My Bibliography

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Lins J, Brock TJ, Hopkins CE, Hart AC. Generation of a C. elegans tdp-1 null allele and humanized TARDBP containing human disease-variants. MicroPubl Biol. 2023;2023. doi: 10.17912/micropub.biology.000693. eCollection 2023. PubMed PMID: 37351305; PubMed Central PMCID: PMC10282831.

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Lins J, Hopkins CE, Brock T, Hart AC. The use of CRISPR to generate a whole-gene humanized MAPT and the examination of P301L and G272V clinical variants, along with the creation of deletion null alleles of ptl-1, pgrn-1 and alfa-1 loci. MicroPubl Biol. 2022;2022. doi: 10.17912/micropub.biology.000615. eCollection 2022. PubMed PMID: 36204657; PubMed Central PMCID: PMC9530923.

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Baskoylu SN, Chapkis N, Unsal B, Lins J, Schuch K, Simon J, Hart AC. Disrupted autophagy and neuronal dysfunction in C. elegans knockin models of FUS amyotrophic lateral sclerosis. Cell Rep. 2022 Jan 25;38(4):110195. doi: 10.1016/j.celrep.2021.110195. PubMed PMID: 35081350.

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Hart AC, Bennett HL. Starting a C. elegans Research Laboratory: Practical Advice. Methods Mol Biol. 2022;2468:1-24. doi: 10.1007/978-1-0716-2181-3_1. PubMed PMID: 35320557.

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Ryan VH, Hart AC. sym-2 loss-of-function causes glutamatergic neurodegeneration after oxidative stress. MicroPubl Biol. 2021 Feb 3;2021. doi: 10.17912/micropub.biology.000363. PubMed PMID: 33554054; PubMed Central PMCID: PMC7859837.

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Ryan VH, Perdikari TM, Naik MT, Saueressig CF, Lins J, Dignon GL, Mittal J, Hart AC, Fawzi NL. Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration. EMBO J. 2021 Feb 1;40(3):e105001. doi: 10.15252/embj.2020105001. Epub 2020 Dec 22. PubMed PMID: 33349959; PubMed Central PMCID: PMC7849316.

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Osborne JF, Yanagi KS, Hart AC. Genetic interactions in a C. elegans sod-1 ALS model: glutamatergic neuron degeneration. MicroPubl Biol. 2021 Jan 15;2021. doi: 10.17912/micropub.biology.000338. PubMed PMID: 33474528; PubMed Central PMCID: PMC7812382.

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Walsh MB, Janzen E, Wingrove E, Hosseinibarkooie S, Muela NR, Davidow L, Dimitriadi M, Norabuena EM, Rubin LL, Wirth B, Hart AC. Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy. BMC Biol. 2020 Sep 16;18(1):127. doi: 10.1186/s12915-020-00845-w. PubMed PMID: 32938453; PubMed Central PMCID: PMC7495824.

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Schuch KN, Govindarajan LN, Guo Y, Baskoylu SN, Kim S, Kimia B, Serre T, Hart AC. Discriminating between sleep and exercise-induced fatigue using computer vision and behavioral genetics. J Neurogenet. 2020 Sep-Dec;34(3-4):453-465. doi: 10.1080/01677063.2020.1804565. Epub 2020 Aug 19. PubMed PMID: 32811254; PubMed Central PMCID: PMC8074569.

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Holdorf AD, Higgins DP, Hart AC, Boag PR, Pazour GJ, Walhout AJM, Walker AK. WormCat: An Online Tool for Annotation and Visualization of Caenorhabditis elegans Genome-Scale Data. Genetics. 2020 Feb;214(2):279-294. doi: 10.1534/genetics.119.302919. Epub 2019 Dec 6. PubMed PMID: 31810987; PubMed Central PMCID: PMC7017019.

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Carskadon MA, Chappell KR, Barker DH, Hart AC, Dwyer K, Gredvig-Ardito C, Starr C, McGeary JE. A pilot prospective study of sleep patterns and DNA methylation-characterized epigenetic aging in young adults. BMC Res Notes. 2019 Sep 16;12(1):583. doi: 10.1186/s13104-019-4633-1. PubMed PMID: 31526398; PubMed Central PMCID: PMC6747743.

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Yanagi KS, Wu Z, Amaya J, Chapkis N, Duffy AM, Hajdarovic KH, Held A, Mathur AD, Russo K, Ryan VH, Steinert BL, Whitt JP, Fallon JR, Fawzi NL, Lipscombe D, Reenan RA, Wharton KA, Hart AC. Meta-analysis of Genetic Modifiers Reveals Candidate Dysregulated Pathways in Amyotrophic Lateral Sclerosis. Neuroscience. 2019 Jan 1;396:A3-A20. doi: 10.1016/j.neuroscience.2018.10.033. PubMed PMID: 30594291; PubMed Central PMCID: PMC6549511.

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Huang H, Hayden DJ, Zhu CT, Bennett HL, Venkatachalam V, Skuja LL, Hart AC. Gap Junctions and NCA Cation Channels Are Critical for Developmentally Timed Sleep and Arousal in Caenorhabditis elegans. Genetics. 2018 Dec;210(4):1369-1381. doi: 10.1534/genetics.118.301551. Epub 2018 Oct 15. PubMed PMID: 30323068; PubMed Central PMCID: PMC6283151.

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Baskoylu SN, Yersak J, O'Hern P, Grosser S, Simon J, Kim S, Schuch K, Dimitriadi M, Yanagi KS, Lins J, Hart AC. Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration. PLoS Genet. 2018 Oct;14(10):e1007682. doi: 10.1371/journal.pgen.1007682. eCollection 2018 Oct. PubMed PMID: 30296255; PubMed Central PMCID: PMC6200258.

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Sorkaç A, DiIorio MA, O'Hern PJ, Baskoylu SN, Graham HK, Hart AC. LIN-12/Notch Regulates GABA Signaling at the Caenorhabditis elegans Neuromuscular Junction. G3 (Bethesda). 2018 Jul 31;8(8):2825-2832. doi: 10.1534/g3.118.200202. PubMed PMID: 29950427; PubMed Central PMCID: PMC6071610.

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Nam YW, Baskoylu SN, Gazgalis D, Orfali R, Cui M, Hart AC, Zhang M. A V-to-F substitution in SK2 channels causes Ca(2+) hypersensitivity and improves locomotion in a C. elegans ALS model. Sci Rep. 2018 Jul 16;8(1):10749. doi: 10.1038/s41598-018-28783-2. PubMed PMID: 30013223; PubMed Central PMCID: PMC6048120.

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Bennett HL, Khoruzhik Y, Hayden D, Huang H, Sanders J, Walsh MB, Biron D, Hart AC. Normal sleep bouts are not essential for C. elegans survival and FoxO is important for compensatory changes in sleep. BMC Neurosci. 2018 Mar 9;19(1):10. doi: 10.1186/s12868-018-0408-1. PubMed PMID: 29523076; PubMed Central PMCID: PMC5845181.

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Huang H, Zhu CT, Skuja LL, Hayden DJ, Hart AC. Genome-Wide Screen for Genes Involved in Caenorhabditis elegans Developmentally Timed Sleep. G3 (Bethesda). 2017 Sep 7;7(9):2907-2917. doi: 10.1534/g3.117.300071. PubMed PMID: 28743807; PubMed Central PMCID: PMC5592919.

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Huang H, Zhu Y, Eliot MN, Knopik VS, McGeary JE, Carskadon MA, Hart AC. Combining Human Epigenetics and Sleep Studies in Caenorhabditis elegans: A Cross-Species Approach for Finding Conserved Genes Regulating Sleep. Sleep. 2017 Jun 1;40(6). doi: 10.1093/sleep/zsx063. PubMed PMID: 28431118; PubMed Central PMCID: PMC6075530.

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O'Hern PJ, do Carmo G Gonçalves I, Brecht J, López Soto EJ, Simon J, Chapkis N, Lipscombe D, Kye MJ, Hart AC. Decreased microRNA levels lead to deleterious increases in neuronal M2 muscarinic receptors in Spinal Muscular Atrophy models. Elife. 2017 May 2;6. doi: 10.7554/eLife.20752. PubMed PMID: 28463115; PubMed Central PMCID: PMC5413352.

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Huang H, Singh K, Hart AC. Measuring Caenorhabditis elegans Sleep During the Transition to Adulthood Using a Microfluidics-based System. Bio Protoc. 2017 Mar 20;7(6). doi: 10.21769/BioProtoc.2174. PubMed PMID: 28966950; PubMed Central PMCID: PMC5616178.

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Riessland M, Kaczmarek A, Schneider S, Swoboda KJ, Löhr H, Bradler C, Grysko V, Dimitriadi M, Hosseinibarkooie S, Torres-Benito L, Peters M, Upadhyay A, Biglari N, Kröber S, Hölker I, Garbes L, Gilissen C, Hoischen A, Nürnberg G, Nürnberg P, Walter M, Rigo F, Bennett CF, Kye MJ, Hart AC, Hammerschmidt M, Kloppenburg P, Wirth B. Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis. Am J Hum Genet. 2017 Feb 2;100(2):297-315. doi: 10.1016/j.ajhg.2017.01.005. Epub 2017 Jan 26. PubMed PMID: 28132687; PubMed Central PMCID: PMC5294679.

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Sorkaç A, Alcantara IC, Hart AC. In Vivo Modelling of ATP1A3 G316S-Induced Ataxia in C. elegans Using CRISPR/Cas9-Mediated Homologous Recombination Reveals Dominant Loss of Function Defects. PLoS One. 2016;11(12):e0167963. doi: 10.1371/journal.pone.0167963. eCollection 2016. PubMed PMID: 27936181; PubMed Central PMCID: PMC5148073.

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Dimitriadi M, Derdowski A, Kalloo G, Maginnis MS, O'Hern P, Bliska B, Sorkaç A, Nguyen KC, Cook SJ, Poulogiannis G, Atwood WJ, Hall DH, Hart AC. Decreased function of survival motor neuron protein impairs endocytic pathways. Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4377-86. doi: 10.1073/pnas.1600015113. Epub 2016 Jul 11. PubMed PMID: 27402754; PubMed Central PMCID: PMC4968725.

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Fry AL, Laboy JT, Huang H, Hart AC, Norman KR. A Conserved GEF for Rho-Family GTPases Acts in an EGF Signaling Pathway to Promote Sleep-like Quiescence in Caenorhabditis elegans. Genetics. 2016 Mar;202(3):1153-66. doi: 10.1534/genetics.115.183038. Epub 2016 Jan 22. PubMed PMID: 26801183; PubMed Central PMCID: PMC4788115.

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Anderson EN, Corkins ME, Li JC, Singh K, Parsons S, Tucey TM, Sorkaç A, Huang H, Dimitriadi M, Sinclair DA, Hart AC. C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins. Mech Ageing Dev. 2016 Mar;154:30-42. doi: 10.1016/j.mad.2016.01.004. Epub 2016 Feb 22. PubMed PMID: 26854551; PubMed Central PMCID: PMC4789167.

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Moroz N, Carmona JJ, Anderson E, Hart AC, Sinclair DA, Blackwell TK. Dietary restriction involves NAD⁺ -dependent mechanisms and a shift toward oxidative metabolism. Aging Cell. 2014 Dec;13(6):1075-85. doi: 10.1111/acel.12273. Epub 2014 Sep 25. PubMed PMID: 25257342; PubMed Central PMCID: PMC4244309.

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Singh K, Ju JY, Walsh MB, DiIorio MA, Hart AC. Deep conservation of genes required for both Drosphila melanogaster and Caenorhabditis elegans sleep includes a role for dopaminergic signaling. Sleep. 2014 Sep 1;37(9):1439-51. doi: 10.5665/sleep.3990. PubMed PMID: 25142568; PubMed Central PMCID: PMC4153065.

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Chalfie M, Hart AC, Rankin CH, Goodman MB. Assaying mechanosensation. WormBook. 2014 Jul 31;. doi: 10.1895/wormbook.1.172.1. Review. PubMed PMID: 25093996; PubMed Central PMCID: PMC4448936.

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Sen A, Dimlich DN, Guruharsha KG, Kankel MW, Hori K, Yokokura T, Brachat S, Richardson D, Loureiro J, Sivasankaran R, Curtis D, Davidow LS, Rubin LL, Hart AC, Van Vactor D, Artavanis-Tsakonas S. Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy. Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):E2371-80. doi: 10.1073/pnas.1301738110. Epub 2013 Jun 11. PubMed PMID: 23757500; PubMed Central PMCID: PMC3696827.

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Kwon DY, Dimitriadi M, Terzic B, Cable C, Hart AC, Chitnis A, Fischbeck KH, Burnett BG. The E3 ubiquitin ligase mind bomb 1 ubiquitinates and promotes the degradation of survival of motor neuron protein. Mol Biol Cell. 2013 Jun;24(12):1863-71. doi: 10.1091/mbc.E13-01-0042. Epub 2013 Apr 24. PubMed PMID: 23615451; PubMed Central PMCID: PMC3681692.

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Dimitriadi M, Kye MJ, Kalloo G, Yersak JM, Sahin M, Hart AC. The neuroprotective drug riluzole acts via small conductance Ca2+-activated K+ channels to ameliorate defects in spinal muscular atrophy models. J Neurosci. 2013 Apr 10;33(15):6557-62. doi: 10.1523/JNEUROSCI.1536-12.2013. PubMed PMID: 23575853; PubMed Central PMCID: PMC3652322.

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Singh K, Huang H, Hart AC. Do C. elegans sleep? A closer look. Sleep. 2013 Mar 1;36(3):307-8. doi: 10.5665/sleep.2436. PubMed PMID: 23450901; PubMed Central PMCID: PMC3571757.

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Walker AK, Jacobs RL, Watts JL, Rottiers V, Jiang K, Finnegan DM, Shioda T, Hansen M, Yang F, Niebergall LJ, Vance DE, Tzoneva M, Hart AC, Näär AM. A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans. Cell. 2011 Nov 11;147(4):840-52. doi: 10.1016/j.cell.2011.09.045. Epub 2011 Oct 27. PubMed PMID: 22035958; PubMed Central PMCID: PMC3384509.

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Liu-Yesucevitz L, Bassell GJ, Gitler AD, Hart AC, Klann E, Richter JD, Warren ST, Wolozin B. Local RNA translation at the synapse and in disease. J Neurosci. 2011 Nov 9;31(45):16086-93. doi: 10.1523/JNEUROSCI.4105-11.2011. Review. PubMed PMID: 22072660; PubMed Central PMCID: PMC3241995.

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Singh K, Chao MY, Somers GA, Komatsu H, Corkins ME, Larkins-Ford J, Tucey T, Dionne HM, Walsh MB, Beaumont EK, Hart DP, Lockery SR, Hart AC. C. elegans Notch signaling regulates adult chemosensory response and larval molting quiescence. Curr Biol. 2011 May 24;21(10):825-34. doi: 10.1016/j.cub.2011.04.010. Epub 2011 May 5. PubMed PMID: 21549604; PubMed Central PMCID: PMC3100419.

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Hyde R, Corkins ME, Somers GA, Hart AC. PKC-1 acts with the ERK MAPK signaling pathway to regulate Caenorhabditis elegans mechanosensory response. Genes Brain Behav. 2011 Apr;10(3):286-98. doi: 10.1111/j.1601-183X.2010.00667.x. Epub 2011 Jan 10. PubMed PMID: 21143768; PubMed Central PMCID: PMC3664539.

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Dimitriadi M, Sleigh JN, Walker A, Chang HC, Sen A, Kalloo G, Harris J, Barsby T, Walsh MB, Satterlee JS, Li C, Van Vactor D, Artavanis-Tsakonas S, Hart AC. Conserved genes act as modifiers of invertebrate SMN loss of function defects. PLoS Genet. 2010 Oct 28;6(10):e1001172. doi: 10.1371/journal.pgen.1001172. PubMed PMID: 21124729; PubMed Central PMCID: PMC2965752.

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Dimitriadi M, Hart AC. Neurodegenerative disorders: insights from the nematode Caenorhabditis elegans. Neurobiol Dis. 2010 Oct;40(1):4-11. doi: 10.1016/j.nbd.2010.05.012. Epub 2010 May 19. Review. PubMed PMID: 20493260; PubMed Central PMCID: PMC2926245.

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Haspel G, O'Donovan MJ, Hart AC. Motoneurons dedicated to either forward or backward locomotion in the nematode Caenorhabditis elegans. J Neurosci. 2010 Aug 18;30(33):11151-6. doi: 10.1523/JNEUROSCI.2244-10.2010. PubMed PMID: 20720122; PubMed Central PMCID: PMC2945236.

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Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev. 2010 Jul 1;24(13):1403-17. doi: 10.1101/gad.1901210. PubMed PMID: 20595232; PubMed Central PMCID: PMC2895199.

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Hart AC, Chao MY. From Odors to Behaviors in Caenorhabditis elegans. 2010;. Review. PubMed PMID: 21882435.

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Guo ZV, Hart AC, Ramanathan S. Optical interrogation of neural circuits in Caenorhabditis elegans. Nat Methods. 2009 Dec;6(12):891-6. doi: 10.1038/nmeth.1397. Epub 2009 Nov 8. PubMed PMID: 19898486; PubMed Central PMCID: PMC3108858.

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Jeong H, Then F, Melia TJ Jr, Mazzulli JR, Cui L, Savas JN, Voisine C, Paganetti P, Tanese N, Hart AC, Yamamoto A, Krainc D. Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell. 2009 Apr 3;137(1):60-72. doi: 10.1016/j.cell.2009.03.018. PubMed PMID: 19345187; PubMed Central PMCID: PMC2940108.

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Chang HC, Dimlich DN, Yokokura T, Mukherjee A, Kankel MW, Sen A, Sridhar V, Fulga TA, Hart AC, Van Vactor D, Artavanis-Tsakonas S. Modeling spinal muscular atrophy in Drosophila. PLoS One. 2008 Sep 15;3(9):e3209. doi: 10.1371/journal.pone.0003209. PubMed PMID: 18791638; PubMed Central PMCID: PMC2527655.

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Komatsu H, Chao MY, Larkins-Ford J, Corkins ME, Somers GA, Tucey T, Dionne HM, White JQ, Wani K, Boxem M, Hart AC. OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development. PLoS Biol. 2008 Aug 12;6(8):e196. doi: 10.1371/journal.pbio.0060196. PubMed PMID: 18700817; PubMed Central PMCID: PMC2504490.

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Varma H, Cheng R, Voisine C, Hart AC, Stockwell BR. Inhibitors of metabolism rescue cell death in Huntington's disease models. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14525-30. doi: 10.1073/pnas.0704482104. Epub 2007 Aug 28. PubMed PMID: 17726098; PubMed Central PMCID: PMC1964858.

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Voisine C, Varma H, Walker N, Bates EA, Stockwell BR, Hart AC. Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans. PLoS One. 2007 Jun 6;2(6):e504. doi: 10.1371/journal.pone.0000504. PubMed PMID: 17551584; PubMed Central PMCID: PMC1876812.

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Varma H, Voisine C, DeMarco CT, Cattaneo E, Lo DC, Hart AC, Stockwell BR. Selective inhibitors of death in mutant huntingtin cells. Nat Chem Biol. 2007 Feb;3(2):99-100. doi: 10.1038/nchembio852. Epub 2006 Dec 31. PubMed PMID: 17195849.

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Jia K, Hart AC, Levine B. Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans. Autophagy. 2007 Jan-Feb;3(1):21-5. doi: 10.4161/auto.3528. Epub 2007 Jan 23. PubMed PMID: 17172799; NIHMSID:NIHMS195311.