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McLean WJ, Hinton AS, Herby JTJ, Salt AN, Hartsock JJ, Wilson S, Lucchino DL, Lenarz T, Warnecke A, Prenzler N, Schmitt H, King S, Jackson LE, Rosenbloom J, Atiee G, Bear M, Runge CL, Gifford RH, Rauch SD, Lee DJ, Langer R, Karp JM, Loose C, LeBel C. Improved Speech Intelligibility in Subjects With Stable Sensorineural Hearing Loss Following Intratympanic Dosing of FX-322 in a Phase 1b Study. Otol Neurotol. 2021 Aug 1;42(7):e849-e857. doi: 10.1097/MAO.0000000000003120. PubMed PMID: 33617194; PubMed Central PMCID: PMC8279894.
Manrique-Huarte R, Linera-Alperi MA, Parilli D, Rodriguez JA, Borro D, Dueck WF, Smyth D, Salt A, Manrique M. Inner ear drug delivery through a cochlear implant: Pharmacokinetics in a Macaque experimental model. Hear Res. 2021 May;404:108228. doi: 10.1016/j.heares.2021.108228. Epub 2021 Mar 19. PubMed PMID: 33784550.
Salt AN, Plontke SK. Steroid Nomenclature in Inner Ear Therapy. Otol Neurotol. 2020 Jul;41(6):722-726. doi: 10.1097/MAO.0000000000002624. PubMed PMID: 32195918; PubMed Central PMCID: PMC7384350.
Salt AN, Hartsock JJ, Hou J, Piu F. Comparison of the Pharmacokinetic Properties of Triamcinolone and Dexamethasone for Local Therapy of the Inner Ear. Front Cell Neurosci. 2019;13:347. doi: 10.3389/fncel.2019.00347. eCollection 2019. PubMed PMID: 31427927; PubMed Central PMCID: PMC6689996.
Lee C, Guinan JJ Jr, Rutherford MA, Kaf WA, Kennedy KM, Buchman CA, Salt AN, Lichtenhan JT. Cochlear compound action potentials from high-level tone bursts originate from wide cochlear regions that are offset toward the most sensitive cochlear region. J Neurophysiol. 2019 Mar 1;121(3):1018-1033. doi: 10.1152/jn.00677.2018. Epub 2019 Jan 23. PubMed PMID: 30673362; PubMed Central PMCID: PMC6520629.
Salt AN, Hartsock JJ, Piu F, Hou J. Dexamethasone and Dexamethasone Phosphate Entry into Perilymph Compared for Middle Ear Applications in Guinea Pigs. Audiol Neurootol. 2018;23(4):245-257. doi: 10.1159/000493846. Epub 2018 Nov 29. PubMed PMID: 30497073; PubMed Central PMCID: PMC6492027.
Salt AN, Plontke SK. Pharmacokinetic principles in the inner ear: Influence of drug properties on intratympanic applications. Hear Res. 2018 Oct;368:28-40. doi: 10.1016/j.heares.2018.03.002. Epub 2018 Mar 11. Review. PubMed PMID: 29551306; PubMed Central PMCID: PMC6133771.
Plontke SK, Salt AN. Local drug delivery to the inner ear: Principles, practice, and future challenges. Hear Res. 2018 Oct;368:1-2. doi: 10.1016/j.heares.2018.06.018. Epub 2018 Jun 28. PubMed PMID: 30006112; PubMed Central PMCID: PMC6489445.
Liebau A, Pogorzelski O, Salt AN, Plontke SK. Hearing Changes After Intratympanic Steroids for Secondary (Salvage) Therapy of Sudden Hearing Loss: A Meta-Analysis Using Mathematical Simulations of Drug Delivery Protocols. Otol Neurotol. 2018 Aug;39(7):803-815. doi: 10.1097/MAO.0000000000001872. PubMed PMID: 29995001; PubMed Central PMCID: PMC6481671.
Li W, Hartsock JJ, Dai C, Salt AN. Permeation Enhancers for Intratympanically-applied Drugs Studied Using Fluorescent Dexamethasone as a Marker. Otol Neurotol. 2018 Jun;39(5):639-647. doi: 10.1097/MAO.0000000000001786. PubMed PMID: 29649043; PubMed Central PMCID: PMC5940507.
Salt AN, Hirose K. Communication pathways to and from the inner ear and their contributions to drug delivery. Hear Res. 2018 May;362:25-37. doi: 10.1016/j.heares.2017.12.010. Epub 2017 Dec 19. Review. PubMed PMID: 29277248; PubMed Central PMCID: PMC5911243.
Salt A, Hartsock J, Gill R, Smyth D, Kirk J, Verhoeven K. Perilymph pharmacokinetics of marker applied through a cochlear implant in guinea pigs. PLoS One. 2017;12(8):e0183374. doi: 10.1371/journal.pone.0183374. eCollection 2017. PubMed PMID: 28817653; PubMed Central PMCID: PMC5560723.
Lichtenhan JT, Hirose K, Buchman CA, Duncan RK, Salt AN. Direct administration of 2-Hydroxypropyl-Beta-Cyclodextrin into guinea pig cochleae: Effects on physiological and histological measurements. PLoS One. 2017;12(4):e0175236. doi: 10.1371/journal.pone.0175236. eCollection 2017. PubMed PMID: 28384320; PubMed Central PMCID: PMC5383289.
Liebau A, Pogorzelski O, Salt AN, Plontke SK. Hearing Changes After Intratympanically Applied Steroids for Primary Therapy of Sudden Hearing Loss: A Meta-analysis Using Mathematical Simulations of Drug Delivery Protocols. Otol Neurotol. 2017 Jan;38(1):19-30. doi: 10.1097/MAO.0000000000001254. PubMed PMID: 27779563; PubMed Central PMCID: PMC5154844.
Salt AN, Hartsock JJ, Gill RM, King E, Kraus FB, Plontke SK. Perilymph pharmacokinetics of locally-applied gentamicin in the guinea pig. Hear Res. 2016 Dec;342:101-111. doi: 10.1016/j.heares.2016.10.003. Epub 2016 Oct 8. PubMed PMID: 27725177; PubMed Central PMCID: PMC5121026.
Lichtenhan JT, Hartsock J, Dornhoffer JR, Donovan KM, Salt AN. Drug delivery into the cochlear apex: Improved control to sequentially affect finely spaced regions along the entire length of the cochlear spiral. J Neurosci Methods. 2016 Nov 1;273:201-209. doi: 10.1016/j.jneumeth.2016.08.005. Epub 2016 Aug 6. PubMed PMID: 27506463; PubMed Central PMCID: PMC5075496.
Plontke SK, Hartsock JJ, Gill RM, Salt AN. Intracochlear Drug Injections through the Round Window Membrane: Measures to Improve Drug Retention. Audiol Neurootol. 2016;21(2):72-9. doi: 10.1159/000442514. Epub 2016 Feb 24. PubMed PMID: 26905306; PubMed Central PMCID: PMC4842307.
Salt AN, Gill RM, Hartsock JJ. Perilymph Kinetics of FITC-Dextran Reveals Homeostasis Dominated by the Cochlear Aqueduct and Cerebrospinal Fluid. J Assoc Res Otolaryngol. 2015 Jun;16(3):357-71. doi: 10.1007/s10162-015-0512-1. Epub 2015 Mar 24. PubMed PMID: 25801074; PubMed Central PMCID: PMC4417094.
Hirose K, Hartsock JJ, Johnson S, Santi P, Salt AN. Systemic lipopolysaccharide compromises the blood-labyrinth barrier and increases entry of serum fluorescein into the perilymph. J Assoc Res Otolaryngol. 2014 Oct;15(5):707-19. doi: 10.1007/s10162-014-0476-6. Epub 2014 Jun 21. PubMed PMID: 24952083; PubMed Central PMCID: PMC4164684.
Eckhard A, Müller M, Salt A, Smolders J, Rask-Andersen H, Löwenheim H. Water permeability of the mammalian cochlea: functional features of an aquaporin-facilitated water shunt at the perilymph-endolymph barrier. Pflugers Arch. 2014 Oct;466(10):1963-85. doi: 10.1007/s00424-013-1421-y. Epub 2014 Jan 3. PubMed PMID: 24385019; PubMed Central PMCID: PMC4081528.
Plontke SK, Glien A, Rahne T, Mäder K, Salt AN. Controlled release dexamethasone implants in the round window niche for salvage treatment of idiopathic sudden sensorineural hearing loss. Otol Neurotol. 2014 Aug;35(7):1168-71. doi: 10.1097/MAO.0000000000000434. PubMed PMID: 24841917; PubMed Central PMCID: PMC4134359.
Lichtenhan JT, Hartsock JJ, Gill RM, Guinan JJ Jr, Salt AN. The auditory nerve overlapped waveform (ANOW) originates in the cochlear apex. J Assoc Res Otolaryngol. 2014 Jun;15(3):395-411. doi: 10.1007/s10162-014-0447-y. Epub 2014 Feb 11. PubMed PMID: 24515339; PubMed Central PMCID: PMC4010591.
Hahn H, Salt AN, Schumacher U, Plontke SK. Gentamicin concentration gradients in scala tympani perilymph following systemic applications. Audiol Neurootol. 2013;18(6):383-91. doi: 10.1159/000355283. Epub 2013 Nov 1. PubMed PMID: 24192668; PubMed Central PMCID: PMC3918439.
King EB, Salt AN, Kel GE, Eastwood HT, O'Leary SJ. Gentamicin administration on the stapes footplate causes greater hearing loss and vestibulotoxicity than round window administration in guinea pigs. Hear Res. 2013 Oct;304:159-66. doi: 10.1016/j.heares.2013.07.013. Epub 2013 Jul 27. PubMed PMID: 23899413; PubMed Central PMCID: PMC3800104.
King EB, Hartsock JJ, O'Leary SJ, Salt AN. Influence of cochleostomy and cochlear implant insertion on drug gradients following intratympanic application in Guinea pigs. Audiol Neurootol. 2013;18(5):307-16. doi: 10.1159/000353534. Epub 2013 Sep 5. PubMed PMID: 24008355; PubMed Central PMCID: PMC3872819.
Salt AN, Lichtenhan JT, Gill RM, Hartsock JJ. Large endolymphatic potentials from low-frequency and infrasonic tones in the guinea pig. J Acoust Soc Am. 2013 Mar;133(3):1561-71. doi: 10.1121/1.4789005. PubMed PMID: 23464026.
Salt AN, Hartsock JJ, Gill RM, Piu F, Plontke SK. Perilymph pharmacokinetics of markers and dexamethasone applied and sampled at the lateral semi-circular canal. J Assoc Res Otolaryngol. 2012 Dec;13(6):771-83. doi: 10.1007/s10162-012-0347-y. Epub 2012 Sep 12. PubMed PMID: 22968908; PubMed Central PMCID: PMC3505589.
Guinan JJ Jr, Salt A, Cheatham MA. Progress in cochlear physiology after Békésy. Hear Res. 2012 Nov;293(1-2):12-20. doi: 10.1016/j.heares.2012.05.005. Epub 2012 May 23. Review. PubMed PMID: 22633944; PubMed Central PMCID: PMC3530189.
Hahn H, Salt AN, Biegner T, Kammerer B, Delabar U, Hartsock JJ, Plontke SK. Dexamethasone levels and base-to-apex concentration gradients in the scala tympani perilymph after intracochlear delivery in the guinea pig. Otol Neurotol. 2012 Jun;33(4):660-5. doi: 10.1097/MAO.0b013e318254501b. PubMed PMID: 22588238; PubMed Central PMCID: PMC3354992.
Salt AN, King EB, Hartsock JJ, Gill RM, O'Leary SJ. Marker entry into vestibular perilymph via the stapes following applications to the round window niche of guinea pigs. Hear Res. 2012 Jan;283(1-2):14-23. doi: 10.1016/j.heares.2011.11.012. Epub 2011 Dec 8. PubMed PMID: 22178981; PubMed Central PMCID: PMC3277668.
King EB, Salt AN, Eastwood HT, O'Leary SJ. Direct entry of gadolinium into the vestibule following intratympanic applications in Guinea pigs and the influence of cochlear implantation. J Assoc Res Otolaryngol. 2011 Dec;12(6):741-51. doi: 10.1007/s10162-011-0280-5. Epub 2011 Jul 19. PubMed PMID: 21769689; PubMed Central PMCID: PMC3214238.
Salt AN, Hartsock J, Plontke S, LeBel C, Piu F. Distribution of dexamethasone and preservation of inner ear function following intratympanic delivery of a gel-based formulation. Audiol Neurootol. 2011;16(5):323-35. doi: 10.1159/000322504. Epub 2010 Dec 19. PubMed PMID: 21178339; PubMed Central PMCID: PMC3023000.
Salt AN, Plontke SK. Endolymphatic hydrops: pathophysiology and experimental models. Otolaryngol Clin North Am. 2010 Oct;43(5):971-83. doi: 10.1016/j.otc.2010.05.007. Review. PubMed PMID: 20713237; PubMed Central PMCID: PMC2923478.
Salt AN, Hullar TE. Responses of the ear to low frequency sounds, infrasound and wind turbines. Hear Res. 2010 Sep 1;268(1-2):12-21. doi: 10.1016/j.heares.2010.06.007. Epub 2010 Jun 16. Review. PubMed PMID: 20561575; PubMed Central PMCID: PMC2923251.
Kakigi A, Salt AN, Takeda T. Effect of artificial endolymph injection into the cochlear duct on perilymph potassium. ORL J Otorhinolaryngol Relat Spec. 2010;71 Suppl 1:16-8. doi: 10.1159/000265118. Epub 2010 Feb 24. PubMed PMID: 20185945; PubMed Central PMCID: PMC3214901.
Salt AN, Plontke SK. Principles of local drug delivery to the inner ear. Audiol Neurootol. 2009;14(6):350-60. doi: 10.1159/000241892. Epub 2009 Nov 16. Review. PubMed PMID: 19923805; PubMed Central PMCID: PMC2820328.
Brown DJ, Hartsock JJ, Gill RM, Fitzgerald HE, Salt AN. Estimating the operating point of the cochlear transducer using low-frequency biased distortion products. J Acoust Soc Am. 2009 Apr;125(4):2129-45. doi: 10.1121/1.3083228. PubMed PMID: 19354389; PubMed Central PMCID: PMC2736732.
Salt AN, Brown DJ, Hartsock JJ, Plontke SK. Displacements of the organ of Corti by gel injections into the cochlear apex. Hear Res. 2009 Apr;250(1-2):63-75. doi: 10.1016/j.heares.2009.02.001. Epub 2009 Feb 13. PubMed PMID: 19217935; PubMed Central PMCID: PMC2664397.
Mikulec AA, Plontke SK, Hartsock JJ, Salt AN. Entry of substances into perilymph through the bone of the otic capsule after intratympanic applications in guinea pigs: implications for local drug delivery in humans. Otol Neurotol. 2009 Feb;30(2):131-8. doi: 10.1097/mao.0b013e318191bff8. PubMed PMID: 19180674; PubMed Central PMCID: PMC2729139.
Mikulec AA, Hartsock JJ, Salt AN. Permeability of the round window membrane is influenced by the composition of applied drug solutions and by common surgical procedures. Otol Neurotol. 2008 Oct;29(7):1020-6. doi: 10.1097/MAO.0b013e31818658ea. PubMed PMID: 18758387; PubMed Central PMCID: PMC2596477.
Salt AN, Gill RM, Plontke SK. Dependence of hearing changes on the dose of intratympanically applied gentamicin: a meta-analysis using mathematical simulations of clinical drug delivery protocols. Laryngoscope. 2008 Oct;118(10):1793-800. doi: 10.1097/MLG.0b013e31817d01cd. PubMed PMID: 18806480; PubMed Central PMCID: PMC2741178.
Plontke SK, Mikulec AA, Salt AN. Rapid clearance of methylprednisolone after intratympanic application in humans. Comment on: Bird PA, Begg EJ, Zhang M, et al. Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph. Otol Neurotol 2007;28:1124-30. Otol Neurotol. 2008 Aug;29(5):732-3; author reply 733. doi: 10.1097/MAO.0b013e318173fcea. PubMed PMID: 18451748; PubMed Central PMCID: PMC2596997.
Plontke SK, Biegner T, Kammerer B, Delabar U, Salt AN. Dexamethasone concentration gradients along scala tympani after application to the round window membrane. Otol Neurotol. 2008 Apr;29(3):401-6. doi: 10.1097/MAO.0b013e318161aaae. PubMed PMID: 18277312; PubMed Central PMCID: PMC2587453.
Salt AN, Sirjani DB, Hartsock JJ, Gill RM, Plontke SK. Marker retention in the cochlea following injections through the round window membrane. Hear Res. 2007 Oct;232(1-2):78-86. doi: 10.1016/j.heares.2007.06.010. Epub 2007 Jun 27. PubMed PMID: 17662546; PubMed Central PMCID: PMC2040295.
Plontke SK, Mynatt R, Gill RM, Borgmann S, Salt AN. Concentration gradient along the scala tympani after local application of gentamicin to the round window membrane. Laryngoscope. 2007 Jul;117(7):1191-8. doi: 10.1097/MLG.0b013e318058a06b. PubMed PMID: 17603318; PubMed Central PMCID: PMC2728588.
Harding GW, Bohne BA, Lee SC, Salt AN. Effect of infrasound on cochlear damage from exposure to a 4 kHz octave band of noise. Hear Res. 2007 Mar;225(1-2):128-38. doi: 10.1016/j.heares.2007.01.016. Epub 2007 Jan 19. PubMed PMID: 17300889; PubMed Central PMCID: PMC2593403.
Salt AN. The endolymphatic sinus is a possible detector of endolymph volume status. Hear Res. 2007 Feb;224(1-2):117-8. doi: 10.1016/j.heares.2006.10.002. Epub 2006 Dec 8. PubMed PMID: 17158008; PubMed Central PMCID: PMC1783907.
Plontke SK, Siedow N, Wegener R, Zenner HP, Salt AN. Cochlear pharmacokinetics with local inner ear drug delivery using a three-dimensional finite-element computer model. Audiol Neurootol. 2007;12(1):37-48. doi: 10.1159/000097246. Epub 2006 Nov 17. PubMed PMID: 17119332; PubMed Central PMCID: PMC1779502.
Plontke SK, Salt AN. Simulation of application strategies for local drug delivery to the inner ear. ORL J Otorhinolaryngol Relat Spec. 2006;68(6):386-92. doi: 10.1159/000095284. Epub 2006 Oct 26. PubMed PMID: 17065834; PubMed Central PMCID: PMC1751485.
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