My Bibliography

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Analysis of N-linked glycan alterations in tissue and serum reveals promising biomarkers for intrahepatic Cholangiocarcinoma. Cancer research communications. . NIHMSID: NIHMS1876078.

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Spatial Omics Reveals that Cancer-Associated Glycan Changes Occur Early in Liver Disease Development in a Western Diet Mouse Model of MASLD. Journal of proteome research. . NIHMSID: NIHMS2093305.

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Maggioncalda J, Mehta A, Fraser NW, Block TM. Analysis of a herpes simplex virus type 1 LAT mutant with a deletion between the putative promoter and the 5' end of the 2.0-kilobase transcript. J Virol. 1994 Dec;68(12):7816-24. doi: 10.1128/JVI.68.12.7816-7824.1994. PubMed PMID: 7966571; PubMed Central PMCID: PMC237243.

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Mehta A, Maggioncalda J, Bagasra O, Thikkavarapu S, Saikumari P, Valyi-Nagy T, Fraser NW, Block TM. In situ DNA PCR and RNA hybridization detection of herpes simplex virus sequences in trigeminal ganglia of latently infected mice. Virology. 1995 Jan 10;206(1):633-40. doi: 10.1016/s0042-6822(95)80080-8. PubMed PMID: 7831818.

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Lu X, Mehta A, Dwek R, Butters T, Block T. Evidence that N-linked glycosylation is necessary for hepatitis B virus secretion. Virology. 1995 Nov 10;213(2):660-5. doi: 10.1006/viro.1995.0038. PubMed PMID: 7491790.

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Maggioncalda J, Mehta A, Bagasra O, Fraser NW, Block TM. A herpes simplex virus type 1 mutant with a deletion immediately upstream of the LAT locus establishes latency and reactivates from latently infected mice with normal kinetics. J Neurovirol. 1996 Aug;2(4):268-78. doi: 10.3109/13550289609146890. PubMed PMID: 8799218.

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Maggioncalda J, Mehta A, Su YH, Fraser NW, Block TM. Correlation between herpes simplex virus type 1 rate of reactivation from latent infection and the number of infected neurons in trigeminal ganglia. Virology. 1996 Nov 1;225(1):72-81. doi: 10.1006/viro.1996.0576. PubMed PMID: 8918535.

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Mehta A, Lu X, Block TM, Blumberg BS, Dwek RA. Hepatitis B virus (HBV) envelope glycoproteins vary drastically in their sensitivity to glycan processing: evidence that alteration of a single N-linked glycosylation site can regulate HBV secretion. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1822-7. doi: 10.1073/pnas.94.5.1822. PubMed PMID: 9050863; PubMed Central PMCID: PMC20001.

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Lu X, Mehta A, Dadmarz M, Dwek R, Blumberg BS, Block TM. Aberrant trafficking of hepatitis B virus glycoproteins in cells in which N-glycan processing is inhibited. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2380-5. doi: 10.1073/pnas.94.6.2380. PubMed PMID: 9122203; PubMed Central PMCID: PMC20096.

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Mehta A, Rudd PM, Block TM, Dwek RA. A strategy for anti-viral intervention: the use of alpha-glucosidase inhibitors to prevent chaperone-mediated folding of viral envelope glycoproteins. Biochem Soc Trans. 1997 Nov;25(4):1188-93. doi: 10.1042/bst0251188. Review. PubMed PMID: 9449973.

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Block TM, Lu X, Mehta AS, Blumberg BS, Tennant B, Ebling M, Korba B, Lansky DM, Jacob GS, Dwek RA. Treatment of chronic hepadnavirus infection in a woodchuck animal model with an inhibitor of protein folding and trafficking. Nat Med. 1998 May;4(5):610-4. doi: 10.1038/nm0598-610. PubMed PMID: 9585237.

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Mehta A, Zitzmann N, Rudd PM, Block TM, Dwek RA. Alpha-glucosidase inhibitors as potential broad based anti-viral agents. FEBS Lett. 1998 Jun 23;430(1-2):17-22. doi: 10.1016/s0014-5793(98)00525-0. Review. PubMed PMID: 9678587.

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Mehta A, Block TM, Dwek RA. The role of N-linked glycosylation in the secretion of hepatitis B virus. Adv Exp Med Biol. 1998;435:195-205. doi: 10.1007/978-1-4615-5383-0_19. PubMed PMID: 9498078.

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Block TM, Lu X, Mehta A, Park J, Blumberg BS, Dwek R. Role of glycan processing in hepatitis B virus envelope protein trafficking. Adv Exp Med Biol. 1998;435:207-16. doi: 10.1007/978-1-4615-5383-0_20. Review. PubMed PMID: 9498079.

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Zitzmann N, Mehta AS, Carrouée S, Butters TD, Platt FM, McCauley J, Blumberg BS, Dwek RA, Block TM. Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: implications for the development of broad spectrum anti-hepatitis virus agents. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11878-82. doi: 10.1073/pnas.96.21.11878. PubMed PMID: 10518544; PubMed Central PMCID: PMC18380.

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Rudd PM, Mattu TS, Zitzmann N, Mehta A, Colominas C, Hart E, Opdenakker G, Dwek RA. Glycoproteins: rapid sequencing technology for N-linked and GPI anchor glycans. Biotechnol Genet Eng Rev. 1999;16:1-21. doi: 10.1080/02648725.1999.10647969. Review. PubMed PMID: 10819075.

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Su YH, Moxley M, Kejariwal R, Mehta A, Fraser NW, Block TM. The HSV 1 genome in quiescently infected NGF differentiated PC12 cells can not be stimulated by HSV superinfection. J Neurovirol. 2000 Aug;6(4):341-9. doi: 10.3109/13550280009030760. PubMed PMID: 10951558.

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Mehta A, Lu X, Block T, Willis A, Dwek R, Tennant B, Blumberg B. Synovial stimulatory protein fragments copurify with woodchuck hepatitis virus: implications for the etiology of arthritis in chronic hepatitis B virus infection. Arthritis Rheum. 2001 Feb;44(2):486-7. doi: 10.1002/1529-0131(200102)44:2<486::AID-ANR69>3.0.CO;2-P. PubMed PMID: 11229482.

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Mehta A, Carrouée S, Conyers B, Jordan R, Butters T, Dwek RA, Block TM. Inhibition of hepatitis B virus DNA replication by imino sugars without the inhibition of the DNA polymerase: therapeutic implications. Hepatology. 2001 Jun;33(6):1488-95. doi: 10.1053/jhep.2001.25103. PubMed PMID: 11391538.

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Durantel D, Branza-Nichita N, Carrouée-Durantel S, Butters TD, Dwek RA, Zitzmann N. Study of the mechanism of antiviral action of iminosugar derivatives against bovine viral diarrhea virus. J Virol. 2001 Oct;75(19):8987-98. doi: 10.1128/JVI.75.19.8987-8998.2001. PubMed PMID: 11533162; PubMed Central PMCID: PMC114467.

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Steel LF, Mattu TS, Mehta A, Hebestreit H, Dwek R, Evans AA, London WT, Block T. A proteomic approach for the discovery of early detection markers of hepatocellular carcinoma. Dis Markers. 2001;17(3):179-89. doi: 10.1155/2001/963023. Review. PubMed PMID: 11790885; PubMed Central PMCID: PMC3851119.

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Jordan R, Nikolaeva OV, Wang L, Conyers B, Mehta A, Dwek RA, Block TM. Inhibition of host ER glucosidase activity prevents Golgi processing of virion-associated bovine viral diarrhea virus E2 glycoproteins and reduces infectivity of secreted virions. Virology. 2002 Mar 30;295(1):10-9. doi: 10.1006/viro.2002.1370. PubMed PMID: 12033761.

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Ouzounov S, Mehta A, Dwek RA, Block TM, Jordan R. The combination of interferon alpha-2b and n-butyl deoxynojirimycin has a greater than additive antiviral effect upon production of infectious bovine viral diarrhea virus (BVDV) in vitro: implications for hepatitis C virus (HCV) therapy. Antiviral Res. 2002 Sep;55(3):425-35. doi: 10.1016/s0166-3542(02)00075-x. PubMed PMID: 12206880.

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Mehta A, Ouzounov S, Jordan R, Simsek E, Lu X, Moriarty RM, Jacob G, Dwek RA, Block TM. Imino sugars that are less toxic but more potent as antivirals, in vitro, compared with N-n-nonyl DNJ. Antivir Chem Chemother. 2002 Sep;13(5):299-304. doi: 10.1177/095632020201300505. PubMed PMID: 12630678.

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Mehta A, Conyers B, Tyrrell DL, Walters KA, Tipples GA, Dwek RA, Block TM. Structure-activity relationship of a new class of anti-hepatitis B virus agents. Antimicrob Agents Chemother. 2002 Dec;46(12):4004-8. doi: 10.1128/AAC.46.12.4004-4008.2002. PubMed PMID: 12435712; PubMed Central PMCID: PMC132742.

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Norton PA, Gong Q, Mehta AS, Lu X, Block TM. Hepatitis B virus-mediated changes of apolipoprotein mRNA abundance in cultured hepatoma cells. J Virol. 2003 May;77(9):5503-6. doi: 10.1128/jvi.77.9.5503-5506.2003. PubMed PMID: 12692252; PubMed Central PMCID: PMC153946.

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Block TM, Mehta AS, Fimmel CJ, Jordan R. Molecular viral oncology of hepatocellular carcinoma. Oncogene. 2003 Aug 11;22(33):5093-107. doi: 10.1038/sj.onc.1206557. Review. PubMed PMID: 12910247.

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Lu X, Tran T, Simsek E, Block TM. The alkylated imino sugar, n-(n-Nonyl)-deoxygalactonojirimycin, reduces the amount of hepatitis B virus nucleocapsid in tissue culture. J Virol. 2003 Nov;77(22):11933-40. doi: 10.1128/jvi.77.22.11933-11940.2003. PubMed PMID: 14581530; PubMed Central PMCID: PMC254279.

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Comunale MA, Mattu TS, Lowman MA, Evans AA, London WT, Semmes OJ, Ward M, Drake R, Romano PR, Steel LF, Block TM, Mehta A. Comparative proteomic analysis of de-N-glycosylated serum from hepatitis B carriers reveals polypeptides that correlate with disease status. Proteomics. 2004 Mar;4(3):826-38. doi: 10.1002/pmic.200300625. PubMed PMID: 14997503.

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Mehta AS, Gu B, Conyers B, Ouzounov S, Wang L, Moriarty RM, Dwek RA, Block TM. alpha-Galactosylceramide and novel synthetic glycolipids directly induce the innate host defense pathway and have direct activity against hepatitis B and C viruses. Antimicrob Agents Chemother. 2004 Jun;48(6):2085-90. doi: 10.1128/AAC.48.6.2085-2090.2004. PubMed PMID: 15155204; PubMed Central PMCID: PMC415597.

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Norton PA, Conyers B, Gong Q, Steel LF, Block TM, Mehta AS. Assays for glucosidase inhibitors with potential antiviral activities: secreted alkaline phosphatase as a surrogate marker. J Virol Methods. 2005 Mar;124(1-2):167-72. doi: 10.1016/j.jviromet.2004.11.019. Epub 2004 Dec 23. PubMed PMID: 15664065.

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Block TM, Comunale MA, Lowman M, Steel LF, Romano PR, Fimmel C, Tennant BC, London WT, Evans AA, Blumberg BS, Dwek RA, Mattu TS, Mehta AS. Use of targeted glycoproteomics to identify serum glycoproteins that correlate with liver cancer in woodchucks and humans. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):779-84. doi: 10.1073/pnas.0408928102. Epub 2005 Jan 10. PubMed PMID: 15642945; PubMed Central PMCID: PMC545516.

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Marrero JA, Romano PR, Nikolaeva O, Steel L, Mehta A, Fimmel CJ, Comunale MA, D'Amelio A, Lok AS, Block TM. GP73, a resident Golgi glycoprotein, is a novel serum marker for hepatocellular carcinoma. J Hepatol. 2005 Dec;43(6):1007-12. doi: 10.1016/j.jhep.2005.05.028. Epub 2005 Jun 28. PubMed PMID: 16137783.

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Simsek E, Mehta A, Zhou T, Dwek RA, Block T. Hepatitis B virus large and middle glycoproteins are degraded by a proteasome pathway in glucosidase-inhibited cells but not in cells with functional glucosidase enzyme. J Virol. 2005 Oct;79(20):12914-20. doi: 10.1128/JVI.79.20.12914-12920.2005. PubMed PMID: 16188993; PubMed Central PMCID: PMC1235823.

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Comunale MA, Lowman M, Long RE, Krakover J, Philip R, Seeholzer S, Evans AA, Hann HW, Block TM, Mehta AS. Proteomic analysis of serum associated fucosylated glycoproteins in the development of primary hepatocellular carcinoma. J Proteome Res. 2006 Feb;5(2):308-15. doi: 10.1021/pr050328x. PubMed PMID: 16457596.

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Block TM, Mehta AS, Blumberg BS, Dwek RA. Does rapid oligomerization of hepatitis B envelope proteins play a role in resistance to proteasome degradation and enhance chronicity?. DNA Cell Biol. 2006 Mar;25(3):165-70. doi: 10.1089/dna.2006.25.165. Review. PubMed PMID: 16569195.

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Zhou T, Guo H, Guo JT, Cuconati A, Mehta A, Block TM. Hepatitis B virus e antigen production is dependent upon covalently closed circular (ccc) DNA in HepAD38 cell cultures and may serve as a cccDNA surrogate in antiviral screening assays. Antiviral Res. 2006 Nov;72(2):116-24. doi: 10.1016/j.antiviral.2006.05.006. Epub 2006 Jun 2. PubMed PMID: 16780964.

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Drake RR, Schwegler EE, Malik G, Diaz J, Block T, Mehta A, Semmes OJ. Lectin capture strategies combined with mass spectrometry for the discovery of serum glycoprotein biomarkers. Mol Cell Proteomics. 2006 Oct;5(10):1957-67. doi: 10.1074/mcp.M600176-MCP200. Epub 2006 Jun 7. Review. PubMed PMID: 16760258.

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Simsek E, Lu X, Ouzounov S, Block TM, Mehta AS. alpha-Glucosidase inhibitors have a prolonged antiviral effect against hepatitis B virus through the sustained inhibition of the large and middle envelope glycoproteins. Antivir Chem Chemother. 2006;17(5):259-67. doi: 10.1177/095632020601700503. PubMed PMID: 17176630.

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Liu Y, Simsek E, Norton P, Sinnathamby G, Philip R, Block T, Zhou T, Mehta A. The role of the downstream signal sequences in the maturation of the HBV middle surface glycoprotein: development of a novel therapeutic vaccine candidate. Virology. 2007 Aug 15;365(1):10-9. doi: 10.1016/j.virol.2007.03.042. Epub 2007 Apr 25. PubMed PMID: 17462693.

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Liu Y, Zhou T, Simsek E, Block T, Mehta A. The degradation pathway for the HBV envelope proteins involves proteolysis prior to degradation via the cytosolic proteasome. Virology. 2007 Dec 5;369(1):69-77. doi: 10.1016/j.virol.2007.06.048. Epub 2007 Aug 23. PubMed PMID: 17716702; PubMed Central PMCID: PMC4422056.

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Dougherty AM, Guo H, Westby G, Liu Y, Simsek E, Guo JT, Mehta A, Norton P, Gu B, Block T, Cuconati A. A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion. Antimicrob Agents Chemother. 2007 Dec;51(12):4427-37. doi: 10.1128/AAC.00541-07. Epub 2007 Sep 17. PubMed PMID: 17875990; PubMed Central PMCID: PMC2167973.

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Mehta AS, Long RE, Comunale MA, Wang M, Rodemich L, Krakover J, Philip R, Marrero JA, Dwek RA, Block TM. Increased levels of galactose-deficient anti-Gal immunoglobulin G in the sera of hepatitis C virus-infected individuals with fibrosis and cirrhosis. J Virol. 2008 Feb;82(3):1259-70. doi: 10.1128/JVI.01600-07. Epub 2007 Nov 28. PubMed PMID: 18045939; PubMed Central PMCID: PMC2224448.

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Gu B, Mason P, Wang L, Norton P, Bourne N, Moriarty R, Mehta A, Despande M, Shah R, Block T. Antiviral profiles of novel iminocyclitol compounds against bovine viral diarrhea virus, West Nile virus, dengue virus and hepatitis B virus. Antivir Chem Chemother. 2007;18(1):49-59. doi: 10.1177/095632020701800105. PubMed PMID: 17354651.

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Balagopal A, Philp FH, Astemborski J, Block TM, Mehta A, Long R, Kirk GD, Mehta SH, Cox AL, Thomas DL, Ray SC. Human immunodeficiency virus-related microbial translocation and progression of hepatitis C. Gastroenterology. 2008 Jul;135(1):226-33. doi: 10.1053/j.gastro.2008.03.022. Epub 2008 Mar 29. PubMed PMID: 18457674; PubMed Central PMCID: PMC2644903.

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Norton PA, Comunale MA, Krakover J, Rodemich L, Pirog N, D'Amelio A, Philip R, Mehta AS, Block TM. N-linked glycosylation of the liver cancer biomarker GP73. J Cell Biochem. 2008 May 1;104(1):136-49. doi: 10.1002/jcb.21610. PubMed PMID: 18004786; PubMed Central PMCID: PMC4620713.

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Simsek E, Sinnathamby G, Block TM, Liu Y, Philip R, Mehta AS, Norton PA. Inhibition of cellular alpha-glucosidases results in increased presentation of hepatitis B virus glycoprotein-derived peptides by MHC class I. Virology. 2009 Feb 5;384(1):12-5. doi: 10.1016/j.virol.2008.11.027. Epub 2008 Dec 16. PubMed PMID: 19091367; PubMed Central PMCID: PMC2765373.

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Mehta A, Block TM. Fucosylated glycoproteins as markers of liver disease. Dis Markers. 2008;25(4-5):259-65. doi: 10.1155/2008/264594. Review. PubMed PMID: 19126969; PubMed Central PMCID: PMC3827789.

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Comunale MA, Wang M, Hafner J, Krakover J, Rodemich L, Kopenhaver B, Long RE, Junaidi O, Bisceglie AM, Block TM, Mehta AS. Identification and development of fucosylated glycoproteins as biomarkers of primary hepatocellular carcinoma. J Proteome Res. 2009 Feb;8(2):595-602. doi: 10.1021/pr800752c. PubMed PMID: 19099421; PubMed Central PMCID: PMC4427194.

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White KY, Rodemich L, Nyalwidhe JO, Comunale MA, Clements MA, Lance RS, Schellhammer PF, Mehta AS, Semmes OJ, Drake RR. Glycomic characterization of prostate-specific antigen and prostatic acid phosphatase in prostate cancer and benign disease seminal plasma fluids. J Proteome Res. 2009 Feb;8(2):620-30. doi: 10.1021/pr8007545. PubMed PMID: 19128049; PubMed Central PMCID: PMC2651839.