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Smith AM, Klugman KP, Coffey TJ, Spratt BG. Genetic diversity of penicillin-binding protein 2B and 2X genes from Streptococcus pneumoniae in South Africa. Antimicrob Agents Chemother. 1993 Sep;37(9):1938-44. doi: 10.1128/aac.37.9.1938. PubMed PMID: 8239609; PubMed Central PMCID: PMC188096.
Klugman KP, Coffey TJ, Smith A, Wasas A, Meyers M, Spratt BG. Cluster of an erythromycin-resistant variant of the Spanish multiply resistant 23F clone of Streptococcus pneumoniae in South Africa. Eur J Clin Microbiol Infect Dis. 1994 Feb;13(2):171-4. doi: 10.1007/bf01982193. PubMed PMID: 8013492.
Rey C, Smith AM, Johnson S, Khitsane S. Preliminary characterization of a Potyvirus, the causal agent of green-sterile disease of Guar. Plant Disease. 1995; 79:172.
Smith AM, Klugman KP. Alterations in penicillin-binding protein 2B from penicillin-resistant wild-type strains of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1995 Apr;39(4):859-67. doi: 10.1128/aac.39.4.859. PubMed PMID: 7785985; PubMed Central PMCID: PMC162643.
Smith AM. The molecular basis and molecular epidemiology of penicillin-resistant Streptococcus pneumoniae. Southern African Journal of Epidemiology and Infection. 1996; 11:120.
Smith AM, Klugman KP. Three predominant clones identified within penicillin-resistant South African isolates of Streptococcus pneumoniae. Microb Drug Resist. 1997 Winter;3(4):385-9. doi: 10.1089/mdr.1997.3.385. PubMed PMID: 9442492.
Smith AM, Klugman KP. "Megaprimer" method of PCR-based mutagenesis: the concentration of megaprimer is a critical factor. Biotechniques. 1997 Mar;22(3):438, 442. doi: 10.2144/97223bm13. PubMed PMID: 9067016.
Smith AM, Klugman KP. Pneumococcal diseases. Methods Mol Med. 1998;15:139-56. doi: 10.1385/0-89603-498-4:139. PubMed PMID: 21390747.
du Plessis M, Smith AM, Klugman KP. Rapid detection of penicillin-resistant Streptococcus pneumoniae in cerebrospinal fluid by a seminested-PCR strategy. J Clin Microbiol. 1998 Feb;36(2):453-7. doi: 10.1128/JCM.36.2.453-457.1998. PubMed PMID: 9466757; PubMed Central PMCID: PMC104558.
Smith AM, Klugman KP. Alterations in PBP 1A essential-for high-level penicillin resistance in Streptococcus pneumoniae. Antimicrob Agents Chemother. 1998 Jun;42(6):1329-33. doi: 10.1128/AAC.42.6.1329. PubMed PMID: 9624469; PubMed Central PMCID: PMC105597.
du Plessis M, Smith AM, Klugman KP. Application of pbp1A PCR in identification of penicillin-resistant Streptococcus pneumoniae. J Clin Microbiol. 1999 Mar;37(3):628-32. doi: 10.1128/JCM.37.3.628-632.1999. PubMed PMID: 9986824; PubMed Central PMCID: PMC84499.
Smith AM, Klugman KP. Non-Penicillin-Binding protein mediated high-level penicillin and cephalosporin resistance in a Hungarian clone of Streptococcus pneumoniae. Microb Drug Resist. 2000 Summer;6(2):105-10. doi: 10.1089/107662900419401. PubMed PMID: 10990264.
Du Plessis M, Smith AM, Klugman KP. Analysis of penicillin-binding protein lb and 2a genes from Streptococcus pneumoniae. Microb Drug Resist. 2000 Summer;6(2):127-31. doi: 10.1089/107662900419438. PubMed PMID: 10990267.
Smith AM. Oligonucleotide-directed mutagenesis using plasmid DNA: A screening step to confirm the first successful step to positive mutagenesis. Technical Tips Online (http://research.bmn.com/tto). 2001; T02084.
Plessis M, Smith AM, Klugman KP. Detection of Penicillin Resistance in Streptococcus pneumoniae by a Seminested PCR Strategy. Methods Mol Med. 2001;48:65-75. doi: 10.1385/1-59259-077-2:65. PubMed PMID: 21374406.
Smith AM, Klugman KP. Alterations in MurM, a cell wall muropeptide branching enzyme, increase high-level penicillin and cephalosporin resistance in Streptococcus pneumoniae. Antimicrob Agents Chemother. 2001 Aug;45(8):2393-6. doi: 10.1128/AAC.45.8.2393-2396.2001. PubMed PMID: 11451707; PubMed Central PMCID: PMC90664.
Smith AM, Botha RF, Koornhof HJ, Klugman KP. Emergence of a pneumococcal clone with cephalosporin resistance and penicillin susceptibility. Antimicrob Agents Chemother. 2001 Sep;45(9):2648-50. doi: 10.1128/aac.45.9.2648-2650.2001. PubMed PMID: 11502545; PubMed Central PMCID: PMC90708.
Smith AM, Klugman KP. Site-specific mutagenesis analysis of PBP 1A from a penicillin-cephalosporin-resistant pneumococcal isolate. Antimicrob Agents Chemother. 2003 Jan;47(1):387-9. doi: 10.1128/aac.47.1.387-389.2003. PubMed PMID: 12499220; PubMed Central PMCID: PMC149026.
Smith AM, Perovic O, Sooka A, Venturas JP, Richards GA. Enterococcus avium with atypical phenotypic characteristics. Southern African Journal of Epidemiology and Infection. 2003; 18:42.
Smith AM, Feldman C, Massidda O, McCarthy K, Ndiweni D, Klugman KP. Altered PBP 2A and its role in the development of penicillin, cefotaxime, and ceftriaxone resistance in a clinical isolate of Streptococcus pneumoniae. Antimicrob Agents Chemother. 2005 May;49(5):2002-7. doi: 10.1128/AAC.49.5.2002-2007.2005. PubMed PMID: 15855525; PubMed Central PMCID: PMC1087663.
Wolter N, Smith AM, Farrell DJ, Schaffner W, Moore M, Whitney CG, Jorgensen JH, Klugman KP. Novel mechanism of resistance to oxazolidinones, macrolides, and chloramphenicol in ribosomal protein L4 of the pneumococcus. Antimicrob Agents Chemother. 2005 Aug;49(8):3554-7. doi: 10.1128/AAC.49.8.3554-3557.2005. PubMed PMID: 16048983; PubMed Central PMCID: PMC1196237.
Smith AM, Klugman KP. Amino acid mutations essential to production of an altered PBP 2X conferring high-level beta-lactam resistance in a clinical isolate of Streptococcus pneumoniae. Antimicrob Agents Chemother. 2005 Nov;49(11):4622-7. doi: 10.1128/AAC.49.11.4622-4627.2005. PubMed PMID: 16251304; PubMed Central PMCID: PMC1280142.
Wolter N, Smith AM, Farrell DJ, Klugman KP. Heterogeneous macrolide resistance and gene conversion in the pneumococcus. Antimicrob Agents Chemother. 2006 Jan;50(1):359-61. doi: 10.1128/AAC.50.1.359-361.2006. PubMed PMID: 16377711; PubMed Central PMCID: PMC1346819.
Coulson GB, von Gottberg A, du Plessis M, Smith AM, de Gouveia L, Klugman KP. Meningococcal disease in South Africa, 1999-2002. Emerg Infect Dis. 2007 Feb;13(2):273-81. doi: 10.3201/eid1302.051553. PubMed PMID: 17479891; PubMed Central PMCID: PMC2725855.
Anderson R, Steel HC, Cockeran R, Smith AM, von Gottberg A, de Gouveia L, Brink A, Klugman KP, Mitchell TJ, Feldman C. Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolide-resistant strains of Streptococcus pneumoniae. J Antimicrob Chemother. 2007 Feb;59(2):224-9. doi: 10.1093/jac/dkl479. Epub 2007 Jan 11. PubMed PMID: 17218449.
Wolter N, Smith AM, Low DE, Klugman KP. High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae. Antimicrob Agents Chemother. 2007 Mar;51(3):1092-5. doi: 10.1128/AAC.01153-06. Epub 2007 Jan 8. PubMed PMID: 17210764; PubMed Central PMCID: PMC1803110.
Smith AM, Gouws AM, Hoyland G, Sooka A, Keddy KH. Outbreaks of food-borne disease--a common occurrence but rarely reported. S Afr Med J. 2007 Dec;97(12):1272. PubMed PMID: 18264607.
Wolter N, Smith AM, Farrell DJ, Northwood JB, Douthwaite S, Klugman KP. Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. Antimicrob Agents Chemother. 2008 Feb;52(2):435-40. doi: 10.1128/AAC.01074-07. Epub 2007 Dec 3. PubMed PMID: 18056269; PubMed Central PMCID: PMC2224760.
von Gottberg A, Klugman KP, Cohen C, Wolter N, de Gouveia L, du Plessis M, Mpembe R, Quan V, Whitelaw A, Hoffmann R, Govender N, Meiring S, Smith AM, Schrag S. Emergence of levofloxacin-non-susceptible Streptococcus pneumoniae and treatment for multidrug-resistant tuberculosis in children in South Africa: a cohort observational surveillance study. Lancet. 2008 Mar 29;371(9618):1108-13. doi: 10.1016/S0140-6736(08)60350-5. Epub 2008 Mar 21. PubMed PMID: 18359074.
Smith AM, Keddy KH, De Wee L. Characterization of cholera outbreak isolates from Namibia, December 2006 to February 2007. Epidemiol Infect. 2008 Sep;136(9):1207-9. doi: 10.1017/S0950268807009685. Epub 2007 Oct 29. PubMed PMID: 17963590; PubMed Central PMCID: PMC2870929.
Smith AM, Sooka A, Ismail H, Nadan S, Crisp N, Weenink E, Keddy KH, For The Group For Enteric Respiratory And Meningeal Disease Surveillance In South Africa Germs-Sa. Analysis of Vibrio cholerae isolates from the Northern Cape province of South Africa. J Med Microbiol. 2009 Jan;58(Pt 1):151-154. doi: 10.1099/jmm.0.000331-0. PubMed PMID: 19074670.
McGee L, Biek D, Ge Y, Klugman M, du Plessis M, Smith AM, Beall B, Whitney CG, Klugman KP. In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. Antimicrob Agents Chemother. 2009 Feb;53(2):552-6. doi: 10.1128/AAC.01324-08. Epub 2008 Nov 17. PubMed PMID: 19015339; PubMed Central PMCID: PMC2630653.
Smith AM, Keddy KH, Sooka A, Ismail H, Dejong GM. Analysis of a temporal cluster of Shigella boydii isolates in Mpumalanga, South Africa, November to December 2007. J Infect Dev Ctries. 2009 Feb 28;3(1):65-70. doi: 10.3855/jidc.107. PubMed PMID: 19749451.
Keddy KH, Dwarika S, Crowther P, Perovic O, Wadula J, Hoosen A, Sooka A, Crewe-Brown HH, Smith AM. Genotypic and demographic characterization of invasive isolates of Salmonella Typhimurium in HIV co-infected patients in South Africa. J Infect Dev Ctries. 2009 Sep 15;3(8):585-92. doi: 10.3855/jidc.549. PubMed PMID: 19801800.
Govender N, Smith AM, Karstaedt AS, Keddy KH. Plasmid-mediated quinolone resistance in Salmonella from South Africa. J Med Microbiol. 2009 Oct;58(Pt 10):1393-1394. doi: 10.1099/jmm.0.009621-0. Epub 2009 Jun 18. PubMed PMID: 19541785.
Smith AM, Govender N, Keddy KH. Quinolone-resistant Salmonella Typhi in South Africa, 2003-2007. Epidemiol Infect. 2010 Jan;138(1):86-90. doi: 10.1017/S0950268809990331. Epub 2009 Jun 29. PubMed PMID: 19563699.
Keddy KH, Smith AM, Sooka A, Ismail H, Oliver S. Fluoroquinolone-resistant typhoid, South Africa. Emerg Infect Dis. 2010 May;16(5):879-80. doi: 10.3201/eid1605.091917. PubMed PMID: 20409393; PubMed Central PMCID: PMC2954527.
Smith AM, Tau NP, Sooka A, Keddy KH, For The Group For Enteric Respiratory And Meningeal Disease Surveillance In South Africa Germs-Sa. Surveillance for enterohaemorrhagic Escherichia coli associated with human diarrhoea in South Africa, 2006-2009. J Med Microbiol. 2011 May;60(Pt 5):681-683. doi: 10.1099/jmm.0.022947-0. Epub 2011 Jan 13. PubMed PMID: 21233292.
Smith AM, Thomas J, Mostert PJ. Fatal case of Clostridium perfringens enteritis and bacteraemia in South Africa. J Infect Dev Ctries. 2011 May 28;5(5):400-2. doi: 10.3855/jidc.1602. PubMed PMID: 21628819.
Niehaus AJ, Apalata T, Coovadia YM, Smith AM, Moodley P. An outbreak of foodborne salmonellosis in rural KwaZulu-Natal, South Africa. Foodborne Pathog Dis. 2011 Jun;8(6):693-7. doi: 10.1089/fpd.2010.0749. Epub 2011 Mar 9. PubMed PMID: 21388293.
Ismail H, Smith AM, Sooka A, Keddy KH. Genetic characterization of multidrug-resistant, extended-spectrum- β-lactamase-producing Vibrio cholerae O1 outbreak strains, Mpumalanga, South Africa, 2008. J Clin Microbiol. 2011 Aug;49(8):2976-9. doi: 10.1128/JCM.00293-11. Epub 2011 Jun 8. PubMed PMID: 21653763; PubMed Central PMCID: PMC3147719.
Keddy KH, Sooka A, Ismail H, Smith AM, Weber I, Letsoalo ME, Harris BN. Molecular epidemiological investigation of a typhoid fever outbreak in South Africa, 2005: the relationship to a previous epidemic in 1993. Epidemiol Infect. 2011 Aug;139(8):1239-45. doi: 10.1017/S0950268810002207. Epub 2010 Sep 28. PubMed PMID: 20875199.
Smith AM, Keddy KH, Ismail H, Thomas J, van der Grÿp R, Manamela MJ, Huma M, Sooka A, Theobald LK, Mennen MA, O'Reilly LC, For The Group For Enteric Respiratory And Meningeal Disease Surveillance In South Africa Germs-Sa. International collaboration tracks typhoid fever cases over two continents from South Africa to Australia. J Med Microbiol. 2011 Sep;60(Pt 9):1405-1407. doi: 10.1099/jmm.0.030700-0. Epub 2011 Apr 7. PubMed PMID: 21474612.
Talkington D, Bopp C, Tarr C, Parsons MB, Dahourou G, Freeman M, Joyce K, Turnsek M, Garrett N, Humphrys M, Gomez G, Stroika S, Boncy J, Ochieng B, Oundo J, Klena J, Smith A, Keddy K, Gerner-Smidt P. Characterization of toxigenic Vibrio cholerae from Haiti, 2010-2011. Emerg Infect Dis. 2011 Nov;17(11):2122-9. doi: 10.3201/eid1711.110805. PubMed PMID: 22099116; PubMed Central PMCID: PMC3310580.
Reimer AR, Van Domselaar G, Stroika S, Walker M, Kent H, Tarr C, Talkington D, Rowe L, Olsen-Rasmussen M, Frace M, Sammons S, Dahourou GA, Boncy J, Smith AM, Mabon P, Petkau A, Graham M, Gilmour MW, Gerner-Smidt P. Comparative genomics of Vibrio cholerae from Haiti, Asia, and Africa. Emerg Infect Dis. 2011 Nov;17(11):2113-21. doi: 10.3201/eid1711.110794. PubMed PMID: 22099115; PubMed Central PMCID: PMC3310578.
Tau NP, Smith AM, Sooka A, Keddy KH, For The Group For Enteric Respiratory And Meningeal Disease Surveillance In South Africa Germs-Sa. Molecular characterization of extended-spectrum β-lactamase-producing Shigella isolates from humans in South Africa, 2003-2009. J Med Microbiol. 2012 Jan;61(Pt 1):162-164. doi: 10.1099/jmm.0.033142-0. Epub 2011 Sep 8. PubMed PMID: 21903820.
Smith AM, Keddy KH, Ismail H, Tau N, Sooka A, Archer BN, Thomas J, Crisp N. Possible laboratory contamination leads to incorrect reporting of Vibrio cholerae O1 and initiates an outbreak response. J Clin Microbiol. 2012 Feb;50(2):480-2. doi: 10.1128/JCM.05785-11. Epub 2011 Dec 7. PubMed PMID: 22162543; PubMed Central PMCID: PMC3264189.
Dlamini NR, Bhamjee A, Levick P, Uniacke E, Ismail H, Smith A. Spontaneous bacterial peritonitis and pneumonia caused by Bordetella bronchiseptica. J Infect Dev Ctries. 2012 Jul 23;6(7):588-91. doi: 10.3855/jidc.2074. PubMed PMID: 22842947.
Tau NP, Meidany P, Smith AM, Sooka A, Keddy KH. Escherichia coli O104 associated with human diarrhea, South Africa, 2004-2011. Emerg Infect Dis. 2012 Aug;18(8):1314-7. doi: 10.3201/eid1808.111616. PubMed PMID: 22840375; PubMed Central PMCID: PMC3414021.
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