Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Ward C, Nallamshetty S, Watrous JD, Acres E, Long T, Mathews IT, Sharma S, Cheng S, Imam F, Jain M. Nontargeted mass spectrometry of dried blood spots for interrogation of the human circulating metabolome. J Mass Spectrom. 2021 May 27;56(8):e4772. doi: 10.1002/jms.4772. [Epub ahead of print] PubMed PMID: 34240506; NIHMSID:NIHMS1709901.
Takahashi M, Lio CJ, Campeau A, Steger M, Ay F, Mann M, Gonzalez DJ, Jain M, Sharma S. The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING-IFN-β pathway. Nat Immunol. 2021 Apr;22(4):485-496. doi: 10.1038/s41590-021-00896-3. Epub 2021 Mar 25. PubMed PMID: 33767426; PubMed Central PMCID: PMC8300883.
Kushnareva Y, Mathews IT, Andreyev AY, Altay G, Lindestam Arlehamn CS, Pandurangan V, Nilsson R, Jain M, Sette A, Peters B, Sharma S. Functional Analysis of Immune Signature Genes in Th1* Memory Cells Links ISOC1 and Pyrimidine Metabolism to IFN-γ and IL-17 Production. J Immunol. 2021 Mar 15;206(6):1181-1193. doi: 10.4049/jimmunol.2000672. Epub 2021 Feb 5. PubMed PMID: 33547171; PubMed Central PMCID: PMC7946769.
Lowey B, Whiteley AT, Keszei AFA, Morehouse BR, Mathews IT, Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F, Mekalanos JJ, Shao S, Lee ASY, Kranzusch PJ. CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection. Cell. 2020 Jul 9;182(1):38-49.e17. doi: 10.1016/j.cell.2020.05.019. Epub 2020 Jun 15. PubMed PMID: 32544385; PubMed Central PMCID: PMC7728545.
Lau RK, Ye Q, Birkholz EA, Berg KR, Patel L, Mathews IT, Watrous JD, Ego K, Whiteley AT, Lowey B, Mekalanos JJ, Kranzusch PJ, Jain M, Pogliano J, Corbett KD. Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity. Mol Cell. 2020 Feb 20;77(4):723-733.e6. doi: 10.1016/j.molcel.2019.12.010. Epub 2020 Jan 10. PubMed PMID: 31932164; PubMed Central PMCID: PMC7065454.
Ye Q, Lau RK, Mathews IT, Birkholz EA, Watrous JD, Azimi CS, Pogliano J, Jain M, Corbett KD. HORMA Domain Proteins and a Trip13-like ATPase Regulate Bacterial cGAS-like Enzymes to Mediate Bacteriophage Immunity. Mol Cell. 2020 Feb 20;77(4):709-722.e7. doi: 10.1016/j.molcel.2019.12.009. Epub 2020 Jan 10. PubMed PMID: 31932165; PubMed Central PMCID: PMC7036143.
Harris LA, Kayser BD, Cefalo C, Marini L, Watrous JD, Ding J, Jain M, McDonald JG, Thompson BM, Fabbrini E, Eagon JC, Patterson BW, Mittendorfer B, Mingrone G, Klein S. Biliopancreatic Diversion Induces Greater Metabolic Improvement Than Roux-en-Y Gastric Bypass. Cell Metab. 2019 Nov 5;30(5):855-864.e3. doi: 10.1016/j.cmet.2019.09.002. Epub 2019 Oct 3. PubMed PMID: 31588013; PubMed Central PMCID: PMC6876863.
Kantz ED, Tiwari S, Watrous JD, Cheng S, Jain M. Deep Neural Networks for Classification of LC-MS Spectral Peaks. Anal Chem. 2019 Oct 1;91(19):12407-12413. doi: 10.1021/acs.analchem.9b02983. Epub 2019 Sep 19. PubMed PMID: 31483992; PubMed Central PMCID: PMC7089603.
Henglin M, Niiranen T, Watrous JD, Lagerborg KA, Antonelli J, Claggett BL, Demosthenes EJ, von Jeinsen B, Demler O, Vasan RS, Larson MG, Jain M, Cheng S. A Single Visualization Technique for Displaying Multiple Metabolite-Phenotype Associations. Metabolites. 2019 Jul 2;9(7). doi: 10.3390/metabo9070128. PubMed PMID: 31269707; PubMed Central PMCID: PMC6680673.
Wollam J, Riopel M, Xu YJ, Johnson AMF, Ofrecio JM, Ying W, El Ouarrat D, Chan LS, Han AW, Mahmood NA, Ryan CN, Lee YS, Watrous JD, Chordia MD, Pan D, Jain M, Olefsky JM. Microbiota-Produced N-Formyl Peptide fMLF Promotes Obesity-Induced Glucose Intolerance. Diabetes. 2019 Jul;68(7):1415-1426. doi: 10.2337/db18-1307. Epub 2019 Apr 22. PubMed PMID: 31010956; PubMed Central PMCID: PMC6609982.
Zhang P, Arora M, Chaleckis R, Isobe T, Jain M, Meister I, Melén E, Perzanowski M, Torta F, Wenk MR, Wheelock CE. Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium. Metabolites. 2019 Jun 6;9(6). doi: 10.3390/metabo9060106. PubMed PMID: 31174297; PubMed Central PMCID: PMC6631702.
Coras R, Kavanaugh A, Boyd T, Huynh Q, Pedersen B, Armando AM, Dahlberg-Wright S, Marsal S, Jain M, Paravar T, Quehenberger O, Guma M. Pro- and anti-inflammatory eicosanoids in psoriatic arthritis. Metabolomics. 2019 Apr 19;15(4):65. doi: 10.1007/s11306-019-1527-0. PubMed PMID: 31004236; PubMed Central PMCID: PMC6533065.
Ahuja G, Bartsch D, Yao W, Geissen S, Frank S, Aguirre A, Russ N, Messling JE, Dodzian J, Lagerborg KA, Vargas NE, Muck JS, Brodesser S, Baldus S, Sachinidis A, Hescheler J, Dieterich C, Trifunovic A, Papantonis A, Petrascheck M, Klinke A, Jain M, Valenzano DR, Kurian L. Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart. EMBO Rep. 2019 Apr;20(4). doi: 10.15252/embr.201847407. Epub 2019 Mar 18. PubMed PMID: 30886000; PubMed Central PMCID: PMC6446199.
Watrous JD, Niiranen TJ, Lagerborg KA, Henglin M, Xu YJ, Rong J, Sharma S, Vasan RS, Larson MG, Armando A, Mora S, Quehenberger O, Dennis EA, Cheng S, Jain M. Directed Non-targeted Mass Spectrometry and Chemical Networking for Discovery of Eicosanoids and Related Oxylipins. Cell Chem Biol. 2019 Mar 21;26(3):433-442.e4. doi: 10.1016/j.chembiol.2018.11.015. Epub 2019 Jan 17. PubMed PMID: 30661990; PubMed Central PMCID: PMC6636917.
Roci I, Watrous JD, Lagerborg KA, Lafranchi L, Lindqvist A, Jain M, Nilsson R. Mapping Metabolic Events in the Cancer Cell Cycle Reveals Arginine Catabolism in the Committed SG2M Phase. Cell Rep. 2019 Feb 12;26(7):1691-1700.e5. doi: 10.1016/j.celrep.2019.01.059. PubMed PMID: 30759381; PubMed Central PMCID: PMC6663478.
Grankvist N, Lagerborg KA, Jain M, Nilsson R. Gabapentin Can Suppress Cell Proliferation Independent of the Cytosolic Branched-Chain Amino Acid Transferase 1 (BCAT1). Biochemistry. 2018 Dec 11;57(49):6762-6766. doi: 10.1021/acs.biochem.8b01031. Epub 2018 Nov 26. PubMed PMID: 30427175; PubMed Central PMCID: PMC6528808.
Grankvist N, Watrous JD, Lagerborg KA, Lyutvinskiy Y, Jain M, Nilsson R. Profiling the Metabolism of Human Cells by Deep 13C Labeling. Cell Chem Biol. 2018 Nov 15;25(11):1419-1427.e4. doi: 10.1016/j.chembiol.2018.09.004. Epub 2018 Sep 27. PubMed PMID: 30270114; PubMed Central PMCID: PMC6239935.
Basu Ball W, Baker CD, Neff JK, Apfel GL, Lagerborg KA, Žun G, Petrovič U, Jain M, Gohil VM. Ethanolamine ameliorates mitochondrial dysfunction in cardiolipin-deficient yeast cells. J Biol Chem. 2018 Jul 13;293(28):10870-10883. doi: 10.1074/jbc.RA118.004014. Epub 2018 Jun 4. PubMed PMID: 29866881; PubMed Central PMCID: PMC6052229.
Zhao X, Chen H, Xiao D, Yang H, Itzhaki I, Qin X, Chour T, Aguirre A, Lehmann K, Kim Y, Shukla P, Holmström A, Zhang JZ, Zhuge Y, Ndoye BC, Zhao M, Neofytou E, Zimmermann WH, Jain M, Wu JC. Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction. Stem Cell Reports. 2018 Feb 13;10(2):422-435. doi: 10.1016/j.stemcr.2018.01.002. Epub 2018 Feb 1. PubMed PMID: 29398480; PubMed Central PMCID: PMC5830958.
Garratt M, Lehmann K, Tsai Y, Galecki A, Jain M, Miller RA. Male lifespan extension with 17 -α estradiol is linked to a sex-specific metabolomic response modulated by gonadal hormones in mice. Aging cell. 2018.
Li Z, Martin M, Zhang J, Huang HY, Bai L, Zhang J, Kang J, He M, Li J, Maurya MR, Gupta S, Zhou G, Sangwung P, Xu YJ, Lei T, Huang HD, Jain M, Jain MK, Subramaniam S, Shyy JY. Krüppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility. Circulation. 2017 Oct 3;136(14):1315-1330. doi: 10.1161/CIRCULATIONAHA.117.027462. Epub 2017 Aug 9. PubMed PMID: 28794002; PubMed Central PMCID: PMC5741092.
Nilsson R, Roci I, Watrous J, Jain M. Estimation of flux ratios without uptake or release data: Application to serine and methionine metabolism. Metab Eng. 2017 Sep;43(Pt B):137-146. doi: 10.1016/j.ymben.2017.02.005. Epub 2017 Feb 20. PubMed PMID: 28232235; PubMed Central PMCID: PMC5563485.
Lyutvinskiy Y, Watrous JD, Jain M, Nilsson R. A Web Service Framework for Interactive Analysis of Metabolomics Data. Anal Chem. 2017 Jun 6;89(11):5713-5718. doi: 10.1021/acs.analchem.7b00890. Epub 2017 May 17. PubMed PMID: 28514166; PubMed Central PMCID: PMC5519509.
Shin CS, Mishra P, Watrous JD, Carelli V, D'Aurelio M, Jain M, Chan DC. The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility. Nat Commun. 2017 Apr 21;8:15074. doi: 10.1038/ncomms15074. PubMed PMID: 28429737; PubMed Central PMCID: PMC5413954.
Cheng S, Shah SH, Corwin EJ, Fiehn O, Fitzgerald RL, Gerszten RE, Illig T, Rhee EP, Srinivas PR, Wang TJ, Jain M. Potential Impact and Study Considerations of Metabolomics in Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association. Circ Cardiovasc Genet. 2017 Apr;10(2). doi: 10.1161/HCG.0000000000000032. Review. PubMed PMID: 28360086; PubMed Central PMCID: PMC6001363.
Watrous JD, Henglin M, Claggett B, Lehmann KA, Larson MG, Cheng S, Jain M. Visualization, Quantification, and Alignment of Spectral Drift in Population Scale Untargeted Metabolomics Data. Anal Chem. 2017 Feb 7;89(3):1399-1404. doi: 10.1021/acs.analchem.6b04337. Epub 2017 Jan 26. PubMed PMID: 28208263; PubMed Central PMCID: PMC5455767.
Roci I, Gallart-Ayala H, Watrous J, Jain M, Wheelock CE, Nilsson R. A Method for Measuring Metabolism in Sorted Subpopulations of Complex Cell Communities Using Stable Isotope Tracing. J Vis Exp. 2017 Feb 4;(120). doi: 10.3791/55011. PubMed PMID: 28190056; PubMed Central PMCID: PMC5408592.
Sapp V, Jain M, Liao R. Viewing Extrinsic Proteotoxic Stress Through the Lens of Amyloid Cardiomyopathy. Physiology (Bethesda). 2016 Jul;31(4):294-9. doi: 10.1152/physiol.00047.2015. Review. PubMed PMID: 27252164; PubMed Central PMCID: PMC6195664.
Nilsson R, Jain M. Simultaneous tracing of carbon and nitrogen isotopes in human cells. Mol Biosyst. 2016 May 24;12(6):1929-37. doi: 10.1039/c6mb00009f. PubMed PMID: 27098229; PubMed Central PMCID: PMC4879607.
Roci I, Gallart-Ayala H, Schmidt A, Watrous J, Jain M, Wheelock CE, Nilsson R. Metabolite Profiling and Stable Isotope Tracing in Sorted Subpopulations of Mammalian Cells. Anal Chem. 2016 Mar 1;88(5):2707-13. doi: 10.1021/acs.analchem.5b04071. Epub 2016 Feb 17. PubMed PMID: 26855138; PubMed Central PMCID: PMC8253378.
Chen H, Ren S, Clish C, Jain M, Mootha V, McCaffery JM, Chan DC. Titration of mitochondrial fusion rescues Mff-deficient cardiomyopathy. J Cell Biol. 2015 Nov 23;211(4):795-805. doi: 10.1083/jcb.201507035. PubMed PMID: 26598616; PubMed Central PMCID: PMC4657172.
Gustafsson Sheppard N, Jarl L, Mahadessian D, Strittmatter L, Schmidt A, Madhusudan N, Tegnér J, Lundberg EK, Asplund A, Jain M, Nilsson R. The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation. Sci Rep. 2015 Oct 13;5:15029. doi: 10.1038/srep15029. PubMed PMID: 26461067; PubMed Central PMCID: PMC4602236.
Ivanisevic J, Elias D, Deguchi H, Averell PM, Kurczy M, Johnson CH, Tautenhahn R, Zhu Z, Watrous J, Jain M, Griffin J, Patti GJ, Siuzdak G. Arteriovenous Blood Metabolomics: A Readout of Intra-Tissue Metabostasis. Sci Rep. 2015 Aug 5;5:12757. doi: 10.1038/srep12757. PubMed PMID: 26244428; PubMed Central PMCID: PMC4525490.
Jain M, Ngoy S, Sheth SA, Swanson RA, Rhee EP, Liao R, Clish CB, Mootha VK, Nilsson R. A systematic survey of lipids across mouse tissues. Am J Physiol Endocrinol Metab. 2014 Apr 15;306(8):E854-68. doi: 10.1152/ajpendo.00371.2013. Epub 2014 Feb 11. PubMed PMID: 24518676; PubMed Central PMCID: PMC3989739.
Knoechel B, Roderick JE, Williamson KE, Zhu J, Lohr JG, Cotton MJ, Gillespie SM, Fernandez D, Ku M, Wang H, Piccioni F, Silver SJ, Jain M, Pearson D, Kluk MJ, Ott CJ, Shultz LD, Brehm MA, Greiner DL, Gutierrez A, Stegmaier K, Kung AL, Root DE, Bradner JE, Aster JC, Kelliher MA, Bernstein BE. An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia. Nat Genet. 2014 Apr;46(4):364-70. doi: 10.1038/ng.2913. Epub 2014 Mar 2. PubMed PMID: 24584072; PubMed Central PMCID: PMC4086945.
Nilsson R, Jain M, Madhusudhan N, Sheppard NG, Strittmatter L, Kampf C, Huang J, Asplund A, Mootha VK. Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer. Nat Commun. 2014;5:3128. doi: 10.1038/ncomms4128. PubMed PMID: 24451681; PubMed Central PMCID: PMC4106362.
Gohil VM, Zhu L, Baker CD, Cracan V, Yaseen A, Jain M, Clish CB, Brookes PS, Bakovic M, Mootha VK. Meclizine inhibits mitochondrial respiration through direct targeting of cytosolic phosphoethanolamine metabolism. J Biol Chem. 2013 Dec 6;288(49):35387-95. doi: 10.1074/jbc.M113.489237. Epub 2013 Oct 19. PubMed PMID: 24142790; PubMed Central PMCID: PMC3853286.
Sharma S, Quintana A, Findlay GM, Mettlen M, Baust B, Jain M, Nilsson R, Rao A, Hogan PG. An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry. Nature. 2013 Jul 11;499(7457):238-42. doi: 10.1038/nature12229. Epub 2013 Jun 23. PubMed PMID: 23792561; PubMed Central PMCID: PMC3846693.
Shi J, Jiang B, Qiu Y, Guan J, Jain M, Cao X, Bauer M, Su L, Burkly LC, Leone TC, Kelly DP, Liao R. PGC1α plays a critical role in TWEAK-induced cardiac dysfunction. PLoS One. 2013;8(1):e54054. doi: 10.1371/journal.pone.0054054. Epub 2013 Jan 16. PubMed PMID: 23342071; PubMed Central PMCID: PMC3546975.
Jain M, Nilsson R, Sharma S, Madhusudhan N, Kitami T, Souza AL, Kafri R, Kirschner MW, Clish CB, Mootha VK. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science. 2012 May 25;336(6084):1040-4. doi: 10.1126/science.1218595. PubMed PMID: 22628656; PubMed Central PMCID: PMC3526189.
Unno K, Jain M, Liao R. Cardiac side population cells: moving toward the center stage in cardiac regeneration. Circ Res. 2012 May 11;110(10):1355-63. doi: 10.1161/CIRCRESAHA.111.243014. Review. PubMed PMID: 22581921; PubMed Central PMCID: PMC3412159.
Bauer M, Cheng S, Jain M, Ngoy S, Theodoropoulos C, Trujillo A, Lin FC, Liao R. Echocardiographic speckle-tracking based strain imaging for rapid cardiovascular phenotyping in mice. Circ Res. 2011 Apr 15;108(8):908-16. doi: 10.1161/CIRCRESAHA.110.239574. Epub 2011 Mar 3. PubMed PMID: 21372284; PubMed Central PMCID: PMC3376717.
Lim CC, Bryan NS, Jain M, Garcia-Saura MF, Fernandez BO, Sawyer DB, Handy DE, Loscalzo J, Feelisch M, Liao R. Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms. Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2144-53. doi: 10.1152/ajpheart.00673.2009. Epub 2009 Oct 2. PubMed PMID: 19801492; PubMed Central PMCID: PMC2793140.
Jain M, Jakubowski A, Cui L, Shi J, Su L, Bauer M, Guan J, Lim CC, Naito Y, Thompson JS, Sam F, Ambrose C, Parr M, Crowell T, Lincecum JM, Wang MZ, Hsu YM, Zheng TS, Michaelson JS, Liao R, Burkly LC. A novel role for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the development of cardiac dysfunction and failure. Circulation. 2009 Apr 21;119(15):2058-68. doi: 10.1161/CIRCULATIONAHA.108.837286. Epub 2009 Apr 6. PubMed PMID: 19349318; PubMed Central PMCID: PMC2924152.
Luptak I, Yan J, Cui L, Jain M, Liao R, Tian R. Long-term effects of increased glucose entry on mouse hearts during normal aging and ischemic stress. Circulation. 2007 Aug 21;116(8):901-9. doi: 10.1161/CIRCULATIONAHA.107.691253. Epub 2007 Aug 6. PubMed PMID: 17679614.
Liao R, Pfister O, Jain M, Mouquet F. The bone marrow--cardiac axis of myocardial regeneration. Prog Cardiovasc Dis. 2007 Jul-Aug;50(1):18-30. doi: 10.1016/j.pcad.2007.03.001. Review. PubMed PMID: 17631435; PubMed Central PMCID: PMC2096729.
Sohn RL, Jain M, Liao R. Adult stem cells and heart regeneration. Expert Rev Cardiovasc Ther. 2007 May;5(3):507-17. doi: 10.1586/14779072.5.3.507. Review. PubMed PMID: 17489674.
Podesser BK, Jain M, Ngoy S, Apstein CS, Eberli FR. Unveiling gender differences in demand ischemia: a study in a rat model of genetic hypertension. Eur J Cardiothorac Surg. 2007 Feb;31(2):298-304. doi: 10.1016/j.ejcts.2006.10.041. Epub 2006 Dec 18. PubMed PMID: 17175162.
Liao R, Jain M. Isolation, culture, and functional analysis of adult mouse cardiomyocytes. Methods Mol Med. 2007;139:251-62. doi: 10.1007/978-1-59745-571-8_16. PubMed PMID: 18287677.
Calvo S, Jain M, Xie X, Sheth SA, Chang B, Goldberger OA, Spinazzola A, Zeviani M, Carr SA, Mootha VK. Systematic identification of human mitochondrial disease genes through integrative genomics. Nat Genet. 2006 May;38(5):576-82. doi: 10.1038/ng1776. Epub 2006 Apr 2. PubMed PMID: 16582907.
What would you like to do?