My Bibliography

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Stehlik C, Fiorentino L, Dorfleutner A, Bruey JM, Ariza EM, Sagara J, Reed JC. The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways. J Exp Med. 2002 Dec 16;196(12):1605-15. doi: 10.1084/jem.20021552. PubMed PMID: 12486103; PubMed Central PMCID: PMC2196065.

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Ruf W, Dorfleutner A, Riewald M. Specificity of coagulation factor signaling. J Thromb Haemost. 2003 Jul;1(7):1495-503. doi: 10.1046/j.1538-7836.2003.00300.x. Review. PubMed PMID: 12871285.

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Dorfleutner A, Ruf W. Regulation of tissue factor cytoplasmic domain phosphorylation by palmitoylation. Blood. 2003 Dec 1;102(12):3998-4005. doi: 10.1182/blood-2003-04-1149. Epub 2003 Aug 14. PubMed PMID: 12920028.

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Stehlik C, Lee SH, Dorfleutner A, Stassinopoulos A, Sagara J, Reed JC. Apoptosis-associated speck-like protein containing a caspase recruitment domain is a regulator of procaspase-1 activation. J Immunol. 2003 Dec 1;171(11):6154-63. doi: 10.4049/jimmunol.171.11.6154. PubMed PMID: 14634131.

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Belting M, Dorrell MI, Sandgren S, Aguilar E, Ahamed J, Dorfleutner A, Carmeliet P, Mueller BM, Friedlander M, Ruf W. Regulation of angiogenesis by tissue factor cytoplasmic domain signaling. Nat Med. 2004 May;10(5):502-9. doi: 10.1038/nm1037. Epub 2004 Apr 18. PubMed PMID: 15098027.

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Stehlik C, Kroismayr R, Dorfleutner A, Binder BR, Lipp J. VIGR--a novel inducible adhesion family G-protein coupled receptor in endothelial cells. FEBS Lett. 2004 Jul 2;569(1-3):149-55. doi: 10.1016/j.febslet.2004.05.038. PubMed PMID: 15225624.

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Kroismayr R, Baranyi U, Stehlik C, Dorfleutner A, Binder BR, Lipp J. HERC5, a HECT E3 ubiquitin ligase tightly regulated in LPS activated endothelial cells. J Cell Sci. 2004 Sep 15;117(Pt 20):4749-56. doi: 10.1242/jcs.01338. Epub 2004 Aug 25. PubMed PMID: 15331633.

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Dorfleutner A, Hintermann E, Tarui T, Takada Y, Ruf W. Cross-talk of integrin alpha3beta1 and tissue factor in cell migration. Mol Biol Cell. 2004 Oct;15(10):4416-25. doi: 10.1091/mbc.e03-09-0640. Epub 2004 Jul 14. PubMed PMID: 15254262; PubMed Central PMCID: PMC519137.

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Helfer B, Boswell BC, Finlay D, Cipres A, Vuori K, Bong Kang T, Wallach D, Dorfleutner A, Lahti JM, Flynn DC, Frisch SM. Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions. Cancer Res. 2006 Apr 15;66(8):4273-8. doi: 10.1158/0008-5472.CAN-05-4183. PubMed PMID: 16618751.

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Dorfleutner A, Bryan NB, Talbott SJ, Funya KN, Rellick SL, Reed JC, Shi X, Rojanasakul Y, Flynn DC, Stehlik C. Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation. Infect Immun. 2007 Mar;75(3):1484-92. doi: 10.1128/IAI.01315-06. Epub 2006 Dec 18. PubMed PMID: 17178784; PubMed Central PMCID: PMC1828547.

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Zhang J, Park SI, Artime MC, Summy JM, Shah AN, Bomser JA, Dorfleutner A, Flynn DC, Gallick GE. AFAP-110 is overexpressed in prostate cancer and contributes to tumorigenic growth by regulating focal contacts. J Clin Invest. 2007 Oct;117(10):2962-73. doi: 10.1172/JCI30710. PubMed PMID: 17885682; PubMed Central PMCID: PMC1978423.

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Dorfleutner A, Talbott SJ, Bryan NB, Funya KN, Rellick SL, Reed JC, Shi X, Rojanasakul Y, Flynn DC, Stehlik C. A Shope Fibroma virus PYRIN-only protein modulates the host immune response. Virus Genes. 2007 Dec;35(3):685-94. doi: 10.1007/s11262-007-0141-9. Epub 2007 Aug 4. PubMed PMID: 17676277; PubMed Central PMCID: PMC4257706.

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Dorfleutner A, Stehlik C, Zhang J, Gallick GE, Flynn DC. AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells. J Cell Physiol. 2007 Dec;213(3):740-9. doi: 10.1002/jcp.21143. PubMed PMID: 17520695.

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Stehlik C, Dorfleutner A. COPs and POPs: modulators of inflammasome activity. J Immunol. 2007 Dec 15;179(12):7993-8. doi: 10.4049/jimmunol.179.12.7993. Review. PubMed PMID: 18056338; PubMed Central PMCID: PMC2645488.

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Dorfleutner A, Cho Y, Vincent D, Cunnick J, Lin H, Weed SA, Stehlik C, Flynn DC. Phosphorylation of AFAP-110 affects podosome lifespan in A7r5 cells. J Cell Sci. 2008 Jul 15;121(Pt 14):2394-405. doi: 10.1242/jcs.026187. Epub 2008 Jun 24. PubMed PMID: 18577577.

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Bryan NB, Dorfleutner A, Rojanasakul Y, Stehlik C. Activation of inflammasomes requires intracellular redistribution of the apoptotic speck-like protein containing a caspase recruitment domain. J Immunol. 2009 Mar 1;182(5):3173-82. doi: 10.4049/jimmunol.0802367. PubMed PMID: 19234215; PubMed Central PMCID: PMC2652671.

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Shahrara S, Pickens SR, Dorfleutner A, Pope RM. IL-17 induces monocyte migration in rheumatoid arthritis. J Immunol. 2009 Mar 15;182(6):3884-91. doi: 10.4049/jimmunol.0802246. PubMed PMID: 19265168; PubMed Central PMCID: PMC2811490.

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Khare S, Luc N, Dorfleutner A, Stehlik C. Inflammasomes and their activation. Crit Rev Immunol. 2010;30(5):463-87. doi: 10.1615/critrevimmunol.v30.i5.50. Review. PubMed PMID: 21083527; PubMed Central PMCID: PMC3086048.

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Bryan NB, Dorfleutner A, Kramer SJ, Yun C, Rojanasakul Y, Stehlik C. Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes. J Inflamm (Lond). 2010 May 18;7:23. doi: 10.1186/1476-9255-7-23. PubMed PMID: 20482797; PubMed Central PMCID: PMC2887861.

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Khare S, Dorfleutner A, Bryan NB, Yun C, Radian AD, de Almeida L, Rojanasakul Y, Stehlik C. An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages. Immunity. 2012 Mar 23;36(3):464-76. doi: 10.1016/j.immuni.2012.02.001. Epub 2012 Feb 21. PubMed PMID: 22361007; PubMed Central PMCID: PMC3315380.

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Shi B, Huang Q, Tak PP, Vervoordeldonk MJ, Huang CC, Dorfleutner A, Stehlik C, Pope RM. SNAPIN: an endogenous Toll-like receptor ligand in rheumatoid arthritis. Ann Rheum Dis. 2012 Aug;71(8):1411-7. doi: 10.1136/annrheumdis-2011-200899. Epub 2012 Apr 20. PubMed PMID: 22523426.

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Huang QQ, Koessler RE, Birkett R, Dorfleutner A, Perlman H, Haines GK 3rd, Stehlik C, Nicchitta CV, Pope RM. Glycoprotein 96 perpetuates the persistent inflammation of rheumatoid arthritis. Arthritis Rheum. 2012 Nov;64(11):3638-48. doi: 10.1002/art.34610. PubMed PMID: 22777994; PubMed Central PMCID: PMC3473144.

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Radian AD, de Almeida L, Dorfleutner A, Stehlik C. NLRP7 and related inflammasome activating pattern recognition receptors and their function in host defense and disease. Microbes Infect. 2013 Jul-Aug;15(8-9):630-9. doi: 10.1016/j.micinf.2013.04.001. Epub 2013 Apr 22. Review. PubMed PMID: 23618810; PubMed Central PMCID: PMC3722249.

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Ratsimandresy RA, Dorfleutner A, Stehlik C. An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology. Front Immunol. 2013 Dec 9;4:440. doi: 10.3389/fimmu.2013.00440. Review. PubMed PMID: 24367371; PubMed Central PMCID: PMC3856626.

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Khare S, Ratsimandresy RA, de Almeida L, Cuda CM, Rellick SL, Misharin AV, Wallin MC, Gangopadhyay A, Forte E, Gottwein E, Perlman H, Reed JC, Greaves DR, Dorfleutner A, Stehlik C. The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses. Nat Immunol. 2014 Apr;15(4):343-53. doi: 10.1038/ni.2829. Epub 2014 Feb 16. PubMed PMID: 24531343; PubMed Central PMCID: PMC4123781.

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Chu LH, Gangopadhyay A, Dorfleutner A, Stehlik C. An updated view on the structure and function of PYRIN domains. Apoptosis. 2015 Feb;20(2):157-73. doi: 10.1007/s10495-014-1065-1. PubMed PMID: 25451010; PubMed Central PMCID: PMC4297229.

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Dorfleutner A, Chu L, Stehlik C. Inhibiting the inflammasome: one domain at a time. Immunol Rev. 2015 May;265(1):205-16. doi: 10.1111/imr.12290. Review. PubMed PMID: 25879295; PubMed Central PMCID: PMC4400809.

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de Almeida L, Khare S, Misharin AV, Patel R, Ratsimandresy RA, Wallin MC, Perlman H, Greaves DR, Hoffman HM, Dorfleutner A, Stehlik C. The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease. Immunity. 2015 Aug 18;43(2):264-76. doi: 10.1016/j.immuni.2015.07.018. Epub 2015 Aug 11. PubMed PMID: 26275995; PubMed Central PMCID: PMC4666005.

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Radian AD, Khare S, Chu LH, Dorfleutner A, Stehlik C. ATP binding by NLRP7 is required for inflammasome activation in response to bacterial lipopeptides. Mol Immunol. 2015 Oct;67(2 Pt B):294-302. doi: 10.1016/j.molimm.2015.06.013. Epub 2015 Jul 2. PubMed PMID: 26143398; PubMed Central PMCID: PMC4565763.

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Cuda CM, Misharin AV, Khare S, Saber R, Tsai F, Archer AM, Homan PJ, Haines GK 3rd, Hutcheson J, Dorfleutner A, Budinger GR, Stehlik C, Perlman H. Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner. Arthritis Res Ther. 2015 Oct 16;17:291. doi: 10.1186/s13075-015-0794-z. PubMed PMID: 26471282; PubMed Central PMCID: PMC4608154.

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Khare S, Radian AD, Dorfleutner A, Stehlik C. Measuring NLR Oligomerization I: Size Exclusion Chromatography, Co-immunoprecipitation, and Cross-Linking. Methods Mol Biol. 2016;1417:131-43. doi: 10.1007/978-1-4939-3566-6_8. PubMed PMID: 27221486; PubMed Central PMCID: PMC5058782.

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Dorfleutner A, Stehlik C. A dRAStic RHOAdblock of Pyrin inflammasome activation. Nat Immunol. 2016 Jul 19;17(8):900-2. doi: 10.1038/ni.3511. PubMed PMID: 27434003; PubMed Central PMCID: PMC5110454.

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de Almeida L, Dorfleutner A, Stehlik C. ASC-particle-induced Peritonitis. Bio Protoc. 2016 Oct 5;6(19). doi: 10.21769/BioProtoc.1944. PubMed PMID: 28516116; PubMed Central PMCID: PMC5431586.

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de Almeida L, Dorfleutner A, Stehlik C. In vivo Analysis of Neutrophil Infiltration during LPS-induced Peritonitis. Bio Protoc. 2016 Oct 5;6(19). doi: 10.21769/BioProtoc.1945. PubMed PMID: 28752106; PubMed Central PMCID: PMC5526106.

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Ratsimandresy RA, Indramohan M, Dorfleutner A, Stehlik C. The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway. Cell Mol Immunol. 2017 Jan;14(1):127-142. doi: 10.1038/cmi.2016.35. Epub 2016 Aug 15. PubMed PMID: 27524110; PubMed Central PMCID: PMC5214942.

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Shi B, Huang QQ, Birkett R, Doyle R, Dorfleutner A, Stehlik C, He C, Pope RM. SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages. Autophagy. 2017 Feb;13(2):285-301. doi: 10.1080/15548627.2016.1261238. Epub 2016 Dec 8. PubMed PMID: 27929705; PubMed Central PMCID: PMC5324844.

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Ratsimandresy RA, Chu LH, Khare S, de Almeida L, Gangopadhyay A, Indramohan M, Misharin AV, Greaves DR, Perlman H, Dorfleutner A, Stehlik C. The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation. Nat Commun. 2017 Jun 5;8:15556. doi: 10.1038/ncomms15556. PubMed PMID: 28580931; PubMed Central PMCID: PMC5465353.

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Tsai F, Homan PJ, Agrawal H, Misharin AV, Abdala-Valencia H, Haines GK 3rd, Dominguez S, Bloomfield CL, Saber R, Chang A, Mohan C, Hutcheson J, Davidson A, Budinger GRS, Bouillet P, Dorfleutner A, Stehlik C, Winter DR, Cuda CM, Perlman H. Bim suppresses the development of SLE by limiting myeloid inflammatory responses. J Exp Med. 2017 Dec 4;214(12):3753-3773. doi: 10.1084/jem.20170479. Epub 2017 Nov 7. PubMed PMID: 29114065; PubMed Central PMCID: PMC5716039.

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Indramohan M, Stehlik C, Dorfleutner A. COPs and POPs Patrol Inflammasome Activation. J Mol Biol. 2018 Jan 19;430(2):153-173. doi: 10.1016/j.jmb.2017.10.004. Epub 2017 Oct 10. Review. PubMed PMID: 29024695; PubMed Central PMCID: PMC5766406.

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Chu LH, Indramohan M, Ratsimandresy RA, Gangopadhyay A, Morris EP, Monack DM, Dorfleutner A, Stehlik C. The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages. Nat Commun. 2018 Mar 8;9(1):996. doi: 10.1038/s41467-018-03409-3. PubMed PMID: 29520027; PubMed Central PMCID: PMC5843631.