My Bibliography

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Shanbhag VC, Anakpeba-Dinguyella S, Gudekar N, Conrad K, Azubuogu C, Probst C, Ralle M, Mediavilla MG, Cricco JA, Garza NM, Gohil VM, Peck S, Kumar S, Natarajan A, Horadigala-Gamage MA, Meloni G, Singh K, Petris MJ. A broad-spectrum inhibitor of copper-exporting P(1B)-type ATPases. Proc Natl Acad Sci U S A. 2026 May 19;123(20):e2604078123. doi: 10.1073/pnas.2604078123. Epub 2026 May 14. PubMed PMID: 42133807; PubMed Central PMCID: PMC13187769.

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Umeta LT, Natarajan A. MAP3K1: A Multifunctional Kinase at the Crossroads of Cancer Progression and Tumor Suppression. Cells. 2026 Mar 28;15(7). doi: 10.3390/cells15070604. Review. PubMed PMID: 41972694; PubMed Central PMCID: PMC13072407.

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Boghean L, Singh S, Mangalaparthi KK, Kizhake S, Umeta L, Wishka D, Grothaus P, Pandey A, Natarajan A. A Selective MAP3K1 Inhibitor Facilitates Discovery of NPM1 as a Member of the Network. Molecules. 2025 Apr 30;30(9). doi: 10.3390/molecules30092001. PubMed PMID: 40363807; PubMed Central PMCID: PMC12073402.

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Mallareddy JR, Yang L, Lin WH, Feathers R, Ayers-Ringler J, Tolosa E, Kizhake AG, Kizhake S, Kubica SP, Boghean L, Alvarez S, Naldrett MJ, Singh S, Rana S, Zahid M, Schaefer-Klein J, Roden A, Kosari F, Anastasiadis PZ, Borad M, Natarajan A, Mansfield AS. Fluorescence based live cell imaging identifies exon 14 skipped hepatocyte growth factor receptor (MET) degraders. RSC Adv. 2025 Mar 28;15(13):10419-10425. doi: 10.1039/d5ra01441g. eCollection 2025 Mar 28. PubMed PMID: 40182503; PubMed Central PMCID: PMC11967169.

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Azadmanesh J, Slobodnik K, Struble LR, Lovelace JJ, Cone EA, Dasgupta M, Lutz WE, Kumar S, Natarajan A, Coates L, Weiss KL, Myles DAA, Kroll T, Borgstahl GEO. The role of Tyr34 in proton coupled electron transfer and product inhibition of manganese superoxide dismutase. Nat Commun. 2025 Feb 22;16(1):1887. doi: 10.1038/s41467-025-57180-3. PubMed PMID: 39987263; PubMed Central PMCID: PMC11846855.

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Tolosa EJ, Yang L, Ayers-Ringler J, Suzuki S, Mallareddy JR, Schaefer-Klein J, Borad M, Kosari F, Natarajan A, Mansfield AS. Proteolysis targeting chimera (PROTAC)-driven antibody internalization of oncogenic cell surface receptors. Commun Biol. 2024 Dec 31;7(1):1719. doi: 10.1038/s42003-024-07439-0. PubMed PMID: 39741170; PubMed Central PMCID: PMC11688428.

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Schmitz E, Ridout A, Smith AL, Eiken AP, Skupa SA, Drengler EM, Singh S, Rana S, Natarajan A, El-Gamal D. Immunogenic Cell Death Traits Emitted from Chronic Lymphocytic Leukemia Cells Following Treatment with a Novel Anti-Cancer Agent, SpiD3. Biomedicines. 2024 Dec 16;12(12). doi: 10.3390/biomedicines12122857. PubMed PMID: 39767763; PubMed Central PMCID: PMC11673838.

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Qiao F, Binkowski TA, Broughan I, Chen W, Natarajan A, Schiltz GE, Scheidt KA, Anderson WF, Bergan R. Protein Structure Inspired Discovery of a Novel Inducer of Anoikis in Human Melanoma. Cancers (Basel). 2024 Sep 17;16(18). doi: 10.3390/cancers16183177. PubMed PMID: 39335149; PubMed Central PMCID: PMC11429909.

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Eiken AP, Schmitz E, Drengler EM, Smith AL, Skupa SA, Mohan K, Rana S, Singh S, Mallareddy JR, Mathew G, Natarajan A, El-Gamal D. The Novel Anti-Cancer Agent, SpiD3, Is Cytotoxic in CLL Cells Resistant to Ibrutinib or Venetoclax. Hemato. 2024 Sep;5(3):321-339. doi: 10.3390/hemato5030024. Epub 2024 Aug 27. PubMed PMID: 39450301; PubMed Central PMCID: PMC11500768.

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Mukthapuram PR, Natarajan A. Domino Reactions Enable Zn-Mediated Direct Synthesis of Spiro-Fused 2-Oxindole-α-Methylene-γ-Butyrolactones/Lactams from Isatin Derivatives and 2-(Bromomethyl)acrylates. Molecules. 2024 Jul 30;29(15). doi: 10.3390/molecules29153612. PubMed PMID: 39125017; PubMed Central PMCID: PMC11314261.

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Mullen NJ, Shukla SK, Thakur R, Kollala SS, Wang D, Chaika N, Santana JF, Miklavcic WR, LaBreck DA, Mallareddy JR, Price DH, Natarajan A, Mehla K, Sykes DB, Hollingsworth MA, Singh PK. DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation. Elife. 2024 Jul 8;12. doi: 10.7554/eLife.87292. PubMed PMID: 38973593; PubMed Central PMCID: PMC11230627.

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Bhat AM, Mohapatra BC, Luan H, Mushtaq I, Chakraborty S, Kumar S, Wu W, Nolan B, Dutta S, Storck MD, Schott M, Meza JL, Lele SM, Lin MF, Cook LM, Corey E, Morrissey C, Coulter DW, Rowley MJ, Natarajan A, Datta K, Band V, Band H. GD2 and its biosynthetic enzyme GD3 synthase promote tumorigenesis in prostate cancer by regulating cancer stem cell behavior. Sci Rep. 2024 Jun 12;14(1):13523. doi: 10.1038/s41598-024-60052-3. PubMed PMID: 38866755; PubMed Central PMCID: PMC11169677.

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Azadmanesh J, Slobodnik K, Struble LR, Cone EA, Dasgupta M, Lutz WE, Kumar S, Natarajan A, Coates L, Weiss KL, Myles DAA, Kroll T, Borgstahl GEO. The role of Tyr34 in proton-coupled electron transfer of human manganese superoxide dismutase. bioRxiv. 2024 May 29;. doi: 10.1101/2024.05.29.596464. PubMed PMID: 38853997; PubMed Central PMCID: PMC11160768.

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Eiken AP, Smith AL, Skupa SA, Schmitz E, Rana S, Singh S, Kumar S, Mallareddy JR, de Cubas AA, Krishna A, Kalluchi A, Rowley MJ, D'Angelo CR, Lunning MA, Bociek RG, Vose JM, Natarajan A, El-Gamal D. Novel Spirocyclic Dimer, SpiD3, Targets Chronic Lymphocytic Leukemia Survival Pathways with Potent Preclinical Effects. Cancer Res Commun. 2024 May 22;4(5):1328-1343. doi: 10.1158/2767-9764.CRC-24-0071. PubMed PMID: 38687198; PubMed Central PMCID: PMC11110724.

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Qiao F, Binknowski TA, Broughan I, Chen W, Natarajan A, Schiltz GE, Scheidt KA, Anderson WF, Bergan R. Protein Structure Inspired Drug Discovery. bioRxiv. 2024 May 20;. doi: 10.1101/2024.05.17.594634. PubMed PMID: 38826221; PubMed Central PMCID: PMC11142055.

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Vorderbruggen M, Velázquez-Martínez CA, Natarajan A, Karpf AR. PROTACs in Ovarian Cancer: Current Advancements and Future Perspectives. Int J Mol Sci. 2024 May 7;25(10). doi: 10.3390/ijms25105067. Review. PubMed PMID: 38791105; PubMed Central PMCID: PMC11121112.

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Murthy D, Attri KS, Shukla SK, Thakur R, Chaika NV, He C, Wang D, Jha K, Dasgupta A, King RJ, Mulder SE, Souchek J, Gebregiworgis T, Rai V, Patel R, Hu T, Rana S, Kollala SS, Pacheco C, Grandgenett PM, Yu F, Kumar V, Lazenby AJ, Black AR, Ulhannan S, Jain A, Edil BH, Klinkebiel DL, Powers R, Natarajan A, Hollingsworth MA, Mehla K, Ly Q, Chaudhary S, Hwang RF, Wellen KE, Singh PK. Author Correction: Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2-SP1-SAT1 axis. Nat Cell Biol. 2024 May;26(5):840. doi: 10.1038/s41556-024-01417-8. PubMed PMID: 38641662; PubMed Central PMCID: PMC11098729.

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Murthy D, Attri KS, Shukla SK, Thakur R, Chaika NV, He C, Wang D, Jha K, Dasgupta A, King RJ, Mulder SE, Souchek J, Gebregiworgis T, Rai V, Patel R, Hu T, Rana S, Kollala SS, Pacheco C, Grandgenett PM, Yu F, Kumar V, Lazenby AJ, Black AR, Ulhannan S, Jain A, Edil BH, Klinkebiel DL, Powers R, Natarajan A, Hollingsworth MA, Mehla K, Ly Q, Chaudhary S, Hwang RF, Wellen KE, Singh PK. Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2-SP1-SAT1 axis. Nat Cell Biol. 2024 Apr;26(4):613-627. doi: 10.1038/s41556-024-01372-4. Epub 2024 Mar 1. PubMed PMID: 38429478; PubMed Central PMCID: PMC11021164.

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Mullen NJ, Shukla SK, Thakur R, Kollala SS, Wang D, Chaika N, Santana JF, Miklavcic WR, LaBreck DA, Mallareddy JR, Price DH, Natarajan A, Mehla K, Sykes DB, Hollingsworth MA, Singh PK. DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation. bioRxiv. 2024 Jan 13;. doi: 10.1101/2023.04.03.535399. PubMed PMID: 37066260; PubMed Central PMCID: PMC10103971.

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Wallin S, Singh S, Borgstahl GEO, Natarajan A. Design, synthesis, and evaluation of a mitoxantrone probe (MXP) for biological studies. Bioorg Med Chem Lett. 2023 Oct 1;94:129465. doi: 10.1016/j.bmcl.2023.129465. Epub 2023 Sep 3. PubMed PMID: 37669721; PubMed Central PMCID: PMC10528225.

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Wallin S, Singh S, Borgstahl GEO, Natarajan A. Design, synthesis, and evaluation of a mitoxantrone probe (MXP) for biological studies. bioRxiv. 2023 Apr 11;. doi: 10.1101/2023.04.11.536471. PubMed PMID: 37090570; PubMed Central PMCID: PMC10120692.

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Pathirage R, Favrot L, Petit C, Yamsek M, Singh S, Mallareddy JR, Rana S, Natarajan A, Ronning DR. Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding. RSC Med Chem. 2023 May 25;14(5):921-933. doi: 10.1039/d3md00058c. eCollection 2023 May 25. PubMed PMID: 37252106; PubMed Central PMCID: PMC10211323.

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Umfress A, Chakraborti A, Priya Sudarsana Devi S, Adams R, Epstein D, Massicano A, Sorace A, Singh S, Iqbal Hossian M, Andrabi SA, Crossman DK, Kumar N, Shahid Mukhtar M, Luo H, Simpson C, Abell K, Stokes M, Wiederhold T, Rosen C, Lu H, Natarajan A, Bibb JA. Cdk5 mediates rotational force-induced brain injury. Sci Rep. 2023 Feb 28;13(1):3394. doi: 10.1038/s41598-023-29322-4. PubMed PMID: 36854738; PubMed Central PMCID: PMC9974974.

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Fatima I, Uppada JP, Chhonker YS, Gowrikumar S, Barman S, Roy S, Tolentino KT, Palermo N, Natarajan A, Beauchamp DR, Vecchio A, Murry DJ, Singh AB, Hopkins CR, Dhawan P. Identification and characterization of a first-generation inhibitor of claudin-1 in colon cancer progression and metastasis. Biomed Pharmacother. 2023 Mar;159:114255. doi: 10.1016/j.biopha.2023.114255. Epub 2023 Jan 23. PubMed PMID: 36696800; PubMed Central PMCID: PMC10824272.

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Gupta P, Strange K, Telange R, Guo A, Hatch H, Sobh A, Elie J, Carter AM, Totenhagen J, Tan C, Sonawane YA, Neuzil J, Natarajan A, Ovens AJ, Oakhill JS, Wiederhold T, Pacak K, Ghayee HK, Meijer L, Reddy S, Bibb JA. Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer. Cell Rep. 2022 Aug 16;40(7):111218. doi: 10.1016/j.celrep.2022.111218. PubMed PMID: 35977518; PubMed Central PMCID: PMC9822535.

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Harris R, Yang M, Schmidt C, Royet C, Singh S, Natarajan A, Morris M, Frezza C, Laman H. Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells. J Cell Biol. 2022 Jul 4;221(7). doi: 10.1083/jcb.202203095. Epub 2022 Jun 7. PubMed PMID: 35670764; PubMed Central PMCID: PMC9178409.

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Umfress A, Singh S, Ryan KJ, Chakraborti A, Plattner F, Sonawane Y, Mallareddy JR, Acosta EP, Natarajan A, Bibb JA. Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior. Front Pharmacol. 2022;13:863762. doi: 10.3389/fphar.2022.863762. eCollection 2022. PubMed PMID: 35645825; PubMed Central PMCID: PMC9134315.

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Napoleon JV, Sagar S, Kubica SP, Boghean L, Kour S, King HM, Sonawane YA, Crawford AJ, Gautam N, Kizhake S, Bialk PA, Kmiec E, Mallareddy JR, Patil PP, Rana S, Singh S, Prahlad J, Grandgenett PM, Borgstahl GEO, Ghosal G, Alnouti Y, Hollingsworth MA, Radhakrishnan P, Natarajan A. Small-molecule IKKβ activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2115071119. doi: 10.1073/pnas.2115071119. Epub 2022 Apr 27. PubMed PMID: 35476515; PubMed Central PMCID: PMC9170026.

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Pramanik S, Chen Y, Song H, Khutsishvili I, Marky LA, Ray S, Natarajan A, Singh PK, Bhakat KK. The human AP-endonuclease 1 (APE1) is a DNA G-quadruplex structure binding protein and regulates KRAS expression in pancreatic ductal adenocarcinoma cells. Nucleic Acids Res. 2022 Apr 8;50(6):3394-3412. doi: 10.1093/nar/gkac172. PubMed PMID: 35286386; PubMed Central PMCID: PMC8990529.

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Kour S, Rana S, Kubica SP, Kizhake S, Ahmad M, Muñoz-Trujillo C, Klinkebiel D, Singh S, Mallareddy JR, Chandra S, Woods NT, Karpf AR, Natarajan A. Spirocyclic dimer SpiD7 activates the unfolded protein response to selectively inhibit growth and induce apoptosis of cancer cells. J Biol Chem. 2022 May;298(5):101890. doi: 10.1016/j.jbc.2022.101890. Epub 2022 Apr 1. PubMed PMID: 35378132; PubMed Central PMCID: PMC9062249.

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Rana S, Kour S, Kizhake S, King HM, Mallareddy JR, Case AJ, Huxford T, Natarajan A. Dimers of isatin derived α-methylene-γ-butyrolactone as potent anti-cancer agents. Bioorg Med Chem Lett. 2022 Jun 1;65:128713. doi: 10.1016/j.bmcl.2022.128713. Epub 2022 Apr 1. PubMed PMID: 35367592; PubMed Central PMCID: PMC9037195.

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Mallareddy JR, Singh S, Boghean L, Natarajan A. Selective CDK9 degradation using a proteolysis-targeting chimera (PROTAC) strategy. Future Med Chem. 2022 Jan;14(3):131-134. doi: 10.4155/fmc-2021-0220. Epub 2021 Nov 24. PubMed PMID: 34814708.

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Yin L, Zeng Y, Zeng R, Chen Y, Wang TL, Rodabaugh KJ, Yu F, Natarajan A, Karpf AR, Dong J. Protein kinase RNA-activated controls mitotic progression and determines paclitaxel chemosensitivity through B-cell lymphoma 2 in ovarian cancer. Oncogene. 2021 Dec;40(50):6772-6785. doi: 10.1038/s41388-021-02117-5. Epub 2021 Nov 19. PubMed PMID: 34799660; PubMed Central PMCID: PMC8688329.

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Rana S, Mallareddy JR, Singh S, Boghean L, Natarajan A. Inhibitors, PROTACs and Molecular Glues as Diverse Therapeutic Modalities to Target Cyclin-Dependent Kinase. Cancers (Basel). 2021 Nov 2;13(21). doi: 10.3390/cancers13215506. Review. PubMed PMID: 34771669; PubMed Central PMCID: PMC8583118.

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Kour S, Rana S, Kizhake S, Lagundžin D, Klinkebiel D, Mallareddy JR, Huxford T, Woods NT, Natarajan A. Stapling proteins in the RELA complex inhibits TNFα-induced nuclear translocation of RELA. RSC Chem Biol. 2022 Jan 5;3(1):32-36. doi: 10.1039/d1cb00183c. eCollection 2022 Jan 5. PubMed PMID: 35128406; PubMed Central PMCID: PMC8729175.

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Sagar S, Singh S, Mallareddy JR, Sonawane YA, Napoleon JV, Rana S, Contreras JI, Rajesh C, Ezell EL, Kizhake S, Garrison JC, Radhakrishnan P, Natarajan A. Structure activity relationship (SAR) study identifies a quinoxaline urea analog that modulates IKKβ phosphorylation for pancreatic cancer therapy. Eur J Med Chem. 2021 Oct 15;222:113579. doi: 10.1016/j.ejmech.2021.113579. Epub 2021 May 30. PubMed PMID: 34098465; PubMed Central PMCID: PMC8373685.

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Napoleon JV, Singh S, Rana S, Bendjennat M, Kumar V, Kizhake S, Palermo NY, Ouellette MM, Huxford T, Natarajan A. Small molecule binding to inhibitor of nuclear factor kappa-B kinase subunit beta in an ATP non-competitive manner. Chem Commun (Camb). 2021 May 11;57(38):4678-4681. doi: 10.1039/d1cc01245b. PubMed PMID: 33977973; PubMed Central PMCID: PMC8162871.

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Kumar B, Ahmad R, Sharma S, Gowrikumar S, Primeaux M, Rana S, Natarajan A, Oupicky D, Hopkins CR, Dhawan P, Singh AB. PIK3C3 Inhibition Promotes Sensitivity to Colon Cancer Therapy by Inhibiting Cancer Stem Cells. Cancers (Basel). 2021 Apr 30;13(9). doi: 10.3390/cancers13092168. PubMed PMID: 33946505; PubMed Central PMCID: PMC8124755.

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King HM, Rana S, Kubica SP, Mallareddy JR, Kizhake S, Ezell EL, Zahid M, Naldrett MJ, Alvarez S, Law HC, Woods NT, Natarajan A. Aminopyrazole based CDK9 PROTAC sensitizes pancreatic cancer cells to venetoclax. Bioorg Med Chem Lett. 2021 Jul 1;43:128061. doi: 10.1016/j.bmcl.2021.128061. Epub 2021 Apr 23. PubMed PMID: 33895280; PubMed Central PMCID: PMC8187316.

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Rana S, Natarajan A. Small molecule induced polymerization of BCL6 facilitates SIAH1 mediated degradation. Signal Transduct Target Ther. 2021 Apr 1;6(1):142. doi: 10.1038/s41392-021-00556-w. PubMed PMID: 33795634; PubMed Central PMCID: PMC8016958.

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Al-Mugotir M, Lovelace JJ, George J, Bessho M, Pal D, Struble L, Kolar C, Rana S, Natarajan A, Bessho T, Borgstahl GEO. Selective killing of homologous recombination-deficient cancer cell lines by inhibitors of the RPA:RAD52 protein-protein interaction. PLoS One. 2021;16(3):e0248941. doi: 10.1371/journal.pone.0248941. eCollection 2021. PubMed PMID: 33784323; PubMed Central PMCID: PMC8009417.

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Rana S, Kour S, Sonawane YA, Robb CM, Contreras JI, Kizhake S, Zahid M, Karpf AR, Natarajan A. Symbiotic prodrugs (SymProDs) dual targeting of NFkappaB and CDK. Chem Biol Drug Des. 2020 Aug;96(2):773-784. doi: 10.1111/cbdd.13684. Epub 2020 Apr 22. PubMed PMID: 32237047; PubMed Central PMCID: PMC8022330.

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Tom EC, Mushtaq I, Mohapatra BC, Luan H, Bhat AM, Zutshi N, Chakraborty S, Islam N, Arya P, Bielecki TA, Iseka FM, Bhattacharyya S, Cypher LR, Goetz BT, Negi SK, Storck MD, Rana S, Barnekow A, Singh PK, Ying G, Guda C, Natarajan A, Band V, Band H. EHD1 and RUSC2 Control Basal Epidermal Growth Factor Receptor Cell Surface Expression and Recycling. Mol Cell Biol. 2020 Mar 16;40(7). doi: 10.1128/MCB.00434-19. Print 2020 Mar 16. PubMed PMID: 31932478; PubMed Central PMCID: PMC7076251.

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Ahmed A, Boulton S, Shao H, Akimoto M, Natarajan A, Cheng X, Melacini G. Recent Advances in EPAC-Targeted Therapies: A Biophysical Perspective. Cells. 2019 Nov 19;8(11). doi: 10.3390/cells8111462. Review. PubMed PMID: 31752286; PubMed Central PMCID: PMC6912387.

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Kour S, Rana S, Contreras JI, King HM, Robb CM, Sonawane YA, Bendjennat M, Crawford AJ, Barger CJ, Kizhake S, Luo X, Hollingsworth MA, Natarajan A. CDK5 Inhibitor Downregulates Mcl-1 and Sensitizes Pancreatic Cancer Cell Lines to Navitoclax. Mol Pharmacol. 2019 Oct;96(4):419-429. doi: 10.1124/mol.119.116855. PubMed PMID: 31467029; PubMed Central PMCID: PMC6726458.

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Nowialis P, Lopusna K, Opavska J, Haney SL, Abraham A, Sheng P, Riva A, Natarajan A, Guryanova O, Simpson M, Hlady R, Xie M, Opavsky R. Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions. Nat Commun. 2019 Sep 26;10(1):4374. doi: 10.1038/s41467-019-12355-7. PubMed PMID: 31558711; PubMed Central PMCID: PMC6763448.

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Zheng XF, Acharya SS, Choe KN, Nikhil K, Adelmant G, Satapathy SR, Sharma S, Viccaro K, Rana S, Natarajan A, Sicinski P, Marto JA, Shah K, Chowdhury D. A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1. Nat Commun. 2019 Sep 18;10(1):4252. doi: 10.1038/s41467-019-12084-x. PubMed PMID: 31534152; PubMed Central PMCID: PMC6751209.

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Rana S, Bendjennat M, Kour S, King HM, Kizhake S, Zahid M, Natarajan A. Selective degradation of CDK6 by a palbociclib based PROTAC. Bioorg Med Chem Lett. 2019 Jun 1;29(11):1375-1379. doi: 10.1016/j.bmcl.2019.03.035. Epub 2019 Mar 26. PubMed PMID: 30935795; PubMed Central PMCID: PMC6487213.

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Al-Mugotir M, Kolar C, Vance K, Kelly DL, Natarajan A, Borgstahl GEO. A simple fluorescent assay for the discovery of protein-protein interaction inhibitors. Anal Biochem. 2019 Mar 15;569:46-52. doi: 10.1016/j.ab.2019.01.010. Epub 2019 Jan 30. PubMed PMID: 30707898; PubMed Central PMCID: PMC7968734.

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Rana S, Sonawane YA, Taylor MA, Kizhake S, Zahid M, Natarajan A. Synthesis of aminopyrazole analogs and their evaluation as CDK inhibitors for cancer therapy. Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3736-3740. doi: 10.1016/j.bmcl.2018.10.020. Epub 2018 Oct 15. PubMed PMID: 30343954; PubMed Central PMCID: PMC6295223.