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Johnson LH, Son HG, Ha DT, Strickley JD, Joh J, Demehri S. Compromised T Cell Immunity Links Increased Cutaneous Papillomavirus Activity to Squamous Cell Carcinoma Risk. JID Innov. 2023 Mar;3(2):100163. doi: 10.1016/j.xjidi.2022.100163. eCollection 2023 Mar. PubMed PMID: 36714811; PubMed Central PMCID: PMC9879970.
Zhang S, Tang K, Wan G, Nguyen N, Lu C, Ugwu-Dike P, Raval N, Seo J, Alexander NA, Jairath R, Phillipps J, Leung BW, Roster K, Chen W, Zubiri L, Boland G, Chen ST, Tsao H, Demehri S, LeBoeuf NR, Reynolds KL, Yu KH, Gusev A, Kwatra SG, Semenov YR. Cutaneous immune-related adverse events are associated with longer overall survival in advanced cancer patients on immune checkpoint inhibitors: a multi-institutional cohort study. J Am Acad Dermatol. 2023 Jan 31;. doi: 10.1016/j.jaad.2022.12.048. [Epub ahead of print] PubMed PMID: 36736626.
Tian J, Chen JH, Chao SX, Pelka K, Giannakis M, Hess J, Burke K, Jorgji V, Sindurakar P, Braverman J, Mehta A, Oka T, Huang M, Lieb D, Spurrell M, Allen JN, Abrams TA, Clark JW, Enzinger AC, Enzinger PC, Klempner SJ, McCleary NJ, Meyerhardt JA, Ryan DP, Yurgelun MB, Kanter K, Van Seventer EE, Baiev I, Chi G, Jarnagin J, Bradford WB, Wong E, Michel AG, Fetter IJ, Siravegna G, Gemma AJ, Sharpe A, Demehri S, Leary R, Campbell CD, Yilmaz O, Getz GA, Parikh AR, Hacohen N, Corcoran RB. Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial. Nat Med. 2023 Jan 26;. doi: 10.1038/s41591-022-02181-8. [Epub ahead of print] PubMed PMID: 36702949.
Park JH, Mortaja M, Azin M, Nazarian RM, Demehri S. Nuclear IL-33 in fibroblasts promotes skin fibrosis. J Invest Dermatol. 2023 Jan 25;. doi: 10.1016/j.jid.2022.12.019. [Epub ahead of print] PubMed PMID: 36708946; NIHMSID:NIHMS1870127.
Zhang S, Tang K, Wan G, Nguyen N, Lu C, Ugwu-Dike P, Raval N, Seo J, Alexander NA, Jairath R, Phillipps J, Leung BW, Roster K, Chen W, Zubiri L, Boland G, Chen ST, Tsao H, Demehri S, LeBoeuf NR, Reynolds KL, Yu KH, Gusev A, Kwatra SG, Semenov YR. Cutaneous immune-related adverse events are associated with longer overall survival in advanced cancer patients on immune checkpoint inhibitors: a multi-institutional cohort study. medRxiv. 2023 Jan 18;. doi: 10.1101/2023.01.16.23284635. PubMed PMID: 36711758; PubMed Central PMCID: PMC9882466.
Vyas M, Requesens M, Nguyen TH, Peigney D, Azin M, Demehri S. Natural killer cells suppress cancer metastasis by eliminating circulating cancer cells. Front Immunol. 2022;13:1098445. doi: 10.3389/fimmu.2022.1098445. eCollection 2022. PubMed PMID: 36733396; PubMed Central PMCID: PMC9887278.
Demehri S, Park JH, Mortaja M, Son H, Azin M, Wang J, Collier M, Mandinova A, Semenov Y, Mino-Kenudson M. Statin prevents cancer development in chronic inflammation by blocking interleukin 33 expression. Res Sq. 2023 Jan 12;. doi: 10.21203/rs.3.rs-2318750/v1. PubMed PMID: 36711701; PubMed Central PMCID: PMC9882616.
Kim J, Savory SA, Demehri S, Gill JG. Prevention of Skin Cancers With Topical Calcipotriol and Fluorouracil in Patients With Xeroderma Pigmentosum. JAMA Dermatol. 2022 Dec 21;. doi: 10.1001/jamadermatol.2022.5261. [Epub ahead of print] PubMed PMID: 36542363.
Boieri M, Marchese E, Pham QM, Azin M, Steidl LE, Malishkevich A, Demehri S. Thymic stromal lymphopoietin-stimulated CD4+ T cells induce senescence in advanced breast cancer. Front Cell Dev Biol. 2022;10:1002692. doi: 10.3389/fcell.2022.1002692. eCollection 2022. PubMed PMID: 36467403; PubMed Central PMCID: PMC9714463.
Cheon SY, Park JH, Ameri AH, Lee RT, Nazarian RM, Demehri S. IL-33/Regulatory T-Cell Axis Suppresses Skin Fibrosis. J Invest Dermatol. 2022 Oct;142(10):2668-2676.e4. doi: 10.1016/j.jid.2022.03.009. Epub 2022 Mar 25. PubMed PMID: 35341735; PubMed Central PMCID: PMC9511765.
Vyas M, Peigney D, Demehri S. Extracellular matrix-natural killer cell interactome: an uncharted territory in health and disease. Curr Opin Immunol. 2022 Oct;78:102246. doi: 10.1016/j.coi.2022.102246. Epub 2022 Sep 26. Review. PubMed PMID: 36174410.
Johnson L, Ha DT, Hall MB, Shoemaker G, Bevins PA, Strickley J, Demehri S, Redman RA, Joh J. Trending Anti-E7 Serology Predicts Mortality and Recurrence of HPV-Associated Cancers of the Oropharynx. J Oncol. 2022;2022:3107990. doi: 10.1155/2022/3107990. eCollection 2022. PubMed PMID: 36199787; PubMed Central PMCID: PMC9529406.
Azin M, Ameri AH, Foreman RK, Neel VA, Lorenzo ME, Demehri S. Lethal Dermal Sarcoma in Immunosuppressed Patients. Oncologist. 2022 Sep 2;27(9):e759-e761. doi: 10.1093/oncolo/oyac141. PubMed PMID: 35867136; PubMed Central PMCID: PMC9438906.
Boieri M, Malishkevich A, Guennoun R, Marchese E, Kroon S, Trerice KE, Awad M, Park JH, Iyer S, Kreuzer J, Haas W, Rivera MN, Demehri S. CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation. J Exp Med. 2022 Jul 4;219(7). doi: 10.1084/jem.20201963. Epub 2022 Jun 3. PubMed PMID: 35657353; PubMed Central PMCID: PMC9170526.
Choi YS, Erlich TH, von Franque M, Rachmin I, Flesher JL, Schiferle EB, Zhang Y, Pereira da Silva M, Jiang A, Dobry AS, Su M, Germana S, Lacher S, Freund O, Feder E, Cortez JL, Ryu S, Babila Propp T, Samuels YL, Zakka LR, Azin M, Burd CE, Sharpless NE, Liu XS, Meyer C, Austen WG Jr, Bojovic B, Cetrulo CL Jr, Mihm MC, Hoon DS, Demehri S, Hawryluk EB, Fisher DE. Topical therapy for regression and melanoma prevention of congenital giant nevi. Cell. 2022 Jun 9;185(12):2071-2085.e12. doi: 10.1016/j.cell.2022.04.025. Epub 2022 May 12. PubMed PMID: 35561684; PubMed Central PMCID: PMC9237838.
Vyas M, Demehri S. The extracellular matrix and immunity: breaking the old barrier in cancer. Trends Immunol. 2022 Jun;43(6):423-425. doi: 10.1016/j.it.2022.04.004. Epub 2022 May 5. PubMed PMID: 35527181.
Azin M, Mahon AB, Isaacman S, Seaman JE, Allen IE, Szarek M, Cornelius LA, Demehri S. Topical Calcipotriol Plus 5-Fluorouracil Immunotherapy for Actinic Keratosis Treatment. JID Innov. 2022 May;2(3):100104. doi: 10.1016/j.xjidi.2022.100104. eCollection 2022 May. PubMed PMID: 35310879; PubMed Central PMCID: PMC8927816.
Guennoun R, Hojanazarova J, Trerice KE, Azin M, McGoldrick MT, Schiferle EB, Stover MP, Demehri S. Thymic Stromal Lymphopoietin Induction Suppresses Lung Cancer Development. Cancers (Basel). 2022 Apr 27;14(9). doi: 10.3390/cancers14092173. PubMed PMID: 35565302; PubMed Central PMCID: PMC9104311.
Azin M, Demehri S. STK11 Loss: A Novel Mechanism for Melanoma Metastasis with Therapeutic Implications. J Invest Dermatol. 2022 Apr;142(4):1007-1009. doi: 10.1016/j.jid.2021.10.003. Epub 2022 Feb 4. PubMed PMID: 35131083.
Hasegawa T, Oka T, Demehri S. Alarmin Cytokines as Central Regulators of Cutaneous Immunity. Front Immunol. 2022;13:876515. doi: 10.3389/fimmu.2022.876515. eCollection 2022. Review. PubMed PMID: 35432341; PubMed Central PMCID: PMC9005840.
Bunting MD, Vyas M, Requesens M, Langenbucher A, Schiferle EB, Manguso RT, Lawrence MS, Demehri S. Extracellular matrix proteins regulate NK cell function in peripheral tissues. Sci Adv. 2022 Mar 18;8(11):eabk3327. doi: 10.1126/sciadv.abk3327. Epub 2022 Mar 16. PubMed PMID: 35294229; PubMed Central PMCID: PMC8926340.
Chang MS, Azin M, Demehri S. Cutaneous Squamous Cell Carcinoma: The Frontier of Cancer Immunoprevention. Annu Rev Pathol. 2022 Jan 24;17:101-119. doi: 10.1146/annurev-pathol-042320-120056. Review. PubMed PMID: 35073167.
Alspach E, Chow RD, Demehri S, Guerriero JL, Gujar S, Hartmann FJ, Helmink BA, Hudson WH, Ho WJ, Ma L, Maier BB, Maltez VI, Miller BC, Moran AE, Parry EM, Pillai PS, Rafiq S, Reina-Campos M, Rosato PC, Rudqvist NP, Ruhland MK, Sagiv-Barfi I, Sahu AD, Samstein RM, Schürch CM, Sen DR, Thommen DS, Wolf Y, Zappasodi R. Supporting the Next Generation of Scientists to Lead Cancer Immunology Research. Cancer Immunol Res. 2021 Nov;9(11):1245-1251. doi: 10.1158/2326-6066.CIR-21-0519. Epub 2021 Sep 20. PubMed PMID: 34544686; PubMed Central PMCID: PMC9644410.
Azin M, Demehri S. Innate Lymphoid Cells: New Targets for Cutaneous Squamous Cell Carcinoma Immunotherapy. J Invest Dermatol. 2021 Oct;141(10):2320-2322. doi: 10.1016/j.jid.2021.04.003. PubMed PMID: 34560914.
Schiferle EB, Cheon SY, Ham S, Son HG, Messerschmidt JL, Lawrence DP, Cohen JV, Flaherty KT, Moon JJ, Lian CG, Sullivan RJ, Demehri S. Rejection of benign melanocytic nevi by nevus-resident CD4+ T cells. Sci Adv. 2021 Jun;7(26). doi: 10.1126/sciadv.abg4498. Print 2021 Jun. PubMed PMID: 34162549; PubMed Central PMCID: PMC8221625.
Li K, Li T, Feng Z, Huang M, Wei L, Yan Z, Long M, Hu Q, Wang J, Liu S, Sgroi DC, Demehri S. CD8+ T cell immunity blocks the metastasis of carcinogen-exposed breast cancer. Sci Adv. 2021 Jun;7(25). doi: 10.1126/sciadv.abd8936. Print 2021 Jun. PubMed PMID: 34144976; PubMed Central PMCID: PMC8213232.
Park JH, Ameri AH, Dempsey KE, Conrad DN, Kem M, Mino-Kenudson M, Demehri S. Nuclear IL-33/SMAD signaling axis promotes cancer development in chronic inflammation. EMBO J. 2021 Apr 1;40(7):e106151. doi: 10.15252/embj.2020106151. Epub 2021 Feb 22. PubMed PMID: 33616251; PubMed Central PMCID: PMC8013835.
Miller MS, Allen PJ, Brown PH, Chan AT, Clapper ML, Dashwood RH, Demehri S, Disis ML, DuBois RN, Glynn RJ, Kensler TW, Khan SA, Johnson BD, Liby KT, Lipkin SM, Mallery SR, Meuillet EJ, Roden RBS, Schoen RE, Sharp ZD, Shirwan H, Siegfried JM, Rao CV, You M, Vilar E, Szabo E, Mohammed A. Meeting Report: Translational Advances in Cancer Prevention Agent Development Meeting. J Cancer Prev. 2021 Mar 30;26(1):71-82. doi: 10.15430/JCP.2021.26.1.71. PubMed PMID: 33842408; PubMed Central PMCID: PMC8020174.
Strickley JD, Messerschmidt JL, Jenson AB, Joh J, Demehri S. Reply to: Beta human papillomaviruses and skin cancer. Nature. 2020 Dec;588(7838):E22-E23. doi: 10.1038/s41586-020-3024-z. PubMed PMID: 33328662.
Khanal S, Strickley JD, Ha T, Demehri S, Ghim SJ, Jenson AB, Redman RA, Joh JJ. Human papillomavirus-positivity is associated with EREG down-regulation and promoter hypermethylation in head and neck squamous cell carcinoma. Exp Mol Pathol. 2020 Dec;117:104549. doi: 10.1016/j.yexmp.2020.104549. Epub 2020 Sep 30. PubMed PMID: 33007298.
Weintraub GS, Su KA, Demehri S, Asgari MM. Enhancing the process for care delivery in a dermatology specialty clinic. J Am Acad Dermatol. 2020 Oct;83(4):1181-1184. doi: 10.1016/j.jaad.2020.02.017. Epub 2020 Feb 14. PubMed PMID: 32068037; PubMed Central PMCID: PMC7426239.
Messerschmidt JL, Dempsey KE, Dillon KS, Demehri S. Divergent Roles of Epithelium-Derived Alarmins in Notch Signaling-Deficient Skin. J Invest Dermatol. 2020 Oct;140(10):2089-2092. doi: 10.1016/j.jid.2020.02.020. Epub 2020 Mar 6. PubMed PMID: 32147504; PubMed Central PMCID: PMC8085680.
Herbosa CM, Hodges W, Mann C, Demehri S, Cornelius LA, Semenov YR. Risk of cancer in psoriasis: study of a nationally representative sample of the US population with comparison to a single-institution cohort. J Eur Acad Dermatol Venereol. 2020 Sep;34(9):e529-e531. doi: 10.1111/jdv.16447. Epub 2020 May 14. PubMed PMID: 32277504.
Hasegawa T, Feng Z, Yan Z, Ngo KH, Hosoi J, Demehri S. Reduction in Human Epidermal Langerhans Cells with Age Is Associated with Decline in CXCL14-Mediated Recruitment of CD14+ Monocytes. J Invest Dermatol. 2020 Jul;140(7):1327-1334. doi: 10.1016/j.jid.2019.11.017. Epub 2019 Dec 25. PubMed PMID: 31881212; PubMed Central PMCID: PMC8142052.
Annapragada A, Sikora A, Bollard C, Conejo-Garcia J, Cruz CR, Demehri S, Demetriou M, Demirdjian L, Fong L, Horowitz M, Hutson A, Kadash-Edmondson K, Kufe D, Lipkin S, Liu S, McCarthy C, Morgan M, Morris Z, Pan Y, Pasquini M, Schoenberger S, Van Allen E, Vilar E, Xing Y, Zha W, Odunsi A. Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer. J Immunother Cancer. 2020 Jun;8(1). doi: 10.1136/jitc-2020-000796. Review. PubMed PMID: 32554617; PubMed Central PMCID: PMC7304845.
Ameri AH, Foreman RK, Vedak P, Chen S, Miller DM, Demehri S. Hypertrophic Lichen Planus with Histological Features of Squamous Cell Carcinoma Associated with Immune Checkpoint Blockade Therapy. Oncologist. 2020 May;25(5):366-368. doi: 10.1634/theoncologist.2019-0796. Epub 2020 Feb 19. PubMed PMID: 32073194; PubMed Central PMCID: PMC7216465.
Nguyen ED, Xue YK, Danesh M, Ameri A, Weng CQ, Klebanov N, Foreman RK, Nazarian RM, Demehri S, Tsao H, Kroshinsky D. A Case of Nivolumab-Induced Cutaneous Toxicity with Multiple Morphologies. Dermatopathology (Basel). 2019 Oct-Dec;6(4):255-259. doi: 10.1159/000505353. eCollection 2019 Oct-Dec. PubMed PMID: 32232031; PubMed Central PMCID: PMC7098352.
Ameri AH, Mooradian MJ, Emerick KS, Park JC, Wirth LJ, Asgari MM, Tsao H, Lawrence D, Sullivan RJ, Demehri S. Immunotherapeutic strategies for cutaneous squamous cell carcinoma prevention in xeroderma pigmentosum. Br J Dermatol. 2019 Nov;181(5):1095-1097. doi: 10.1111/bjd.18144. Epub 2019 Aug 7. PubMed PMID: 31102460.
Strickley JD, Messerschmidt JL, Awad ME, Li T, Hasegawa T, Ha DT, Nabeta HW, Bevins PA, Ngo KH, Asgari MM, Nazarian RM, Neel VA, Jenson AB, Joh J, Demehri S. Immunity to commensal papillomaviruses protects against skin cancer. Nature. 2019 Nov;575(7783):519-522. doi: 10.1038/s41586-019-1719-9. Epub 2019 Oct 30. PubMed PMID: 31666702; PubMed Central PMCID: PMC6872936.
Choi BD, Yu X, Castano AP, Bouffard AA, Schmidts A, Larson RC, Bailey SR, Boroughs AC, Frigault MJ, Leick MB, Scarfò I, Cetrulo CL, Demehri S, Nahed BV, Cahill DP, Wakimoto H, Curry WT, Carter BS, Maus MV. CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity. Nat Biotechnol. 2019 Sep;37(9):1049-1058. doi: 10.1038/s41587-019-0192-1. Epub 2019 Jul 22. PubMed PMID: 31332324.
Molina GE, Khalifian S, Mull JL, Chen L, Rosman IS, Faulkner-Jones BE, Ngo KH, Demehri S, Cornelius LA, Wu PA. Topical Combination of Fluorouracil and Calcipotriene as a Palliative Therapy for Refractory Extramammary Paget Disease. JAMA Dermatol. 2019 May 1;155(5):599-603. doi: 10.1001/jamadermatol.2018.4793. PubMed PMID: 30785593; PubMed Central PMCID: PMC6506893.
Rosenberg AR, Tabacchi M, Ngo KH, Wallendorf M, Rosman IS, Cornelius LA, Demehri S. Skin cancer precursor immunotherapy for squamous cell carcinoma prevention. JCI Insight. 2019 Mar 21;4(6). doi: 10.1172/jci.insight.125476. eCollection 2019 Mar 21. PubMed PMID: 30895944; PubMed Central PMCID: PMC6483001.
Boroughs AC, Larson RC, Choi BD, Bouffard AA, Riley LS, Schiferle E, Kulkarni AS, Cetrulo CL, Ting D, Blazar BR, Demehri S, Maus MV. Chimeric antigen receptor costimulation domains modulate human regulatory T cell function. JCI Insight. 2019 Mar 14;5. doi: 10.1172/jci.insight.126194. PubMed PMID: 30869654; PubMed Central PMCID: PMC6538349.
Ameri AH, Moradi Tuchayi S, Zaalberg A, Park JH, Ngo KH, Li T, Lopez E, Colonna M, Lee RT, Mino-Kenudson M, Demehri S. IL-33/regulatory T cell axis triggers the development of a tumor-promoting immune environment in chronic inflammation. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2646-2651. doi: 10.1073/pnas.1815016116. Epub 2019 Jan 29. PubMed PMID: 30696763; PubMed Central PMCID: PMC6377481.
Zaalberg A, Moradi Tuchayi S, Ameri AH, Ngo KH, Cunningham TJ, Eliane JP, Livneh M, Horn TD, Rosman IS, Musiek A, Anadkat MJ, Demehri S. Chronic Inflammation Promotes Skin Carcinogenesis in Cancer-Prone Discoid Lupus Erythematosus. J Invest Dermatol. 2019 Jan;139(1):62-70. doi: 10.1016/j.jid.2018.06.185. Epub 2018 Jul 17. PubMed PMID: 30030152; PubMed Central PMCID: PMC6309656.
Wang W, Ollila HM, Whittemore AS, Demehri S, Ioannidis NM, Jorgenson E, Mignot E, Asgari MM. Genetic variants in the HLA class II region associated with risk of cutaneous squamous cell carcinoma. Cancer Immunol Immunother. 2018 Jul;67(7):1123-1133. doi: 10.1007/s00262-018-2168-2. Epub 2018 May 12. PubMed PMID: 29754218; PubMed Central PMCID: PMC7081741.
Blomberg M, He SY, Harwood C, Arron ST, Demehri S, Green A, Asgari MM. Research gaps in the management and prevention of cutaneous squamous cell carcinoma in organ transplant recipients. Br J Dermatol. 2017 Nov;177(5):1225-1233. doi: 10.1111/bjd.15950. Epub 2017 Oct 30. Review. PubMed PMID: 29086412; PubMed Central PMCID: PMC5711582.
Kawakubo M, Cunningham TJ, Demehri S, Manstein D. Fractional Laser Releases Tumor-Associated Antigens in Poorly Immunogenic Tumor and Induces Systemic Immunity. Sci Rep. 2017 Oct 6;7(1):12751. doi: 10.1038/s41598-017-13095-8. PubMed PMID: 28986576; PubMed Central PMCID: PMC5630620.
Kawakubo M, Demehri S, Manstein D. Fractional laser exposure induces neutrophil infiltration (N1 phenotype) into the tumor and stimulates systemic anti-tumor immune response. PLoS One. 2017;12(9):e0184852. doi: 10.1371/journal.pone.0184852. eCollection 2017. PubMed PMID: 28922374; PubMed Central PMCID: PMC5602663.
Yesantharao P, Wang W, Ioannidis NM, Demehri S, Whittemore AS, Asgari MM. Cutaneous squamous cell cancer (cSCC) risk and the human leukocyte antigen (HLA) system. Hum Immunol. 2017 Apr;78(4):327-335. doi: 10.1016/j.humimm.2017.02.002. Epub 2017 Feb 7. Review. PubMed PMID: 28185865; PubMed Central PMCID: PMC5428079.
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