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Weinstein JJ, van de Giessen E, Rosengard RJ, Xu X, Ojeil N, Brucato G, Gil RB, Kegeles LS, Laruelle M, Slifstein M, Abi-Dargham A. PET imaging of dopamine-D2 receptor internalization in schizophrenia. Mol Psychiatry. 2018 Jun;23(6):1506-1511. doi: 10.1038/mp.2017.107. Epub 2017 May 16. PubMed PMID: 28507321; PubMed Central PMCID: PMC5690884.
Cassidy CM, Balsam PD, Weinstein JJ, Rosengard RJ, Slifstein M, Daw ND, Abi-Dargham A, Horga G. A Perceptual Inference Mechanism for Hallucinations Linked to Striatal Dopamine. Curr Biol. 2018 Feb 19;28(4):503-514.e4. doi: 10.1016/j.cub.2017.12.059. Epub 2018 Feb 2. PubMed PMID: 29398218; PubMed Central PMCID: PMC5820222.
Mingote S, Chuhma N, Kalmbach A, Thomsen GM, Wang Y, Mihali A, Sferrazza C, Zucker-Scharff I, Siena AC, Welch MG, Lizardi-Ortiz J, Sulzer D, Moore H, Gaisler-Salomon I, Rayport S. Dopamine neuron dependent behaviors mediated by glutamate cotransmission. Elife. 2017 Jul 13;6. doi: 10.7554/eLife.27566. PubMed PMID: 28703706; PubMed Central PMCID: PMC5599237.
Delevich K, Abi-Dargham A, Hall J, Sawa A. Studying schizophrenia in the post-genomic era: perspectives from the 2016 summer Banbury Workshop at Cold Spring Harbor Laboratory. Mol Psychiatry. 2017 Jan;22(1):2-3. doi: 10.1038/mp.2016.197. Epub 2016 Oct 25. PubMed PMID: 27777417.
Chuhma N, Mingote S, Kalmbach A, Yetnikoff L, Rayport S. Heterogeneity in Dopamine Neuron Synaptic Actions Across the Striatum and Its Relevance for Schizophrenia. Biol Psychiatry. 2017 Jan 1;81(1):43-51. doi: 10.1016/j.biopsych.2016.07.002. Epub 2016 Jul 12. Review. PubMed PMID: 27692238; PubMed Central PMCID: PMC5121049.
Simpson EH, Kellendonk C. Insights About Striatal Circuit Function and Schizophrenia From a Mouse Model of Dopamine D2 Receptor Upregulation. Biol Psychiatry. 2017 Jan 1;81(1):21-30. doi: 10.1016/j.biopsych.2016.07.004. Epub 2016 Jul 14. Review. PubMed PMID: 27720388; PubMed Central PMCID: PMC5121031.
Weinstein JJ, Chohan MO, Slifstein M, Kegeles LS, Moore H, Abi-Dargham A. Pathway-Specific Dopamine Abnormalities in Schizophrenia. Biol Psychiatry. 2017 Jan 1;81(1):31-42. doi: 10.1016/j.biopsych.2016.03.2104. Epub 2016 Mar 31. Review. PubMed PMID: 27206569; PubMed Central PMCID: PMC5177794.
Abi-Dargham A. A Dual Hit Model for Dopamine in Schizophrenia. Biol Psychiatry. 2017 Jan 1;81(1):2-4. doi: 10.1016/j.biopsych.2016.10.008. PubMed PMID: 27876155.
Lehembre-Shiah E, Leong W, Brucato G, Abi-Dargham A, Lieberman JA, Horga G, Girgis RR. Distinct Relationships Between Visual and Auditory Perceptual Abnormalities and Conversion to Psychosis in a Clinical High-Risk Population. JAMA Psychiatry. 2017 Jan 1;74(1):104-106. doi: 10.1001/jamapsychiatry.2016.3055. PubMed PMID: 27851840; PubMed Central PMCID: PMC5337304.
van de Giessen E, Weinstein JJ, Cassidy CM, Haney M, Dong Z, Ghazzaoui R, Ojeil N, Kegeles LS, Xu X, Vadhan NP, Volkow ND, Slifstein M, Abi-Dargham A. Deficits in striatal dopamine release in cannabis dependence. Mol Psychiatry. 2017 Jan;22(1):68-75. doi: 10.1038/mp.2016.21. Epub 2016 Mar 22. PubMed PMID: 27001613; PubMed Central PMCID: PMC5033654.
Reinen JM, Van Snellenberg JX, Horga G, Abi-Dargham A, Daw ND, Shohamy D. Motivational Context Modulates Prediction Error Response in Schizophrenia. Schizophr Bull. 2016 Nov;42(6):1467-1475. doi: 10.1093/schbul/sbw045. Epub 2016 Apr 22. PubMed PMID: 27105903; PubMed Central PMCID: PMC5049527.
Abi-Dargham A, Horga G. The search for imaging biomarkers in psychiatric disorders. Nat Med. 2016 Nov;22(11):1248-1255. doi: 10.1038/nm.4190. Epub 2016 Oct 26. PubMed PMID: 27783066.
Van Snellenberg JX, Girgis RR, Horga G, van de Giessen E, Slifstein M, Ojeil N, Weinstein JJ, Moore H, Lieberman JA, Shohamy D, Smith EE, Abi-Dargham A. Mechanisms of Working Memory Impairment in Schizophrenia. Biol Psychiatry. 2016 Oct 15;80(8):617-26. doi: 10.1016/j.biopsych.2016.02.017. Epub 2016 Feb 23. PubMed PMID: 27056754; PubMed Central PMCID: PMC4995154.
Girgis RR, Slifstein M, D'Souza D, Lee Y, Periclou A, Ghahramani P, Laszlovszky I, Durgam S, Adham N, Nabulsi N, Huang Y, Carson RE, Kiss B, Kapás M, Abi-Dargham A, Rakhit A. Preferential binding to dopamine D3 over D2 receptors by cariprazine in patients with schizophrenia using PET with the D3/D2 receptor ligand [(11)C]-(+)-PHNO. Psychopharmacology (Berl). 2016 Oct;233(19-20):3503-12. doi: 10.1007/s00213-016-4382-y. Epub 2016 Aug 15. PubMed PMID: 27525990; PubMed Central PMCID: PMC5035321.
Wiers CE, Shokri-Kojori E, Wong CT, Abi-Dargham A, Demiral ŞB, Tomasi D, Wang GJ, Volkow ND. Cannabis Abusers Show Hypofrontality and Blunted Brain Responses to a Stimulant Challenge in Females but not in Males. Neuropsychopharmacology. 2016 Sep;41(10):2596-605. doi: 10.1038/npp.2016.67. Epub 2016 May 9. PubMed PMID: 27156854; PubMed Central PMCID: PMC4987858.
Heinz A, Voss M, Lawrie SM, Mishara A, Bauer M, Gallinat J, Juckel G, Lang U, Rapp M, Falkai P, Strik W, Krystal J, Abi-Dargham A, Galderisi S. Shall we really say goodbye to first rank symptoms?. Eur Psychiatry. 2016 Sep;37:8-13. doi: 10.1016/j.eurpsy.2016.04.010. Epub 2016 Jul 16. PubMed PMID: 27429167.
Horga G, Cassidy CM, Xu X, Moore H, Slifstein M, Van Snellenberg JX, Abi-Dargham A. Dopamine-Related Disruption of Functional Topography of Striatal Connections in Unmedicated Patients With Schizophrenia. JAMA Psychiatry. 2016 Aug 1;73(8):862-70. doi: 10.1001/jamapsychiatry.2016.0178. PubMed PMID: 27145361; PubMed Central PMCID: PMC5310843.
Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AFT, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA Jr, Carter CS, Cook EH Jr, Daskalakis ZJ, DiLeone RJ, Duman RS, Grace AA, Hariri AR, Harrison PJ, Hiroi N, Kenny PJ, Kleinman JE, Krystal AD, Lewis DA, Lipska BK, Marder SR, Mason GF, Mathalon DH, McClung CA, McDougle CJ, McIntosh AM, McMahon FJ, Mirnics K, Monteggia LM, Narendran R, Nestler EJ, Neumeister A, O'Donovan MC, Öngür D, Pariante CM, Paulus MP, Pearlson G, Phillips ML, Pine DS, Pizzagalli DA, Pletnikov MV, Ragland JD, Rapoport JL, Ressler KJ, Russo SJ, Sanacora G, Sawa A, Schatzberg AF, Shaham Y, Shamay-Tsoory SG, Sklar P, State MW, Stein MB, Strakowski SM, Taylor SF, Turecki G, Turetsky BI, Weissman MM, Zachariou V, Zarate CA Jr, Zubieta JK. Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research. Biol Psychiatry. 2016 Jul 15;80(2):84-86. doi: 10.1016/j.biopsych.2016.05.004. PubMed PMID: 27346079; PubMed Central PMCID: PMC6150945.
Krystal JH, Abi-Dargham A, Barch DM, Bullmore ET, Carter CS, Geschwind DH, Harrison PJ, Nestler EJ, Stein MB. Biological Psychiatry and Biological Psychiatry: Cognitive Neuroscience and Neuroimaging Adopt Neuroscience-Based Nomenclature. Biol Psychiatry. 2016 Jul 1;80(1):2-3. doi: 10.1016/j.biopsych.2016.03.2103. PubMed PMID: 27312230.
Roffman JL, Tanner AS, Eryilmaz H, Rodriguez-Thompson A, Silverstein NJ, Ho NF, Nitenson AZ, Chonde DB, Greve DN, Abi-Dargham A, Buckner RL, Manoach DS, Rosen BR, Hooker JM, Catana C. Dopamine D1 signaling organizes network dynamics underlying working memory. Sci Adv. 2016 Jun;2(6):e1501672. doi: 10.1126/sciadv.1501672. eCollection 2016 Jun. PubMed PMID: 27386561; PubMed Central PMCID: PMC4928887.
Bolkan SS, Carvalho Poyraz F, Kellendonk C. Using human brain imaging studies as a guide toward animal models of schizophrenia. Neuroscience. 2016 May 3;321:77-98. doi: 10.1016/j.neuroscience.2015.05.055. Epub 2015 May 30. Review. PubMed PMID: 26037801; PubMed Central PMCID: PMC4664583.
Girgis RR, Van Snellenberg JX, Glass A, Kegeles LS, Thompson JL, Wall M, Cho RY, Carter CS, Slifstein M, Abi-Dargham A, Lieberman JA. A proof-of-concept, randomized controlled trial of DAR-0100A, a dopamine-1 receptor agonist, for cognitive enhancement in schizophrenia. J Psychopharmacol. 2016 May;30(5):428-35. doi: 10.1177/0269881116636120. Epub 2016 Mar 10. PubMed PMID: 26966119.
Cassidy CM, Van Snellenberg JX, Benavides C, Slifstein M, Wang Z, Moore H, Abi-Dargham A, Horga G. Dynamic Connectivity between Brain Networks Supports Working Memory: Relationships to Dopamine Release and Schizophrenia. J Neurosci. 2016 Apr 13;36(15):4377-88. doi: 10.1523/JNEUROSCI.3296-15.2016. PubMed PMID: 27076432; PubMed Central PMCID: PMC4829655.
Colibazzi T, Horga G, Wang Z, Huo Y, Corcoran C, Klahr K, Brucato G, Girgis R, Gill K, Abi-Dargham A, Peterson BS. Neural Dysfunction in Cognitive Control Circuits in Persons at Clinical High-Risk for Psychosis. Neuropsychopharmacology. 2016 Apr;41(5):1241-50. doi: 10.1038/npp.2015.273. Epub 2015 Sep 10. PubMed PMID: 26354046; PubMed Central PMCID: PMC4793108.
Corbin WR, Papova A, Morean ME, O'Malley SS, Krishnan-Sarin S, Abi-Dargham A, Anticevic A, Pearlson G, Petrakis I, Pittman BP, Krystal JH. Integrating acquired preparedness and dual process models of risk for heavy drinking and related problems. Psychol Addict Behav. 2015 Dec;29(4):864-74. doi: 10.1037/adb0000093. Epub 2015 Sep 7. PubMed PMID: 26348221; PubMed Central PMCID: PMC6223629.
Abi-Dargham A. Imaging the "GABA shift" in schizophrenia. Am J Psychiatry. 2015 Nov 1;172(11):1062-3. doi: 10.1176/appi.ajp.2015.15081088. PubMed PMID: 26575447.
Girgis RR, Xu X, Gil RB, Hackett E, Ojeil N, Lieberman JA, Slifstein M, Abi-Dargham A. Antipsychotic binding to the dopamine-3 receptor in humans: A PET study with [(11)C]-(+)-PHNO. Schizophr Res. 2015 Oct;168(1-2):373-6. doi: 10.1016/j.schres.2015.06.027. Epub 2015 Jul 17. PubMed PMID: 26190300; PubMed Central PMCID: PMC4591174.
Ward RD, Winiger V, Higa KK, Kahn JB, Kandel ER, Balsam PD, Simpson EH. The impact of motivation on cognitive performance in an animal model of the negative and cognitive symptoms of schizophrenia. Behav Neurosci. 2015 Jun;129(3):292-9. doi: 10.1037/bne0000051. Epub 2015 Apr 27. PubMed PMID: 25914923; PubMed Central PMCID: PMC4880016.
Cazorla M, Kang UJ, Kellendonk C. Balancing the basal ganglia circuitry: a possible new role for dopamine D2 receptors in health and disease. Mov Disord. 2015 Jun;30(7):895-903. doi: 10.1002/mds.26282. Epub 2015 May 28. PubMed PMID: 26018615; PubMed Central PMCID: PMC4913465.
Slifstein M, van de Giessen E, Van Snellenberg J, Thompson JL, Narendran R, Gil R, Hackett E, Girgis R, Ojeil N, Moore H, D'Souza D, Malison RT, Huang Y, Lim K, Nabulsi N, Carson RE, Lieberman JA, Abi-Dargham A. Deficits in prefrontal cortical and extrastriatal dopamine release in schizophrenia: a positron emission tomographic functional magnetic resonance imaging study. JAMA Psychiatry. 2015 Apr;72(4):316-24. doi: 10.1001/jamapsychiatry.2014.2414. PubMed PMID: 25651194; PubMed Central PMCID: PMC4768742.
Van Snellenberg JX, Slifstein M, Read C, Weber J, Thompson JL, Wager TD, Shohamy D, Abi-Dargham A, Smith EE. Dynamic shifts in brain network activation during supracapacity working memory task performance. Hum Brain Mapp. 2015 Apr;36(4):1245-64. doi: 10.1002/hbm.22699. Epub 2014 Nov 24. PubMed PMID: 25422039; PubMed Central PMCID: PMC4722876.
Rosell DR, Zaluda LC, McClure MM, Perez-Rodriguez MM, Strike KS, Barch DM, Harvey PD, Girgis RR, Hazlett EA, Mailman RB, Abi-Dargham A, Lieberman JA, Siever LJ. Effects of the D1 dopamine receptor agonist dihydrexidine (DAR-0100A) on working memory in schizotypal personality disorder. Neuropsychopharmacology. 2015 Jan;40(2):446-53. doi: 10.1038/npp.2014.192. Epub 2014 Jul 30. PubMed PMID: 25074637; PubMed Central PMCID: PMC4443959.
Ridler K, Cunningham V, Huiban M, Martarello L, Pampols-Maso S, Passchier J, Gunn RN, Searle G, Abi-Dargham A, Slifstein M, Watson J, Laruelle M, Rabiner EA. An evaluation of the brain distribution of [(11)C]GSK1034702, a muscarinic-1 (M 1) positive allosteric modulator in the living human brain using positron emission tomography. EJNMMI Res. 2014 Dec;4(1):66. doi: 10.1186/s13550-014-0066-y. Epub 2014 Dec 5. PubMed PMID: 26116126; PubMed Central PMCID: PMC4452589.
van de Giessen E, Rosell DR, Thompson JL, Xu X, Girgis RR, Ehrlich Y, Slifstein M, Abi-Dargham A, Siever LJ. Serotonin transporter availability in impulsive aggressive personality disordered patients: a PET study with [11C]DASB. J Psychiatr Res. 2014 Nov;58:147-54. doi: 10.1016/j.jpsychires.2014.07.025. Epub 2014 Aug 6. PubMed PMID: 25145808.
Abi-Dargham A. Schizophrenia: overview and dopamine dysfunction. J Clin Psychiatry. 2014 Nov;75(11):e31. doi: 10.4088/JCP.13078tx2c. Review. PubMed PMID: 25470107.
Thompson JL, Rosell DR, Slifstein M, Girgis RR, Xu X, Ehrlich Y, Kegeles LS, Hazlett EA, Abi-Dargham A, Siever LJ. Prefrontal dopamine D1 receptors and working memory in schizotypal personality disorder: a PET study with [¹¹C]NNC112. Psychopharmacology (Berl). 2014 Oct;231(21):4231-40. doi: 10.1007/s00213-014-3566-6. Epub 2014 Apr 30. PubMed PMID: 24781514; PubMed Central PMCID: PMC4194223.
Ghazzaoui R, Abi-Dargham A. Imaging dopamine transmission parameters in cannabis dependence. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jul 3;52:28-32. doi: 10.1016/j.pnpbp.2013.10.013. Epub 2013 Oct 25. Review. PubMed PMID: 24513022.
Horga G, Schatz KC, Abi-Dargham A, Peterson BS. Deficits in predictive coding underlie hallucinations in schizophrenia. J Neurosci. 2014 Jun 11;34(24):8072-82. doi: 10.1523/JNEUROSCI.0200-14.2014. PubMed PMID: 24920613; PubMed Central PMCID: PMC4051966.
Kambeitz J, Abi-Dargham A, Kapur S, Howes OD. Alterations in cortical and extrastriatal subcortical dopamine function in schizophrenia: systematic review and meta-analysis of imaging studies. Br J Psychiatry. 2014 Jun;204(6):420-9. doi: 10.1192/bjp.bp.113.132308. Review. PubMed PMID: 25029687.
Horga G, Abi-Dargham A. The striatum and dopamine: a crossroad of risk for schizophrenia. JAMA Psychiatry. 2014 May;71(5):489-91. doi: 10.1001/jamapsychiatry.2014.191. PubMed PMID: 24622875.
Hwang DR, Hu E, Rumfelt S, Easwaramoorthy B, Castrillon J, Davis C, Allen JR, Chen H, Treanor J, Abi-Dargham A, Slifstein M. Initial characterization of a PDE10A selective positron emission tomography tracer [11C]AMG 7980 in non-human primates. Nucl Med Biol. 2014 Apr;41(4):343-9. doi: 10.1016/j.nucmedbio.2014.01.007. Epub 2014 Jan 17. PubMed PMID: 24607437.
Chen CM, Stanford AD, Mao X, Abi-Dargham A, Shungu DC, Lisanby SH, Schroeder CE, Kegeles LS. GABA level, gamma oscillation, and working memory performance in schizophrenia. Neuroimage Clin. 2014;4:531-9. doi: 10.1016/j.nicl.2014.03.007. eCollection 2014. PubMed PMID: 24749063; PubMed Central PMCID: PMC3989525.
Van Snellenberg JX, Conway AR, Spicer J, Read C, Smith EE. Capacity estimates in working memory: Reliability and interrelationships among tasks. Cogn Affect Behav Neurosci. 2014 Mar;14(1):106-16. doi: 10.3758/s13415-013-0235-x. PubMed PMID: 24399681; PubMed Central PMCID: PMC3972343.
Abi-Dargham A, Meyer JM. Schizophrenia: the role of dopamine and glutamate. J Clin Psychiatry. 2014 Mar;75(3):274-5. doi: 10.4088/JCP.13078co7c. PubMed PMID: 24717380.
Poels EM, Kegeles LS, Kantrowitz JT, Javitt DC, Lieberman JA, Abi-Dargham A, Girgis RR. Glutamatergic abnormalities in schizophrenia: a review of proton MRS findings. Schizophr Res. 2014 Feb;152(2-3):325-32. doi: 10.1016/j.schres.2013.12.013. Epub 2014 Jan 11. Review. PubMed PMID: 24418122; PubMed Central PMCID: PMC3951718.
Ravan S, Martinez D, Slifstein M, Abi-Dargham A. Molecular imaging in alcohol dependence. Handb Clin Neurol. 2014;125:293-311. doi: 10.1016/B978-0-444-62619-6.00018-5. Review. PubMed PMID: 25307582.
Poels EM, Kegeles LS, Kantrowitz JT, Slifstein M, Javitt DC, Lieberman JA, Abi-Dargham A, Girgis RR. Imaging glutamate in schizophrenia: review of findings and implications for drug discovery. Mol Psychiatry. 2014 Jan;19(1):20-9. doi: 10.1038/mp.2013.136. Epub 2013 Oct 29. Review. PubMed PMID: 24166406.
Moore H, Geyer MA, Carter CS, Barch DM. Harnessing cognitive neuroscience to develop new treatments for improving cognition in schizophrenia: CNTRICS selected cognitive paradigms for animal models. Neurosci Biobehav Rev. 2013 Nov;37(9 Pt B):2087-91. doi: 10.1016/j.neubiorev.2013.09.011. Epub 2013 Sep 30. PubMed PMID: 24090823; PubMed Central PMCID: PMC3965347.
Trifilieff P, Feng B, Urizar E, Winiger V, Ward RD, Taylor KM, Martinez D, Moore H, Balsam PD, Simpson EH, Javitch JA. Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation. Mol Psychiatry. 2013 Sep;18(9):1025-33. doi: 10.1038/mp.2013.57. Epub 2013 May 28. PubMed PMID: 23711983; PubMed Central PMCID: PMC4030518.
Thompson JL, Urban N, Slifstein M, Xu X, Kegeles LS, Girgis RR, Beckerman Y, Harkavy-Friedman JM, Gil R, Abi-Dargham A. Striatal dopamine release in schizophrenia comorbid with substance dependence. Mol Psychiatry. 2013 Aug;18(8):909-15. doi: 10.1038/mp.2012.109. Epub 2012 Aug 7. PubMed PMID: 22869037; PubMed Central PMCID: PMC4128915.
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