My Bibliography

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Minns MS, Liboro K, Lima TS, Abbondante S, Miller BA, Marshall ME, Tran-Chau J, Roistacher A, Rietsch A, Dubyak GR, Pearlman E. NLRP3 selectively drives IL-1β secretion by Pseudomonas aeruginosa infected neutrophils and regulates corneal disease severity. Nature Communications. Forthcoming.

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Minns MS, Liboro K, Lima TS, Abbondante S, Miller BA, Marshall ME, Tran Chau J, Roistacher A, Rietsch A, Dubyak GR, Pearlman E. NLRP3 selectively drives IL-1β secretion by Pseudomonas aeruginosa infected neutrophils and regulates corneal disease severity. Nat Commun. 2023 Sep 20;14(1):5832. doi: 10.1038/s41467-023-41391-7. PubMed PMID: 37730693; PubMed Central PMCID: PMC10511713.

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Dubyak GR, Miller BA, Pearlman E. Pyroptosis in neutrophils: Multimodal integration of inflammasome and regulated cell death signaling pathways. Immunol Rev. 2023 Mar;314(1):229-249. doi: 10.1111/imr.13186. Epub 2023 Jan 19. Review. PubMed PMID: 36656082; PubMed Central PMCID: PMC10407921.

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Kundracik E, Trichka J, Díaz Aponte J, Roistacher A, Rietsch A. PopB-PcrV Interactions Are Essential for Pore Formation in the Pseudomonas aeruginosa Type III Secretion System Translocon. mBio. 2022 Oct 26;13(5):e0238122. doi: 10.1128/mbio.02381-22. Epub 2022 Sep 26. PubMed PMID: 36154276; PubMed Central PMCID: PMC9600203.

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Ratitong B, Marshall ME, Dragan MA, Anunciado CM, Abbondante S, Pearlman E. Differential Roles for IL-1α and IL-1β in Pseudomonas aeruginosa Corneal Infection. J Immunol. 2022 Aug 1;209(3):548-558. doi: 10.4049/jimmunol.2200110. PubMed PMID: 35851538; PubMed Central PMCID: PMC9922050.

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Armentrout EI, Kundracik EC, Rietsch A. Cell-type-specific hypertranslocation of effectors by the Pseudomonas aeruginosa type III secretion system. Mol Microbiol. 2021 Feb;115(2):305-319. doi: 10.1111/mmi.14617. Epub 2020 Nov 5. PubMed PMID: 33012037; PubMed Central PMCID: PMC7897236.

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Ngo TD, Perdu C, Jneid B, Ragno M, Novion Ducassou J, Kraut A, Couté Y, Stopford C, Attrée I, Rietsch A, Faudry E. The PopN Gate-keeper Complex Acts on the ATPase PscN to Regulate the T3SS Secretion Switch from Early to Middle Substrates in Pseudomonas aeruginosa. J Mol Biol. 2020 Dec 4;432(24):166690. doi: 10.1016/j.jmb.2020.10.024. Epub 2020 Oct 22. PubMed PMID: 33289667.

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Jensen JL, Yamini S, Rietsch A, Spiller BW. "The structure of the Type III secretion system export gate with CdsO, an ATPase lever arm". PLoS Pathog. 2020 Oct;16(10):e1008923. doi: 10.1371/journal.ppat.1008923. eCollection 2020 Oct. PubMed PMID: 33048983; PubMed Central PMCID: PMC7584215.

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Karmakar M, Minns M, Greenberg EN, Diaz-Aponte J, Pestonjamasp K, Johnson JL, Rathkey JK, Abbott DW, Wang K, Shao F, Catz SD, Dubyak GR, Pearlman E. N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis. Nat Commun. 2020 May 5;11(1):2212. doi: 10.1038/s41467-020-16043-9. PubMed PMID: 32371889; PubMed Central PMCID: PMC7200749.

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Sharp JS, Rietsch A, Dove SL. RNase E Promotes Expression of Type III Secretion System Genes in Pseudomonas aeruginosa. J Bacteriol. 2019 Nov 15;201(22). doi: 10.1128/JB.00336-19. Print 2019 Nov 15. PubMed PMID: 31481542; PubMed Central PMCID: PMC6805110.

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Rathkey JK, Zhao J, Liu Z, Chen Y, Yang J, Kondolf HC, Benson BL, Chirieleison SM, Huang AY, Dubyak GR, Xiao TS, Li X, Abbott DW. Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis. Sci Immunol. 2018 Aug 24;3(26). doi: 10.1126/sciimmunol.aat2738. PubMed PMID: 30143556; PubMed Central PMCID: PMC6462819.

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Vareechon C, Zmina SE, Karmakar M, Pearlman E, Rietsch A. Pseudomonas aeruginosa Effector ExoS Inhibits ROS Production in Human Neutrophils. Cell Host Microbe. 2017 May 10;21(5):611-618.e5. doi: 10.1016/j.chom.2017.04.001. PubMed PMID: 28494242; PubMed Central PMCID: PMC5478421.

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Russo HM, Rathkey J, Boyd-Tressler A, Katsnelson MA, Abbott DW, Dubyak GR. Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides. J Immunol. 2016 Aug 15;197(4):1353-67. doi: 10.4049/jimmunol.1600699. Epub 2016 Jul 6. PubMed PMID: 27385778; PubMed Central PMCID: PMC4976007.

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Armentrout EI, Rietsch A. The Type III Secretion Translocation Pore Senses Host Cell Contact. PLoS Pathog. 2016 Mar;12(3):e1005530. doi: 10.1371/journal.ppat.1005530. eCollection 2016 Mar. PubMed PMID: 27022930; PubMed Central PMCID: PMC4811590.

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Karmakar M, Katsnelson MA, Dubyak GR, Pearlman E. Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP. Nat Commun. 2016 Feb 15;7:10555. doi: 10.1038/ncomms10555. PubMed PMID: 26877061; PubMed Central PMCID: PMC4756306.

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Lee PC, Rietsch A. Fueling type III secretion. Trends Microbiol. 2015 May;23(5):296-300. doi: 10.1016/j.tim.2015.01.012. Epub 2015 Feb 17. Review. PubMed PMID: 25701111; PubMed Central PMCID: PMC4417389.

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Karmakar M, Katsnelson M, Malak HA, Greene NG, Howell SJ, Hise AG, Camilli A, Kadioglu A, Dubyak GR, Pearlman E. Neutrophil IL-1β processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux. J Immunol. 2015 Feb 15;194(4):1763-75. doi: 10.4049/jimmunol.1401624. Epub 2015 Jan 21. PubMed PMID: 25609842; PubMed Central PMCID: PMC4369676.

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Lee PC, Zmina SE, Stopford CM, Toska J, Rietsch A. Control of type III secretion activity and substrate specificity by the cytoplasmic regulator PcrG. Proc Natl Acad Sci U S A. 2014 May 13;111(19):E2027-36. doi: 10.1073/pnas.1402658111. Epub 2014 Apr 28. PubMed PMID: 24778208; PubMed Central PMCID: PMC4024851.

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Toska J, Sun Y, Carbonell DA, Foster AN, Jacobs MR, Pearlman E, Rietsch A. Diversity of virulence phenotypes among type III secretion negative Pseudomonas aeruginosa clinical isolates. PLoS One. 2014;9(1):e86829. doi: 10.1371/journal.pone.0086829. eCollection 2014. PubMed PMID: 24466261; PubMed Central PMCID: PMC3900666.

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Tomalka AG, Zmina SE, Stopford CM, Rietsch A. Dimerization of the Pseudomonas aeruginosa translocator chaperone PcrH is required for stability, not function. J Bacteriol. 2013 Nov;195(21):4836-43. doi: 10.1128/JB.00335-13. Epub 2013 Aug 23. PubMed PMID: 23974025; PubMed Central PMCID: PMC3807485.

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Karthikeyan RS, Priya JL, Leal SM Jr, Toska J, Rietsch A, Prajna V, Pearlman E, Lalitha P. Host response and bacterial virulence factor expression in Pseudomonas aeruginosa and Streptococcus pneumoniae corneal ulcers. PLoS One. 2013;8(6):e64867. doi: 10.1371/journal.pone.0064867. Print 2013. PubMed PMID: 23750216; PubMed Central PMCID: PMC3672173.

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Pearlman E, Sun Y, Roy S, Karmakar M, Hise AG, Szczotka-Flynn L, Ghannoum M, Chinnery HR, McMenamin PG, Rietsch A. Host defense at the ocular surface. Int Rev Immunol. 2013 Feb;32(1):4-18. doi: 10.3109/08830185.2012.749400. Review. PubMed PMID: 23360155; PubMed Central PMCID: PMC3750950.

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Tomalka AG, Stopford CM, Lee PC, Rietsch A. A translocator-specific export signal establishes the translocator-effector secretion hierarchy that is important for type III secretion system function. Mol Microbiol. 2012 Dec;86(6):1464-81. doi: 10.1111/mmi.12069. Epub 2012 Nov 5. PubMed PMID: 23121689; PubMed Central PMCID: PMC3524397.

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Karmakar M, Sun Y, Hise AG, Rietsch A, Pearlman E. Cutting edge: IL-1β processing during Pseudomonas aeruginosa infection is mediated by neutrophil serine proteases and is independent of NLRC4 and caspase-1. J Immunol. 2012 Nov 1;189(9):4231-5. doi: 10.4049/jimmunol.1201447. Epub 2012 Sep 28. PubMed PMID: 23024281; PubMed Central PMCID: PMC3482477.

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Sun Y, Karmakar M, Taylor PR, Rietsch A, Pearlman E. ExoS and ExoT ADP ribosyltransferase activities mediate Pseudomonas aeruginosa keratitis by promoting neutrophil apoptosis and bacterial survival. J Immunol. 2012 Feb 15;188(4):1884-95. doi: 10.4049/jimmunol.1102148. Epub 2012 Jan 16. PubMed PMID: 22250085; PubMed Central PMCID: PMC3273577.

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Sun Y, Karmakar M, Roy S, Ramadan RT, Williams SR, Howell S, Shive CL, Han Y, Stopford CM, Rietsch A, Pearlman E. TLR4 and TLR5 on corneal macrophages regulate Pseudomonas aeruginosa keratitis by signaling through MyD88-dependent and -independent pathways. J Immunol. 2010 Oct 1;185(7):4272-83. doi: 10.4049/jimmunol.1000874. Epub 2010 Sep 8. PubMed PMID: 20826748; PubMed Central PMCID: PMC3392180.

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Carlson EC, Sun Y, Auletta J, Kao WW, Liu CY, Perez VL, Pearlman E. Regulation of corneal inflammation by neutrophil-dependent cleavage of keratan sulfate proteoglycans as a model for breakdown of the chemokine gradient. J Leukoc Biol. 2010 Sep;88(3):517-22. doi: 10.1189/jlb.0310134. Epub 2010 May 21. PubMed PMID: 20495072; PubMed Central PMCID: PMC2924604.

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Hayashi Y, Call MK, Chikama T, Liu H, Carlson EC, Sun Y, Pearlman E, Funderburgh JL, Babcock G, Liu CY, Ohashi Y, Kao WW. Lumican is required for neutrophil extravasation following corneal injury and wound healing. J Cell Sci. 2010 Sep 1;123(Pt 17):2987-95. doi: 10.1242/jcs.068221. Epub 2010 Aug 10. PubMed PMID: 20699360; PubMed Central PMCID: PMC2923572.

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Szczotka-Flynn LB, Pearlman E, Ghannoum M. Microbial contamination of contact lenses, lens care solutions, and their accessories: a literature review. Eye Contact Lens. 2010 Mar;36(2):116-29. doi: 10.1097/ICL.0b013e3181d20cae. Review. PubMed PMID: 20168237; PubMed Central PMCID: PMC3482476.

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Lee PC, Stopford CM, Svenson AG, Rietsch A. Control of effector export by the Pseudomonas aeruginosa type III secretion proteins PcrG and PcrV. Mol Microbiol. 2010 Feb;75(4):924-41. doi: 10.1111/j.1365-2958.2009.07027.x. PubMed PMID: 20487288; PubMed Central PMCID: PMC3124366.

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Szczotka-Flynn LB, Imamura Y, Chandra J, Yu C, Mukherjee PK, Pearlman E, Ghannoum MA. Increased resistance of contact lens-related bacterial biofilms to antimicrobial activity of soft contact lens care solutions. Cornea. 2009 Sep;28(8):918-26. doi: 10.1097/ICO.0b013e3181a81835. PubMed PMID: 19654521; PubMed Central PMCID: PMC4020144.

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Sun Y, Pearlman E. Inhibition of corneal inflammation by the TLR4 antagonist Eritoran tetrasodium (E5564). Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1247-54. doi: 10.1167/iovs.08-2628. Epub 2008 Oct 20. PubMed PMID: 18936141; PubMed Central PMCID: PMC3909488.

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Chinnery HR, Carlson EC, Sun Y, Lin M, Burnett SH, Perez VL, McMenamin PG, Pearlman E. Bone marrow chimeras and c-fms conditional ablation (Mafia) mice reveal an essential role for resident myeloid cells in lipopolysaccharide/TLR4-induced corneal inflammation. J Immunol. 2009 Mar 1;182(5):2738-44. doi: 10.4049/jimmunol.0803505. PubMed PMID: 19234168; PubMed Central PMCID: PMC3909485.

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Pearlman E, Johnson A, Adhikary G, Sun Y, Chinnery HR, Fox T, Kester M, McMenamin PG. Toll-like receptors at the ocular surface. Ocul Surf. 2008 Jul;6(3):108-16. doi: 10.1016/s1542-0124(12)70279-3. Review. PubMed PMID: 18781257; PubMed Central PMCID: PMC3403823.

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Sun Y, Fox T, Adhikary G, Kester M, Pearlman E. Inhibition of corneal inflammation by liposomal delivery of short-chain, C-6 ceramide. J Leukoc Biol. 2008 Jun;83(6):1512-21. doi: 10.1189/jlb.0108076. Epub 2008 Apr 17. PubMed PMID: 18372342; PubMed Central PMCID: PMC3584160.

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Chinnery HR, Pearlman E, McMenamin PG. Cutting edge: Membrane nanotubes in vivo: a feature of MHC class II+ cells in the mouse cornea. J Immunol. 2008 May 1;180(9):5779-83. doi: 10.4049/jimmunol.180.9.5779. PubMed PMID: 18424694; PubMed Central PMCID: PMC3392179.

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Cisz M, Lee PC, Rietsch A. ExoS controls the cell contact-mediated switch to effector secretion in Pseudomonas aeruginosa. J Bacteriol. 2008 Apr;190(8):2726-38. doi: 10.1128/JB.01553-07. Epub 2007 Nov 26. PubMed PMID: 18039770; PubMed Central PMCID: PMC2293250.

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Adhikary G, Sun Y, Pearlman E. C-Jun NH2 terminal kinase (JNK) is an essential mediator of Toll-like receptor 2-induced corneal inflammation. J Leukoc Biol. 2008 Apr;83(4):991-7. doi: 10.1189/jlb.1107783. Epub 2008 Jan 24. PubMed PMID: 18218857; PubMed Central PMCID: PMC3959745.

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Carlson EC, Lin M, Liu CY, Kao WW, Perez VL, Pearlman E. Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1. J Biol Chem. 2007 Dec 7;282(49):35502-9. doi: 10.1074/jbc.M705823200. Epub 2007 Oct 2. PubMed PMID: 17911102; PubMed Central PMCID: PMC3909483.

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Chinnery HR, Ruitenberg MJ, Plant GW, Pearlman E, Jung S, McMenamin PG. The chemokine receptor CX3CR1 mediates homing of MHC class II-positive cells to the normal mouse corneal epithelium. Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1568-74. doi: 10.1167/iovs.06-0746. PubMed PMID: 17389486; PubMed Central PMCID: PMC3392181.

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Lin M, Carlson E, Diaconu E, Pearlman E. CXCL1/KC and CXCL5/LIX are selectively produced by corneal fibroblasts and mediate neutrophil infiltration to the corneal stroma in LPS keratitis. J Leukoc Biol. 2007 Mar;81(3):786-92. doi: 10.1189/jlb.0806502. Epub 2006 Nov 16. PubMed PMID: 17110418; PubMed Central PMCID: PMC3909486.

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Rietsch A, Mekalanos JJ. Metabolic regulation of type III secretion gene expression in Pseudomonas aeruginosa. Mol Microbiol. 2006 Feb;59(3):807-20. doi: 10.1111/j.1365-2958.2005.04990.x. PubMed PMID: 16420353; PubMed Central PMCID: PMC2654213.

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Rietsch A, Vallet-Gely I, Dove SL, Mekalanos JJ. ExsE, a secreted regulator of type III secretion genes in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2005 May 31;102(22):8006-11. doi: 10.1073/pnas.0503005102. Epub 2005 May 23. PubMed PMID: 15911752; PubMed Central PMCID: PMC1142391.

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Vance RE, Rietsch A, Mekalanos JJ. Role of the type III secreted exoenzymes S, T, and Y in systemic spread of Pseudomonas aeruginosa PAO1 in vivo. Infect Immun. 2005 Mar;73(3):1706-13. doi: 10.1128/IAI.73.3.1706-1713.2005. PubMed PMID: 15731071; PubMed Central PMCID: PMC1064930.

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Goodman AL, Kulasekara B, Rietsch A, Boyd D, Smith RS, Lory S. A signaling network reciprocally regulates genes associated with acute infection and chronic persistence in Pseudomonas aeruginosa. Dev Cell. 2004 Nov;7(5):745-54. doi: 10.1016/j.devcel.2004.08.020. PubMed PMID: 15525535.

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Budzik JM, Rosche WA, Rietsch A, O'Toole GA. Isolation and characterization of a generalized transducing phage for Pseudomonas aeruginosa strains PAO1 and PA14. J Bacteriol. 2004 May;186(10):3270-3. doi: 10.1128/JB.186.10.3270-3273.2004. PubMed PMID: 15126493; PubMed Central PMCID: PMC400619.

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Rietsch A, Wolfgang MC, Mekalanos JJ. Effect of metabolic imbalance on expression of type III secretion genes in Pseudomonas aeruginosa. Infect Immun. 2004 Mar;72(3):1383-90. doi: 10.1128/IAI.72.3.1383-1390.2004. PubMed PMID: 14977942; PubMed Central PMCID: PMC356022.

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Mössner E, Huber-Wunderlich M, Rietsch A, Beckwith J, Glockshuber R, Aslund F. Importance of redox potential for the in vivo function of the cytoplasmic disulfide reductant thioredoxin from Escherichia coli. J Biol Chem. 1999 Sep 3;274(36):25254-9. doi: 10.1074/jbc.274.36.25254. PubMed PMID: 10464247.

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Rietsch A, Beckwith J. The genetics of disulfide bond metabolism. Annu Rev Genet. 1998;32:163-84. doi: 10.1146/annurev.genet.32.1.163. Review. PubMed PMID: 9928478.

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Rietsch A, Bessette P, Georgiou G, Beckwith J. Reduction of the periplasmic disulfide bond isomerase, DsbC, occurs by passage of electrons from cytoplasmic thioredoxin. J Bacteriol. 1997 Nov;179(21):6602-8. doi: 10.1128/jb.179.21.6602-6608.1997. PubMed PMID: 9352906; PubMed Central PMCID: PMC179585.