Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
  • Page of 1
Tsai CW, Liu TY, Chao FY, Tu YC, Rodriguez MX, Van Keuren AM, Ma Z, Bankston J, Tsai MF. Evidence supporting the MICU1 occlusion mechanism and against the potentiation model in the mitochondrial calcium uniporter complex. Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2217665120. doi: 10.1073/pnas.2217665120. Epub 2023 Apr 10. PubMed PMID: 37036971; PubMed Central PMCID: PMC10120041.
Tsai CW, Rodriguez MX, Van Keuren AM, Phillips CB, Shushunov HM, Lee JE, Garcia AM, Ambardekar AV, Cleveland JC Jr, Reisz JA, Proenza C, Chatfield KC, Tsai MF. Mechanisms and significance of tissue-specific MICU regulation of the mitochondrial calcium uniporter complex. Mol Cell. 2022 Oct 6;82(19):3661-3676.e8. doi: 10.1016/j.molcel.2022.09.006. PubMed PMID: 36206740; PubMed Central PMCID: PMC9557913.
Rodriguez MX, Van Keuren AM, Tsai MF. Quantitative assays to measure the transport activity of the mitochondrial calcium uniporter in cell lines or Xenopus oocytes. STAR Protoc. 2021 Dec 17;2(4):100979. doi: 10.1016/j.xpro.2021.100979. eCollection 2021 Dec 17. PubMed PMID: 34877549; PubMed Central PMCID: PMC8633362.
Woods JJ, Rodriguez MX, Tsai CW, Tsai MF, Wilson JJ. Cobalt amine complexes and Ru265 interact with the DIME region of the mitochondrial calcium uniporter. Chem Commun (Camb). 2021 Jun 22;57(50):6161-6164. doi: 10.1039/d1cc01623g. PubMed PMID: 34042919; PubMed Central PMCID: PMC8240128.
Van Keuren AM, Tsai CW, Balderas E, Rodriguez MX, Chaudhuri D, Tsai MF. Mechanisms of EMRE-Dependent MCU Opening in the Mitochondrial Calcium Uniporter Complex. Cell Rep. 2020 Dec 8;33(10):108486. doi: 10.1016/j.celrep.2020.108486. PubMed PMID: 33296646; PubMed Central PMCID: PMC7764451.
Fan M, Zhang J, Tsai CW, Orlando BJ, Rodriguez M, Xu Y, Liao M, Tsai MF, Feng L. Structure and mechanism of the mitochondrial Ca(2+) uniporter holocomplex. Nature. 2020 Jun;582(7810):129-133. doi: 10.1038/s41586-020-2309-6. Epub 2020 May 20. PubMed PMID: 32494073; PubMed Central PMCID: PMC7544431.
Phillips CB, Tsai CW, Tsai MF. The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex. Elife. 2019 Jan 15;8. doi: 10.7554/eLife.41112. PubMed PMID: 30638448; PubMed Central PMCID: PMC6347451.
Tsai CW, Tsai MF. Electrical recordings of the mitochondrial calcium uniporter in Xenopus oocytes. J Gen Physiol. 2018 Jul 2;150(7):1035-1043. doi: 10.1085/jgp.201812015. Epub 2018 Jun 11. PubMed PMID: 29891485; PubMed Central PMCID: PMC6028504.
Tsai CW, Wu Y, Pao PC, Phillips CB, Williams C, Miller C, Ranaghan M, Tsai MF. Proteolytic control of the mitochondrial calcium uniporter complex. Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4388-4393. doi: 10.1073/pnas.1702938114. Epub 2017 Apr 10. PubMed PMID: 28396416; PubMed Central PMCID: PMC5410796.
Tsai MF, Phillips CB, Ranaghan M, Tsai CW, Wu Y, Willliams C, Miller C. Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex. Elife. 2016 Apr 21;5. doi: 10.7554/eLife.15545. PubMed PMID: 27099988; PubMed Central PMCID: PMC4892889.
Yu Y, Tsai MF, Yu WP, Chen TY. Modulation of the slow/common gating of CLC channels by intracellular cadmium. J Gen Physiol. 2015 Dec;146(6):495-508. doi: 10.1085/jgp.201511413. PubMed PMID: 26621774; PubMed Central PMCID: PMC4664824.
Stockbridge RB, Tsai MF. Lipid reconstitution and recording of recombinant ion channels. Methods Enzymol. 2015;556:385-404. doi: 10.1016/bs.mie.2014.12.028. Epub 2015 Mar 21. PubMed PMID: 25857792.
Tsai MF, Miller C. Building a temperature-sensitive ion channel. Cell. 2014 Aug 28;158(5):977-979. doi: 10.1016/j.cell.2014.08.008. PubMed PMID: 25171401.
Tsai MF, Jiang D, Zhao L, Clapham D, Miller C. Functional reconstitution of the mitochondrial Ca2+/H+ antiporter Letm1. J Gen Physiol. 2014 Jan;143(1):67-73. doi: 10.1085/jgp.201311096. Epub 2013 Dec 16. PubMed PMID: 24344246; PubMed Central PMCID: PMC3874562.
Tsai MF, McCarthy P, Miller C. Substrate selectivity in glutamate-dependent acid resistance in enteric bacteria. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):5898-902. doi: 10.1073/pnas.1301444110. Epub 2013 Mar 25. PubMed PMID: 23530225; PubMed Central PMCID: PMC3625338.
Tsai MF, Miller C. Substrate selectivity in arginine-dependent acid resistance in enteric bacteria. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):5893-7. doi: 10.1073/pnas.1301442110. Epub 2013 Mar 25. PubMed PMID: 23530220; PubMed Central PMCID: PMC3625328.
Tsai MF. CFTR: an ion channel with a transporter-type energy-coupling mechanism. J Gen Physiol. 2012 Oct;140(4):343-5. doi: 10.1085/jgp.201210882. Epub 2012 Sep 10. PubMed PMID: 22966013; PubMed Central PMCID: PMC3457686.
Tsai MF, Fang Y, Miller C. Sided functions of an arginine-agmatine antiporter oriented in liposomes. Biochemistry. 2012 Feb 28;51(8):1577-85. doi: 10.1021/bi201897t. Epub 2012 Feb 13. PubMed PMID: 22304019; PubMed Central PMCID: PMC3290904.
Tsai MF, Jih KY, Shimizu H, Li M, Hwang TC. Optimization of the degenerated interfacial ATP binding site improves the function of disease-related mutant cystic fibrosis transmembrane conductance regulator (CFTR) channels. J Biol Chem. 2010 Nov 26;285(48):37663-71. doi: 10.1074/jbc.M110.172817. Epub 2010 Sep 22. PubMed PMID: 20861014; PubMed Central PMCID: PMC2988371.
Tsai MF, Li M, Hwang TC. Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel. J Gen Physiol. 2010 May;135(5):399-414. doi: 10.1085/jgp.201010399. PubMed PMID: 20421370; PubMed Central PMCID: PMC2860585.
Tsai MF, Shimizu H, Sohma Y, Li M, Hwang TC. State-dependent modulation of CFTR gating by pyrophosphate. J Gen Physiol. 2009 Apr;133(4):405-19. doi: 10.1085/jgp.200810186. PubMed PMID: 19332621; PubMed Central PMCID: PMC2699106.
What would you like to do?
  • Page of 1