A, Santos C, Martin D, Ghigo A, Perino A, Brewer A, Ward C, Hirsch E, Lederer W, Shah A. Contractile Function During Angiotensin-II Activation. Journal of the American College of Cardiology. 2015 July; 66(3):261-272. doi: 10.1016/j.jacc.2015.05.020.

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Zhang M, Prosser BL, Bamboye MA, Gondim ANS, Santos CX, Martin D, Ghigo A, Perino A, Brewer AC, Ward CW, Hirsch E, Lederer WJ, Shah AM. Contractile Function During Angiotensin-II Activation: Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban Phosphorylation. J Am Coll Cardiol. 2015 Jul 21;66(3):261-272. doi: 10.1016/j.jacc.2015.05.020. PubMed PMID: 26184620; PubMed Central PMCID: PMC4509515.

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Kerr JP, Robison P, Shi G, Bogush AI, Kempema AM, Hexum JK, Becerra N, Harki DA, Martin SS, Raiteri R, Prosser BL, Ward CW. Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle. Nat Commun. 2015 Oct 8;6:8526. doi: 10.1038/ncomms9526. PubMed PMID: 26446751; PubMed Central PMCID: PMC4633818.

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Limbu S, Hoang-Trong TM, Prosser BL, Lederer WJ, Jafri MS. Modeling Local X-ROS and Calcium Signaling in the Heart. Biophys J. 2015 Nov 17;109(10):2037-50. doi: 10.1016/j.bpj.2015.09.031. PubMed PMID: 26588563; PubMed Central PMCID: PMC4656861.

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Previs MJ, Prosser BL, Mun JY, Previs SB, Gulick J, Lee K, Robbins J, Craig R, Lederer WJ, Warshaw DM. Myosin-binding protein C corrects an intrinsic inhomogeneity in cardiac excitation-contraction coupling. Sci Adv. 2015;1(1). doi: 10.1126/sciadv.1400205. PubMed PMID: 25839057; PubMed Central PMCID: PMC4380226.

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Robison P, Caporizzo MA, Ahmadzadeh H, Bogush AI, Chen CY, Margulies KB, Shenoy VB, Prosser BL. Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes. Science. 2016 Apr 22;352(6284):aaf0659. doi: 10.1126/science.aaf0659. PubMed PMID: 27102488; PubMed Central PMCID: PMC5441927.

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Chiou KK, Rocks JW, Chen CY, Cho S, Merkus KE, Rajaratnam A, Robison P, Tewari M, Vogel K, Majkut SF, Prosser BL, Discher DE, Liu AJ. Mechanical signaling coordinates the embryonic heartbeat. Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):8939-44. doi: 10.1073/pnas.1520428113. Epub 2016 Jul 25. PubMed PMID: 27457951; PubMed Central PMCID: PMC4987837.

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Robison P, Prosser BL. Microtubule mechanics in the working myocyte. J Physiol. 2017 Jun 15;595(12):3931-3937. doi: 10.1113/JP273046. Epub 2017 Mar 9. Review. PubMed PMID: 28116814; PubMed Central PMCID: PMC5471505.

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Hu LR, Ackermann MA, Hecker PA, Prosser BL, King B, O'Connell KA, Grogan A, Meyer LC, Berndsen CE, Wright NT, Jonathan Lederer W, Kontrogianni-Konstantopoulos A. Deregulated Ca(2+) cycling underlies the development of arrhythmia and heart disease due to mutant obscurin. Sci Adv. 2017 Jun;3(6):e1603081. doi: 10.1126/sciadv.1603081. eCollection 2017 Jun. PubMed PMID: 28630914; PubMed Central PMCID: PMC5462502.

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Nemani N, Carvalho E, Tomar D, Dong Z, Ketschek A, Breves S, Jaña F, Worth A, Heffler J, Palaniappan P, Tripathi A, Subbiah R, Riitano M, Seelam A, Manfred T, Itoh K, Meng S, Sesaki H, Craigen W, Rajan S, Shanmughapriya S, Caplan J, Prosser B, Gill D, Stathopulos P, Gallo G, Chan D, Mishra P, Madesh M. MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca2+ Stress. Cell Reports. 2018 April; 23(4):1005-1019. doi: 10.1016/j.celrep.2018.03.098.

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Chen CY, Caporizzo MA, Bedi K, Vite A, Bogush AI, Robison P, Heffler JG, Salomon AK, Kelly NA, Babu A, Morley MP, Margulies KB, Prosser BL. Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure. Nat Med. 2018 Aug;24(8):1225-1233. doi: 10.1038/s41591-018-0046-2. Epub 2018 Jun 11. PubMed PMID: 29892068; PubMed Central PMCID: PMC6195768.

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Caporizzo MA, Chen CY, Salomon AK, Margulies KB, Prosser BL. Microtubules Provide a Viscoelastic Resistance to Myocyte Motion. Biophys J. 2018 Nov 6;115(9):1796-1807. doi: 10.1016/j.bpj.2018.09.019. Epub 2018 Sep 28. PubMed PMID: 30322798; PubMed Central PMCID: PMC6224693.

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Cho S, Vashisth M, Abbas A, Majkut S, Vogel K, Xia Y, Ivanovska IL, Irianto J, Tewari M, Zhu K, Tichy ED, Mourkioti F, Tang HY, Greenberg RA, Prosser BL, Discher DE. Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest. Dev Cell. 2019 Jun 17;49(6):920-935.e5. doi: 10.1016/j.devcel.2019.04.020. Epub 2019 May 16. PubMed PMID: 31105008; PubMed Central PMCID: PMC6581604.

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Caporizzo MA, Chen CY, Prosser BL. Cardiac microtubules in health and heart disease. Exp Biol Med (Maywood). 2019 Nov;244(15):1255-1272. doi: 10.1177/1535370219868960. Epub 2019 Aug 9. Review. PubMed PMID: 31398994; PubMed Central PMCID: PMC6880149.

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Heffler J, Shah PP, Robison P, Phyo S, Veliz K, Uchida K, Bogush A, Rhoades J, Jain R, Prosser BL. A Balance Between Intermediate Filaments and Microtubules Maintains Nuclear Architecture in the Cardiomyocyte. Circ Res. 2020 Jan 31;126(3):e10-e26. doi: 10.1161/CIRCRESAHA.119.315582. Epub 2019 Dec 11. PubMed PMID: 31822208; PubMed Central PMCID: PMC7029779.

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Caporizzo MA, Chen CY, Bedi K, Margulies KB, Prosser BL. Microtubules Increase Diastolic Stiffness in Failing Human Cardiomyocytes and Myocardium. Circulation. 2020 Mar 17;141(11):902-915. doi: 10.1161/CIRCULATIONAHA.119.043930. Epub 2020 Jan 16. PubMed PMID: 31941365; PubMed Central PMCID: PMC7078018.

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Chen CY, Salomon AK, Caporizzo MA, Curry S, Kelly NA, Bedi K, Bogush AI, Krämer E, Schlossarek S, Janiak P, Moutin MJ, Carrier L, Margulies KB, Prosser BL. Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes. Circ Res. 2020 Jul 3;127(2):e14-e27. doi: 10.1161/CIRCRESAHA.119.315947. Epub 2020 Apr 10. PubMed PMID: 32272864; PubMed Central PMCID: PMC7334093.

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Margulies KB, Prosser BL. Tubulin Detyrosination: An Emerging Therapeutic Target in Hypertrophic Cardiomyopathy. Circ Heart Fail. 2021 Jan;14(1):e008006. doi: 10.1161/CIRCHEARTFAILURE.120.008006. Epub 2021 Jan 12. PubMed PMID: 33430601; PubMed Central PMCID: PMC7855801.

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Shah PP, Lv W, Rhoades JH, Poleshko A, Abbey D, Caporizzo MA, Linares-Saldana R, Heffler JG, Sayed N, Thomas D, Wang Q, Stanton LJ, Bedi K, Morley MP, Cappola TP, Owens AT, Margulies KB, Frank DB, Wu JC, Rader DJ, Yang W, Prosser BL, Musunuru K, Jain R. Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes. Cell Stem Cell. 2021 May 6;28(5):938-954.e9. doi: 10.1016/j.stem.2020.12.016. Epub 2021 Feb 1. PubMed PMID: 33529599; PubMed Central PMCID: PMC8106635.

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Liu CF, Ni Y, Moravec CS, Morley M, Ashley EA, Cappola TP, Margulies KB, Tang WHW. Whole-Transcriptome Profiling of Human Heart Tissues Reveals the Potential Novel Players and Regulatory Networks in Different Cardiomyopathy Subtypes of Heart Failure. Circ Genom Precis Med. 2021 Feb;14(1):e003142. doi: 10.1161/CIRCGEN.120.003142. Epub 2021 Feb 1. PubMed PMID: 33517678; PubMed Central PMCID: PMC7887094.

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Scarborough EA, Uchida K, Vogel M, Erlitzki N, Iyer M, Phyo SA, Bogush A, Kehat I, Prosser BL. Microtubules orchestrate local translation to enable cardiac growth. Nat Commun. 2021 Mar 11;12(1):1547. doi: 10.1038/s41467-021-21685-4. PubMed PMID: 33707436; PubMed Central PMCID: PMC7952726.

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Chen T, Rohacek AM, Caporizzo M, Nankali A, Smits JJ, Oostrik J, Lanting CP, Kücük E, Gilissen C, van de Kamp JM, Pennings RJE, Rakowiecki SM, Kaestner KH, Ohlemiller KK, Oghalai JS, Kremer H, Prosser BL, Epstein DJ. Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing. Dev Cell. 2021 May 17;56(10):1526-1540.e7. doi: 10.1016/j.devcel.2021.04.017. Epub 2021 May 7. PubMed PMID: 33964205; PubMed Central PMCID: PMC8137675.

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Limbu S, Prosser BL, Lederer WJ, Ward CW, Jafri MS. X-ROS Signaling Depends on Length-Dependent Calcium Buffering by Troponin. Cells. 2021 May 13;10(5). doi: 10.3390/cells10051189. PubMed PMID: 34068012; PubMed Central PMCID: PMC8152234.

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Salomon A, Phyo S, Okami N, Heffler J, Robison P, Bogush A, Prosser B. Desmin intermediate filaments and tubulin detyrosination stabilize growing microtubules in the cardiomyocyte. [Preprint]. 2021 May. doi: 10.1101/2021.05.26.445641.

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Caporizzo MA, Prosser BL. Need for Speed: The Importance of Physiological Strain Rates in Determining Myocardial Stiffness. Front Physiol. 2021;12:696694. doi: 10.3389/fphys.2021.696694. eCollection 2021. PubMed PMID: 34393820; PubMed Central PMCID: PMC8361601.

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Uchida K, Scarborough EA, Prosser BL. Cardiomyocyte Microtubules: Control of Mechanics, Transport, and Remodeling. Annu Rev Physiol. 2022 Feb 10;84:257-283. doi: 10.1146/annurev-physiol-062421-040656. Epub 2021 Oct 6. Review. PubMed PMID: 34614374; PubMed Central PMCID: PMC9097619.

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McAfee Q, Chen CY, Yang Y, Caporizzo MA, Morley M, Babu A, Jeong S, Brandimarto J, Bedi KC Jr, Flam E, Cesare J, Cappola TP, Margulies K, Prosser B, Arany Z. Truncated titin proteins in dilated cardiomyopathy. Sci Transl Med. 2021 Nov 3;13(618):eabd7287. doi: 10.1126/scitranslmed.abd7287. Epub 2021 Nov 3. PubMed PMID: 34731015; PubMed Central PMCID: PMC9236909.

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Phyo SA, Uchida K, Chen CY, Caporizzo MA, Bedi K, Griffin J, Margulies K, Prosser BL. Transcriptional, Post-Transcriptional, and Post-Translational Mechanisms Rewrite the Tubulin Code During Cardiac Hypertrophy and Failure. Front Cell Dev Biol. 2022;10:837486. doi: 10.3389/fcell.2022.837486. eCollection 2022. PubMed PMID: 35433678; PubMed Central PMCID: PMC9010559.

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Caporizzo MA, Prosser BL. The microtubule cytoskeleton in cardiac mechanics and heart failure. Nat Rev Cardiol. 2022 Jun;19(6):364-378. doi: 10.1038/s41569-022-00692-y. Epub 2022 Apr 19. Review. PubMed PMID: 35440741; PubMed Central PMCID: PMC9270871.

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Prosser BL, Helbig I. Base editing the synapse: Modeling a complex neurological disorder in non-human primates. Mol Ther. 2022 Jun 1;30(6):2114-2116. doi: 10.1016/j.ymthe.2022.05.009. Epub 2022 May 24. PubMed PMID: 35613622; PubMed Central PMCID: PMC9171259.

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Prosser B, Helbig I. Base editing the synapse: Modeling a complex neurological disorder in non-human primates. Molecular Therapy. 2022 June; 30(6):2114-2116. doi: 10.1016/j.ymthe.2022.05.009.

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Xian J, Parthasarathy S, Ruggiero SM, Balagura G, Fitch E, Helbig K, Gan J, Ganesan S, Kaufman MC, Ellis CA, Lewis-Smith D, Galer P, Cunningham K, O'Brien M, Cosico M, Baker K, Darling A, Veiga de Goes F, El Achkar CM, Doering JH, Furia F, García-Cazorla Á, Gardella E, Geertjens L, Klein C, Kolesnik-Taylor A, Lammertse H, Lee J, Mackie A, Misra-Isrie M, Olson H, Sexton E, Sheidley B, Smith L, Sotero L, Stamberger H, Syrbe S, Thalwitzer KM, van Berkel A, van Haelst M, Yuskaitis C, Weckhuysen S, Prosser B, Son Rigby C, Demarest S, Pierce S, Zhang Y, Møller RS, Bruining H, Poduri A, Zara F, Verhage M, Striano P, Helbig I. Assessing the landscape of STXBP1-related disorders in 534 individuals. Brain. 2022 Jun 3;145(5):1668-1683. doi: 10.1093/brain/awab327. PubMed PMID: 35190816; PubMed Central PMCID: PMC9166568.