Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging.
Nat Commun.
2017 Feb 8;8:14293. doi: 10.1038/ncomms14293. PubMed PMID:
28176769; PubMed Central PMCID:
PMC5309815.
Quantitating drug-target engagement in single cells in vitro and in vivo.
Nat Chem Biol.
2017 Feb;13(2):168-173. doi: 10.1038/nchembio.2248. Epub 2016 Dec 5. PubMed PMID:
27918558; PubMed Central PMCID:
PMC5630128.
Two-photon Fluorescence Anisotropy Microscopy for Imaging and Direct Measurement of Intracellular Drug Target Engagement.
IEEE J Sel Top Quantum Electron.
2016 May-Jun;22(3). doi: 10.1109/JSTQE.2015.2501384. Epub 2016 Mar 10. PubMed PMID:
27440991; PubMed Central PMCID:
PMC4946648.
Advances in measuring single-cell pharmacology in vivo.
Drug Discov Today.
2015 Sep;20(9):1087-92. doi: 10.1016/j.drudis.2015.05.011. Epub 2015 May 27. Review. PubMed PMID:
26024776; PubMed Central PMCID:
PMC4567932.
Optimized Near-IR Fluorescent Agents for in Vivo Imaging of Btk Expression.
Bioconjug Chem.
2015 Aug 19;26(8):1513-8. doi: 10.1021/acs.bioconjchem.5b00152. Epub 2015 Jun 9. PubMed PMID:
26017814; PubMed Central PMCID:
PMC4772718.
Fluorescent sensors for the basic metabolic panel enable measurement with a smart phone device over the physiological range.
Analyst.
2014 Oct 21;139(20):5230-8. doi: 10.1039/c4an00999a. Epub 2014 Aug 15. PubMed PMID:
25126649.
Steady state anisotropy two-photon microscopy resolves multiple, spectrally similar fluorophores, enabling in vivo multilabel imaging.
Opt Lett.
2014 Aug 1;39(15):4482-5. doi: 10.1364/OL.39.004482. PubMed PMID:
25078208; PubMed Central PMCID:
PMC4341989.
In vivo imaging of specific drug-target binding at subcellular resolution.
Nat Commun.
2014 May 28;5:3946. doi: 10.1038/ncomms4946. PubMed PMID:
24867710; PubMed Central PMCID:
PMC4362617.
Polymer-free optode nanosensors for dynamic, reversible, and ratiometric sodium imaging in the physiological range.
Sci Rep.
2013 Nov 28;3:3366. doi: 10.1038/srep03366. PubMed PMID:
24284431; PubMed Central PMCID:
PMC3842545.
Diet and kidney disease in high-risk individuals with type 2 diabetes mellitus.
JAMA Intern Med.
2013 Oct 14;173(18):1682-92. doi: 10.1001/jamainternmed.2013.9051. PubMed PMID:
23939297.
Fluorescent nanoparticles for the measurement of ion concentration in biological systems.
J Vis Exp.
2011 Jul 4;(53). doi: 10.3791/2896. PubMed PMID:
21750495; PubMed Central PMCID:
PMC3196184.
Microworm optode sensors limit particle diffusion to enable in vivo measurements.
Proc Natl Acad Sci U S A.
2011 Feb 15;108(7):2656-61. doi: 10.1073/pnas.1015544108. Epub 2011 Jan 31. PubMed PMID:
21282619; PubMed Central PMCID:
PMC3041079.
In vivo sodium concentration continuously monitored with fluorescent sensors.
Integr Biol (Camb).
2011 Feb;3(2):142-8. doi: 10.1039/c0ib00020e. Epub 2010 Nov 19. PubMed PMID:
21088796.
The design and development of fluorescent nano-optodes for in vivo glucose monitoring.
J Diabetes Sci Technol.
2011 Jan 1;5(1):68-75. doi: 10.1177/193229681100500110. PubMed PMID:
21303627; PubMed Central PMCID:
PMC3045232.
Monochloramine-induced toxicity and dysregulation of intracellular Zn2+ in parietal cells of rabbit gastric glands.
Am J Physiol Gastrointest Liver Physiol.
2010 Jul;299(1):G170-8. doi: 10.1152/ajpgi.00355.2009. Epub 2010 Apr 29. PubMed PMID:
20430873; PubMed Central PMCID:
PMC2904116.
Fluorescent nano-optodes for glucose detection.
Anal Chem.
2010 May 1;82(9):3707-13. doi: 10.1021/ac100042e. PubMed PMID:
20355725; PubMed Central PMCID:
PMC2862111.
Ion-selective optodes measure extracellular potassium flux in excitable cells.
Macromol Rapid Commun.
2010 Jan 18;31(2):217-21. doi: 10.1002/marc.200900297. Epub 2009 Aug 13. PubMed PMID:
21590894; PubMed Central PMCID:
PMC3483785.
Visualizing sodium dynamics in isolated cardiomyocytes using fluorescent nanosensors.
Proc Natl Acad Sci U S A.
2009 Sep 22;106(38):16145-50. doi: 10.1073/pnas.0905909106. Epub 2009 Sep 3. PubMed PMID:
19805271; PubMed Central PMCID:
PMC2752587.
Protection of sensors for biological applications by photoinitiated chemical vapor deposition of hydrogel thin films.
Biomacromolecules.
2008 Oct;9(10):2857-62. doi: 10.1021/bm800632d. Epub 2008 Sep 11. PubMed PMID:
18783272.
Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: a randomised controlled trial.
Lancet.
2008 Sep 27;372(9644):1174-83. doi: 10.1016/S0140-6736(08)61242-8. Epub 2008 Aug 29. PubMed PMID:
18757085.
Telmisartan, ramipril, or both in patients at high risk for vascular events.
N Engl J Med.
2008 Apr 10;358(15):1547-59. doi: 10.1056/NEJMoa0801317. Epub 2008 Mar 31. PubMed PMID:
18378520.
Thiol-oxidant monochloramine mobilizes intracellular Ca2+ in parietal cells of rabbit gastric glands.
Am J Physiol Cell Physiol.
2007 Nov;293(5):C1687-97. doi: 10.1152/ajpcell.00189.2006. Epub 2007 Feb 7. PubMed PMID:
17287368.
Ion-selective nano-optodes incorporating quantum dots.
J Am Chem Soc.
2007 Jul 11;129(27):8418-9. doi: 10.1021/ja072522l. Epub 2007 Jun 14. PubMed PMID:
17567136.
Fluorescent ion-selective nanosensors for intracellular analysis with improved lifetime and size.
Nano Lett.
2007 Jun;7(6):1827-31. doi: 10.1021/nl0707860. Epub 2007 May 11. PubMed PMID:
17497824.
Intracellular Ca(2+) and Zn(2+) signals during monochloramine-induced oxidative stress in isolated rat colon crypts.
Am J Physiol Gastrointest Liver Physiol.
2006 Feb;290(2):G250-61. doi: 10.1152/ajpgi.00501.2004. Epub 2005 Jul 7. PubMed PMID:
16002562.
What would you like to do?