My Bibliography

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Alzate-Grisales JA, Mora-Rubio A, Perán-Teruel M, Beltrán AN, Torres CR, García JMO, García-García F, Tabares-Soto R, García-Gómez JM, de la Iglesia-Vayá M. Clinically significant prostate cancer detection with deep learning in a multi-center magnetic resonance imaging study. Sci Rep. 2026 Mar 26;16(1). doi: 10.1038/s41598-026-42214-7. PubMed PMID: 41888535; PubMed Central PMCID: PMC13039332.

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Llopis NÁ, Ocampo Osorio F, Álzate-Grisales JA, Mora Rubio A, García García F, Tabares-Soto R, Vaya MI. From diverse CT scans to generalization: towards robust abdominal organ segmentation. BMC Med Imaging. 2026 Mar 2;26(1). doi: 10.1186/s12880-026-02206-5. PubMed PMID: 41772476; PubMed Central PMCID: PMC13023199.

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Martín-Urdiales B, Perpiñá-Clérigues C, Mellado S, Rojas-Pirela M, Aguilar Sánchez ML, Puertas-Miranda D, García-García F, Marcos M, Pascual M. Deciphering Lipidomics Landscape of Urine Extracellular Vesicles in Alcohol Use Disorder Patients. J Proteome Res. 2025 Nov 7;24(11):5653-5663. doi: 10.1021/acs.jproteome.5c00515. Epub 2025 Oct 3. PubMed PMID: 41042609.

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Mellado S, Touahri N, Montagud-Romero S, Perpiñá-Clérigues C, García-García F, Moreno-Manzano V, Guerri C, Rodríguez-Arias M, Pascual M. Role of miRNAs from mesenchymal stem cell-derived extracellular vesicles in neuroinflammation and behavioral impairments induced by chronic alcohol consumption in female mice. Neural Regen Res. 2026 Jun 1;21(6):2370-2379. doi: 10.4103/NRR.NRR-D-24-01260. Epub 2025 Jun 19. PubMed PMID: 40537146.

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Galán A, García-García F. Revisiting gender differences in obesity and type 2 diabetes: Response letter. Metabolism. 2025 Sep;170:156307. doi: 10.1016/j.metabol.2025.156307. Epub 2025 May 29. PubMed PMID: 40449616.

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Moldovan RA, Hidalgo MR, Castañé H, Jiménez-Franco A, Joven J, Burks DJ, Galán A, García-García F. Landscape of sex differences in obesity and type 2 diabetes in subcutaneous adipose tissue: a systematic review and meta-analysis of transcriptomics studies. Metabolism. 2025 Jul;168:156241. doi: 10.1016/j.metabol.2025.156241. Epub 2025 Mar 27. PubMed PMID: 40157598.

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Perpiñá-Clérigues C, Mellado S, Galiana-Roselló C, García-García F, Pascual M. Unraveling the Impact of TLR4 and Sex on Chronic Alcohol Consumption-Induced Lipidome Dysregulation in Extracellular Vesicles. J Proteome Res. 2025 Mar 7;24(3):1197-1208. doi: 10.1021/acs.jproteome.4c00786. Epub 2025 Feb 5. PubMed PMID: 39907520.

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Grillo-Risco R, Hidalgo MR, Martínez-Rojas B, Moreno-Manzano V, García-García F. A comprehensive transcriptional reference for severity and progression in spinal cord injury reveals novel translational biomarker genes. J Transl Med. 2025 Feb 4;23(1):160. doi: 10.1186/s12967-024-06009-6. PubMed PMID: 39905473; PubMed Central PMCID: PMC11796280.

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Zheng H, Mizokami A, Romera-Giner S, Llera-Oyola J, Yamawaki Y, Sano T, Jimi E, García-García F, Kanematsu T. Sex differences in the neuroinflammatory signaling pathway: effect of miRNAs on fatty acid synthesis in microglia. Biol Sex Differ. 2025 Feb 4;16(1):9. doi: 10.1186/s13293-025-00686-8. PubMed PMID: 39905477; PubMed Central PMCID: PMC11792555.

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Domínguez-Pino M, Mellado S, Cuesta CM, Grillo-Risco R, García-García F, Pascual M. Metagenomics Reveals Sex-Based Differences in Murine Fecal Microbiota Profiles Induced by Chronic Alcohol Consumption. Int J Mol Sci. 2024 Nov 22;25(23). doi: 10.3390/ijms252312534. PubMed PMID: 39684246; PubMed Central PMCID: PMC11641112.

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Soler-Sáez I, Karz A, Hidalgo MR, Gómez-Cabañes B, López-Cerdán A, Català-Senent JF, Prutisto-Chang K, Eskow NM, Izar B, Redmer T, Kumar S, Davies MA, de la Iglesia-Vayá M, Hernando E, García-García F. Unveiling Common Transcriptomic Features between Melanoma Brain Metastases and Neurodegenerative Diseases. J Invest Dermatol. 2025 May;145(5):1135-1146. doi: 10.1016/j.jid.2024.09.005. Epub 2024 Sep 24. PubMed PMID: 39326662.

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Malmierca-Merlo P, Sánchez-Garcia R, Grillo-Risco R, Pérez-Díez I, Català-Senent JF, de la Iglesia-Vayá M, Hidalgo MR, Garcia-Garcia F. MetaFun: unveiling sex-based differences in multiple transcriptomic studies through comprehensive functional meta-analysis. Biol Sex Differ. 2024 Aug 27;15(1):66. doi: 10.1186/s13293-024-00640-0. PubMed PMID: 39192356; PubMed Central PMCID: PMC11351081.

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Andreu Z, Hidalgo MR, Masiá E, Romera-Giner S, Malmierca-Merlo P, López-Guerrero JA, García-García F, Vicent MJ. Comparative profiling of whole-cell and exosome samples reveals protein signatures that stratify breast cancer subtypes. Cell Mol Life Sci. 2024 Aug 22;81(1):363. doi: 10.1007/s00018-024-05403-z. PubMed PMID: 39172142; PubMed Central PMCID: PMC11342910.

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Carceller H, Hidalgo MR, Escartí MJ, Nacher J, de la Iglesia-Vayá M, García-García F. The impact of sex on gene expression in the brain of schizophrenic patients: a systematic review and meta-analysis of transcriptomic studies. Biol Sex Differ. 2024 Jul 27;15(1):59. doi: 10.1186/s13293-024-00635-x. PubMed PMID: 39068467; PubMed Central PMCID: PMC11282642.

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Sánchez-Monteagudo A, Ripollés E, Murillo O, Domènech S, Álvarez-Sauco M, Girona E, Sastre-Bataller I, Bono A, García-Villarreal L, Tugores A, García-García F, González-Aseguinolaza G, Berenguer M, Espinós C. Profile of plasma microRNAs as a potential biomarker of Wilson's disease. J Gastroenterol. 2024 Oct;59(10):921-931. doi: 10.1007/s00535-024-02135-6. Epub 2024 Jul 26. PubMed PMID: 39060521; PubMed Central PMCID: PMC11415402.

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López-Cerdán A, Andreu Z, Hidalgo MR, Soler-Sáez I, de la Iglesia-Vayá M, Mikozami A, Guerini FR, García-García F. An integrated approach to identifying sex-specific genes, transcription factors, and pathways relevant to Alzheimer's disease. Neurobiol Dis. 2024 Sep;199:106605. doi: 10.1016/j.nbd.2024.106605. Epub 2024 Jul 14. PubMed PMID: 39009097.

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Mellado S, Morillo-Bargues MJ, Perpiñá-Clérigues C, García-García F, Moreno-Manzano V, Guerri C, Pascual M. The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence. Neural Regen Res. 2025 Apr 1;20(4):1153-1163. doi: 10.4103/NRR.NRR-D-23-01397. Epub 2024 Jun 24. PubMed PMID: 38989953; PubMed Central PMCID: PMC11438346.

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Llera-Oyola J, Carceller H, Andreu Z, Hidalgo MR, Soler-Sáez I, Gordillo F, Gómez-Cabañes B, Roson B, de la Iglesia-Vayá M, Mancuso R, Guerini FR, Mizokami A, García-García F. The role of microRNAs in understanding sex-based differences in Alzheimer's disease. Biol Sex Differ. 2024 Jan 31;15(1):13. doi: 10.1186/s13293-024-00588-1. PubMed PMID: 38297404; PubMed Central PMCID: PMC10832236.

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Perpiñá-Clérigues C, Mellado S, Galiana-Roselló C, Fernández-Regueras M, Marcos M, García-García F, Pascual M. Novel insight into the lipid network of plasma extracellular vesicles reveal sex-based differences in the lipidomic profile of alcohol use disorder patients. Biol Sex Differ. 2024 Jan 25;15(1):10. doi: 10.1186/s13293-024-00584-5. PubMed PMID: 38273378; PubMed Central PMCID: PMC10809459.

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Fuster-Martínez I, Català-Senent JF, Hidalgo MR, Roig FJ, Esplugues JV, Apostolova N, García-García F, Blas-García A. Integrated transcriptomic landscape of the effect of anti-steatotic treatments in high-fat diet mouse models of non-alcoholic fatty liver disease. J Pathol. 2024 Mar;262(3):377-389. doi: 10.1002/path.6242. Epub 2024 Jan 5. PubMed PMID: 38180387.

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Alvarez-Mora MI, Garrabou G, Molina-Porcel L, Grillo-Risco R, Garcia-Garcia F, Barcos T, Cantó-Santos J, Rodriguez-Revenga L. Exploration of SUMO2/3 Expression Levels and Autophagy Process in Fragile X-Associated Tremor/Ataxia Syndrome: Addressing Study Limitations and Insights for Future Research. Cells. 2023 Sep 26;12(19). doi: 10.3390/cells12192364. PubMed PMID: 37830578; PubMed Central PMCID: PMC10571773.

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Marin N, Moragon A, Gil D, Garcia-Garcia F, Bisbal V. Acclimation and Blood Sampling: Effects on Stress Markers in C57Bl/6J Mice. Animals (Basel). 2023 Sep 5;13(18). doi: 10.3390/ani13182816. PubMed PMID: 37760216; PubMed Central PMCID: PMC10525122.

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Soriano B, Hafez AI, Naya-Català F, Moroni F, Moldovan RA, Toxqui-Rodríguez S, Piazzon MC, Arnau V, Llorens C, Pérez-Sánchez J. SAMBA: Structure-Learning of Aquaculture Microbiomes Using a Bayesian Approach. Genes (Basel). 2023 Aug 19;14(8). doi: 10.3390/genes14081650. PubMed PMID: 37628701; PubMed Central PMCID: PMC10454057.

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Álvarez-Torres MDM, López-Cerdán A, Andreu Z, de la Iglesia Vayá M, Fuster-Garcia E, García-García F, García-Gómez JM. Vascular differences between IDH-wildtype glioblastoma and astrocytoma IDH-mutant grade 4 at imaging and transcriptomic levels. NMR Biomed. 2023 Nov;36(11):e5004. doi: 10.1002/nbm.5004. Epub 2023 Jul 21. PubMed PMID: 37482922.

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Iborra FJ, Martí C, Calabuig-Navarro V, Papadopoulos P, Meseguer S, Iborra PM, García F, Martínez-Lorente A, Almazán F, Calabuig J. Chemotherapy induces cell plasticity; controlling plasticity increases therapeutic response. Signal Transduct Target Ther. 2023 Jul 3;8(1):256. doi: 10.1038/s41392-023-01500-w. PubMed PMID: 37394666; PubMed Central PMCID: PMC10315372.

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León M, Prieto J, Molina-Navarro MM, García-García F, Barneo-Muñoz M, Ponsoda X, Sáez R, Palau F, Dopazo J, Izpisua Belmonte JC, Torres J. Rapid degeneration of iPSC-derived motor neurons lacking Gdap1 engages a mitochondrial-sustained innate immune response. Cell Death Discov. 2023 Jul 1;9(1):217. doi: 10.1038/s41420-023-01531-w. PubMed PMID: 37393339; PubMed Central PMCID: PMC10314916.

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Pérez-Díez I, Andreu Z, Hidalgo MR, Perpiñá-Clérigues C, Fantín L, Fernandez-Serra A, de la Iglesia-Vaya M, Lopez-Guerrero JA, García-García F. A Comprehensive Transcriptional Signature in Pancreatic Ductal Adenocarcinoma Reveals New Insights into the Immune and Desmoplastic Microenvironments. Cancers (Basel). 2023 May 24;15(11). doi: 10.3390/cancers15112887. Review. PubMed PMID: 37296850; PubMed Central PMCID: PMC10252129.

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Perpiñá-Clérigues C, Mellado S, Català-Senent JF, Ibáñez F, Costa P, Marcos M, Guerri C, García-García F, Pascual M. Lipidomic landscape of circulating extracellular vesicles isolated from adolescents exposed to ethanol intoxication: a sex difference study. Biol Sex Differ. 2023 Apr 21;14(1):22. doi: 10.1186/s13293-023-00502-1. PubMed PMID: 37085905; PubMed Central PMCID: PMC10120207.

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Guaita-Cespedes M, Grillo-Risco R, Hidalgo MR, Fernández-Veledo S, Burks DJ, de la Iglesia-Vayá M, Galán A, Garcia-Garcia F. Deciphering the sex bias in housekeeping gene expression in adipose tissue: a comprehensive meta-analysis of transcriptomic studies. Biol Sex Differ. 2023 Apr 18;14(1):20. doi: 10.1186/s13293-023-00506-x. PubMed PMID: 37072826; PubMed Central PMCID: PMC10114345.

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Català-Senent JF, Andreu Z, Hidalgo MR, Soler-Sáez I, Roig FJ, Yanguas-Casás N, Neva-Alejo A, López-Cerdán A, de la Iglesia-Vayá M, Stranger BE, García-García F. A deep transcriptome meta-analysis reveals sex differences in multiple sclerosis. Neurobiol Dis. 2023 Jun 1;181:106113. doi: 10.1016/j.nbd.2023.106113. Epub 2023 Apr 5. PubMed PMID: 37023829.

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Meseguer S, Rubio MP, Lainez B, Pérez-Benavente B, Pérez-Moraga R, Romera-Giner S, García-García F, Martinez-Macias O, Cremades A, Iborra FJ, Candelas-Rivera O, Almazan F, Esplugues E. SARS-CoV-2-encoded small RNAs are able to repress the host expression of SERINC5 to facilitate viral replication. Front Microbiol. 2023;14:1066493. doi: 10.3389/fmicb.2023.1066493. eCollection 2023. PubMed PMID: 36876111; PubMed Central PMCID: PMC9978209.

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López-Cerdán A, Andreu Z, Hidalgo MR, Grillo-Risco R, Català-Senent JF, Soler-Sáez I, Neva-Alejo A, Gordillo F, de la Iglesia-Vayá M, García-García F. Unveiling sex-based differences in Parkinson's disease: a comprehensive meta-analysis of transcriptomic studies. Biol Sex Differ. 2022 Nov 22;13(1):68. doi: 10.1186/s13293-022-00477-5. PubMed PMID: 36414996; PubMed Central PMCID: PMC9682715.

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Casanova-Ferrer F, García-Cena CE, Gallego JJ, Fiorillo A, Urios A, Calvo-Córdoba A, Ballester MP, Ríos MP, Durbán L, Hidalgo MR, García F, Felipo V, Montoliu C. Minimal hepatic encephalopathy is associated to alterations in eye movements. Sci Rep. 2022 Oct 7;12(1):16837. doi: 10.1038/s41598-022-21230-3. PubMed PMID: 36207472; PubMed Central PMCID: PMC9547018.

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Martínez-Rojas B, Giraldo E, Grillo-Risco R, Hidalgo MR, López-Mocholi E, Alastrue-Agudo A, García-García F, Moreno-Manzano V. NPC transplantation rescues sci-driven cAMP/EPAC2 alterations, leading to neuroprotection and microglial modulation. Cell Mol Life Sci. 2022 Jul 29;79(8):455. doi: 10.1007/s00018-022-04494-w. PubMed PMID: 35904607; PubMed Central PMCID: PMC9338125.

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Cancino-Muñoz I, López MG, Torres-Puente M, Villamayor LM, Borrás R, Borrás-Máñez M, Bosque M, Camarena JJ, Colijn C, Colomer-Roig E, Colomina J, Escribano I, Esparcia-Rodríguez O, García-García F, Gil-Brusola A, Gimeno C, Gimeno-Gascón A, Gomila-Sard B, Gónzales-Granda D, Gonzalo-Jiménez N, Guna-Serrano MR, López-Hontangas JL, Martín-González C, Moreno-Muñoz R, Navarro D, Navarro M, Orta N, Pérez E, Prat J, Rodríguez JC, Ruiz-García MM, Vanaclocha H, Valencia Region Tuberculosis Working Group, Comas I. Population-based sequencing of Mycobacterium tuberculosis reveals how current population dynamics are shaped by past epidemics. Elife. 2022 Jul 26;11. doi: 10.7554/eLife.76605. PubMed PMID: 35880398; PubMed Central PMCID: PMC9323001.

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Provencio M, Serna-Blasco R, Nadal E, Insa A, García-Campelo MR, Casal Rubio J, Dómine M, Majem M, Rodríguez-Abreu D, Martínez-Martí A, De Castro Carpeño J, Cobo M, López Vivanco G, Del Barco E, Bernabé Caro R, Viñolas N, Barneto Aranda I, Viteri S, Pereira E, Royuela A, Calvo V, Martín-López J, García-García F, Casarrubios M, Franco F, Sánchez-Herrero E, Massuti B, Cruz-Bermúdez A, Romero A. Overall Survival and Biomarker Analysis of Neoadjuvant Nivolumab Plus Chemotherapy in Operable Stage IIIA Non-Small-Cell Lung Cancer (NADIM phase II trial). J Clin Oncol. 2022 Sep 1;40(25):2924-2933. doi: 10.1200/JCO.21.02660. Epub 2022 May 16. PubMed PMID: 35576508; PubMed Central PMCID: PMC9426809.

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Biosca EG, Català-Senent JF, Figàs-Segura À, Bertolini E, López MM, Álvarez B. Genomic Analysis of the First European Bacteriophages with Depolymerase Activity and Biocontrol Efficacy against the Phytopathogen Ralstonia solanacearum. Viruses. 2021 Dec 17;13(12). doi: 10.3390/v13122539. PubMed PMID: 34960808; PubMed Central PMCID: PMC8703784.

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Barettino C, Ballesteros-Gonzalez Á, Aylón A, Soler-Sanchis X, Ortí L, Díaz S, Reillo I, García-García F, Iborra FJ, Lai C, Dehorter N, Leinekugel X, Flames N, Del Pino I. Developmental Disruption of Erbb4 in Pet1+ Neurons Impairs Serotonergic Sub-System Connectivity and Memory Formation. Front Cell Dev Biol. 2021;9:770458. doi: 10.3389/fcell.2021.770458. eCollection 2021. PubMed PMID: 34957103; PubMed Central PMCID: PMC8703035.

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Cuesta CM, Pascual M, Pérez-Moraga R, Rodríguez-Navarro I, García-García F, Ureña-Peralta JR, Guerri C. TLR4 Deficiency Affects the Microbiome and Reduces Intestinal Dysfunctions and Inflammation in Chronic Alcohol-Fed Mice. Int J Mol Sci. 2021 Nov 27;22(23). doi: 10.3390/ijms222312830. PubMed PMID: 34884634; PubMed Central PMCID: PMC8657603.

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Romera-Giner S, Andreu Martínez Z, García-García F, Hidalgo MR. Common pathways and functional profiles reveal underlying patterns in Breast, Kidney and Lung cancers. Biol Direct. 2021 May 26;16(1):9. doi: 10.1186/s13062-021-00293-8. PubMed PMID: 34039407; PubMed Central PMCID: PMC8152308.

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Rian K, Hidalgo MR, Çubuk C, Falco MM, Loucera C, Esteban-Medina M, Alamo-Alvarez I, Peña-Chilet M, Dopazo J. Genome-scale mechanistic modeling of signaling pathways made easy: A bioconductor/cytoscape/web server framework for the analysis of omic data. Comput Struct Biotechnol J. 2021;19:2968-2978. doi: 10.1016/j.csbj.2021.05.022. eCollection 2021. PubMed PMID: 34136096; PubMed Central PMCID: PMC8170118.

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Català-Senent JF, Hidalgo MR, Berenguer M, Parthasarathy G, Malhi H, Malmierca-Merlo P, de la Iglesia-Vayá M, García-García F. Hepatic steatosis and steatohepatitis: a functional meta-analysis of sex-based differences in transcriptomic studies. Biol Sex Differ. 2021 Mar 25;12(1):29. doi: 10.1186/s13293-021-00368-1. PubMed PMID: 33766130; PubMed Central PMCID: PMC7995602.

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Rian K, Esteban-Medina M, Hidalgo MR, Çubuk C, Falco MM, Loucera C, Gunyel D, Ostaszewski M, Peña-Chilet M, Dopazo J. Mechanistic modeling of the SARS-CoV-2 disease map. BioData Min. 2021 Jan 21;14(1):5. doi: 10.1186/s13040-021-00234-1. PubMed PMID: 33478554; PubMed Central PMCID: PMC7817765.

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Peña-Chilet M, Roldán G, Perez-Florido J, Ortuño FM, Carmona R, Aquino V, Lopez-Lopez D, Loucera C, Fernandez-Rueda JL, Gallego A, García-Garcia F, González-Neira A, Pita G, Núñez-Torres R, Santoyo-López J, Ayuso C, Minguez P, Avila-Fernandez A, Corton M, Moreno-Pelayo MÁ, Morin M, Gallego-Martinez A, Lopez-Escamez JA, Borrego S, Antiñolo G, Amigo J, Salgado-Garrido J, Pasalodos-Sanchez S, Morte B, Spanish Exome Crowdsourcing Consortium, Carracedo Á, Alonso Á, Dopazo J. CSVS, a crowdsourcing database of the Spanish population genetic variability. Nucleic Acids Res. 2021 Jan 8;49(D1):D1130-D1137. doi: 10.1093/nar/gkaa794. PubMed PMID: 32990755; PubMed Central PMCID: PMC7778906.

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Pérez-Díez I, Hidalgo MR, Malmierca-Merlo P, Andreu Z, Romera-Giner S, Farràs R, de la Iglesia-Vayá M, Provencio M, Romero A, García-García F. Functional Signatures in Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis of Sex-Based Differences in Transcriptomic Studies. Cancers (Basel). 2021 Jan 5;13(1). doi: 10.3390/cancers13010143. Review. PubMed PMID: 33526761; PubMed Central PMCID: PMC7796260.

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León C, García-García F, Llames S, García-Pérez E, Carretero M, Arriba MDC, Dopazo J, Del Río M, Escámez MJ, Martínez-Santamaría L. Transcriptomic Analysis of a Diabetic Skin-Humanized Mouse Model Dissects Molecular Pathways Underlying the Delayed Wound Healing Response. Genes (Basel). 2020 Dec 31;12(1). doi: 10.3390/genes12010047. PubMed PMID: 33396192; PubMed Central PMCID: PMC7824036.

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Ontoria-Oviedo I, Palacios I, Panadero J, Sánchez B, García-García F, López-Cerdán A, Dorronsoro A, Castellano D, Rodríguez-Borlado L, Bernad A, Sepúlveda P. Plasmatic Membrane Expression of Adhesion Molecules in Human Cardiac Progenitor/Stem Cells Might Explain Their Superior Cell Engraftment after Cell Transplantation. Stem Cells Int. 2020;2020:8872009. doi: 10.1155/2020/8872009. eCollection 2020. PubMed PMID: 33101423; PubMed Central PMCID: PMC7569451.

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Casanova Ferrer F, Pascual M, Hidalgo MR, Malmierca-Merlo P, Guerri C, García-García F. Unveiling Sex-Based Differences in the Effects of Alcohol Abuse: A Comprehensive Functional Meta-Analysis of Transcriptomic Studies. Genes (Basel). 2020 Sep 21;11(9). doi: 10.3390/genes11091106. PubMed PMID: 32967293; PubMed Central PMCID: PMC7564639.

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Ureña-Peralta JR, Pérez-Moraga R, García-García F, Guerri C. Lack of TLR4 modifies the miRNAs profile and attenuates inflammatory signaling pathways. PLoS One. 2020;15(8):e0237066. doi: 10.1371/journal.pone.0237066. eCollection 2020. PubMed PMID: 32780740; PubMed Central PMCID: PMC7418977.

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Fass MI, Rivarola M, Ehrenbolger GF, Maringolo CA, Montecchia JF, Quiroz F, García-García F, Blázquez JD, Hopp HE, Heinz RA, Paniego NB, Lia VV. Exploring sunflower responses to Sclerotinia head rot at early stages of infection using RNA-seq analysis. Sci Rep. 2020 Aug 7;10(1):13347. doi: 10.1038/s41598-020-70315-4. PubMed PMID: 32770047; PubMed Central PMCID: PMC7414910.