My Bibliography

select

Yusof M, Neal R, Aykin N, Ercal N. High performance liquid chromatography analysis of D-penicillamine by derivatization with N-(1-pyrenyl)maleimide (NPM). Biomed Chromatogr. 2000 Dec;14(8):535-40. doi: 10.1002/1099-0801(200012)14:8<535::AID-BMC11>3.0.CO;2-G. PubMed PMID: 11113937.

select

Ercal N, Yang P, Aykin N. Determination of biological thiols by high-performance liquid chromatography following derivatization by ThioGlo maleimide reagents. J Chromatogr B Biomed Sci Appl. 2001 Apr 5;753(2):287-92. doi: 10.1016/s0378-4347(00)00560-0. PubMed PMID: 11334342.

select

Aykin N, Neal R, Yusof M, Ercal N. Determination of captopril in biological samples by high-performance liquid chromatography with ThioGlo 3 derivatization. Biomed Chromatogr. 2001 Nov;15(7):427-32. doi: 10.1002/bmc.95. PubMed PMID: 11746237.

select

Ercal N, Gurer-Orhan H, Aykin-Burns N. Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage. Curr Top Med Chem. 2001 Dec;1(6):529-39. doi: 10.2174/1568026013394831. Review. PubMed PMID: 11895129.

select

Ercal N, Aykin-Burns N, Gurer-Orhan H, McDonald JD. Oxidative stress in a phenylketonuria animal model. Free Radic Biol Med. 2002 May 1;32(9):906-11. doi: 10.1016/s0891-5849(02)00781-5. PubMed PMID: 11978492.

select

Aykin-Burns N, Laegeler A, Kellogg G, Ercal N. Oxidative effects of lead in young and adult Fisher 344 rats. Arch Environ Contam Toxicol. 2003 Apr;44(3):417-20. doi: 10.1007/s00244-002-2023-4. PubMed PMID: 12712304; PubMed Central PMCID: PMC2887597.

select

Ahmad IM, Aykin-Burns N, Sim JE, Walsh SA, Higashikubo R, Buettner GR, Venkataraman S, Mackey MA, Flanagan SW, Oberley LW, Spitz DR. Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells. J Biol Chem. 2005 Feb 11;280(6):4254-63. doi: 10.1074/jbc.M411662200. Epub 2004 Nov 23. PubMed PMID: 15561720.

select

Aykin-Burns N, Franklin EA, Ercal N. Effects of N-acetylcysteine on lead-exposed PC-12 cells. Arch Environ Contam Toxicol. 2005 Jul;49(1):119-23. doi: 10.1007/s00244-004-0025-0. Epub 2005 Jun 20. PubMed PMID: 15981033.

select

Neal R, Aykin-Burns N, Ercal N, Zigler JS Jr. Pb2+ exposure alters the lens alpha A-crystallin protein profile in vivo and induces cataract formation in lens organ culture. Toxicology. 2005 Aug 15;212(1):1-9. doi: 10.1016/j.tox.2005.03.015. PubMed PMID: 15905016.

select

Andringa KK, Coleman MC, Aykin-Burns N, Hitchler MJ, Walsh SA, Domann FE, Spitz DR. Inhibition of glutamate cysteine ligase activity sensitizes human breast cancer cells to the toxicity of 2-deoxy-D-glucose. Cancer Res. 2006 Feb 1;66(3):1605-10. doi: 10.1158/0008-5472.CAN-05-3462. PubMed PMID: 16452219.

select

Aykin-Burns N, Ercal N. Effects of selenocystine on lead-exposed Chinese hamster ovary (CHO) and PC-12 cells. Toxicol Appl Pharmacol. 2006 Jul 15;214(2):136-43. doi: 10.1016/j.taap.2005.12.002. Epub 2006 Jan 24. PubMed PMID: 16442139.

select

Slane BG, Aykin-Burns N, Smith BJ, Kalen AL, Goswami PC, Domann FE, Spitz DR. Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability. Cancer Res. 2006 Aug 1;66(15):7615-20. doi: 10.1158/0008-5472.CAN-06-0833. PubMed PMID: 16885361.

select

Coleman MC, Asbury CR, Daniels D, Du J, Aykin-Burns N, Smith BJ, Li L, Spitz DR, Cullen JJ. 2-deoxy-D-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer. Free Radic Biol Med. 2008 Feb 1;44(3):322-31. doi: 10.1016/j.freeradbiomed.2007.08.032. Epub 2007 Oct 16. PubMed PMID: 18215740.

select

Weydert CJ, Zhang Y, Sun W, Waugh TA, Teoh ML, Andringa KK, Aykin-Burns N, Spitz DR, Smith BJ, Oberley LW. Increased oxidative stress created by adenoviral MnSOD or CuZnSOD plus BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) inhibits breast cancer cell growth. Free Radic Biol Med. 2008 Mar 1;44(5):856-67. doi: 10.1016/j.freeradbiomed.2007.11.009. Epub 2007 Nov 28. PubMed PMID: 18155673; PubMed Central PMCID: PMC3649000.

select

Ahmad IM, Abdalla MY, Aykin-Burns N, Simons AL, Oberley LW, Domann FE, Spitz DR. 2-Deoxyglucose combined with wild-type p53 overexpression enhances cytotoxicity in human prostate cancer cells via oxidative stress. Free Radic Biol Med. 2008 Mar 1;44(5):826-34. doi: 10.1016/j.freeradbiomed.2007.11.007. Epub 2007 Nov 28. PubMed PMID: 18155176; PubMed Central PMCID: PMC2350201.

select

Erickson JR, Joiner ML, Guan X, Kutschke W, Yang J, Oddis CV, Bartlett RK, Lowe JS, O'Donnell SE, Aykin-Burns N, Zimmerman MC, Zimmerman K, Ham AJ, Weiss RM, Spitz DR, Shea MA, Colbran RJ, Mohler PJ, Anderson ME. A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell. 2008 May 2;133(3):462-74. doi: 10.1016/j.cell.2008.02.048. PubMed PMID: 18455987; PubMed Central PMCID: PMC2435269.

select

Jacobs KM, Pennington JD, Bisht KS, Aykin-Burns N, Kim HS, Mishra M, Sun L, Nguyen P, Ahn BH, Leclerc J, Deng CX, Spitz DR, Gius D. SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. Int J Biol Sci. 2008 Sep 5;4(5):291-9. doi: 10.7150/ijbs.4.291. PubMed PMID: 18781224; PubMed Central PMCID: PMC2532794.

select

Mattson DM, Ahmad IM, Dayal D, Parsons AD, Aykin-Burns N, Li L, Orcutt KP, Spitz DR, Dornfeld KJ, Simons AL. Cisplatin combined with zidovudine enhances cytotoxicity and oxidative stress in human head and neck cancer cells via a thiol-dependent mechanism. Free Radic Biol Med. 2009 Jan 15;46(2):232-7. doi: 10.1016/j.freeradbiomed.2008.10.023. Epub 2008 Oct 18. PubMed PMID: 18983911; PubMed Central PMCID: PMC2659778.

select

Aykin-Burns N, Ahmad IM, Zhu Y, Oberley LW, Spitz DR. Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation. Biochem J. 2009 Feb 15;418(1):29-37. doi: 10.1042/BJ20081258. PubMed PMID: 18937644; PubMed Central PMCID: PMC2678564.

select

Nyunoya T, Monick MM, Klingelhutz AL, Glaser H, Cagley JR, Brown CO, Matsumoto E, Aykin-Burns N, Spitz DR, Oshima J, Hunninghake GW. Cigarette smoke induces cellular senescence via Werner's syndrome protein down-regulation. Am J Respir Crit Care Med. 2009 Feb 15;179(4):279-87. doi: 10.1164/rccm.200802-320OC. Epub 2008 Nov 14. PubMed PMID: 19011155; PubMed Central PMCID: PMC2643077.

select

Fath MA, Diers AR, Aykin-Burns N, Simons AL, Hua L, Spitz DR. Mitochondrial electron transport chain blockers enhance 2-deoxy-D-glucose induced oxidative stress and cell killing in human colon carcinoma cells. Cancer Biol Ther. 2009 Jul;8(13):1228-36. doi: 10.4161/cbt.8.13.8631. Epub 2009 Jul 6. PubMed PMID: 19411865; PubMed Central PMCID: PMC2771689.

select

Dayal D, Martin SM, Owens KM, Aykin-Burns N, Zhu Y, Boominathan A, Pain D, Limoli CL, Goswami PC, Domann FE, Spitz DR. Mitochondrial complex II dysfunction can contribute significantly to genomic instability after exposure to ionizing radiation. Radiat Res. 2009 Dec;172(6):737-45. doi: 10.1667/RR1617.1. PubMed PMID: 19929420; PubMed Central PMCID: PMC2793528.

select

Zhu Y, Kalen AL, Li L, Lehmler HJ, Robertson LW, Goswami PC, Spitz DR, Aykin-Burns N. Polychlorinated-biphenyl-induced oxidative stress and cytotoxicity can be mitigated by antioxidants after exposure. Free Radic Biol Med. 2009 Dec 15;47(12):1762-71. doi: 10.1016/j.freeradbiomed.2009.09.024. Epub 2009 Sep 28. PubMed PMID: 19796678; PubMed Central PMCID: PMC2785439.

select

Kim HS, Patel K, Muldoon-Jacobs K, Bisht KS, Aykin-Burns N, Pennington JD, van der Meer R, Nguyen P, Savage J, Owens KM, Vassilopoulos A, Ozden O, Park SH, Singh KK, Abdulkadir SA, Spitz DR, Deng CX, Gius D. SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell. 2010 Jan 19;17(1):41-52. doi: 10.1016/j.ccr.2009.11.023. PubMed PMID: 20129246; PubMed Central PMCID: PMC3711519.

select

Hadzic T, Aykin-Burns N, Zhu Y, Coleman MC, Leick K, Jacobson GM, Spitz DR. Paclitaxel combined with inhibitors of glucose and hydroperoxide metabolism enhances breast cancer cell killing via H2O2-mediated oxidative stress. Free Radic Biol Med. 2010 Apr 15;48(8):1024-33. doi: 10.1016/j.freeradbiomed.2010.01.018. Epub 2010 Jan 18. PubMed PMID: 20083194; PubMed Central PMCID: PMC2843822.

select

Shutt DC, O'Dorisio MS, Aykin-Burns N, Spitz DR. 2-deoxy-D-glucose induces oxidative stress and cell killing in human neuroblastoma cells. Cancer Biol Ther. 2010 Jun 1;9(11):853-61. doi: 10.4161/cbt.9.11.11632. Epub 2010 Jun 26. PubMed PMID: 20364116; PubMed Central PMCID: PMC3215774.

select

Chaudhuri L, Sarsour EH, Kalen AL, Aykin-Burns N, Spitz DR, Goswami PC. Polychlorinated biphenyl induced ROS signaling delays the entry of quiescent human breast epithelial cells into the proliferative cycle. Free Radic Biol Med. 2010 Jul 1;49(1):40-9. doi: 10.1016/j.freeradbiomed.2010.03.012. Epub 2010 Mar 20. PubMed PMID: 20307652; PubMed Central PMCID: PMC2875331.

select

Ross C, Alston M, Bickenbach JR, Aykin-Burns N. Oxygen tension changes the rate of migration of human skin keratinocytes in an age-related manner. Exp Dermatol. 2011 Jan;20(1):58-63. doi: 10.1111/j.1600-0625.2010.01190.x. PubMed PMID: 21158939; PubMed Central PMCID: PMC3188434.

select

Aykin-Burns N, Slane BG, Liu AT, Owens KM, O'Malley MS, Smith BJ, Domann FE, Spitz DR. Sensitivity to low-dose/low-LET ionizing radiation in mammalian cells harboring mutations in succinate dehydrogenase subunit C is governed by mitochondria-derived reactive oxygen species. Radiat Res. 2011 Feb;175(2):150-8. doi: 10.1667/rr2220.1. Epub 2010 Nov 17. PubMed PMID: 21268708; PubMed Central PMCID: PMC3080019.

select

Westin ER, Aykin-Burns N, Buckingham EM, Spitz DR, Goldman FD, Klingelhutz AJ. The p53/p21(WAF/CIP) pathway mediates oxidative stress and senescence in dyskeratosis congenita cells with telomerase insufficiency. Antioxid Redox Signal. 2011 Mar 15;14(6):985-97. doi: 10.1089/ars.2010.3444. Epub 2011 Jan 17. PubMed PMID: 21087144; PubMed Central PMCID: PMC3043957.

select

Schickling BM, Aykin-Burns N, Leslie KK, Spitz DR, Korovkina VP. An inhibitor of K+ channels modulates human endometrial tumor-initiating cells. Cancer Cell Int. 2011 Aug 2;11(1):25. doi: 10.1186/1475-2867-11-25. PubMed PMID: 21810252; PubMed Central PMCID: PMC3175438.

select

Park SH, Ozden O, Jiang H, Cha YI, Pennington JD, Aykin-Burns N, Spitz DR, Gius D, Kim HS. Sirt3, mitochondrial ROS, ageing, and carcinogenesis. Int J Mol Sci. 2011;12(9):6226-39. doi: 10.3390/ijms12096226. Epub 2011 Sep 23. Review. PubMed PMID: 22016654; PubMed Central PMCID: PMC3189778.

select

Owens KM, Aykin-Burns N, Dayal D, Coleman MC, Domann FE, Spitz DR. Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(-•) and H2O2. Free Radic Biol Med. 2012 Jan 1;52(1):160-6. doi: 10.1016/j.freeradbiomed.2011.10.435. Epub 2011 Oct 19. PubMed PMID: 22041456; PubMed Central PMCID: PMC3249516.

select

Jacobus JA, Duda CG, Coleman MC, Martin SM, Mapuskar K, Mao G, Smith BJ, Aykin-Burns N, Guida P, Gius D, Domann FE, Knudson CM, Spitz DR. Low-dose radiation-induced enhancement of thymic lymphomagenesis in Lck-Bax mice is dependent on LET and gender. Radiat Res. 2013 Aug;180(2):156-65. doi: 10.1667/RR3293.1. Epub 2013 Jul 2. PubMed PMID: 23819597; PubMed Central PMCID: PMC3821998.

select

Zhu Y, Mapuskar KA, Marek RF, Xu W, Lehmler HJ, Robertson LW, Hornbuckle KC, Spitz DR, Aykin-Burns N. A new player in environmentally induced oxidative stress: polychlorinated biphenyl congener, 3,3'-dichlorobiphenyl (PCB11). Toxicol Sci. 2013 Nov;136(1):39-50. doi: 10.1093/toxsci/kft186. Epub 2013 Aug 31. PubMed PMID: 23997111; PubMed Central PMCID: PMC3829572.

select

Xiao W, Zhu Y, Sarsour EH, Kalen AL, Aykin-Burns N, Spitz DR, Goswami PC. Selenoprotein P regulates 1-(4-Chlorophenyl)-benzo-2,5-quinone-induced oxidative stress and toxicity in human keratinocytes. Free Radic Biol Med. 2013 Dec;65:70-77. doi: 10.1016/j.freeradbiomed.2013.06.010. Epub 2013 Jun 11. PubMed PMID: 23770201; PubMed Central PMCID: PMC3830697.

select

Marine A, Krager KJ, Aykin-Burns N, Macmillan-Crow LA. Peroxynitrite induced mitochondrial biogenesis following MnSOD knockdown in normal rat kidney (NRK) cells. Redox Biol. 2014;2:348-57. doi: 10.1016/j.redox.2014.01.014. eCollection 2014. PubMed PMID: 24563852; PubMed Central PMCID: PMC3926114.

select

Sridharan V, Aykin-Burns N, Tripathi P, Krager KJ, Sharma SK, Moros EG, Corry PM, Nowak G, Hauer-Jensen M, Boerma M. Radiation-induced alterations in mitochondria of the rat heart. Radiat Res. 2014 Mar;181(3):324-34. doi: 10.1667/RR13452.1. Epub 2014 Feb 25. PubMed PMID: 24568130; PubMed Central PMCID: PMC4029615.

select

Pathak R, Pawar SA, Fu Q, Gupta PK, Berbée M, Garg S, Sridharan V, Wang W, Biju PG, Krager KJ, Boerma M, Ghosh SP, Cheema AK, Hendrickson HP, Aykin-Burns N, Hauer-Jensen M. Characterization of transgenic Gfrp knock-in mice: implications for tetrahydrobiopterin in modulation of normal tissue radiation responses. Antioxid Redox Signal. 2014 Mar 20;20(9):1436-46. doi: 10.1089/ars.2012.5025. Epub 2013 May 3. PubMed PMID: 23521531; PubMed Central PMCID: PMC3936502.

select

Miousse IR, Chalbot MC, Aykin-Burns N, Wang X, Basnakian A, Kavouras IG, Koturbash I. Epigenetic alterations induced by ambient particulate matter in mouse macrophages. Environ Mol Mutagen. 2014 Jun;55(5):428-35. doi: 10.1002/em.21855. Epub 2014 Feb 17. PubMed PMID: 24535919; PubMed Central PMCID: PMC4162398.

select

Cheema AK, Pathak R, Zandkarimi F, Kaur P, Alkhalil L, Singh R, Zhong X, Ghosh S, Aykin-Burns N, Hauer-Jensen M. Liver metabolomics reveals increased oxidative stress and fibrogenic potential in gfrp transgenic mice in response to ionizing radiation. J Proteome Res. 2014 Jun 6;13(6):3065-74. doi: 10.1021/pr500278t. Epub 2014 May 22. PubMed PMID: 24824572; PubMed Central PMCID: PMC4053308.

select

Pathak R, Cheema AK, Boca SM, Krager KJ, Hauer-Jensen M, Aykin-Burns N. Modulation of Radiation Response by the Tetrahydrobiopterin Pathway. Antioxidants (Basel). 2015 Jan 22;4(1):68-81. doi: 10.3390/antiox4010068. Review. PubMed PMID: 26785338; PubMed Central PMCID: PMC4665563.

select

Schickling BM, England SK, Aykin-Burns N, Norian LA, Leslie KK, Frieden-Korovkina VP. BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway. Oncol Rep. 2015 Feb;33(2):533-8. doi: 10.3892/or.2014.3617. Epub 2014 Nov 24. PubMed PMID: 25422049; PubMed Central PMCID: PMC4306270.

select

Sridharan V, Tripathi P, Aykin-Burns N, Krager KJ, Sharma SK, Moros EG, Melnyk SB, Pavliv O, Hauer-Jensen M, Boerma M. A tocotrienol-enriched formulation protects against radiation-induced changes in cardiac mitochondria without modifying late cardiac function or structure. Radiat Res. 2015 Mar;183(3):357-66. doi: 10.1667/RR13915.1. Epub 2015 Feb 24. PubMed PMID: 25710576; PubMed Central PMCID: PMC4688041.

select

Krager KJ, Pineda EN, Kharade SV, Kordsmeier M, Howard L, Breen PJ, Compadre CM, Hauer-Jensen M, Aykin-Burns N. Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity. Evid Based Complement Alternat Med. 2015;2015:148791. doi: 10.1155/2015/148791. Epub 2015 Aug 26. PubMed PMID: 26425129; PubMed Central PMCID: PMC4573888.

select

Miousse IR, Chalbot MC, Pathak R, Lu X, Nzabarushimana E, Krager K, Aykin-Burns N, Hauer-Jensen M, Demokritou P, Kavouras IG, Koturbash I. In Vitro Toxicity and Epigenotoxicity of Different Types of Ambient Particulate Matter. Toxicol Sci. 2015 Dec;148(2):473-87. doi: 10.1093/toxsci/kfv200. Epub 2015 Sep 4. PubMed PMID: 26342214; PubMed Central PMCID: PMC5009441.

select

Banerjee S, Melnyk SB, Krager KJ, Aykin-Burns N, Letzig LG, James LP, Hinson JA. The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes. Free Radic Biol Med. 2015 Dec;89:750-7. doi: 10.1016/j.freeradbiomed.2015.09.022. Epub 2015 Oct 9. PubMed PMID: 26454079; PubMed Central PMCID: PMC5012542.

select

Chang J, Wang Y, Shao L, Laberge RM, Demaria M, Campisi J, Janakiraman K, Sharpless NE, Ding S, Feng W, Luo Y, Wang X, Aykin-Burns N, Krager K, Ponnappan U, Hauer-Jensen M, Meng A, Zhou D. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nat Med. 2016 Jan;22(1):78-83. doi: 10.1038/nm.4010. Epub 2015 Dec 14. PubMed PMID: 26657143; PubMed Central PMCID: PMC4762215.

select

Pathak R, Wang J, Garg S, Aykin-Burns N, Petersen KU, Hauer-Jensen M. Recombinant Thrombomodulin (Solulin) Ameliorates Early Intestinal Radiation Toxicity in a Preclinical Rat Model. Radiat Res. 2016 Aug;186(2):112-20. doi: 10.1667/RR14408.1. Epub 2016 Jul 26. PubMed PMID: 27459702; PubMed Central PMCID: PMC4995594.

select

Banerjee S, Aykin-Burns N, Krager KJ, Shah SK, Melnyk SB, Hauer-Jensen M, Pawar SA. Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction. Free Radic Biol Med. 2016 Oct;99:296-307. doi: 10.1016/j.freeradbiomed.2016.08.022. Epub 2016 Aug 20. PubMed PMID: 27554969; PubMed Central PMCID: PMC5673253.