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Audesse AJ, Karashchuk G, Gardell ZA, Lakis NS, Maybury-Lewis SY, Brown AK, Leeman DS, Teo YV, Neretti N, Anthony D, Brodsky AS, Webb AE. FOXO3 regulates a common genomic program in aging and glioblastoma stem cells. Aging and cancer. Forthcoming; 2(4):137.
Maybury-Lewis SY, Brown AK, Yeary M, Sloutskin A, Dhakal S, Juven-Gershon T, Webb AE. Changing and stable chromatin accessibility supports transcriptional overhaul during neural stem cell activation and is altered with age. Aging Cell. 2021 Nov;20(11):e13499. doi: 10.1111/acel.13499. Epub 2021 Oct 23. PubMed PMID: 34687484; PubMed Central PMCID: PMC8590101.
Hajdarovic KH, Yu D, Lexi-Amber H, Evans S, Neretti N, Webb AE. Single cell analysis of the aging hypothalamus. bioRxiv. 2021 March. doi: https://doi.org/10.1101/2021.03.07.434282.
Audesse AJ, Webb AE. Mechanisms of enhanced quiescence in neural stem cell aging. Mech Ageing Dev. 2020 Oct;191:111323. doi: 10.1016/j.mad.2020.111323. Epub 2020 Aug 8. Review. PubMed PMID: 32781077; PubMed Central PMCID: PMC7592125.
Maybury-Lewis SY, Webb AE. Taking Prisoners: Vimentin Cages Capture Proteasomes during NSC Activation. Cell Stem Cell. 2020 Apr 2;26(4):473-475. doi: 10.1016/j.stem.2020.03.001. PubMed PMID: 32243805.
Audesse AJ, Dhakal S, Hassell LA, Gardell Z, Nemtsova Y, Webb AE. FOXO3 directly regulates an autophagy network to functionally regulate proteostasis in adult neural stem cells. PLoS Genet. 2019 Apr;15(4):e1008097. doi: 10.1371/journal.pgen.1008097. eCollection 2019 Apr. PubMed PMID: 30973875; PubMed Central PMCID: PMC6478346.
Schäffner I, Minakaki G, Khan MA, Balta EA, Schlötzer-Schrehardt U, Schwarz TJ, Beckervordersandforth R, Winner B, Webb AE, DePinho RA, Paik J, Wurst W, Klucken J, Lie DC. FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis. Neuron. 2018 Sep 19;99(6):1188-1203.e6. doi: 10.1016/j.neuron.2018.08.017. Epub 2018 Sep 6. PubMed PMID: 30197237; PubMed Central PMCID: PMC6186958.
Atkinson EG, Audesse AJ, Palacios JA, Bobo DM, Webb AE, Ramachandran S, Henn BM. No Evidence for Recent Selection at FOXP2 among Diverse Human Populations. Cell. 2018 Sep 6;174(6):1424-1435.e15. doi: 10.1016/j.cell.2018.06.048. Epub 2018 Aug 2. PubMed PMID: 30078708; PubMed Central PMCID: PMC6128738.
Audesse AJ, Webb AE. Enhancing Lysosomal Activation Restores Neural Stem Cell Function During Aging. J Exp Neurosci. 2018;12:1179069518795874. doi: 10.1177/1179069518795874. eCollection 2018. PubMed PMID: 30158826; PubMed Central PMCID: PMC6109844.
Leeman DS, Hebestreit K, Ruetz T, Webb AE, McKay A, Pollina EA, Dulken BW, Zhao X, Yeo RW, Ho TT, Mahmoudi S, Devarajan K, Passegué E, Rando TA, Frydman J, Brunet A. Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging. Science. 2018 Mar 16;359(6381):1277-1283. doi: 10.1126/science.aag3048. Epub 2018 Mar 15. PubMed PMID: 29590078; PubMed Central PMCID: PMC5915358.
Brown AK, Webb AE. Regulation of FOXO Factors in Mammalian Cells. Curr Top Dev Biol. 2018;127:165-192. doi: 10.1016/bs.ctdb.2017.10.006. Epub 2017 Nov 15. Review. PubMed PMID: 29433737; PubMed Central PMCID: PMC6383790.
Kim SY, Webb AE. Neuronal functions of FOXO/DAF-16. Nutr Healthy Aging. 2017 Mar 31;4(2):113-126. doi: 10.3233/NHA-160009. Review. PubMed PMID: 28447066; PubMed Central PMCID: PMC5389038.
Webb AE, Kundaje A, Brunet A. Characterization of the direct targets of FOXO transcription factors throughout evolution. Aging Cell. 2016 Aug;15(4):673-85. doi: 10.1111/acel.12479. Epub 2016 Apr 8. PubMed PMID: 27061590; PubMed Central PMCID: PMC4933671.
Ahlenius H, Chanda S, Webb AE, Yousif I, Karmazin J, Prusiner SB, Brunet A, Südhof TC, Wernig M. FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice. Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):8514-9. doi: 10.1073/pnas.1607079113. Epub 2016 Jul 11. PubMed PMID: 27402759; PubMed Central PMCID: PMC4968717.
Gopinath SD, Webb AE, Brunet A, Rando TA. FOXO3 promotes quiescence in adult muscle stem cells during the process of self-renewal. Stem Cell Reports. 2014 Apr 8;2(4):414-26. doi: 10.1016/j.stemcr.2014.02.002. eCollection 2014 Apr 8. PubMed PMID: 24749067; PubMed Central PMCID: PMC3986584.
Webb AE, Brunet A. FOXO transcription factors: key regulators of cellular quality control. Trends Biochem Sci. 2014 Apr;39(4):159-69. doi: 10.1016/j.tibs.2014.02.003. Epub 2014 Mar 13. Review. PubMed PMID: 24630600; PubMed Central PMCID: PMC4021867.
Brunet A, Mahmoudi S, Mancini E, Rafalski VA, Webb AE. Longevity pathways in mammalian cells. Annual Review of Gerontology and Geriatrics. 2014; 34.
Wapinski OL, Vierbuchen T, Qu K, Lee QY, Chanda S, Fuentes DR, Giresi PG, Ng YH, Marro S, Neff NF, Drechsel D, Martynoga B, Castro DS, Webb AE, Südhof TC, Brunet A, Guillemot F, Chang HY, Wernig M. Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons. Cell. 2013 Oct 24;155(3):621-35. doi: 10.1016/j.cell.2013.09.028. Epub 2013 Oct 24. PubMed PMID: 24243019; PubMed Central PMCID: PMC3871197.
Webb AE, Pollina EA, Vierbuchen T, Urbán N, Ucar D, Leeman DS, Martynoga B, Sewak M, Rando TA, Guillemot F, Wernig M, Brunet A. FOXO3 shares common targets with ASCL1 genome-wide and inhibits ASCL1-dependent neurogenesis. Cell Rep. 2013 Aug 15;4(3):477-91. doi: 10.1016/j.celrep.2013.06.035. Epub 2013 Jul 25. PubMed PMID: 23891001; PubMed Central PMCID: PMC3838667.
Webb AE, Brunet A. FOXO flips the longevity SWItch. Nat Cell Biol. 2013 May;15(5):444-6. doi: 10.1038/ncb2749. PubMed PMID: 23636422.
Calnan DR, Webb AE, White JL, Stowe TR, Goswami T, Shi X, Espejo A, Bedford MT, Gozani O, Gygi SP, Brunet A. Methylation by Set9 modulates FoxO3 stability and transcriptional activity. Aging (Albany NY). 2012 Jul;4(7):462-79. doi: 10.18632/aging.100471. PubMed PMID: 22820736; PubMed Central PMCID: PMC3433933.
Brett JO, Renault VM, Rafalski VA, Webb AE, Brunet A. The microRNA cluster miR-106b~25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation. Aging (Albany NY). 2011 Feb;3(2):108-24. doi: 10.18632/aging.100285. PubMed PMID: 21386132; PubMed Central PMCID: PMC3082007.
Renault VM, Rafalski VA, Morgan AA, Salih DA, Brett JO, Webb AE, Villeda SA, Thekkat PU, Guillerey C, Denko NC, Palmer TD, Butte AJ, Brunet A. FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell. 2009 Nov 6;5(5):527-39. doi: 10.1016/j.stem.2009.09.014. PubMed PMID: 19896443; PubMed Central PMCID: PMC2775802.
Webb AE, Driever W, Kimelman D. psoriasis regulates epidermal development in zebrafish. Dev Dyn. 2008 Apr;237(4):1153-64. doi: 10.1002/dvdy.21509. PubMed PMID: 18351656.
Webb AE, Sanderford J, Frank D, Talbot WS, Driever W, Kimelman D. Laminin alpha5 is essential for the formation of the zebrafish fins. Dev Biol. 2007 Nov 15;311(2):369-82. doi: 10.1016/j.ydbio.2007.08.034. Epub 2007 Aug 28. PubMed PMID: 17919534.
Choudhury SA, Asefa B, Webb A, Ramotar D, Chow TY. Functional and genetic analysis of the Saccharomyces cerevisiae RNC1/TRM2: evidences for its involvement in DNA double-strand break repair. Mol Cell Biochem. 2007 Jun;300(1-2):215-26. doi: 10.1007/s11010-006-9386-1. Epub 2007 Jan 5. PubMed PMID: 17205207.
Pyati UJ, Webb AE, Kimelman D. Transgenic zebrafish reveal stage-specific roles for Bmp signaling in ventral and posterior mesoderm development. Development. 2005 May;132(10):2333-43. doi: 10.1242/dev.01806. Epub 2005 Apr 13. PubMed PMID: 15829520.
Webb AE, Kimelman D. Analysis of early epidermal development in zebrafish. Methods Mol Biol. 2005;289:137-46. doi: 10.1385/1-59259-830-7:137. PubMed PMID: 15502179.
Lemieux J, Lakowski B, Webb A, Meng Y, Ubach A, Bussière F, Barnes T, Hekimi S. Regulation of physiological rates in Caenorhabditis elegans by a tRNA-modifying enzyme in the mitochondria. Genetics. 2001 Sep;159(1):147-57. doi: 10.1093/genetics/159.1.147. PubMed PMID: 11560893; PubMed Central PMCID: PMC1461807.
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