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Broichhagen J, Schönberger M, Cork SC, Frank JA, Marchetti P, Bugliani M, Shapiro AM, Trapp S, Rutter GA, Hodson DJ, Trauner D. Optical control of insulin release using a photoswitchable sulfonylurea. Nat Commun. 2014 Oct 14;5:5116. doi: 10.1038/ncomms6116. PubMed PMID: 25311795; PubMed Central PMCID: PMC4208094.
Broichhagen J, Frank JA, Johnston NR, Mitchell RK, Šmid K, Marchetti P, Bugliani M, Rutter GA, Trauner D, Hodson DJ. A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function. Chem Commun (Camb). 2015 Apr 7;51(27):6018-21. doi: 10.1039/c5cc01224d. Epub 2015 Mar 11. PubMed PMID: 25744824; PubMed Central PMCID: PMC6101206.
Frank JA, Moroni M, Moshourab R, Sumser M, Lewin GR, Trauner D. Photoswitchable fatty acids enable optical control of TRPV1. Nat Commun. 2015 May 22;6:7118. doi: 10.1038/ncomms8118. PubMed PMID: 25997690; PubMed Central PMCID: PMC4455067.
Broichhagen J, Frank JA, Trauner D. A roadmap to success in photopharmacology. Acc Chem Res. 2015 Jul 21;48(7):1947-60. doi: 10.1021/acs.accounts.5b00129. Epub 2015 Jun 23. PubMed PMID: 26103428.
Konrad DB, Frank JA, Trauner D. Synthesis of Redshifted Azobenzene Photoswitches by Late-Stage Functionalization. Chemistry. 2016 Mar 18;22(13):4364-8. doi: 10.1002/chem.201505061. Epub 2016 Feb 17. PubMed PMID: 26889884.
Frank JA, Yushchenko DA, Hodson DJ, Lipstein N, Nagpal J, Rutter GA, Rhee JS, Gottschalk A, Brose N, Schultz C, Trauner D. Photoswitchable diacylglycerols enable optical control of protein kinase C. Nat Chem Biol. 2016 Sep;12(9):755-62. doi: 10.1038/nchembio.2141. Epub 2016 Jul 25. PubMed PMID: 27454932; PubMed Central PMCID: PMC6101201.
Frank JA, Franquelim HG, Schwille P, Trauner D. Optical Control of Lipid Rafts with Photoswitchable Ceramides. J Am Chem Soc. 2016 Oct 5;138(39):12981-12986. doi: 10.1021/jacs.6b07278. Epub 2016 Sep 26. PubMed PMID: 27626130.
Pernpeintner C, Frank JA, Urban P, Roeske CR, Pritzl SD, Trauner D, Lohmüller T. Light-Controlled Membrane Mechanics and Shape Transitions of Photoswitchable Lipid Vesicles. Langmuir. 2017 Apr 25;33(16):4083-4089. doi: 10.1021/acs.langmuir.7b01020. Epub 2017 Apr 12. PubMed PMID: 28361538.
Frank JA, Yushchenko DA, Fine NHF, Duca M, Citir M, Broichhagen J, Hodson DJ, Schultz C, Trauner D. Optical control of GPR40 signalling in pancreatic β-cells. Chem Sci. 2017 Nov 1;8(11):7604-7610. doi: 10.1039/c7sc01475a. Epub 2017 Aug 30. PubMed PMID: 29568424; PubMed Central PMCID: PMC5848828.
Westphal MV, Schafroth MA, Sarott RC, Imhof MA, Bold CP, Leippe P, Dhopeshwarkar A, Grandner JM, Katritch V, Mackie K, Trauner D, Carreira EM, Frank JA. Synthesis of Photoswitchable Δ(9)-Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling. J Am Chem Soc. 2017 Dec 20;139(50):18206-18212. doi: 10.1021/jacs.7b06456. Epub 2017 Dec 12. PubMed PMID: 29161035.
Leinders-Zufall T, Storch U, Bleymehl K, Mederos Y Schnitzler M, Frank JA, Konrad DB, Trauner D, Gudermann T, Zufall F. PhoDAGs Enable Optical Control of Diacylglycerol-Sensitive Transient Receptor Potential Channels. Cell Chem Biol. 2018 Feb 15;25(2):215-223.e3. doi: 10.1016/j.chembiol.2017.11.008. Epub 2017 Dec 21. PubMed PMID: 29276045.
Park S, Frank JA, Anikeeva P. Silicon biointerfaces for all scales. Nat Biomed Eng. 2018 Jul;2(7):471-472. doi: 10.1038/s41551-018-0268-0. PubMed PMID: 30948826.
Fehrentz T, Huber FME, Hartrampf N, Bruegmann T, Frank JA, Fine NHF, Malan D, Danzl JG, Tikhonov DB, Sumser M, Sasse P, Hodson DJ, Zhorov BS, Klöcker N, Trauner D. Optical control of L-type Ca(2+) channels using a diltiazem photoswitch. Nat Chem Biol. 2018 Aug;14(8):764-767. doi: 10.1038/s41589-018-0090-8. Epub 2018 Jul 16. PubMed PMID: 30013061.
Urban P, Pritzl SD, Konrad DB, Frank JA, Pernpeintner C, Roeske CR, Trauner D, Lohmüller T. Light-Controlled Lipid Interaction and Membrane Organization in Photolipid Bilayer Vesicles. Langmuir. 2018 Nov 6;34(44):13368-13374. doi: 10.1021/acs.langmuir.8b03241. Epub 2018 Oct 22. PubMed PMID: 30346771.
Frank JA, Broichhagen J, Yushchenko DA, Trauner D, Schultz C, Hodson DJ. Optical tools for understanding the complexity of β-cell signalling and insulin release. Nat Rev Endocrinol. 2018 Dec;14(12):721-737. doi: 10.1038/s41574-018-0105-2. Review. PubMed PMID: 30356209.
Kol M, Williams B, Toombs-Ruane H, Franquelim HG, Korneev S, Schroeer C, Schwille P, Trauner D, Holthuis JC, Frank JA. Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides. Elife. 2019 Feb 5;8. doi: 10.7554/eLife.43230. PubMed PMID: 30720434; PubMed Central PMCID: PMC6386522.
Morstein J, Hill RZ, Novak AJE, Feng S, Norman DD, Donthamsetti PC, Frank JA, Harayama T, Williams BM, Parrill AL, Tigyi GJ, Riezman H, Isacoff EY, Bautista DM, Trauner D. Optical control of sphingosine-1-phosphate formation and function. Nat Chem Biol. 2019 Jun;15(6):623-631. doi: 10.1038/s41589-019-0269-7. Epub 2019 Apr 29. PubMed PMID: 31036923; PubMed Central PMCID: PMC7428055.
Leippe P, Frank JA. Designing azobenzene-based tools for controlling neurotransmission. Curr Opin Struct Biol. 2019 Aug;57:23-30. doi: 10.1016/ Epub 2019 Feb 28. Review. PubMed PMID: 30825844.
Frank JA, Antonini MJ, Anikeeva P. Next-generation interfaces for studying neural function. Nat Biotechnol. 2019 Sep;37(9):1013-1023. doi: 10.1038/s41587-019-0198-8. Epub 2019 Aug 12. Review. PubMed PMID: 31406326; PubMed Central PMCID: PMC7243676.
Urban P, Pritzl SD, Ober MF, Dirscherl CF, Pernpeintner C, Konrad DB, Frank JA, Trauner D, Nickel B, Lohmueller T. A Lipid Photoswitch Controls Fluidity in Supported Bilayer Membranes. Langmuir. 2020 Mar 17;36(10):2629-2634. doi: 10.1021/acs.langmuir.9b02942. Epub 2020 Mar 3. PubMed PMID: 32069411.
Morstein J, Dacheux MA, Norman DD, Shemet A, Donthamsetti PC, Citir M, Frank JA, Schultz C, Isacoff EY, Parrill AL, Tigyi GJ, Trauner D. Optical Control of Lysophosphatidic Acid Signaling. J Am Chem Soc. 2020 Jun 17;142(24):10612-10616. doi: 10.1021/jacs.0c02154. Epub 2020 Jun 5. PubMed PMID: 32469525; PubMed Central PMCID: PMC7920854.
Scheidt HA, Kolocaj K, Konrad DB, Frank JA, Trauner D, Langosch D, Huster D. Light-induced lipid mixing implies a causal role of lipid splay in membrane fusion. Biochim Biophys Acta Biomembr. 2020 Nov 1;1862(11):183438. doi: 10.1016/j.bbamem.2020.183438. Epub 2020 Aug 8. PubMed PMID: 32781156.
Pritzl SD, Urban P, Prasselsperger A, Konrad DB, Frank JA, Trauner D, Lohmüller T. Photolipid Bilayer Permeability is Controlled by Transient Pore Formation. Langmuir. 2020 Nov 17;36(45):13509-13515. doi: 10.1021/acs.langmuir.0c02229. Epub 2020 Nov 3. PubMed PMID: 33143416.
Frank JA, Antonini MJ, Chiang PH, Canales A, Konrad DB, Garwood IC, Rajic G, Koehler F, Fink Y, Anikeeva P. In Vivo Photopharmacology Enabled by Multifunctional Fibers. ACS Chem Neurosci. 2020 Nov 18;11(22):3802-3813. doi: 10.1021/acschemneuro.0c00577. Epub 2020 Oct 27. PubMed PMID: 33108719; PubMed Central PMCID: PMC10251749.
Sarott RC, Viray AEG, Pfaff P, Sadybekov A, Rajic G, Katritch V, Carreira EM, Frank JA. Optical Control of Cannabinoid Receptor 2-Mediated Ca(2+) Release Enabled by Synthesis of Photoswitchable Probes. J Am Chem Soc. 2021 Jan 20;143(2):736-743. doi: 10.1021/jacs.0c08926. Epub 2021 Jan 5. PubMed PMID: 33399457.
Tobias JM, Rajic G, Viray AEG, Icka-Araki D, Frank JA. Genetically-targeted photorelease of endocannabinoids enables optical control of GPR55 in pancreatic β-cells. Chem Sci. 2021 Oct 20;12(40):13506-13512. doi: 10.1039/d1sc02527a. eCollection 2021 Oct 20. PubMed PMID: 34777770; PubMed Central PMCID: PMC8528030.
Pritzl SD, Konrad DB, Ober MF, Richter AF, Frank JA, Nickel B, Trauner D, Lohmüller T. Optical Membrane Control with Red Light Enabled by Red-Shifted Photolipids. Langmuir. 2022 Jan 11;38(1):385-393. doi: 10.1021/acs.langmuir.1c02745. Epub 2021 Dec 31. PubMed PMID: 34969246.
Frank JA. Optofluidic neural interfaces for in vivo photopharmacology. Curr Opin Pharmacol. 2022 Apr;63:102195. doi: 10.1016/j.coph.2022.102195. Epub 2022 Mar 5. Review. PubMed PMID: 35259575.
Hartrampf N, Leitao SM, Winter N, Toombs-Ruane H, Frank JA, Schwille P, Trauner D, Franquelim HG. Structural diversity of photoswitchable sphingolipids for optodynamic control of lipid microdomains. Biophys J. 2023 Jun 6;122(11):2325-2341. doi: 10.1016/j.bpj.2023.02.029. Epub 2023 Mar 3. PubMed PMID: 36869591; PubMed Central PMCID: PMC10257215.
Kosar M, Sykes DA, Viray AEG, Vitale RM, Sarott RC, Ganzoni RL, Onion D, Tobias JM, Leippe P, Ullmer C, Zirwes EA, Guba W, Grether U, Frank JA, Veprintsev DB, Carreira EM. Platform Reagents Enable Synthesis of Ligand-Directed Covalent Probes: Study of Cannabinoid Receptor 2 in Live Cells. J Am Chem Soc. 2023 Jul 19;145(28):15094-15108. doi: 10.1021/jacs.2c13629. Epub 2023 Jul 4. PubMed PMID: 37401816.
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