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Gibb AA, LaPenna K, Gaspar RB, Latchman NR, Tan Y, Choya-Foces C, Doiron JE, Li Z, Xia H, Lazaropoulos MP, Conwell M, Sharp TE 3rd, Goodchild TT, Lefer DJ, Elrod JW. Integrated systems biology identifies disruptions in mitochondrial function and metabolism as key contributors to heart failure with preserved ejection fraction (HFpEF). bioRxiv. 2024 Oct 25;. doi: 10.1101/2024.10.25.619450. PubMed PMID: 39484400; PubMed Central PMCID: PMC11527111.
Joladarashi D, Thej C, Mallaredy V, Magadum A, Cimini M, Gonzalez C, Truongcao M, Nigro JT, Sethi MK, Gibb AA, Benedict C, Koch WJ, Kishore R. GPC3-mediated metabolic rewiring of diabetic mesenchymal stromal cells enhances their cardioprotective functions via PKM2 activation. iScience. 2024 Oct 18;27(10):111021. doi: 10.1016/j.isci.2024.111021. eCollection 2024 Oct 18. PubMed PMID: 39429777; PubMed Central PMCID: PMC11490746.
Lazaropoulos MP, Gibb AA, Chapski DJ, Nair AA, Reiter AN, Roy R, Eaton DM, Bedi KC Jr, Margulies KB, Wellen KE, Estarás C, Vondriska TM, Elrod JW. Nuclear ATP-citrate lyase regulates chromatin-dependent activation and maintenance of the myofibroblast gene program. Nat Cardiovasc Res. 2024 Jul;3(7):869-882. doi: 10.1038/s44161-024-00502-3. Epub 2024 Jul 5. PubMed PMID: 39196175; PubMed Central PMCID: PMC11358007.
Sharma R, Gibb AA, Barnts K, Elrod JW, Puri S. Alternative oxidase promotes high iron tolerance in Candida albicans. Microbiol Spectr. 2023 Dec 12;11(6):e0215723. doi: 10.1128/spectrum.02157-23. Epub 2023 Nov 6. PubMed PMID: 37929974; PubMed Central PMCID: PMC10714975.
Demetriadou C, Gibb AA, Elrod JW, Snyder NW. Propionyl-CoA metabolism links chromatin acylation to cardiac transcription. Nat Cardiovasc Res. 2023 Dec;2(12):1109-1111. doi: 10.1038/s44161-023-00381-0. Epub 2023 Dec 4. PubMed PMID: 39188987; PubMed Central PMCID: PMC11346590.
Zheng Y, Gibb AA, Xu H, Liu S, Hill BG. The metabolic state of the heart regulates mitochondrial supercomplex abundance in mice. Redox Biol. 2023 Jul;63:102740. doi: 10.1016/j.redox.2023.102740. Epub 2023 May 15. PubMed PMID: 37210780; PubMed Central PMCID: PMC10209883.
Gibb AA, Huynh AT, Gaspar RB, Ploesch TL, Lombardi AA, Lorkiewicz PK, Lazaropoulos MP, Bedi K, Arany Z, Margulies KB, Hill BG, Elrod JW. Glutamine uptake and catabolism is required for myofibroblast formation and persistence. J Mol Cell Cardiol. 2022 Nov;172:78-89. doi: 10.1016/j.yjmcc.2022.08.002. Epub 2022 Aug 18. PubMed PMID: 35988357; PubMed Central PMCID: PMC10486318.
Gibb AA, Murray EK, Huynh AT, Gaspar RB, Ploesch TL, Bedi K, Lombardi AA, Lorkiewicz PK, Roy R, Arany Z, Kelly DP, Margulies KB, Hill BG, Elrod JW. Glutaminolysis is Essential for Myofibroblast Persistence and In Vivo Targeting Reverses Fibrosis and Cardiac Dysfunction in Heart Failure. Circulation. 2022 May 24;145(21):1625-1628. doi: 10.1161/CIRCULATIONAHA.121.057879. Epub 2022 May 23. PubMed PMID: 35605036; PubMed Central PMCID: PMC9179236.
Gibb AA, Murray EK, Eaton DM, Huynh AT, Tomar D, Garbincius JF, Kolmetzky DW, Berretta RM, Wallner M, Houser SR, Elrod JW. Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model. JACC Basic Transl Sci. 2021 Aug;6(8):650-672. doi: 10.1016/j.jacbts.2021.07.004. eCollection 2021 Aug. PubMed PMID: 34466752; PubMed Central PMCID: PMC8385567.
Gross P, Johnson J, Romero CM, Eaton DM, Poulet C, Sanchez-Alonso J, Lucarelli C, Ross J, Gibb AA, Garbincius JF, Lambert J, Varol E, Yang Y, Wallner M, Feldsott EA, Kubo H, Berretta RM, Yu D, Rizzo V, Elrod J, Sabri A, Gorelik J, Chen X, Houser SR. Interaction of the Joining Region in Junctophilin-2 With the L-Type Ca(2+) Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca(2+) Dynamics. Circ Res. 2021 Jan 8;128(1):92-114. doi: 10.1161/CIRCRESAHA.119.315715. Epub 2020 Oct 23. PubMed PMID: 33092464; PubMed Central PMCID: PMC7790862.
Gibb AA, Lazaropoulos MP, Elrod JW. Myofibroblasts and Fibrosis: Mitochondrial and Metabolic Control of Cellular Differentiation. Circ Res. 2020 Jul 17;127(3):427-447. doi: 10.1161/CIRCRESAHA.120.316958. Epub 2020 Jul 16. Review. PubMed PMID: 32673537; PubMed Central PMCID: PMC7982967.
Liu M, Tong Z, Ding C, Luo F, Wu S, Wu C, Albeituni S, He L, Hu X, Tieri D, Rouchka EC, Hamada M, Takahashi S, Gibb AA, Kloecker G, Zhang HG, Bousamra M 2nd, Hill BG, Zhang X, Yan J. Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer. J Clin Invest. 2020 Apr 1;130(4):2081-2096. doi: 10.1172/JCI131335. PubMed PMID: 31945018; PubMed Central PMCID: PMC7108920.
Lombardi AA, Gibb AA, Arif E, Kolmetzky DW, Tomar D, Luongo TS, Jadiya P, Murray EK, Lorkiewicz PK, Hajnóczky G, Murphy E, Arany ZP, Kelly DP, Margulies KB, Hill BG, Elrod JW. Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation. Nat Commun. 2019 Oct 4;10(1):4509. doi: 10.1038/s41467-019-12103-x. PubMed PMID: 31586055; PubMed Central PMCID: PMC6778142.
Lorkiewicz PK, Gibb AA, Rood BR, He L, Zheng Y, Clem BF, Zhang X, Hill BG. Integration of flux measurements and pharmacological controls to optimize stable isotope-resolved metabolomics workflows and interpretation. Sci Rep. 2019 Sep 23;9(1):13705. doi: 10.1038/s41598-019-50183-3. PubMed PMID: 31548575; PubMed Central PMCID: PMC6757038.
Gibb AA, Elrod JW. Not just correlative: a new pathway defines how an ALDH2 SNP contributes to atherosclerosis. J Clin Invest. 2019 Jan 2;129(1):63-65. doi: 10.1172/JCI125433. Epub 2018 Dec 3. PubMed PMID: 30507608; PubMed Central PMCID: PMC6307930.
Dassanayaka S, Zheng Y, Gibb AA, Cummins TD, McNally LA, Brittian KR, Jagatheesan G, Audam TN, Long BW, Brainard RE, Jones SP, Hill BG. Cardiac-specific overexpression of aldehyde dehydrogenase 2 exacerbates cardiac remodeling in response to pressure overload. Redox Biol. 2018 Jul;17:440-449. doi: 10.1016/j.redox.2018.05.016. Epub 2018 Jun 1. PubMed PMID: 29885625; PubMed Central PMCID: PMC5991908.
Gibb AA, Hill BG. Metabolic Coordination of Physiological and Pathological Cardiac Remodeling. Circ Res. 2018 Jun 22;123(1):107-128. doi: 10.1161/CIRCRESAHA.118.312017. Review. PubMed PMID: 29929976; PubMed Central PMCID: PMC6023588.
Osuma EA, Riggs DW, Gibb AA, Hill BG. High throughput measurement of metabolism in planarians reveals activation of glycolysis during regeneration. Regeneration (Oxf). 2018 Mar;5(1):78-86. doi: 10.1002/reg2.95. eCollection 2018 Mar. PubMed PMID: 29721328; PubMed Central PMCID: PMC5911454.
Hindi SM, Sato S, Xiong G, Bohnert KR, Gibb AA, Gallot YS, McMillan JD, Hill BG, Uchida S, Kumar A. TAK1 regulates skeletal muscle mass and mitochondrial function. JCI Insight. 2018 Feb 8;3(3). doi: 10.1172/jci.insight.98441. eCollection 2018 Feb 8. PubMed PMID: 29415881; PubMed Central PMCID: PMC5821216.
Gibb AA, Lorkiewicz PK, Zheng YT, Zhang X, Bhatnagar A, Jones SP, Hill BG. Correction: Integration of flux measurements to resolve changes in anabolic and catabolic metabolism in cardiac myocytes. Biochem J. 2017 Dec 14;474(24):4271-4272. doi: 10.1042/BCJ20170474_COR. PubMed PMID: 29242383; PubMed Central PMCID: PMC5735646.
Gibb AA, Epstein PN, Uchida S, Zheng Y, McNally LA, Obal D, Katragadda K, Trainor P, Conklin DJ, Brittian KR, Tseng MT, Wang J, Jones SP, Bhatnagar A, Hill BG. Exercise-Induced Changes in Glucose Metabolism Promote Physiological Cardiac Growth. Circulation. 2017 Nov 28;136(22):2144-2157. doi: 10.1161/CIRCULATIONAHA.117.028274. Epub 2017 Aug 31. PubMed PMID: 28860122; PubMed Central PMCID: PMC5704654.
Gibb AA, McNally LA, Riggs DW, Conklin DJ, Bhatnagar A, Hill BG. Corrigendum: FVB/NJ Mice Are a Useful Model for Examining Cardiac Adaptations to Treadmill Exercise. Front Physiol. 2017;8:800. doi: 10.3389/fphys.2017.00800. eCollection 2017. PubMed PMID: 29042855; PubMed Central PMCID: PMC5641387.
Gibb AA, Lorkiewicz PK, Zheng YT, Zhang X, Bhatnagar A, Jones SP, Hill BG. Integration of flux measurements to resolve changes in anabolic and catabolic metabolism in cardiac myocytes. Biochem J. 2017 Aug 7;474(16):2785-2801. doi: 10.1042/BCJ20170474. PubMed PMID: 28706006; PubMed Central PMCID: PMC5545928.
Gibb AA, McNally LA, Riggs DW, Conklin DJ, Bhatnagar A, Hill BG. FVB/NJ Mice Are a Useful Model for Examining Cardiac Adaptations to Treadmill Exercise. Front Physiol. 2016;7:636. doi: 10.3389/fphys.2016.00636. eCollection 2016. PubMed PMID: 28066267; PubMed Central PMCID: PMC5174104.
Salabei JK, Lorkiewicz PK, Mehra P, Gibb AA, Haberzettl P, Hong KU, Wei X, Zhang X, Li Q, Wysoczynski M, Bolli R, Bhatnagar A, Hill BG. Type 2 Diabetes Dysregulates Glucose Metabolism in Cardiac Progenitor Cells. J Biol Chem. 2016 Jun 24;291(26):13634-48. doi: 10.1074/jbc.M116.722496. Epub 2016 May 5. PubMed PMID: 27151219; PubMed Central PMCID: PMC4919448.
Cummins TD, Holden CR, Sansbury BE, Gibb AA, Shah J, Zafar N, Tang Y, Hellmann J, Rai SN, Spite M, Bhatnagar A, Hill BG. Metabolic remodeling of white adipose tissue in obesity. Am J Physiol Endocrinol Metab. 2014 Aug 1;307(3):E262-77. doi: 10.1152/ajpendo.00271.2013. Epub 2014 Jun 10. PubMed PMID: 24918202; PubMed Central PMCID: PMC4121575.
Salabei JK, Gibb AA, Hill BG. Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis. Nat Protoc. 2014 Feb;9(2):421-38. doi: 10.1038/nprot.2014.018. Epub 2014 Jan 23. PubMed PMID: 24457333; PubMed Central PMCID: PMC4063296.
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