My Bibliography

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Han X, YU H, Liu X, Bao X, Yu B, Li C, Hui Y. Complete 1H and 13C NMR assignments of diosgenyl saponins. Magn. Reson. Chem.. 1999; 37:140-144.

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YU B, Yu H, Hui Y, Han X. Trichloroacetimidate as an efficient protective group for alcohols. Synlett. 1999; 6:753-755.

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Yu B, Yu H, Hui Y, Han X. Synthesis of a group of diosgenyl saponins by a one-pot sequential glycosylation. Tetrahedron Lett.. 1999; 40:8591-8594.

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Deng S, Yu B, Hui Y, Yu H, Han X. Synthesis of three diosgenyl saponins: dioscin, polyphyllin D, and balanitin 7. Carbohydr Res. 1999 Apr 30;317(1-4):53-62. doi: 10.1016/s0008-6215(99)00066-x. PubMed PMID: 10466206.

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Yu H, Han X, Liu X, Yu B, Hui Y, Bao X. 88. Yu, H.; Han, X.; Liu, X.; Yu, B.; Hui, Y.; Bao, X. NMR studies on synthesized diosgenyl saponins analogs. Magn. Reson. Chem.. 2000; 38:704-706.

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Yu H, Yu B, Wu X, Hui Y, Han X. Synthesis of a group of diosgenyl saponins with a combined used of glycosyl trichloroacetimidate and thioglycoside donors. J. Chem. Soc. Perkins Trans. 1. 2000; 9:1445-1453.

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Yu H, Ensley HE. An efficient method for the preparation of glycosides with free C-2 hydroxyl group from thioglycosides. Tetrahedron Lett.. 2003; 44:9363-5366..

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Yu H, Yu H, Karpel R, Chen X. Chemoenzymatic synthesis of CMP-sialic acid derivatives by a one-pot two-enzyme system: comparison of substrate flexibility of three microbial CMP-sialic acid synthetases. Bioorg Med Chem. 2004 Dec 15;12(24):6427-35. doi: 10.1016/j.bmc.2004.09.030. PubMed PMID: 15556760.

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Yu H, Williams DL, Ensley HE. 4-Acetoxy-2,2-dimethylbutanoate: a useful carbohydrate protecting group for the selective formation of β-(1→3)-d-glucans. Tetrahedron Lett. 2005 May;46(19):3417-3421. doi: 10.1016/j.tetlet.2005.03.099. PubMed PMID: 26236049; PubMed Central PMCID: PMC4520321.

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Yu H, Chokhawala H, Karpel R, Yu H, Wu B, Zhang J, Zhang Y, Jia Q, Chen X. A multifunctional Pasteurella multocida sialyltransferase: a powerful tool for the synthesis of sialoside libraries. J Am Chem Soc. 2005 Dec 21;127(50):17618-9. doi: 10.1021/ja0561690. PubMed PMID: 16351087.

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Yu H, Ryan W, Yu H, Chen X. Characterization of a bifunctional cytidine 5'-monophosphate N-acetylneuraminic acid synthetase cloned from Streptococcus agalactiae. Biotechnol Lett. 2006 Jan;28(2):107-13. doi: 10.1007/s10529-005-4955-z. PubMed PMID: 16369694.

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Yu H, Chokhawala HA, Huang S, Chen X. One-pot three-enzyme chemoenzymatic approach to the synthesis of sialosides containing natural and non-natural functionalities. Nat Protoc. 2006;1(5):2485-92. doi: 10.1038/nprot.2006.401. PubMed PMID: 17406495; PubMed Central PMCID: PMC2586341.

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Ni L, Sun M, Yu H, Chokhawala H, Chen X, Fisher AJ. Cytidine 5'-monophosphate (CMP)-induced structural changes in a multifunctional sialyltransferase from Pasteurella multocida. Biochemistry. 2006 Feb 21;45(7):2139-48. doi: 10.1021/bi0524013. PubMed PMID: 16475803.

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Yu H, Chen X. Aldolase-catalyzed synthesis of beta-D-galp-(1-->9)-D-KDN: a novel acceptor for sialyltransferases. Org Lett. 2006 May 25;8(11):2393-6. doi: 10.1021/ol060736m. PubMed PMID: 16706534.

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Yu H, Huang S, Chokhawala H, Sun M, Zheng H, Chen X. Highly efficient chemoenzymatic synthesis of naturally occurring and non-natural alpha-2,6-linked sialosides: a P. damsela alpha-2,6-sialyltransferase with extremely flexible donor-substrate specificity. Angew Chem Int Ed Engl. 2006 Jun 12;45(24):3938-44. doi: 10.1002/anie.200600572. PubMed PMID: 16721893; PubMed Central PMCID: PMC2728590.

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Huang S, Yu H, Chen X. Disaccharides as sialic acid aldolase substrates: synthesis of disaccharides containing a sialic acid at the reducing end. Angew Chem Int Ed Engl. 2007;46(13):2249-53. doi: 10.1002/anie.200604799. PubMed PMID: 17309109.

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Chokhawala HA, Yu H, Chen X. High-throughput substrate specificity studies of sialidases by using chemoenzymatically synthesized sialoside libraries. Chembiochem. 2007 Jan 22;8(2):194-201. doi: 10.1002/cbic.200600410. PubMed PMID: 17195254; PubMed Central PMCID: PMC2610223.

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Yu H, Chen X. Carbohydrate post-glycosylational modifications. Org Biomol Chem. 2007 Mar 21;5(6):865-72. doi: 10.1039/b700034k. Epub 2007 Feb 6. PubMed PMID: 17340000; PubMed Central PMCID: PMC2769254.

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Ni L, Chokhawala HA, Cao H, Henning R, Ng L, Huang S, Yu H, Chen X, Fisher AJ. Crystal structures of Pasteurella multocida sialyltransferase complexes with acceptor and donor analogues reveal substrate binding sites and catalytic mechanism. Biochemistry. 2007 May 29;46(21):6288-98. doi: 10.1021/bi700346w. Epub 2007 May 8. PubMed PMID: 17487984; NIHMSID:NIHMS62351.

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Yu H, Chokhawala HA, Varki A, Chen X. Efficient chemoenzymatic synthesis of biotinylated human serum albumin-sialoglycoside conjugates containing O-acetylated sialic acids. Org Biomol Chem. 2007 Aug 7;5(15):2458-63. doi: 10.1039/b706507h. Epub 2007 Jun 27. PubMed PMID: 17637967; PubMed Central PMCID: PMC2769491.

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Chokhawala HA, Cao H, Yu H, Chen X. Enzymatic synthesis of fluorinated mechanistic probes for sialidases and sialyltransferases. J Am Chem Soc. 2007 Sep 5;129(35):10630-1. doi: 10.1021/ja072687u. Epub 2007 Aug 14. PubMed PMID: 17696347.

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Li Y, Sun M, Huang S, Yu H, Chokhawala HA, Thon V, Chen X. The Hd0053 gene of Haemophilus ducreyi encodes an alpha2,3-sialyltransferase. Biochem Biophys Res Commun. 2007 Sep 21;361(2):555-60. doi: 10.1016/j.bbrc.2007.07.063. Epub 2007 Jul 23. PubMed PMID: 17662691; PubMed Central PMCID: PMC2084346.

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Muthana S, Yu H, Huang S, Chen X. Chemoenzymatic synthesis of size-defined polysaccharides by sialyltransferase-catalyzed block transfer of oligosaccharides. J Am Chem Soc. 2007 Oct 3;129(39):11918-9. doi: 10.1021/ja075736b. Epub 2007 Sep 11. PubMed PMID: 17845050.

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Adams EL, Rice PJ, Graves B, Ensley HE, Yu H, Brown GD, Gordon S, Monteiro MA, Papp-Szabo E, Lowman DW, Power TD, Wempe MF, Williams DL. Differential high-affinity interaction of dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side-chain branching. J Pharmacol Exp Ther. 2008 Apr;325(1):115-23. doi: 10.1124/jpet.107.133124. Epub 2008 Jan 2. PubMed PMID: 18171906.

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Linman MJ, Taylor JD, Yu H, Chen X, Cheng Q. Surface plasmon resonance study of protein-carbohydrate interactions using biotinylated sialosides. Anal Chem. 2008 Jun 1;80(11):4007-13. doi: 10.1021/ac702566e. Epub 2008 May 8. PubMed PMID: 18461973; PubMed Central PMCID: PMC2586005.

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Li Y, Yu H, Cao H, Lau K, Muthana S, Tiwari VK, Son B, Chen X. Pasteurella multocida sialic acid aldolase: a promising biocatalyst. Appl Microbiol Biotechnol. 2008 Jul;79(6):963-70. doi: 10.1007/s00253-008-1506-2. Epub 2008 Jun 3. PubMed PMID: 18521592; PubMed Central PMCID: PMC2588431.

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Wang Z, Gilbert M, Eguchi H, Yu H, Cheng J, Muthana S, Zhou L, Wang PG, Chen X, Huang X. Chemoenzymatic Syntheses of Tumor-Associated Carbohydrate Antigen Globo-H and Stage-Specific Embryonic Antigen 4. Adv Synth Catal. 2008 Aug 4;350(11-12):1717-1728. doi: 10.1002/adsc.200800129. PubMed PMID: 20305750; PubMed Central PMCID: PMC2842016.

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Cheng J, Yu H, Lau K, Huang S, Chokhawala HA, Li Y, Tiwari VK, Chen X. Multifunctionality of Campylobacter jejuni sialyltransferase CstII: characterization of GD3/GT3 oligosaccharide synthase, GD3 oligosaccharide sialidase, and trans-sialidase activities. Glycobiology. 2008 Sep;18(9):686-97. doi: 10.1093/glycob/cwn047. Epub 2008 May 28. PubMed PMID: 18509108; PubMed Central PMCID: PMC2588429.

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Chokhawala HA, Huang S, Lau K, Yu H, Cheng J, Thon V, Hurtado-Ziola N, Guerrero JA, Varki A, Chen X. Combinatorial chemoenzymatic synthesis and high-throughput screening of sialosides. ACS Chem Biol. 2008 Sep 19;3(9):567-76. doi: 10.1021/cb800127n. Epub 2008 Aug 27. PubMed PMID: 18729452; PubMed Central PMCID: PMC2588434.

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Padler-Karavani V, Yu H, Cao H, Chokhawala H, Karp F, Varki N, Chen X, Varki A. Diversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: potential implications for disease. Glycobiology. 2008 Oct;18(10):818-30. doi: 10.1093/glycob/cwn072. Epub 2008 Jul 31. PubMed PMID: 18669916; PubMed Central PMCID: PMC2586336.

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Byres E, Paton AW, Paton JC, Löfling JC, Smith DF, Wilce MC, Talbot UM, Chong DC, Yu H, Huang S, Chen X, Varki NM, Varki A, Rossjohn J, Beddoe T. Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin. Nature. 2008 Dec 4;456(7222):648-52. doi: 10.1038/nature07428. Epub 2008 Oct 29. PubMed PMID: 18971931; PubMed Central PMCID: PMC2723748.

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Diaz SL, Padler-Karavani V, Ghaderi D, Hurtado-Ziola N, Yu H, Chen X, Brinkman-Van der Linden EC, Varki A, Varki NM. Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products. PLoS One. 2009;4(1):e4241. doi: 10.1371/journal.pone.0004241. Epub 2009 Jan 21. PubMed PMID: 19156207; PubMed Central PMCID: PMC2626223.

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Muthana S, Yu H, Cao H, Cheng J, Chen X. Chemoenzymatic synthesis of a new class of macrocyclic oligosaccharides. J Org Chem. 2009 Apr 17;74(8):2928-36. doi: 10.1021/jo8027856. PubMed PMID: 19296596.

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Linman MJ, Yu H, Chen X, Cheng Q. Fabrication and characterization of a sialoside-based carbohydrate microarray biointerface for protein binding analysis with surface plasmon resonance imaging. ACS Appl Mater Interfaces. 2009 Aug;1(8):1755-62. doi: 10.1021/am900290g. PubMed PMID: 20355792.

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Cao H, Li Y, Lau K, Muthana S, Yu H, Cheng J, Chokhawala HA, Sugiarto G, Zhang L, Chen X. Sialidase substrate specificity studies using chemoenzymatically synthesized sialosides containing C5-modified sialic acids. Org Biomol Chem. 2009 Dec 21;7(24):5137-45. doi: 10.1039/b916305k. Epub 2009 Oct 26. PubMed PMID: 20024109.

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Yu H, Cheng J, Ding L, Khedri Z, Chen Y, Chin S, Lau K, Tiwari VK, Chen X. Chemoenzymatic synthesis of GD3 oligosaccharides and other disialyl glycans containing natural and non-natural sialic acids. J Am Chem Soc. 2009 Dec 30;131(51):18467-77. doi: 10.1021/ja907750r. PubMed PMID: 19947630; PubMed Central PMCID: PMC2811049.

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Cheng J, Huang S, Yu H, Li Y, Lau K, Chen X. Trans-sialidase activity of Photobacterium damsela alpha2,6-sialyltransferase and its application in the synthesis of sialosides. Glycobiology. 2010 Feb;20(2):260-8. doi: 10.1093/glycob/cwp172. Epub 2009 Oct 30. PubMed PMID: 19880425; PubMed Central PMCID: PMC2800248.

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Muiá RP, Yu H, Prescher JA, Hellman U, Chen X, Bertozzi CR, Campetella O. Identification of glycoproteins targeted by Trypanosoma cruzi trans-sialidase, a virulence factor that disturbs lymphocyte glycosylation. Glycobiology. 2010 Jul;20(7):833-42. doi: 10.1093/glycob/cwq037. Epub 2010 Mar 30. PubMed PMID: 20354005; PubMed Central PMCID: PMC2900898.

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Taylor RE, Gregg CJ, Padler-Karavani V, Ghaderi D, Yu H, Huang S, Sorensen RU, Chen X, Inostroza J, Nizet V, Varki A. Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acid N-glycolylneuraminic acid. J Exp Med. 2010 Aug 2;207(8):1637-46. doi: 10.1084/jem.20100575. Epub 2010 Jul 12. PubMed PMID: 20624889; PubMed Central PMCID: PMC2916132.

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Zhang L, Lau K, Cheng J, Yu H, Li Y, Sugiarto G, Huang S, Ding L, Thon V, Wang PG, Chen X. Helicobacter hepaticus Hh0072 gene encodes a novel alpha1-3-fucosyltransferase belonging to CAZy GT11 family. Glycobiology. 2010 Sep;20(9):1077-88. doi: 10.1093/glycob/cwq068. Epub 2010 May 6. PubMed PMID: 20466652; PubMed Central PMCID: PMC2948817.

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Lau K, Thon V, Yu H, Ding L, Chen Y, Muthana MM, Wong D, Huang R, Chen X. Highly efficient chemoenzymatic synthesis of beta1-4-linked galactosides with promiscuous bacterial beta1-4-galactosyltransferases. Chem Commun (Camb). 2010 Sep 7;46(33):6066-8. doi: 10.1039/c0cc01381a. Epub 2010 Jul 12. PubMed PMID: 20625591; PubMed Central PMCID: PMC3114949.

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Yu H, Thon V, Lau K, Cai L, Chen Y, Mu S, Li Y, Wang PG, Chen X. Highly efficient chemoenzymatic synthesis of β1-3-linked galactosides. Chem Commun (Camb). 2010 Oct 28;46(40):7507-9. doi: 10.1039/c0cc02850a. Epub 2010 Sep 10. PubMed PMID: 20830443; PubMed Central PMCID: PMC3114946.

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Shengshu H, Hai Y, Xi C. Chemoenzymatic synthesis of α2-3-sialylated carbohydrate epitopes. Sci China Chem. 2011 Jan;54(1):117-128. doi: 10.1007/s11426-010-4175-9. PubMed PMID: 21686057; PubMed Central PMCID: PMC3115702.

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Sugiarto G, Lau K, Yu H, Vuong S, Thon V, Li Y, Huang S, Chen X. Cloning and characterization of a viral α2-3-sialyltransferase (vST3Gal-I) for the synthesis of sialyl Lewisx. Glycobiology. 2011 Mar;21(3):387-96. doi: 10.1093/glycob/cwq172. Epub 2010 Oct 26. PubMed PMID: 20978012; PubMed Central PMCID: PMC3033747.

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Li Y, Cao H, Yu H, Chen Y, Lau K, Qu J, Thon V, Sugiarto G, Chen X. Identifying selective inhibitors against the human cytosolic sialidase NEU2 by substrate specificity studies. Mol Biosyst. 2011 Apr;7(4):1060-72. doi: 10.1039/c0mb00244e. Epub 2011 Jan 4. PubMed PMID: 21206954; PubMed Central PMCID: PMC3114945.

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Lau K, Yu H, Thon V, Khedri Z, Leon ME, Tran BK, Chen X. Sequential two-step multienzyme synthesis of tumor-associated sialyl T-antigens and derivatives. Org Biomol Chem. 2011 Apr 21;9(8):2784-9. doi: 10.1039/c0ob01269f. Epub 2011 Mar 1. PubMed PMID: 21359399; PubMed Central PMCID: PMC3114947.

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Chen GY, Chen X, King S, Cavassani KA, Cheng J, Zheng X, Cao H, Yu H, Qu J, Fang D, Wu W, Bai XF, Liu JQ, Woodiga SA, Chen C, Sun L, Hogaboam CM, Kunkel SL, Zheng P, Liu Y. Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction. Nat Biotechnol. 2011 May;29(5):428-35. doi: 10.1038/nbt.1846. Epub 2011 Apr 10. PubMed PMID: 21478876; PubMed Central PMCID: PMC4090080.

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Padler-Karavani V, Hurtado-Ziola N, Pu M, Yu H, Huang S, Muthana S, Chokhawala HA, Cao H, Secrest P, Friedmann-Morvinski D, Singer O, Ghaderi D, Verma IM, Liu YT, Messer K, Chen X, Varki A, Schwab R. Human xeno-autoantibodies against a non-human sialic acid serve as novel serum biomarkers and immunotherapeutics in cancer. Cancer Res. 2011 May 1;71(9):3352-63. doi: 10.1158/0008-5472.CAN-10-4102. Epub 2011 Apr 19. PubMed PMID: 21505105; PubMed Central PMCID: PMC3085609.

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Li Y, Cao H, Dao N, Luo Z, Yu H, Chen Y, Xing Z, Baumgarth N, Cardona C, Chen X. High-throughput neuraminidase substrate specificity study of human and avian influenza A viruses. Virology. 2011 Jun 20;415(1):12-9. doi: 10.1016/j.virol.2011.03.024. Epub 2011 Apr 17. PubMed PMID: 21501853; PubMed Central PMCID: PMC3114948.

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Li Y, Yu H, Chen Y, Lau K, Cai L, Cao H, Tiwari VK, Qu J, Thon V, Wang PG, Chen X. Substrate promiscuity of N-acetylhexosamine 1-kinases. Molecules. 2011 Jul 28;16(8):6396-407. doi: 10.3390/molecules16086396. PubMed PMID: 21799473; PubMed Central PMCID: PMC6264712.