My Bibliography

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Alspach E, Chow RD, Demehri S, Guerriero JL, Gujar S, Hartmann FJ, Helmink BA, Hudson WH, Ho WJ, Ma L, Maier BB, Maltez VI, Miller BC, Moran AE, Parry EM, Pillai PS, Rafiq S, Reina-Campos M, Rosato PC, Rudqvist NP, Ruhland MK, Sagiv-Barfi I, Sahu AD, Samstein RM, Schürch CM, Sen DR, Thommen DS, Wolf Y, Zappasodi R. Supporting the Next Generation of Scientists to Lead Cancer Immunology Research. Cancer Immunol Res. 2021 Nov;9(11):1245-1251. doi: 10.1158/2326-6066.CIR-21-0519. Epub 2021 Sep 20. PubMed PMID: 34544686.

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Azin M, Demehri S. Innate Lymphoid Cells: New Targets for Cutaneous Squamous Cell Carcinoma Immunotherapy. J Invest Dermatol. 2021 Oct;141(10):2320-2322. doi: 10.1016/j.jid.2021.04.003. PubMed PMID: 34560914.

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Schiferle EB, Cheon SY, Ham S, Son HG, Messerschmidt JL, Lawrence DP, Cohen JV, Flaherty KT, Moon JJ, Lian CG, Sullivan RJ, Demehri S. Rejection of benign melanocytic nevi by nevus-resident CD4⁺ T cells. Sci Adv. 2021 Jun;7(26). doi: 10.1126/sciadv.abg4498. Print 2021 Jun. PubMed PMID: 34162549; PubMed Central PMCID: PMC8221625.

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Li K, Li T, Feng Z, Huang M, Wei L, Yan Z, Long M, Hu Q, Wang J, Liu S, Sgroi DC, Demehri S. CD8⁺ T cell immunity blocks the metastasis of carcinogen-exposed breast cancer. Sci Adv. 2021 Jun;7(25). doi: 10.1126/sciadv.abd8936. Print 2021 Jun. PubMed PMID: 34144976; PubMed Central PMCID: PMC8213232.

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Park JH, Ameri AH, Dempsey KE, Conrad DN, Kem M, Mino-Kenudson M, Demehri S. Nuclear IL-33/SMAD signaling axis promotes cancer development in chronic inflammation. EMBO J. 2021 Apr 1;40(7):e106151. doi: 10.15252/embj.2020106151. Epub 2021 Feb 22. PubMed PMID: 33616251; PubMed Central PMCID: PMC8013835.

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Miller MS, Allen PJ, Brown PH, Chan AT, Clapper ML, Dashwood RH, Demehri S, Disis ML, DuBois RN, Glynn RJ, Kensler TW, Khan SA, Johnson BD, Liby KT, Lipkin SM, Mallery SR, Meuillet EJ, Roden RBS, Schoen RE, Sharp ZD, Shirwan H, Siegfried JM, Rao CV, You M, Vilar E, Szabo E, Mohammed A. Meeting Report: Translational Advances in Cancer Prevention Agent Development Meeting. J Cancer Prev. 2021 Mar 30;26(1):71-82. doi: 10.15430/JCP.2021.26.1.71. PubMed PMID: 33842408; PubMed Central PMCID: PMC8020174.

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Strickley JD, Messerschmidt JL, Jenson AB, Joh J, Demehri S. Reply to: Beta human papillomaviruses and skin cancer. Nature. 2020 Dec;588(7838):E22-E23. doi: 10.1038/s41586-020-3024-z. PubMed PMID: 33328662.

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Khanal S, Strickley JD, Ha T, Demehri S, Ghim SJ, Jenson AB, Redman RA, Joh JJ. Human papillomavirus-positivity is associated with EREG down-regulation and promoter hypermethylation in head and neck squamous cell carcinoma. Exp Mol Pathol. 2020 Dec;117:104549. doi: 10.1016/j.yexmp.2020.104549. Epub 2020 Sep 30. PubMed PMID: 33007298.

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Weintraub GS, Su KA, Demehri S, Asgari MM. Enhancing the process for care delivery in a dermatology specialty clinic. J Am Acad Dermatol. 2020 Oct;83(4):1181-1184. doi: 10.1016/j.jaad.2020.02.017. Epub 2020 Feb 14. PubMed PMID: 32068037; PubMed Central PMCID: PMC7426239.

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Messerschmidt JL, Dempsey KE, Dillon KS, Demehri S. Divergent Roles of Epithelium-Derived Alarmins in Notch Signaling-Deficient Skin. J Invest Dermatol. 2020 Oct;140(10):2089-2092. doi: 10.1016/j.jid.2020.02.020. Epub 2020 Mar 6. PubMed PMID: 32147504; PubMed Central PMCID: PMC8085680.

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Herbosa CM, Hodges W, Mann C, Demehri S, Cornelius LA, Semenov YR. Risk of cancer in psoriasis: study of a nationally representative sample of the US population with comparison to a single-institution cohort. J Eur Acad Dermatol Venereol. 2020 Sep;34(9):e529-e531. doi: 10.1111/jdv.16447. Epub 2020 May 14. PubMed PMID: 32277504.

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Hasegawa T, Feng Z, Yan Z, Ngo KH, Hosoi J, Demehri S. Reduction in Human Epidermal Langerhans Cells with Age Is Associated with Decline in CXCL14-Mediated Recruitment of CD14⁺ Monocytes. J Invest Dermatol. 2020 Jul;140(7):1327-1334. doi: 10.1016/j.jid.2019.11.017. Epub 2019 Dec 25. PubMed PMID: 31881212; PubMed Central PMCID: PMC8142052.

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Annapragada A, Sikora A, Bollard C, Conejo-Garcia J, Cruz CR, Demehri S, Demetriou M, Demirdjian L, Fong L, Horowitz M, Hutson A, Kadash-Edmondson K, Kufe D, Lipkin S, Liu S, McCarthy C, Morgan M, Morris Z, Pan Y, Pasquini M, Schoenberger S, Van Allen E, Vilar E, Xing Y, Zha W, Odunsi A. Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer. J Immunother Cancer. 2020 Jun;8(1). doi: 10.1136/jitc-2020-000796. Review. PubMed PMID: 32554617; PubMed Central PMCID: PMC7304845.

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Ameri AH, Foreman RK, Vedak P, Chen S, Miller DM, Demehri S. Hypertrophic Lichen Planus with Histological Features of Squamous Cell Carcinoma Associated with Immune Checkpoint Blockade Therapy. Oncologist. 2020 May;25(5):366-368. doi: 10.1634/theoncologist.2019-0796. Epub 2020 Feb 19. PubMed PMID: 32073194; PubMed Central PMCID: PMC7216465.

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Nguyen ED, Xue YK, Danesh M, Ameri A, Weng CQ, Klebanov N, Foreman RK, Nazarian RM, Demehri S, Tsao H, Kroshinsky D. A Case of Nivolumab-Induced Cutaneous Toxicity with Multiple Morphologies. Dermatopathology (Basel). 2019 Oct-Dec;6(4):255-259. doi: 10.1159/000505353. eCollection 2019 Oct-Dec. PubMed PMID: 32232031; PubMed Central PMCID: PMC7098352.

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Ameri AH, Mooradian MJ, Emerick KS, Park JC, Wirth LJ, Asgari MM, Tsao H, Lawrence D, Sullivan RJ, Demehri S. Immunotherapeutic strategies for cutaneous squamous cell carcinoma prevention in xeroderma pigmentosum. Br J Dermatol. 2019 Nov;181(5):1095-1097. doi: 10.1111/bjd.18144. Epub 2019 Aug 7. PubMed PMID: 31102460.

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Strickley JD, Messerschmidt JL, Awad ME, Li T, Hasegawa T, Ha DT, Nabeta HW, Bevins PA, Ngo KH, Asgari MM, Nazarian RM, Neel VA, Jenson AB, Joh J, Demehri S. Immunity to commensal papillomaviruses protects against skin cancer. Nature. 2019 Nov;575(7783):519-522. doi: 10.1038/s41586-019-1719-9. Epub 2019 Oct 30. PubMed PMID: 31666702; PubMed Central PMCID: PMC6872936.

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Choi BD, Yu X, Castano AP, Bouffard AA, Schmidts A, Larson RC, Bailey SR, Boroughs AC, Frigault MJ, Leick MB, Scarfò I, Cetrulo CL, Demehri S, Nahed BV, Cahill DP, Wakimoto H, Curry WT, Carter BS, Maus MV. CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity. Nat Biotechnol. 2019 Sep;37(9):1049-1058. doi: 10.1038/s41587-019-0192-1. Epub 2019 Jul 22. PubMed PMID: 31332324.

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Molina GE, Khalifian S, Mull JL, Chen L, Rosman IS, Faulkner-Jones BE, Ngo KH, Demehri S, Cornelius LA, Wu PA. Topical Combination of Fluorouracil and Calcipotriene as a Palliative Therapy for Refractory Extramammary Paget Disease. JAMA Dermatol. 2019 May 1;155(5):599-603. doi: 10.1001/jamadermatol.2018.4793. PubMed PMID: 30785593; PubMed Central PMCID: PMC6506893.

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Rosenberg AR, Tabacchi M, Ngo KH, Wallendorf M, Rosman IS, Cornelius LA, Demehri S. Skin cancer precursor immunotherapy for squamous cell carcinoma prevention. JCI Insight. 2019 Mar 21;4(6). doi: 10.1172/jci.insight.125476. eCollection 2019 Mar 21. PubMed PMID: 30895944; PubMed Central PMCID: PMC6483001.

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Boroughs AC, Larson RC, Choi BD, Bouffard AA, Riley LS, Schiferle E, Kulkarni AS, Cetrulo CL, Ting D, Blazar BR, Demehri S, Maus MV. Chimeric antigen receptor costimulation domains modulate human regulatory T cell function. JCI Insight. 2019 Mar 14;5. doi: 10.1172/jci.insight.126194. PubMed PMID: 30869654; PubMed Central PMCID: PMC6538349.

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Ameri AH, Moradi Tuchayi S, Zaalberg A, Park JH, Ngo KH, Li T, Lopez E, Colonna M, Lee RT, Mino-Kenudson M, Demehri S. IL-33/regulatory T cell axis triggers the development of a tumor-promoting immune environment in chronic inflammation. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2646-2651. doi: 10.1073/pnas.1815016116. Epub 2019 Jan 29. PubMed PMID: 30696763; PubMed Central PMCID: PMC6377481.

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Zaalberg A, Moradi Tuchayi S, Ameri AH, Ngo KH, Cunningham TJ, Eliane JP, Livneh M, Horn TD, Rosman IS, Musiek A, Anadkat MJ, Demehri S. Chronic Inflammation Promotes Skin Carcinogenesis in Cancer-Prone Discoid Lupus Erythematosus. J Invest Dermatol. 2019 Jan;139(1):62-70. doi: 10.1016/j.jid.2018.06.185. Epub 2018 Jul 17. PubMed PMID: 30030152; PubMed Central PMCID: PMC6309656.

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Wang W, Ollila HM, Whittemore AS, Demehri S, Ioannidis NM, Jorgenson E, Mignot E, Asgari MM. Genetic variants in the HLA class II region associated with risk of cutaneous squamous cell carcinoma. Cancer Immunol Immunother. 2018 Jul;67(7):1123-1133. doi: 10.1007/s00262-018-2168-2. Epub 2018 May 12. PubMed PMID: 29754218; PubMed Central PMCID: PMC7081741.

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Blomberg M, He SY, Harwood C, Arron ST, Demehri S, Green A, Asgari MM. Research gaps in the management and prevention of cutaneous squamous cell carcinoma in organ transplant recipients. Br J Dermatol. 2017 Nov;177(5):1225-1233. doi: 10.1111/bjd.15950. Epub 2017 Oct 30. Review. PubMed PMID: 29086412; PubMed Central PMCID: PMC5711582.

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Kawakubo M, Cunningham TJ, Demehri S, Manstein D. Fractional Laser Releases Tumor-Associated Antigens in Poorly Immunogenic Tumor and Induces Systemic Immunity. Sci Rep. 2017 Oct 6;7(1):12751. doi: 10.1038/s41598-017-13095-8. PubMed PMID: 28986576; PubMed Central PMCID: PMC5630620.

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Kawakubo M, Demehri S, Manstein D. Fractional laser exposure induces neutrophil infiltration (N1 phenotype) into the tumor and stimulates systemic anti-tumor immune response. PLoS One. 2017;12(9):e0184852. doi: 10.1371/journal.pone.0184852. eCollection 2017. PubMed PMID: 28922374; PubMed Central PMCID: PMC5602663.

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Yesantharao P, Wang W, Ioannidis NM, Demehri S, Whittemore AS, Asgari MM. Cutaneous squamous cell cancer (cSCC) risk and the human leukocyte antigen (HLA) system. Hum Immunol. 2017 Apr;78(4):327-335. doi: 10.1016/j.humimm.2017.02.002. Epub 2017 Feb 7. Review. PubMed PMID: 28185865; PubMed Central PMCID: PMC5428079.

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Cunningham TJ, Tabacchi M, Eliane JP, Tuchayi SM, Manivasagam S, Mirzaalian H, Turkoz A, Kopan R, Schaffer A, Saavedra AP, Wallendorf M, Cornelius LA, Demehri S. Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy. J Clin Invest. 2017 Jan 3;127(1):106-116. doi: 10.1172/JCI89820. Epub 2016 Nov 21. PubMed PMID: 27869649; PubMed Central PMCID: PMC5199703.

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Demehri S, Cunningham TJ, Manivasagam S, Ngo KH, Moradi Tuchayi S, Reddy R, Meyers MA, DeNardo DG, Yokoyama WM. Thymic stromal lymphopoietin blocks early stages of breast carcinogenesis. J Clin Invest. 2016 Apr 1;126(4):1458-70. doi: 10.1172/JCI83724. Epub 2016 Feb 29. PubMed PMID: 26927668; PubMed Central PMCID: PMC4811115.

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Demehri S, Cunningham TJ, Hurst EA, Schaffer A, Sheinbein DM, Yokoyama WM. Chronic allergic contact dermatitis promotes skin cancer. J Clin Invest. 2014 Nov;124(11):5037-41. doi: 10.1172/JCI77843. Epub 2014 Oct 8. PubMed PMID: 25295539; PubMed Central PMCID: PMC4347218.

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Demehri S, Yockey LJ, Visness CM, Jaffee KF, Turkoz A, Wood RA, O'Connor GT, Kattan M, Gern JE, Gergen PJ, Holtzman M, Bloomberg G, Kopan R. Circulating TSLP associates with decreased wheezing in non-atopic preschool children: data from the URECA birth cohort. Clin Exp Allergy. 2014 Jun;44(6):851-7. doi: 10.1111/cea.12270. PubMed PMID: 24397611; PubMed Central PMCID: PMC4037448.

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Yockey LJ, Demehri S, Turkoz M, Turkoz A, Ahern PP, Jassim O, Manivasagam S, Kearney JF, Gordon JI, Kopan R. The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation. J Invest Dermatol. 2013 Dec;133(12):2714-2721. doi: 10.1038/jid.2013.228. Epub 2013 May 22. PubMed PMID: 23698100; PubMed Central PMCID: PMC3796202.

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Zhao ZQ, Huo FQ, Jeffry J, Hampton L, Demehri S, Kim S, Liu XY, Barry DM, Wan L, Liu ZC, Li H, Turkoz A, Ma K, Cornelius LA, Kopan R, Battey JF Jr, Zhong J, Chen ZF. Chronic itch development in sensory neurons requires BRAF signaling pathways. J Clin Invest. 2013 Nov;123(11):4769-80. doi: 10.1172/JCI70528. PubMed PMID: 24216512; PubMed Central PMCID: PMC3809799.

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Demehri S, Turkoz A, Manivasagam S, Yockey LJ, Turkoz M, Kopan R. Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin. Cancer Cell. 2012 Oct 16;22(4):494-505. doi: 10.1016/j.ccr.2012.08.017. PubMed PMID: 23079659; PubMed Central PMCID: PMC3480666.

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Dumortier A, Durham AD, Di Piazza M, Vauclair S, Koch U, Ferrand G, Ferrero I, Demehri S, Song LL, Farr AG, Leonard WJ, Kopan R, Miele L, Hohl D, Finke D, Radtke F. Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLoS One. 2010 Feb 18;5(2):e9258. doi: 10.1371/journal.pone.0009258. PubMed PMID: 20174635; PubMed Central PMCID: PMC2823782.

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Demehri S, O'Hare T, Eide CA, Smith CA, Tyner JW, Druker BJ, Deininger MW. The function of the pleckstrin homology domain in BCR-ABL-mediated leukemogenesis. Leukemia. 2010 Jan;24(1):226-9. doi: 10.1038/leu.2009.196. Epub 2009 Sep 17. PubMed PMID: 19759561.

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Bazzi H, Demehri S, Potter CS, Barber AG, Awgulewitsch A, Kopan R, Christiano AM. Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation. Differentiation. 2009 Dec;78(5):292-300. doi: 10.1016/j.diff.2009.06.004. Epub 2009 Aug 15. PubMed PMID: 19683850; PubMed Central PMCID: PMC2945291.

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Demehri S, Turkoz A, Kopan R. Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer Cell. 2009 Jul 7;16(1):55-66. doi: 10.1016/j.ccr.2009.05.016. PubMed PMID: 19573812; PubMed Central PMCID: PMC2705757.

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Demehri S, Morimoto M, Holtzman MJ, Kopan R. Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma. PLoS Biol. 2009 May 19;7(5):e1000067. doi: 10.1371/journal.pbio.1000067. Epub 2009 May 19. PubMed PMID: 19557146; PubMed Central PMCID: PMC2700555.

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Demehri S, Kopan R. Notch signaling in bulge stem cells is not required for selection of hair follicle fate. Development. 2009 Mar;136(6):891-6. doi: 10.1242/dev.030700. Epub 2009 Feb 11. PubMed PMID: 19211676; PubMed Central PMCID: PMC2727555.

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Pazolli E, Luo X, Brehm S, Carbery K, Chung JJ, Prior JL, Doherty J, Demehri S, Salavaggione L, Piwnica-Worms D, Stewart SA. Senescent stromal-derived osteopontin promotes preneoplastic cell growth. Cancer Res. 2009 Feb 1;69(3):1230-9. doi: 10.1158/0008-5472.CAN-08-2970. Epub 2009 Jan 20. PubMed PMID: 19155301; PubMed Central PMCID: PMC2633422.

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Demehri S, Liu Z, Lee J, Lin MH, Crosby SD, Roberts CJ, Grigsby PW, Miner JH, Farr AG, Kopan R. Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS Biol. 2008 May 27;6(5):e123. doi: 10.1371/journal.pbio.0060123. PubMed PMID: 18507503; PubMed Central PMCID: PMC2430908.

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Lee J, Basak JM, Demehri S, Kopan R. Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes. Development. 2007 Aug;134(15):2795-806. doi: 10.1242/dev.02868. Epub 2007 Jul 4. PubMed PMID: 17611229; PubMed Central PMCID: PMC2583345.

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La Rosée P, Jia T, Demehri S, Härtel N, de Vries P, Bonham L, Hollenback D, Singer JW, Melo JV, Druker BJ, Deininger MW. Antileukemic activity of lysophosphatidic acid acyltransferase-beta inhibitor CT32228 in chronic myelogenous leukemia sensitive and resistant to imatinib. Clin Cancer Res. 2006 Nov 1;12(21):6540-6. doi: 10.1158/1078-0432.CCR-06-0140. PubMed PMID: 17085669.

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Demehri S, Corbin A, Loriaux M, Druker BJ, Deininger MW. Establishment of a murine model of aggressive systemic mastocytosis/mast cell leukemia. Exp Hematol. 2006 Mar;34(3):284-8. doi: 10.1016/j.exphem.2005.11.015. PubMed PMID: 16543062.

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Willis SG, Lange T, Demehri S, Otto S, Crossman L, Niederwieser D, Stoffregen EP, McWeeney S, Kovacs I, Park B, Druker BJ, Deininger MW. High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: correlation with clonal cytogenetic evolution but not response to therapy. Blood. 2005 Sep 15;106(6):2128-37. doi: 10.1182/blood-2005-03-1036. Epub 2005 May 24. PubMed PMID: 15914554.

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Corbin AS, Demehri S, Griswold IJ, Wang Y, Metcalf CA 3rd, Sundaramoorthi R, Shakespeare WC, Snodgrass J, Wardwell S, Dalgarno D, Iuliucci J, Sawyer TK, Heinrich MC, Druker BJ, Deininger MW. In vitro and in vivo activity of ATP-based kinase inhibitors AP23464 and AP23848 against activation-loop mutants of Kit. Blood. 2005 Jul 1;106(1):227-34. doi: 10.1182/blood-2004-12-4771. Epub 2005 Mar 3. PubMed PMID: 15746079.

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Demehri S, Paschka P, Schultheis B, Lange T, Koizumi T, Sugimoto T, Branford S, Lim LC, Kegel T, Martinelli G, Hochhaus A, Druker BJ, Deininger MW. e8a2 BCR-ABL: more frequent than other atypical BCR-ABL variants?. Leukemia. 2005 Apr;19(4):681-4. doi: 10.1038/sj.leu.2403604. Review. PubMed PMID: 15703785.

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Griswold IJ, Shen LJ, La Rosée P, Demehri S, Heinrich MC, Braziel RM, McGreevey L, Haley AD, Giese N, Druker BJ, Deininger MW. Effects of MLN518, a dual FLT3 and KIT inhibitor, on normal and malignant hematopoiesis. Blood. 2004 Nov 1;104(9):2912-8. doi: 10.1182/blood-2003-05-1669. Epub 2004 Jul 8. PubMed PMID: 15242881.