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Cuccarese MF, Dubach JM, Pfirschke C, Engblom C, Garris C, Miller MA, Pittet MJ, Weissleder R. Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging. Nat Commun. 2017 Feb 8;8:14293. doi: 10.1038/ncomms14293. PubMed PMID: 28176769; PubMed Central PMCID: PMC5309815.
Dubach JM, Kim E, Yang K, Cuccarese M, Giedt RJ, Meimetis LG, Vinegoni C, Weissleder R. Quantitating drug-target engagement in single cells in vitro and in vivo. Nat Chem Biol. 2017 Feb;13(2):168-173. doi: 10.1038/nchembio.2248. Epub 2016 Dec 5. PubMed PMID: 27918558; PubMed Central PMCID: PMC5630128.
Vinegoni C, Dubach JM, Feruglio PF, Weissleder R. Two-photon Fluorescence Anisotropy Microscopy for Imaging and Direct Measurement of Intracellular Drug Target Engagement. IEEE J Sel Top Quantum Electron. 2016 May-Jun;22(3). doi: 10.1109/JSTQE.2015.2501384. Epub 2016 Mar 10. PubMed PMID: 27440991; PubMed Central PMCID: PMC4946648.
Vinegoni C, Dubach JM, Thurber GM, Miller MA, Mazitschek R, Weissleder R. Advances in measuring single-cell pharmacology in vivo. Drug Discov Today. 2015 Sep;20(9):1087-92. doi: 10.1016/j.drudis.2015.05.011. Epub 2015 May 27. Review. PubMed PMID: 26024776; PubMed Central PMCID: PMC4567932.
Kim E, Yang KS, Kohler RH, Dubach JM, Mikula H, Weissleder R. Optimized Near-IR Fluorescent Agents for in Vivo Imaging of Btk Expression. Bioconjug Chem. 2015 Aug 19;26(8):1513-8. doi: 10.1021/acs.bioconjchem.5b00152. Epub 2015 Jun 9. PubMed PMID: 26017814; PubMed Central PMCID: PMC4772718.
Awqatty B, Samaddar S, Cash KJ, Clark HA, Dubach JM. Fluorescent sensors for the basic metabolic panel enable measurement with a smart phone device over the physiological range. Analyst. 2014 Oct 21;139(20):5230-8. doi: 10.1039/c4an00999a. Epub 2014 Aug 15. PubMed PMID: 25126649.
Dubach JM, Vinegoni C, Weissleder R. Steady state anisotropy two-photon microscopy resolves multiple, spectrally similar fluorophores, enabling in vivo multilabel imaging. Opt Lett. 2014 Aug 1;39(15):4482-5. doi: 10.1364/OL.39.004482. PubMed PMID: 25078208; PubMed Central PMCID: PMC4341989.
Dubach JM, Vinegoni C, Mazitschek R, Fumene Feruglio P, Cameron LA, Weissleder R. In vivo imaging of specific drug-target binding at subcellular resolution. Nat Commun. 2014 May 28;5:3946. doi: 10.1038/ncomms4946. PubMed PMID: 24867710; PubMed Central PMCID: PMC4362617.
Ruckh TT, Mehta AA, Dubach JM, Clark HA. Polymer-free optode nanosensors for dynamic, reversible, and ratiometric sodium imaging in the physiological range. Sci Rep. 2013 Nov 28;3:3366. doi: 10.1038/srep03366. PubMed PMID: 24284431; PubMed Central PMCID: PMC3842545.
Dunkler D, Dehghan M, Teo KK, Heinze G, Gao P, Kohl M, Clase CM, Mann JF, Yusuf S, Oberbauer R. Diet and kidney disease in high-risk individuals with type 2 diabetes mellitus. JAMA Intern Med. 2013 Oct 14;173(18):1682-92. doi: 10.1001/jamainternmed.2013.9051. PubMed PMID: 23939297.
Dubach JM, Balaconis MK, Clark HA. Fluorescent nanoparticles for the measurement of ion concentration in biological systems. J Vis Exp. 2011 Jul 4;(53). doi: 10.3791/2896. PubMed PMID: 21750495; PubMed Central PMCID: PMC3196184.
Ozaydin-Ince G, Dubach JM, Gleason KK, Clark HA. Microworm optode sensors limit particle diffusion to enable in vivo measurements. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2656-61. doi: 10.1073/pnas.1015544108. Epub 2011 Jan 31. PubMed PMID: 21282619; PubMed Central PMCID: PMC3041079.
Dubach JM, Lim E, Zhang N, Francis KP, Clark H. In vivo sodium concentration continuously monitored with fluorescent sensors. Integr Biol (Camb). 2011 Feb;3(2):142-8. doi: 10.1039/c0ib00020e. Epub 2010 Nov 19. PubMed PMID: 21088796.
Balaconis MK, Billingsley K, Dubach MJ, Cash KJ, Clark HA. The design and development of fluorescent nano-optodes for in vivo glucose monitoring. J Diabetes Sci Technol. 2011 Jan 1;5(1):68-75. doi: 10.1177/193229681100500110. PubMed PMID: 21303627; PubMed Central PMCID: PMC3045232.
Kohler JE, Dubach JM, Naik HB, Tai K, Blass AL, Soybel DI. Monochloramine-induced toxicity and dysregulation of intracellular Zn2+ in parietal cells of rabbit gastric glands. Am J Physiol Gastrointest Liver Physiol. 2010 Jul;299(1):G170-8. doi: 10.1152/ajpgi.00355.2009. Epub 2010 Apr 29. PubMed PMID: 20430873; PubMed Central PMCID: PMC2904116.
Billingsley K, Balaconis MK, Dubach JM, Zhang N, Lim E, Francis KP, Clark HA. Fluorescent nano-optodes for glucose detection. Anal Chem. 2010 May 1;82(9):3707-13. doi: 10.1021/ac100042e. PubMed PMID: 20355725; PubMed Central PMCID: PMC2862111.
Harjes DI, Dubach JM, Rosenzweig A, Das S, Clark HA. Ion-selective optodes measure extracellular potassium flux in excitable cells. Macromol Rapid Commun. 2010 Jan 18;31(2):217-21. doi: 10.1002/marc.200900297. Epub 2009 Aug 13. PubMed PMID: 21590894; PubMed Central PMCID: PMC3483785.
Dubach JM, Das S, Rosenzweig A, Clark HA. Visualizing sodium dynamics in isolated cardiomyocytes using fluorescent nanosensors. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16145-50. doi: 10.1073/pnas.0905909106. Epub 2009 Sep 3. PubMed PMID: 19805271; PubMed Central PMCID: PMC2752587.
Baxamusa SH, Montero L, Dubach JM, Clark HA, Borros S, Gleason KK. Protection of sensors for biological applications by photoinitiated chemical vapor deposition of hydrogel thin films. Biomacromolecules. 2008 Oct;9(10):2857-62. doi: 10.1021/bm800632d. Epub 2008 Sep 11. PubMed PMID: 18783272.
Yusuf S, Teo K, Anderson C, Pogue J, Dyal L, Copland I, Schumacher H, Dagenais G, Sleight P. Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: a randomised controlled trial. Lancet. 2008 Sep 27;372(9644):1174-83. doi: 10.1016/S0140-6736(08)61242-8. Epub 2008 Aug 29. PubMed PMID: 18757085.
Yusuf S, Teo KK, Pogue J, Dyal L, Copland I, Schumacher H, Dagenais G, Sleight P, Anderson C. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med. 2008 Apr 10;358(15):1547-59. doi: 10.1056/NEJMoa0801317. Epub 2008 Mar 31. PubMed PMID: 18378520.
Walsh BM, Naik HB, Dubach JM, Beshire M, Wieland AM, Soybel DI. Thiol-oxidant monochloramine mobilizes intracellular Ca2+ in parietal cells of rabbit gastric glands. Am J Physiol Cell Physiol. 2007 Nov;293(5):C1687-97. doi: 10.1152/ajpcell.00189.2006. Epub 2007 Feb 7. PubMed PMID: 17287368.
Dubach JM, Harjes DI, Clark HA. Ion-selective nano-optodes incorporating quantum dots. J Am Chem Soc. 2007 Jul 11;129(27):8418-9. doi: 10.1021/ja072522l. Epub 2007 Jun 14. PubMed PMID: 17567136.
Dubach JM, Harjes DI, Clark HA. Fluorescent ion-selective nanosensors for intracellular analysis with improved lifetime and size. Nano Lett. 2007 Jun;7(6):1827-31. doi: 10.1021/nl0707860. Epub 2007 May 11. PubMed PMID: 17497824.
Cima RR, Dubach JM, Wieland AM, Walsh BM, Soybel DI. Intracellular Ca(2+) and Zn(2+) signals during monochloramine-induced oxidative stress in isolated rat colon crypts. Am J Physiol Gastrointest Liver Physiol. 2006 Feb;290(2):G250-61. doi: 10.1152/ajpgi.00501.2004. Epub 2005 Jul 7. PubMed PMID: 16002562.
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