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Tang Q, Precit MR, Thomason MK, Blanc SF, Ahmed-Qadri F, McFarland AP, Wolter DJ, Hoffman LR, Woodward JJ. Thymidine starvation promotes c-di-AMP-dependent inflammation during pathogenic bacterial infection. Cell Host Microbe. 2022 Jul 13;30(7):961-974.e6. doi: 10.1016/j.chom.2022.03.028. Epub 2022 Apr 18. PubMed PMID: 35439435; PubMed Central PMCID: PMC9283248.
Pollock AJ, Choi PH, Zaver SA, Tong L, Woodward JJ. A Rationally Designed c-di-AMP Förster Resonance Energy Transfer Biosensor To Monitor Nucleotide Dynamics. J Bacteriol. 2021 Sep 8;203(19):e0008021. doi: 10.1128/JB.00080-21. Epub 2021 Sep 8. PubMed PMID: 34309402; PubMed Central PMCID: PMC8425405.
Soveg FW, Schwerk J, Gokhale NS, Cerosaletti K, Smith JR, Pairo-Castineira E, Kell AM, Forero A, Zaver SA, Esser-Nobis K, Roby JA, Hsiang TY, Ozarkar S, Clingan JM, McAnarney ET, Stone AE, Malhotra U, Speake C, Perez J, Balu C, Allenspach EJ, Hyde JL, Menachery VD, Sarkar SN, Woodward JJ, Stetson DB, Baillie JK, Buckner JH, Gale M Jr, Savan R. Endomembrane targeting of human OAS1 p46 augments antiviral activity. Elife. 2021 Aug 3;10. doi: 10.7554/eLife.71047. PubMed PMID: 34342578; PubMed Central PMCID: PMC8357416.
Tabakh H, McFarland AP, Thomason MK, Pollock AJ, Glover RC, Zaver SA, Woodward JJ. 4-Hydroxy-2-nonenal antimicrobial toxicity is neutralized by an intracellular pathogen. Elife. 2021 May 6;10. doi: 10.7554/eLife.59295. PubMed PMID: 33955352; PubMed Central PMCID: PMC8174450.
Zaver SA, Pollock AJ, Boradia VM, Woodward JJ. A Luminescence-Based Coupled Enzyme Assay Enables High-Throughput Quantification of the Bacterial Second Messenger 3'3'-Cyclic-Di-AMP. Chembiochem. 2021 Mar 16;22(6):1030-1041. doi: 10.1002/cbic.202000667. Epub 2020 Dec 4. PubMed PMID: 33142009; PubMed Central PMCID: PMC8715907.
Peterson BN, Young MKM, Luo S, Wang J, Whiteley AT, Woodward JJ, Tong L, Wang JD, Portnoy DA. (p)ppGpp and c-di-AMP Homeostasis Is Controlled by CbpB in Listeria monocytogenes. mBio. 2020 Aug 25;11(4). doi: 10.1128/mBio.01625-20. PubMed PMID: 32843560; PubMed Central PMCID: PMC8549634.
Pollock AJ, Zaver SA, Woodward JJ. A STING-based biosensor affords broad cyclic dinucleotide detection within single living eukaryotic cells. Nat Commun. 2020 Jul 15;11(1):3533. doi: 10.1038/s41467-020-17228-y. PubMed PMID: 32669552; PubMed Central PMCID: PMC7363834.
Zaver SA, Woodward JJ. Cyclic dinucleotides at the forefront of innate immunity. Curr Opin Cell Biol. 2020 Apr;63:49-56. doi: 10.1016/ Epub 2020 Jan 17. Review. PubMed PMID: 31958669; PubMed Central PMCID: PMC7247925.
Luteijn RD, Zaver SA, Gowen BG, Wyman SK, Garelis NE, Onia L, McWhirter SM, Katibah GE, Corn JE, Woodward JJ, Raulet DH. Author Correction: SLC19A1 transports immunoreactive cyclic dinucleotides. Nature. 2020 Mar;579(7800):E12. doi: 10.1038/s41586-020-2064-8. PubMed PMID: 32144410.
Vogt D, Zaver S, Ranjan A, DiMaio T, Gounder AP, Smith JG, Lagunoff M. STING is dispensable during KSHV infection of primary endothelial cells. Virology. 2020 Jan 15;540:150-159. doi: 10.1016/j.virol.2019.11.012. Epub 2019 Nov 25. PubMed PMID: 31928996; PubMed Central PMCID: PMC6961814.
Camargo AC, Moura A, Avillan J, Herman N, McFarland AP, Sreevatsan S, Call DR, Woodward JJ, Lecuit M, Nero LA. Whole-genome sequencing reveals Listeria monocytogenes diversity and allows identification of long-term persistent strains in Brazil. Environ Microbiol. 2019 Dec;21(12):4478-4487. doi: 10.1111/1462-2920.14726. Epub 2019 Jul 15. PubMed PMID: 31251828; PubMed Central PMCID: PMC7644123.
Luteijn RD, Zaver SA, Gowen BG, Wyman SK, Garelis NE, Onia L, McWhirter SM, Katibah GE, Corn JE, Woodward JJ, Raulet DH. SLC19A1 transports immunoreactive cyclic dinucleotides. Nature. 2019 Sep;573(7774):434-438. doi: 10.1038/s41586-019-1553-0. Epub 2019 Sep 11. PubMed PMID: 31511694; PubMed Central PMCID: PMC6785039.
An J, Woodward JJ, Lai W, Minie M, Sun X, Tanaka L, Snyder JM, Sasaki T, Elkon KB. Inhibition of Cyclic GMP-AMP Synthase Using a Novel Antimalarial Drug Derivative in Trex1-Deficient Mice. Arthritis Rheumatol. 2018 Nov;70(11):1807-1819. doi: 10.1002/art.40559. Epub 2018 Sep 14. PubMed PMID: 29781188.
Pham HT, Nhiep NTH, Vu TNM, Huynh TN, Zhu Y, Huynh ALD, Chakrabortti A, Marcellin E, Lo R, Howard CB, Bansal N, Woodward JJ, Liang ZX, Turner MS. Enhanced uptake of potassium or glycine betaine or export of cyclic-di-AMP restores osmoresistance in a high cyclic-di-AMP Lactococcus lactis mutant. PLoS Genet. 2018 Aug;14(8):e1007574. doi: 10.1371/journal.pgen.1007574. eCollection 2018 Aug. PubMed PMID: 30074984; PubMed Central PMCID: PMC6108528.
McFarland AP, Burke TP, Carletti AA, Glover RC, Tabakh H, Welch MD, Woodward JJ. RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread. mBio. 2018 May 15;9(3). doi: 10.1128/mBio.00526-18. PubMed PMID: 29764944; PubMed Central PMCID: PMC5954220.
Rubin BE, Huynh TN, Welkie DG, Diamond S, Simkovsky R, Pierce EC, Taton A, Lowe LC, Lee JJ, Rifkin SA, Woodward JJ, Golden SS. High-throughput interaction screens illuminate the role of c-di-AMP in cyanobacterial nighttime survival. PLoS Genet. 2018 Apr;14(4):e1007301. doi: 10.1371/journal.pgen.1007301. eCollection 2018 Apr. PubMed PMID: 29608558; PubMed Central PMCID: PMC5897029.
Townsley L, Yannarell SM, Huynh TN, Woodward JJ, Shank EA. Cyclic di-AMP Acts as an Extracellular Signal That Impacts Bacillus subtilis Biofilm Formation and Plant Attachment. mBio. 2018 Mar 27;9(2). doi: 10.1128/mBio.00341-18. PubMed PMID: 29588402; PubMed Central PMCID: PMC5874923.
Camargo AC, Woodward JJ, Call DR, Nero LA. Listeria monocytogenes in Food-Processing Facilities, Food Contamination, and Human Listeriosis: The Brazilian Scenario. Foodborne Pathog Dis. 2017 Nov;14(11):623-636. doi: 10.1089/fpd.2016.2274. Epub 2017 Aug 2. Review. PubMed PMID: 28767285.
Choi PH, Vu TMN, Pham HT, Woodward JJ, Turner MS, Tong L. Structural and functional studies of pyruvate carboxylase regulation by cyclic di-AMP in lactic acid bacteria. Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):E7226-E7235. doi: 10.1073/pnas.1704756114. Epub 2017 Aug 14. PubMed PMID: 28808024; PubMed Central PMCID: PMC5584425.
Lang KS, Hall AN, Merrikh CN, Ragheb M, Tabakh H, Pollock AJ, Woodward JJ, Dreifus JE, Merrikh H. Replication-Transcription Conflicts Generate R-Loops that Orchestrate Bacterial Stress Survival and Pathogenesis. Cell. 2017 Aug 10;170(4):787-799.e18. doi: 10.1016/j.cell.2017.07.044. PubMed PMID: 28802046; PubMed Central PMCID: PMC5630229.
Whiteley AT, Garelis NE, Peterson BN, Choi PH, Tong L, Woodward JJ, Portnoy DA. c-di-AMP modulates Listeria monocytogenes central metabolism to regulate growth, antibiotic resistance and osmoregulation. Mol Microbiol. 2017 Apr;104(2):212-233. doi: 10.1111/mmi.13622. Epub 2017 Mar 8. PubMed PMID: 28097715; PubMed Central PMCID: PMC5391996.
An J, Durcan L, Karr RM, Briggs TA, Rice GI, Teal TH, Woodward JJ, Elkon KB. Expression of Cyclic GMP-AMP Synthase in Patients With Systemic Lupus Erythematosus. Arthritis Rheumatol. 2017 Apr;69(4):800-807. doi: 10.1002/art.40002. Epub 2017 Mar 7. PubMed PMID: 27863149.
McFarland AP, Luo S, Ahmed-Qadri F, Zuck M, Thayer EF, Goo YA, Hybiske K, Tong L, Woodward JJ. Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State. Immunity. 2017 Mar 21;46(3):433-445. doi: 10.1016/j.immuni.2017.02.014. PubMed PMID: 28329705; PubMed Central PMCID: PMC5404390.
An J, Minie M, Sasaki T, Woodward JJ, Elkon KB. Antimalarial Drugs as Immune Modulators: New Mechanisms for Old Drugs. Annu Rev Med. 2017 Jan 14;68:317-330. doi: 10.1146/annurev-med-043015-123453. Epub 2016 Oct 21. Review. PubMed PMID: 27813878.
Huynh TN, Choi PH, Sureka K, Ledvina HE, Campillo J, Tong L, Woodward JJ. Cyclic di-AMP targets the cystathionine beta-synthase domain of the osmolyte transporter OpuC. Mol Microbiol. 2016 Oct;102(2):233-243. doi: 10.1111/mmi.13456. Epub 2016 Jul 26. PubMed PMID: 27378384; PubMed Central PMCID: PMC5118871.
Camargo AC, Woodward JJ, Nero LA. The Continuous Challenge of Characterizing the Foodborne Pathogen Listeria monocytogenes. Foodborne Pathog Dis. 2016 Aug;13(8):405-16. doi: 10.1089/fpd.2015.2115. Epub 2016 Apr 27. Review. PubMed PMID: 27120361.
McFarland AP, Woodward JJ. Flying Under the Radar: Immune Evasion by Group B Streptococcus. Cell Host Microbe. 2016 Jul 13;20(1):4-6. doi: 10.1016/j.chom.2016.06.015. PubMed PMID: 27414494.
Huynh TN, Woodward JJ. Too much of a good thing: regulated depletion of c-di-AMP in the bacterial cytoplasm. Curr Opin Microbiol. 2016 Apr;30:22-29. doi: 10.1016/j.mib.2015.12.007. Epub 2016 Jan 7. Review. PubMed PMID: 26773214; PubMed Central PMCID: PMC4821758.
Gray EE, Treuting PM, Woodward JJ, Stetson DB. Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome. J Immunol. 2015 Sep 1;195(5):1939-43. doi: 10.4049/jimmunol.1500969. Epub 2015 Jul 29. PubMed PMID: 26223655; PubMed Central PMCID: PMC4546858.
Choi PH, Sureka K, Woodward JJ, Tong L. Molecular basis for the recognition of cyclic-di-AMP by PstA, a PII-like signal transduction protein. Microbiologyopen. 2015 Jun;4(3):361-74. doi: 10.1002/mbo3.243. Epub 2015 Feb 18. PubMed PMID: 25693966; PubMed Central PMCID: PMC4475381.
An J, Woodward JJ, Sasaki T, Minie M, Elkon KB. Cutting edge: Antimalarial drugs inhibit IFN-β production through blockade of cyclic GMP-AMP synthase-DNA interaction. J Immunol. 2015 May 1;194(9):4089-93. doi: 10.4049/jimmunol.1402793. Epub 2015 Mar 27. PubMed PMID: 25821216.
Fu J, Kanne DB, Leong M, Glickman LH, McWhirter SM, Lemmens E, Mechette K, Leong JJ, Lauer P, Liu W, Sivick KE, Zeng Q, Soares KC, Zheng L, Portnoy DA, Woodward JJ, Pardoll DM, Dubensky TW Jr, Kim Y. STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade. Sci Transl Med. 2015 Apr 15;7(283):283ra52. doi: 10.1126/scitranslmed.aaa4306. PubMed PMID: 25877890; PubMed Central PMCID: PMC4504692.
Huynh TN, Luo S, Pensinger D, Sauer JD, Tong L, Woodward JJ. An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence. Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E747-56. doi: 10.1073/pnas.1416485112. Epub 2015 Jan 12. PubMed PMID: 25583510; PubMed Central PMCID: PMC4343097.
Sureka K, Choi PH, Precit M, Delince M, Pensinger DA, Huynh TN, Jurado AR, Goo YA, Sadilek M, Iavarone AT, Sauer JD, Tong L, Woodward JJ. The cyclic dinucleotide c-di-AMP is an allosteric regulator of metabolic enzyme function. Cell. 2014 Sep 11;158(6):1389-1401. doi: 10.1016/j.cell.2014.07.046. PubMed PMID: 25215494; PubMed Central PMCID: PMC4166403.
Witte CE, Whiteley AT, Burke TP, Sauer JD, Portnoy DA, Woodward JJ. Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection. mBio. 2013 May 28;4(3):e00282-13. doi: 10.1128/mBio.00282-13. PubMed PMID: 23716572; PubMed Central PMCID: PMC3663569.
Winter MB, Woodward JJ, Marletta MA. An Escherichia coli expression-based approach for porphyrin substitution in heme proteins. Methods Mol Biol. 2013;987:95-106. doi: 10.1007/978-1-62703-321-3_8. PubMed PMID: 23475670.
Witte CE, Archer KA, Rae CS, Sauer JD, Woodward JJ, Portnoy DA. Innate immune pathways triggered by Listeria monocytogenes and their role in the induction of cell-mediated immunity. Adv Immunol. 2012;113:135-56. doi: 10.1016/B978-0-12-394590-7.00002-6. Review. PubMed PMID: 22244582.
Sauer JD, Sotelo-Troha K, von Moltke J, Monroe KM, Rae CS, Brubaker SW, Hyodo M, Hayakawa Y, Woodward JJ, Portnoy DA, Vance RE. The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Infect Immun. 2011 Feb;79(2):688-94. doi: 10.1128/IAI.00999-10. Epub 2010 Nov 22. PubMed PMID: 21098106; PubMed Central PMCID: PMC3028833.
Stoll S, NejatyJahromy Y, Woodward JJ, Ozarowski A, Marletta MA, Britt RD. Nitric oxide synthase stabilizes the tetrahydrobiopterin cofactor radical by controlling its protonation state. J Am Chem Soc. 2010 Aug 25;132(33):11812-23. doi: 10.1021/ja105372s. PubMed PMID: 20669954.
Woodward JJ, Iavarone AT, Portnoy DA. c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response. Science. 2010 Jun 25;328(5986):1703-5. doi: 10.1126/science.1189801. Epub 2010 May 27. PubMed PMID: 20508090; PubMed Central PMCID: PMC3156580.
Woodward JJ, Nejatyjahromy Y, Britt RD, Marletta MA. Pterin-centered radical as a mechanistic probe of the second step of nitric oxide synthase. J Am Chem Soc. 2010 Apr 14;132(14):5105-13. doi: 10.1021/ja909378n. PubMed PMID: 20307068.
Latypova E, Yang S, Wang YS, Wang T, Chavkin TA, Hackett M, Schäfer H, Kalyuzhnaya MG. Genetics of the glutamate-mediated methylamine utilization pathway in the facultative methylotrophic beta-proteobacterium Methyloversatilis universalis FAM5. Mol Microbiol. 2010 Jan;75(2):426-39. doi: 10.1111/j.1365-2958.2009.06989.x. Epub 2009 Nov 25. PubMed PMID: 19943898.
Agapie T, Suseno S, Woodward JJ, Stoll S, Britt RD, Marletta MA. NO formation by a catalytically self-sufficient bacterial nitric oxide synthase from Sorangium cellulosum. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16221-6. doi: 10.1073/pnas.0908443106. Epub 2009 Sep 10. PubMed PMID: 19805284; PubMed Central PMCID: PMC2752531.
Reece SY, Woodward JJ, Marletta MA. Synthesis of nitric oxide by the NOS-like protein from deinococcus radiodurans: a direct role for tetrahydrofolate. Biochemistry. 2009 Jun 16;48(23):5483-91. doi: 10.1021/bi900385g. PubMed PMID: 19388666.
Zemansky J, Kline BC, Woodward JJ, Leber JH, Marquis H, Portnoy DA. Development of a mariner-based transposon and identification of Listeria monocytogenes determinants, including the peptidyl-prolyl isomerase PrsA2, that contribute to its hemolytic phenotype. J Bacteriol. 2009 Jun;191(12):3950-64. doi: 10.1128/JB.00016-09. Epub 2009 Apr 17. PubMed PMID: 19376879; PubMed Central PMCID: PMC2698408.
Martin NI, Woodward JJ, Winter MB, Marletta MA. 4,4-Difluorinated analogues of l-arginine and N(G)-hydroxy-l-arginine as mechanistic probes for nitric oxide synthase. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1758-62. doi: 10.1016/j.bmcl.2009.01.076. Epub 2009 Feb 18. PubMed PMID: 19230661.
Woodward JJ, Chang MM, Martin NI, Marletta MA. The second step of the nitric oxide synthase reaction: evidence for ferric-peroxo as the active oxidant. J Am Chem Soc. 2009 Jan 14;131(1):297-305. doi: 10.1021/ja807299t. PubMed PMID: 19128180.
Martin NI, Beeson WT, Woodward JJ, Marletta MA. N(G)-aminoguanidines from primary amines and the preparation of nitric oxide synthase inhibitors. J Med Chem. 2008 Feb 28;51(4):924-31. doi: 10.1021/jm701119v. Epub 2008 Jan 26. PubMed PMID: 18220331.
Martin NI, Woodward JJ, Winter MB, Beeson WT, Marletta MA. Design and synthesis of C5 methylated L-arginine analogues as active site probes for nitric oxide synthase. J Am Chem Soc. 2007 Oct 17;129(41):12563-70. doi: 10.1021/ja0746159. Epub 2007 Sep 25. PubMed PMID: 17892291.
Woodward JJ, Martin NI, Marletta MA. An Escherichia coli expression-based method for heme substitution. Nat Methods. 2007 Jan;4(1):43-5. doi: 10.1038/nmeth984. Epub 2006 Dec 24. PubMed PMID: 17187078.
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