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Goldberg D, Charni-Natan M, Buchshtab N, Bar-Shimon M, Goldstein I. Hormone-controlled cooperative binding of transcription factors drives synergistic induction of fasting-regulated genes. Nucleic Acids Res. 2022 Jun 10;50(10):5528-5544. doi: 10.1093/nar/gkac358. PubMed PMID: 35556130; PubMed Central PMCID: PMC9177981.
Ron I, Lerner RK, Rathaus M, Livne R, Ron S, Barhod E, Hemi R, Tirosh A, Strauss T, Ofir K, Goldstein I, Pessach IM, Tirosh A. The adipokine FABP4 is a key regulator of neonatal glucose homeostasis. JCI Insight. 2021 Oct 22;6(20). doi: 10.1172/jci.insight.138288. PubMed PMID: 34676825; PubMed Central PMCID: PMC8564897.
Korenfeld N, Finkel M, Buchshtab N, Bar-Shimon M, Charni-Natan M, Goldstein I. Fasting Hormones Synergistically Induce Amino Acid Catabolism Genes to Promote Gluconeogenesis. Cell Mol Gastroenterol Hepatol. 2021;12(3):1021-1036. doi: 10.1016/j.jcmgh.2021.04.017. Epub 2021 May 3. PubMed PMID: 33957303; PubMed Central PMCID: PMC8346669.
Charni-Natan M, Goldstein I. Protocol for Primary Mouse Hepatocyte Isolation. STAR Protoc. 2020 Sep 18;1(2):100086. doi: 10.1016/j.xpro.2020.100086. eCollection 2020 Sep 18. PubMed PMID: 33111119; PubMed Central PMCID: PMC7580103.
Goldstein I. Chromatin Regulation and Transcription Factor Cooperation in Liver Cells. The Liver (eds I.M. Arias, H.J. Alter, J.L. Boyer, D.E. Cohen, D.A. Shafritz, S.S. Thorgeirsson and A.W. Wolkoff). 2020 January.
Grøntved L, Goldstein I. Editorial: Regulating Liver Transcriptional Networks by Endocrine, Extracellular, and Intrinsic Cues. Front Endocrinol (Lausanne). 2019;10:878. doi: 10.3389/fendo.2019.00878. eCollection 2019. PubMed PMID: 31920987; PubMed Central PMCID: PMC6923206.
Goldstein I, Hager GL. The Three Ds of Transcription Activation by Glucagon: Direct, Delayed, and Dynamic. Endocrinology. 2018 Jan 1;159(1):206-216. doi: 10.1210/en.2017-00521. Review. PubMed PMID: 29077799; PubMed Central PMCID: PMC6283435.
Goldstein I, Hager GL. Dynamic enhancer function in the chromatin context. Wiley Interdiscip Rev Syst Biol Med. 2018 Jan;10(1). doi: 10.1002/wsbm.1390. Epub 2017 May 22. Review. PubMed PMID: 28544514; PubMed Central PMCID: PMC6638546.
Goldstein I, Paakinaho V, Baek S, Sung MH, Hager GL. Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading. Nat Commun. 2017 Nov 29;8(1):1849. doi: 10.1038/s41467-017-02055-5. PubMed PMID: 29185442; PubMed Central PMCID: PMC5707366.
Baek S, Goldstein I, Hager GL. Bivariate Genomic Footprinting Detects Changes in Transcription Factor Activity. Cell Rep. 2017 May 23;19(8):1710-1722. doi: 10.1016/j.celrep.2017.05.003. PubMed PMID: 28538187; PubMed Central PMCID: PMC5530758.
Goldstein I, Baek S, Presman DM, Paakinaho V, Swinstead EE, Hager GL. Transcription factor assisted loading and enhancer dynamics dictate the hepatic fasting response. Genome Res. 2017 Mar;27(3):427-439. doi: 10.1101/gr.212175.116. Epub 2016 Dec 28. PubMed PMID: 28031249; PubMed Central PMCID: PMC5340970.
Isaac R, Goldstein I, Furth N, Zilber N, Streim S, Boura-Halfon S, Elhanany E, Rotter V, Oren M, Zick Y. TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response. Cell Death Differ. 2017 Jan;24(1):132-143. doi: 10.1038/cdd.2016.108. Epub 2016 Oct 14. PubMed PMID: 27740623; PubMed Central PMCID: PMC5260493.
Swinstead EE, Miranda TB, Paakinaho V, Baek S, Goldstein I, Hawkins M, Karpova TS, Ball D, Mazza D, Lavis LD, Grimm JB, Morisaki T, Grøntved L, Presman DM, Hager GL. Steroid Receptors Reprogram FoxA1 Occupancy through Dynamic Chromatin Transitions. Cell. 2016 Apr 21;165(3):593-605. doi: 10.1016/j.cell.2016.02.067. Epub 2016 Apr 7. PubMed PMID: 27062924; PubMed Central PMCID: PMC4842147.
Charni M, Molchadsky A, Goldstein I, Solomon H, Tal P, Goldfinger N, Yang P, Porat Z, Lozano G, Rotter V. Novel p53 target genes secreted by the liver are involved in non-cell-autonomous regulation. Cell Death Differ. 2016 Mar;23(3):509-20. doi: 10.1038/cdd.2015.119. Epub 2015 Sep 11. PubMed PMID: 26358154; PubMed Central PMCID: PMC5072444.
Goldstein I, Hager GL. Transcriptional and Chromatin Regulation during Fasting - The Genomic Era. Trends Endocrinol Metab. 2015 Dec;26(12):699-710. doi: 10.1016/j.tem.2015.09.005. Epub 2015 Oct 29. Review. PubMed PMID: 26520657; PubMed Central PMCID: PMC4673016.
Shetzer Y, Kagan S, Koifman G, Sarig R, Kogan-Sakin I, Charni M, Kaufman T, Zapatka M, Molchadsky A, Rivlin N, Dinowitz N, Levin S, Landan G, Goldstein I, Goldfinger N, Pe'er D, Radlwimmer B, Lichter P, Rotter V, Aloni-Grinstein R. The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele. Cell Death Differ. 2014 Sep;21(9):1419-31. doi: 10.1038/cdd.2014.57. Epub 2014 May 16. PubMed PMID: 24832469; PubMed Central PMCID: PMC4131174.
Madar S, Goldstein I, Rotter V. 'Cancer associated fibroblasts'--more than meets the eye. Trends Mol Med. 2013 Aug;19(8):447-53. doi: 10.1016/j.molmed.2013.05.004. Epub 2013 Jun 13. Review. PubMed PMID: 23769623.
Madar S, Harel E, Goldstein I, Stein Y, Kogan-Sakin I, Kamer I, Solomon H, Dekel E, Tal P, Goldfinger N, Friedlander G, Rotter V. Mutant p53 attenuates the anti-tumorigenic activity of fibroblasts-secreted interferon beta. PLoS One. 2013;8(4):e61353. doi: 10.1371/journal.pone.0061353. Print 2013. PubMed PMID: 23630584; PubMed Central PMCID: PMC3632588.
Goldstein I, Yizhak K, Madar S, Goldfinger N, Ruppin E, Rotter V. p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production. Cancer Metab. 2013 Feb 4;1(1):9. doi: 10.1186/2049-3002-1-9. PubMed PMID: 24280180; PubMed Central PMCID: PMC4178212.
Goldstein I, Rivlin N, Shoshana OY, Ezra O, Madar S, Goldfinger N, Rotter V. Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53. Carcinogenesis. 2013 Jan;34(1):190-8. doi: 10.1093/carcin/bgs318. Epub 2012 Oct 10. PubMed PMID: 23054612.
Kalo E, Kogan-Sakin I, Solomon H, Bar-Nathan E, Shay M, Shetzer Y, Dekel E, Goldfinger N, Buganim Y, Stambolsky P, Goldstein I, Madar S, Rotter V. Mutant p53R273H attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species. J Cell Sci. 2012 Nov 15;125(Pt 22):5578-86. doi: 10.1242/jcs.106815. Epub 2012 Aug 16. PubMed PMID: 22899716.
Goldstein I, Rotter V. Regulation of lipid metabolism by p53 - fighting two villains with one sword. Trends Endocrinol Metab. 2012 Nov;23(11):567-75. doi: 10.1016/j.tem.2012.06.007. Epub 2012 Jul 20. Review. PubMed PMID: 22819212.
Solomon H, Buganim Y, Kogan-Sakin I, Pomeraniec L, Assia Y, Madar S, Goldstein I, Brosh R, Kalo E, Beatus T, Goldfinger N, Rotter V. Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature. J Cell Sci. 2012 Jul 1;125(Pt 13):3144-52. doi: 10.1242/jcs.099663. Epub 2012 Mar 16. PubMed PMID: 22427690.
Goldstein I, Madar S, Rotter V. Cancer research, a field on the verge of a paradigm shift?. Trends Mol Med. 2012 Jun;18(6):299-303. doi: 10.1016/j.molmed.2012.04.002. Epub 2012 May 19. PubMed PMID: 22609171.
Goldstein I, Ezra O, Rivlin N, Molchadsky A, Madar S, Goldfinger N, Rotter V. p53, a novel regulator of lipid metabolism pathways. J Hepatol. 2012 Mar;56(3):656-62. doi: 10.1016/j.jhep.2011.08.022. Epub 2011 Oct 26. PubMed PMID: 22037227.
Madar S, Goldstein I, Neeman O, Rotter V. Beyond tumor suppression: p53 controls blastocyst implantation. Cell Cycle. 2011 Dec 15;10(24):4203. doi: 10.4161/cc.10.24.18412. Epub 2011 Dec 15. PubMed PMID: 22157227.
Buganim Y, Madar S, Rais Y, Pomeraniec L, Harel E, Solomon H, Kalo E, Goldstein I, Brosh R, Haimov O, Avivi C, Polak-Charcon S, Goldfinger N, Barshack I, Rotter V. Transcriptional activity of ATF3 in the stromal compartment of tumors promotes cancer progression. Carcinogenesis. 2011 Dec;32(12):1749-57. doi: 10.1093/carcin/bgr203. Epub 2011 Sep 7. PubMed PMID: 21900211.
Leshem O, Madar S, Kogan-Sakin I, Kamer I, Goldstein I, Brosh R, Cohen Y, Jacob-Hirsch J, Ehrlich M, Ben-Sasson S, Goldfinger N, Loewenthal R, Gazit E, Rotter V, Berger R. TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model. PLoS One. 2011;6(7):e21650. doi: 10.1371/journal.pone.0021650. Epub 2011 Jul 1. PubMed PMID: 21747944; PubMed Central PMCID: PMC3128608.
Bornstein C, Brosh R, Molchadsky A, Madar S, Kogan-Sakin I, Goldstein I, Chakravarti D, Flores ER, Goldfinger N, Sarig R, Rotter V. SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63. Mol Cell Biol. 2011 Apr;31(8):1679-89. doi: 10.1128/MCB.01072-10. Epub 2011 Feb 7. PubMed PMID: 21300779; PubMed Central PMCID: PMC3126342.
Goldstein I, Marcel V, Olivier M, Oren M, Rotter V, Hainaut P. Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies. Cancer Gene Ther. 2011 Jan;18(1):2-11. doi: 10.1038/cgt.2010.63. Epub 2010 Oct 22. Review. PubMed PMID: 20966976.
Buganim Y, Solomon H, Rais Y, Kistner D, Nachmany I, Brait M, Madar S, Goldstein I, Kalo E, Adam N, Gordin M, Rivlin N, Kogan I, Brosh R, Sefadia-Elad G, Goldfinger N, Sidransky D, Kloog Y, Rotter V. p53 Regulates the Ras circuit to inhibit the expression of a cancer-related gene signature by various molecular pathways. Cancer Res. 2010 Mar 15;70(6):2274-84. doi: 10.1158/0008-5472.CAN-09-2661. Epub 2010 Mar 2. PubMed PMID: 20197462.
Buganim Y, Goldstein I, Lipson D, Milyavsky M, Polak-Charcon S, Mardoukh C, Solomon H, Kalo E, Madar S, Brosh R, Perelman M, Navon R, Goldfinger N, Barshack I, Yakhini Z, Rotter V. A novel translocation breakpoint within the BPTF gene is associated with a pre-malignant phenotype. PLoS One. 2010 Mar 11;5(3):e9657. doi: 10.1371/journal.pone.0009657. PubMed PMID: 20300178; PubMed Central PMCID: PMC2836376.
Daniel-Carmi V, Makovitzki-Avraham E, Reuven EM, Goldstein I, Zilkha N, Rotter V, Tzehoval E, Eisenbach L. The human 1-8D gene (IFITM2) is a novel p53 independent pro-apoptotic gene. Int J Cancer. 2009 Dec 15;125(12):2810-9. doi: 10.1002/ijc.24669. PubMed PMID: 19544527.
Goldstein I, Rotter V. Mutations in the tetramerization domain of p53: more than just keeping monomers apart. Cell Cycle. 2009 Oct 15;8(20):3259-60. Epub 2009 Oct 15. PubMed PMID: 19823022.
Madar S, Goldstein I, Rotter V. Did experimental biology die? Lessons from 30 years of p53 research. Cancer Res. 2009 Aug 15;69(16):6378-80. doi: 10.1158/0008-5472.CAN-09-0940. Epub 2009 Aug 4. Review. PubMed PMID: 19654301.
Madar S, Brosh R, Buganim Y, Ezra O, Goldstein I, Solomon H, Kogan I, Goldfinger N, Klocker H, Rotter V. Modulated expression of WFDC1 during carcinogenesis and cellular senescence. Carcinogenesis. 2009 Jan;30(1):20-7. doi: 10.1093/carcin/bgn232. Epub 2008 Oct 8. PubMed PMID: 18842679; PubMed Central PMCID: PMC2639035.
Brosh R, Shalgi R, Liran A, Landan G, Korotayev K, Nguyen GH, Enerly E, Johnsen H, Buganim Y, Solomon H, Goldstein I, Madar S, Goldfinger N, Børresen-Dale AL, Ginsberg D, Harris CC, Pilpel Y, Oren M, Rotter V. p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation. Mol Syst Biol. 2008;4:229. doi: 10.1038/msb.2008.65. Epub 2008 Nov 25. PubMed PMID: 19034270; PubMed Central PMCID: PMC2600669.
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