My Bibliography

select

Iwamoto T, You M, Li E, Spangler J, Tomich JM, Hristova K. Synthesis and initial characterization of FGFR3 transmembrane domain: consequences of sequence modifications. Biochim Biophys Acta. 2005 Mar 1;1668(2):240-7. doi: 10.1016/j.bbamem.2004.12.012. Epub 2005 Jan 28. PubMed PMID: 15737335.

select

You M, Spangler J, Li E, Han X, Ghosh P, Hristova K. Effect of pathogenic cysteine mutations on FGFR3 transmembrane domain dimerization in detergents and lipid bilayers. Biochemistry. 2007 Oct 2;46(39):11039-46. doi: 10.1021/bi700986n. Epub 2007 Sep 11. PubMed PMID: 17845056.

select

Engineered proteins including mutant fibronectin domains. USA patent application PCT/US10/45490. 2010.

select

Spangler JB, Neil JR, Abramovitch S, Yarden Y, White FM, Lauffenburger DA, Wittrup KD. Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling. Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13252-7. doi: 10.1073/pnas.0913476107. Epub 2010 Jul 7. PubMed PMID: 20616078; PubMed Central PMCID: PMC2922117.

select

Bispecific antibodies directed against tyrosine kinase receptors. USA patent application PCT/US2011/048529. 2011.

select

Spangler JB, Manzari MT, Rosalia EK, Chen TF, Wittrup KD. Triepitopic antibody fusions inhibit cetuximab-resistant BRAF and KRAS mutant tumors via EGFR signal repression. J Mol Biol. 2012 Sep 28;422(4):532-44. doi: 10.1016/j.jmb.2012.06.014. Epub 2012 Jun 15. PubMed PMID: 22706026; PubMed Central PMCID: PMC4041985.

select

Spangler JB, Feltus FA. Conserved Non-Coding Sequences are Associated with Rates of mRNA Decay in Arabidopsis. Front Plant Sci. 2013;4:129. doi: 10.3389/fpls.2013.00129. eCollection 2013. PubMed PMID: 23675377; PubMed Central PMCID: PMC3650315.

select

Spangler JB, Moraga I, Mendoza JL, Garcia KC. Insights into cytokine-receptor interactions from cytokine engineering. Annu Rev Immunol. 2015;33:139-67. doi: 10.1146/annurev-immunol-032713-120211. Epub 2014 Dec 10. Review. PubMed PMID: 25493332; PubMed Central PMCID: PMC4445396.

select

Moraga I, Spangler J, Mendoza JL, Garcia KC. Multifarious determinants of cytokine receptor signaling specificity. Adv Immunol. 2014;121:1-39. doi: 10.1016/B978-0-12-800100-4.00001-5. Review. PubMed PMID: 24388212; PubMed Central PMCID: PMC4449261.

select

Spangler JB, Tomala J, Luca VC, Jude KM, Dong S, Ring AM, Votavova P, Pepper M, Kovar M, Garcia KC. Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms. Immunity. 2015 May 19;42(5):815-25. doi: 10.1016/j.immuni.2015.04.015. PubMed PMID: 25992858; PubMed Central PMCID: PMC4439582.

select

Mitra S, Ring AM, Amarnath S, Spangler JB, Li P, Ju W, Fischer S, Oh J, Spolski R, Weiskopf K, Kohrt H, Foley JE, Rajagopalan S, Long EO, Fowler DH, Waldmann TA, Garcia KC, Leonard WJ. Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps. Immunity. 2015 May 19;42(5):826-38. doi: 10.1016/j.immuni.2015.04.018. PubMed PMID: 25992859; PubMed Central PMCID: PMC4560365.

select

Wang N, Keszei M, Halibozek P, Yigit B, Engel P, Terhorst C. Slamf6 negatively regulates autoimmunity. Clin Immunol. 2016 Dec;173:19-26. doi: 10.1016/j.clim.2016.06.009. Epub 2016 Jun 29. PubMed PMID: 27368806; PubMed Central PMCID: PMC5206809.

select

Biswas M, Rogers GL, Sherman A, Byrne BJ, Markusic DM, Jiang H, Herzog RW. Combination therapy for inhibitor reversal in haemophilia A using monoclonal anti-CD20 and rapamycin. Thromb Haemost. 2017 Jan 5;117(1):33-43. doi: 10.1160/TH16-05-0404. Epub 2016 Sep 29. PubMed PMID: 27683758; PubMed Central PMCID: PMC5222884.

select

Perrin GQ, Zolotukhin I, Sherman A, Biswas M, de Jong YP, Terhorst C, Davidoff AM, Herzog RW. Dynamics of antigen presentation to transgene product-specific CD4(+) T cells and of Treg induction upon hepatic AAV gene transfer. Mol Ther Methods Clin Dev. 2016;3:16083. doi: 10.1038/mtm.2016.83. eCollection 2016. PubMed PMID: 27933310; PubMed Central PMCID: PMC5142511.

select

Herzog RW, Nichols TC, Su J, Zhang B, Sherman A, Merricks EP, Raymer R, Perrin GQ, Häger M, Wiinberg B, Daniell H. Oral Tolerance Induction in Hemophilia B Dogs Fed with Transplastomic Lettuce. Mol Ther. 2017 Feb 1;25(2):512-522. doi: 10.1016/j.ymthe.2016.11.009. PubMed PMID: 28153098; PubMed Central PMCID: PMC5368425.

select

Kumar SRP, Hoffman BE, Terhorst C, de Jong YP, Herzog RW. The Balance between CD8(+) T Cell-Mediated Clearance of AAV-Encoded Antigen in the Liver and Tolerance Is Dependent on the Vector Dose. Mol Ther. 2017 Apr 5;25(4):880-891. doi: 10.1016/j.ymthe.2017.02.014. Epub 2017 Mar 9. PubMed PMID: 28284982; PubMed Central PMCID: PMC5383644.

select

Wang X, Herzog RW, Byrne BJ, Kumar SRP, Zhou Q, Buchholz CJ, Biswas M. Immune Modulatory Cell Therapy for Hemophilia B Based on CD20-Targeted Lentiviral Gene Transfer to Primary B Cells. Mol Ther Methods Clin Dev. 2017 Jun 16;5:76-82. doi: 10.1016/j.omtm.2017.03.005. eCollection 2017 Jun 16. PubMed PMID: 28480307; PubMed Central PMCID: PMC5415320.

select

Palaschak B, Marsic D, Herzog RW, Zolotukhin S, Markusic DM. An Immune-Competent Murine Model to Study Elimination of AAV-Transduced Hepatocytes by Capsid-Specific CD8(+) T Cells. Mol Ther Methods Clin Dev. 2017 Jun 16;5:142-152. doi: 10.1016/j.omtm.2017.04.004. eCollection 2017 Jun 16. PubMed PMID: 28480313; PubMed Central PMCID: PMC5415329.

select

Markusic DM, Nichols TC, Merricks EP, Palaschak B, Zolotukhin I, Marsic D, Zolotukhin S, Srivastava A, Herzog RW. Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models. J Transl Med. 2017 May 1;15(1):94. doi: 10.1186/s12967-017-1200-1. PubMed PMID: 28460646; PubMed Central PMCID: PMC5412045.

select

Moraga I, Spangler JB, Mendoza JL, Gakovic M, Wehrman TS, Krutzik P, Garcia KC. Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers. Elife. 2017 May 12;6. doi: 10.7554/eLife.22882. PubMed PMID: 28498099; PubMed Central PMCID: PMC5429090.

select

Herzog RW. Complexity of immune responses to AAV transgene products - Example of factor IX. Cell Immunol. 2019 Aug;342:103658. doi: 10.1016/j.cellimm.2017.05.006. Epub 2017 May 29. Review. PubMed PMID: 28645365; PubMed Central PMCID: PMC5708148.

select

Herzog RW, Cooper M, Perrin GQ, Biswas M, Martino AT, Morel L, Terhorst C, Hoffman BE. Regulatory T cells and TLR9 activation shape antibody formation to a secreted transgene product in AAV muscle gene transfer. Cell Immunol. 2019 Aug;342:103682. doi: 10.1016/j.cellimm.2017.07.012. Epub 2017 Aug 1. PubMed PMID: 28888664; PubMed Central PMCID: PMC5794662.

select

Sherman A, Biswas M, Herzog RW. Innovative Approaches for Immune Tolerance to Factor VIII in the Treatment of Hemophilia A. Front Immunol. 2017;8:1604. doi: 10.3389/fimmu.2017.01604. eCollection 2017. Review. PubMed PMID: 29225598; PubMed Central PMCID: PMC5705551.

select

Kureshi R, Bahri M, Spangler JB. Reprogramming immune proteins as therapeutics using molecular engineering. Current opinion in chemical engineering. 2018 March; 19:27-34.

select

Biswas M, Kumar SRP, Terhorst C, Herzog RW. Gene Therapy With Regulatory T Cells: A Beneficial Alliance. Front Immunol. 2018;9:554. doi: 10.3389/fimmu.2018.00554. eCollection 2018. Review. PubMed PMID: 29616042; PubMed Central PMCID: PMC5868074.

select

Xiao W, Gao G, Ling C, Herzog RW, Xiao X, Samulski RJ. Impact of neutralizing antibodies against AAV is a key consideration in gene transfer to nonhuman primates. Nat Med. 2018 Jun;24(6):699. doi: 10.1038/s41591-018-0062-2. PubMed PMID: 29867233; PubMed Central PMCID: PMC6290466.

select

Spangler JB, Trotta E, Tomala J, Peck A, Young TA, Savvides CS, Silveria S, Votavova P, Salafsky J, Pande VS, Kovar M, Bluestone JA, Garcia KC. Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy. J Immunol. 2018 Oct 1;201(7):2094-2106. doi: 10.4049/jimmunol.1800578. Epub 2018 Aug 13. PubMed PMID: 30104245; PubMed Central PMCID: PMC6173196.

select

Sherman A, Biswas M, Herzog RW. Tolerance induction in hemophilia: innovation and accomplishments. Curr Opin Hematol. 2018 Sep;25(5):365-372. doi: 10.1097/MOH.0000000000000446. Review. PubMed PMID: 29994897; PubMed Central PMCID: PMC10546904.

select

Yigit B, Wang N, Herzog RW, Terhorst C. SLAMF6 in health and disease: Implications for therapeutic targeting. Clin Immunol. 2019 Jul;204:3-13. doi: 10.1016/j.clim.2018.10.013. Epub 2018 Oct 23. Review. PubMed PMID: 30366106; PubMed Central PMCID: PMC8969216.

select

Perrin GQ, Herzog RW, Markusic DM. Update on clinical gene therapy for hemophilia. Blood. 2019 Jan 31;133(5):407-414. doi: 10.1182/blood-2018-07-820720. Epub 2018 Dec 17. Review. PubMed PMID: 30559260; PubMed Central PMCID: PMC6356985.

select

Silva DA, Yu S, Ulge UY, Spangler JB, Jude KM, Labão-Almeida C, Ali LR, Quijano-Rubio A, Ruterbusch M, Leung I, Biary T, Crowley SJ, Marcos E, Walkey CD, Weitzner BD, Pardo-Avila F, Castellanos J, Carter L, Stewart L, Riddell SR, Pepper M, Bernardes GJL, Dougan M, Garcia KC, Baker D. De novo design of potent and selective mimics of IL-2 and IL-15. Nature. 2019 Jan;565(7738):186-191. doi: 10.1038/s41586-018-0830-7. Epub 2019 Jan 9. PubMed PMID: 30626941; PubMed Central PMCID: PMC6521699.

select

Herzog RW, Kuteyeva V, Saboungi R, Terhorst C, Biswas M. Reprogrammed CD4(+) T Cells That Express FoxP3(+) Control Inhibitory Antibody Formation in Hemophilia A Mice. Front Immunol. 2019;10:274. doi: 10.3389/fimmu.2019.00274. eCollection 2019. PubMed PMID: 30842776; PubMed Central PMCID: PMC6391332.

select

Krohl PJ, Ludwig SD, Spangler JB. Emerging technologies in protein interface engineering for biomedical applications. Curr Opin Biotechnol. 2019 Dec;60:82-88. doi: 10.1016/j.copbio.2019.01.017. Epub 2019 Feb 23. Review. PubMed PMID: 30802788.

select

Leonard EK, Leff MI, Spangler JB. Weaponizing T-cell receptors through molecular engineering. J Biol Chem. 2019 Apr 12;294(15):5805-5806. doi: 10.1074/jbc.H119.008479. PubMed PMID: 30979848; PubMed Central PMCID: PMC6463730.

select

Butterfield JSS, Biswas M, Shirley JL, Kumar SRP, Sherman A, Terhorst C, Ling C, Herzog RW. TLR9-Activating CpG-B ODN but Not TLR7 Agonists Triggers Antibody Formation to Factor IX in Muscle Gene Transfer. Hum Gene Ther Methods. 2019 Jun;30(3):81-92. doi: 10.1089/hgtb.2019.013. PubMed PMID: 31140323; PubMed Central PMCID: PMC6590725.

select

Spangler JB, Moraga I, Jude KM, Savvides CS, Garcia KC. A strategy for the selection of monovalent antibodies that span protein dimer interfaces. J Biol Chem. 2019 Sep 20;294(38):13876-13886. doi: 10.1074/jbc.RA119.009213. Epub 2019 Aug 6. PubMed PMID: 31387945; PubMed Central PMCID: PMC6755802.

select

Butterfield JSS, Hege KM, Herzog RW, Kaczmarek R. A Molecular Revolution in the Treatment of Hemophilia. Mol Ther. 2020 Apr 8;28(4):997-1015. doi: 10.1016/j.ymthe.2019.11.006. Epub 2019 Nov 13. Review. PubMed PMID: 31843450; PubMed Central PMCID: PMC7132613.

select

Shirley JL, Keeler GD, Sherman A, Zolotukhin I, Markusic DM, Hoffman BE, Morel LM, Wallet MA, Terhorst C, Herzog RW. Type I IFN Sensing by cDCs and CD4(+) T Cell Help Are Both Requisite for Cross-Priming of AAV Capsid-Specific CD8(+) T Cells. Mol Ther. 2020 Mar 4;28(3):758-770. doi: 10.1016/j.ymthe.2019.11.011. Epub 2019 Nov 15. PubMed PMID: 31780366; PubMed Central PMCID: PMC7054715.

select

Yang H, Kureshi R, Spangler JB. Structural Basis for Signaling Through Shared Common γ Chain Cytokines. Adv Exp Med Biol. 2019;1172:1-19. doi: 10.1007/978-981-13-9367-9_1. Review. PubMed PMID: 31628649.

select

Palaschak B, Herzog RW, Markusic DM. AAV-Mediated Gene Delivery to the Liver: Overview of Current Technologies and Methods. Methods Mol Biol. 2019;1950:333-360. doi: 10.1007/978-1-4939-9139-6_20. Review. PubMed PMID: 30783984.

select

Michailidis E, Vercauteren K, Mancio-Silva L, Andrus L, Jahan C, Ricardo-Lax I, Zou C, Kabbani M, Park P, Quirk C, Pyrgaki C, Razooky B, Verhoye L, Zoluthkin I, Lu WY, Forbes SJ, Chiriboga L, Theise ND, Herzog RW, Suemizu H, Schneider WM, Shlomai A, Meuleman P, Bhatia SN, Rice CM, de Jong YP. Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes. Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1678-1688. doi: 10.1073/pnas.1919035117. Epub 2020 Jan 8. PubMed PMID: 31915293; PubMed Central PMCID: PMC6983380.

select

Shirley JL, de Jong YP, Terhorst C, Herzog RW. Immune Responses to Viral Gene Therapy Vectors. Mol Ther. 2020 Mar 4;28(3):709-722. doi: 10.1016/j.ymthe.2020.01.001. Epub 2020 Jan 10. Review. PubMed PMID: 31968213; PubMed Central PMCID: PMC7054714.

select

Zou C, Vercauteren KOA, Michailidis E, Kabbani M, Zoluthkin I, Quirk C, Chiriboga L, Yazicioglu M, Anguela XM, Meuleman P, High KA, Herzog RW, de Jong YP. Experimental Variables that Affect Human Hepatocyte AAV Transduction in Liver Chimeric Mice. Mol Ther Methods Clin Dev. 2020 Sep 11;18:189-198. doi: 10.1016/j.omtm.2020.05.033. eCollection 2020 Sep 11. PubMed PMID: 32637450; PubMed Central PMCID: PMC7326722.

select

Kureshi R, Zhu A, Shen J, Tzeng SY, Astrab LR, Sargunas PR, Green JJ, Campochiaro PA, Spangler JB. Structure-Guided Molecular Engineering of a Vascular Endothelial Growth Factor Antagonist to Treat Retinal Diseases. Cell Mol Bioeng. 2020 Oct;13(5):405-418. doi: 10.1007/s12195-020-00641-0. eCollection 2020 Oct. PubMed PMID: 33184574; PubMed Central PMCID: PMC7596137.

select

Biswas M, Marsic D, Li N, Zou C, Gonzalez-Aseguinolaza G, Zolotukhin I, Kumar SRP, Rana J, Butterfield JSS, Kondratov O, de Jong YP, Herzog RW, Zolotukhin S. Engineering and In Vitro Selection of a Novel AAV3B Variant with High Hepatocyte Tropism and Reduced Seroreactivity. Mol Ther Methods Clin Dev. 2020 Dec 11;19:347-361. doi: 10.1016/j.omtm.2020.09.019. eCollection 2020 Dec 11. PubMed PMID: 33145371; PubMed Central PMCID: PMC7591349.

select

Stabach PR, Zimmerman K, Adame A, Kavanagh D, Saeui CT, Agatemor C, Gray S, Cao W, De La Cruz EM, Yarema KJ, Braddock DT. Improving the Pharmacodynamics and In Vivo Activity of ENPP1-Fc Through Protein and Glycosylation Engineering. Clin Transl Sci. 2021 Jan;14(1):362-372. doi: 10.1111/cts.12887. Epub 2020 Oct 20. PubMed PMID: 33064927; PubMed Central PMCID: PMC7877847.

select

Mertz JL, Sun S, Yin B, Hu Y, Bhattacharya R, Bettenbaugh MJ, Yarema KJ, Zhang H. Comparison of Three Glycoproteomic Methods for the Analysis of the Secretome of CHO Cells Treated with 1,3,4-O-Bu(3)ManNAc. Bioengineering (Basel). 2020 Nov 10;7(4). doi: 10.3390/bioengineering7040144. PubMed PMID: 33182731; PubMed Central PMCID: PMC7712478.

select

Bertolini TB, Biswas M, Terhorst C, Daniell H, Herzog RW, Piñeros AR. Role of orally induced regulatory T cells in immunotherapy and tolerance. Cell Immunol. 2021 Jan;359:104251. doi: 10.1016/j.cellimm.2020.104251. Epub 2020 Nov 14. Review. PubMed PMID: 33248367; PubMed Central PMCID: PMC8919860.

select

VanDyke D, Wang W, Spangler J. Innovative synthetic signaling technologies for immunotherapy. Current opinion in biomedical engineering. 2020 December; 16:1-8.

select

Krohl P, Kim K, Lew L, VanDyke D, Ludwig S, Spangler J. A suspension cell-based interaction platform for interrogation of membrane proteins. AIChE journal. American Institute of Chemical Engineers. 2020; 66(12):e16995.