My Bibliography

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Charlton DC, Peterson MG, Spiller K, Lowman A, Torzilli PA, Maher SA. Semi-degradable scaffold for articular cartilage replacement. Tissue Eng Part A. 2008 Jan;14(1):207-13. doi: 10.1089/ten.a.2006.0344. PubMed PMID: 18333818; PubMed Central PMCID: PMC2705060.

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Spiller KL, Laurencin SJ, Charlton D, Maher SA, Lowman AM. Superporous hydrogels for cartilage repair: Evaluation of the morphological and mechanical properties. Acta Biomater. 2008 Jan;4(1):17-25. doi: 10.1016/j.actbio.2007.09.001. Epub 2007 Sep 22. PubMed PMID: 18029236.

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Spiller KL, Laurencin SJ, Lowman AM. Characterization of the behavior of porous hydrogels in model osmotically-conditioned articular cartilage systems. J Biomed Mater Res B Appl Biomater. 2009 Aug;90(2):752-9. doi: 10.1002/jbm.b.31344. PubMed PMID: 19274725.

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Holloway JL, Spiller KL, Lowman AM, Palmese GR. Analysis of the in vitro swelling behavior of poly(vinyl alcohol) hydrogels in osmotic pressure solution for soft tissue replacement. Acta Biomater. 2011 Jun;7(6):2477-82. doi: 10.1016/j.actbio.2011.02.016. Epub 2011 Feb 15. PubMed PMID: 21329769.

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Spiller KL, Holloway JL, Gribb ME, Lowman AM. Design of semi-degradable hydrogels based on poly(vinyl alcohol) and poly(lactic-co-glycolic acid) for cartilage tissue engineering. J Tissue Eng Regen Med. 2011 Aug;5(8):636-47. doi: 10.1002/term.356. Epub 2010 Dec 29. PubMed PMID: 21774087.

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Spiller KL, Maher SA, Lowman AM. Hydrogels for the repair of articular cartilage defects. Tissue Eng Part B Rev. 2011 Aug;17(4):281-99. doi: 10.1089/ten.TEB.2011.0077. Epub 2011 Jun 30. Review. PubMed PMID: 21510824; PubMed Central PMCID: PMC3171151.

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Spiller KL, Liu Y, Holloway JL, Maher SA, Cao Y, Liu W, Zhou G, Lowman AM. A novel method for the direct fabrication of growth factor-loaded microspheres within porous nondegradable hydrogels: controlled release for cartilage tissue engineering. J Control Release. 2012 Jan 10;157(1):39-45. doi: 10.1016/j.jconrel.2011.09.057. Epub 2011 Sep 10. PubMed PMID: 21930167.

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Gadjanski I, Spiller K, Vunjak-Novakovic G. Time-dependent processes in stem cell-based tissue engineering of articular cartilage. Stem Cell Rev Rep. 2012 Sep;8(3):863-81. doi: 10.1007/s12015-011-9328-5. PubMed PMID: 22016073; PubMed Central PMCID: PMC3412929.

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Gadjanski I, Yodmuang S, Spiller K, Bhumiratana S, Vunjak-Novakovic G. Supplementation of exogenous adenosine 5'-triphosphate enhances mechanical properties of 3D cell-agarose constructs for cartilage tissue engineering. Tissue Eng Part A. 2013 Oct;19(19-20):2188-200. doi: 10.1089/ten.TEA.2012.0352. Epub 2013 Jun 25. PubMed PMID: 23651296; PubMed Central PMCID: PMC3761430.

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Nassiri S, Graney PL, Spiller KL. Manipulation of macrophages to enhance bone repair and regeneration. In: Zreiqat H, Rosen V, editors. A Tissue Regeneration Approach to Bone Repair Switzerland: Springer; 2014.

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Spiller KL, Anfang RR, Spiller KJ, Ng J, Nakazawa KR, Daulton JW, Vunjak-Novakovic G. The role of macrophage phenotype in vascularization of tissue engineering scaffolds. Biomaterials. 2014 May;35(15):4477-88. doi: 10.1016/j.biomaterials.2014.02.012. Epub 2014 Feb 28. PubMed PMID: 24589361; PubMed Central PMCID: PMC4000280.

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Yu T, Tutwiler VJ, Spiller KL. The role of macrophages in the foreign body response to implanted biomaterials. In: Santambrogio L, editor. Biomaterials in Regenerative Medicine and the Immune System Switzerland: Springer; 2015. 424p.

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Spiller KL, Nassiri S, Witherel CE, Anfang RR, Ng J, Nakazawa KR, Yu T, Vunjak-Novakovic G. Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds. Biomaterials. 2015 Jan;37:194-207. doi: 10.1016/j.biomaterials.2014.10.017. Epub 2014 Oct 23. PubMed PMID: 25453950; PubMed Central PMCID: PMC4312192.

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Pentecost A, Lurier E, Spiller KL. Nanoparticulate systems for controlling monocyte/macrophage behavior. In: Singh A, Gaharwar A, editors. Microscale Technologies for Cell Engineering Applications New York, NY: Springer; 2015.

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Spiller KL, Freytes DO, Vunjak-Novakovic G. Macrophages modulate engineered human tissues for enhanced vascularization and healing. Ann Biomed Eng. 2015 Mar;43(3):616-27. doi: 10.1007/s10439-014-1156-8. Epub 2014 Oct 21. PubMed PMID: 25331098; PubMed Central PMCID: PMC4380684.

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Spiller KL, Vunjak-Novakovic G. Clinical translation of controlled protein delivery systems for tissue engineering. Drug Deliv Transl Res. 2015 Apr;5(2):101-15. doi: 10.1007/s13346-013-0135-1. Review. PubMed PMID: 25787736; PubMed Central PMCID: PMC4311895.

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Nassiri S, Zakeri I, Weingarten MS, Spiller KL. Relative Expression of Proinflammatory and Antiinflammatory Genes Reveals Differences between Healing and Nonhealing Human Chronic Diabetic Foot Ulcers. J Invest Dermatol. 2015 Jun;135(6):1700-1703. doi: 10.1038/jid.2015.30. Epub 2015 Feb 3. PubMed PMID: 25647438.

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Reeves AR, Spiller KL, Freytes DO, Vunjak-Novakovic G, Kaplan DL. Controlled release of cytokines using silk-biomaterials for macrophage polarization. Biomaterials. 2015 Dec;73:272-83. doi: 10.1016/j.biomaterials.2015.09.027. Epub 2015 Sep 21. PubMed PMID: 26421484; PubMed Central PMCID: PMC4605898.

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Tutwiler V, Litvinov RI, Lozhkin AP, Peshkova AD, Lebedeva T, Ataullakhanov FI, Spiller KL, Cines DB, Weisel JW. Kinetics and mechanics of clot contraction are governed by the molecular and cellular composition of the blood. Blood. 2016 Jan 7;127(1):149-59. doi: 10.1182/blood-2015-05-647560. Epub 2015 Nov 24. PubMed PMID: 26603837; PubMed Central PMCID: PMC4705605.

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Yu T, Wang W, Nassiri S, Kwan T, Dang C, Liu W, Spiller KL. Temporal and spatial distribution of macrophage phenotype markers in the foreign body response to glutaraldehyde-crosslinked gelatin hydrogels. J Biomater Sci Polym Ed. 2016;27(8):721-42. doi: 10.1080/09205063.2016.1155881. Epub 2016 Mar 11. PubMed PMID: 26902292; PubMed Central PMCID: PMC4879875.

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Witherel CE, Graney PL, Freytes DO, Weingarten MS, Spiller KL. Response of human macrophages to wound matrices in vitro. Wound Repair Regen. 2016 May;24(3):514-24. doi: 10.1111/wrr.12423. Epub 2016 Apr 6. PubMed PMID: 26874797.

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Garash R, Bajpai A, Marcinkiewicz BM, Spiller KL. Drug delivery strategies to control macrophages for tissue repair and regeneration. Exp Biol Med (Maywood). 2016 May;241(10):1054-63. doi: 10.1177/1535370216649444. Epub 2016 May 6. Review. PubMed PMID: 27190256; PubMed Central PMCID: PMC4950366.

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Graney PL, Roohani-Esfahani SI, Zreiqat H, Spiller KL. In vitro response of macrophages to ceramic scaffolds used for bone regeneration. J R Soc Interface. 2016 Jul;13(120). doi: 10.1098/rsif.2016.0346. PubMed PMID: 27466438; PubMed Central PMCID: PMC4971223.

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Ersumo N, Witherel CE, Spiller KL. Differences in time-dependent mechanical properties between extruded and molded hydrogels. Biofabrication. 2016 Aug 22;8(3):035012. doi: 10.1088/1758-5090/8/3/035012. PubMed PMID: 27550945; PubMed Central PMCID: PMC5118821.

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Hind LE, Lurier EB, Dembo M, Spiller KL, Hammer DA. Effect of M1-M2 Polarization on the Motility and Traction Stresses of Primary Human Macrophages. Cell Mol Bioeng. 2016 Sep;9(3):455-465. doi: 10.1007/s12195-016-0435-x. Epub 2016 Apr 18. PubMed PMID: 28458726; PubMed Central PMCID: PMC5404741.

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Spiller KL, Wrona EA, Romero-Torres S, Pallotta I, Graney PL, Witherel CE, Panicker LM, Feldman RA, Urbanska AM, Santambrogio L, Vunjak-Novakovic G, Freytes DO. Differential gene expression in human, murine, and cell line-derived macrophages upon polarization. Exp Cell Res. 2016 Sep 10;347(1):1-13. doi: 10.1016/j.yexcr.2015.10.017. Epub 2015 Oct 21. PubMed PMID: 26500109.

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Graney PL, Witherel CE, Spiller KL. iomaterials and bioactive factor delivery systems for the control of macrophage activation in regenerative medicine. ACS biomaterials science & engineering. 2017; 4(4):1137-1148.

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Zhu Y, Lyapichev K, Lee DH, Motti D, Ferraro NM, Zhang Y, Yahn S, Soderblom C, Zha J, Bethea JR, Spiller KL, Lemmon VP, Lee JK. Macrophage Transcriptional Profile Identifies Lipid Catabolic Pathways That Can Be Therapeutically Targeted after Spinal Cord Injury. J Neurosci. 2017 Mar 1;37(9):2362-2376. doi: 10.1523/JNEUROSCI.2751-16.2017. Epub 2017 Jan 27. PubMed PMID: 28130359; PubMed Central PMCID: PMC5354348.

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Wofford KL, Harris JP, Browne KD, Brown DP, Grovola MR, Mietus CJ, Wolf JA, Duda JE, Putt ME, Spiller KL, Cullen DK. Rapid neuroinflammatory response localized to injured neurons after diffuse traumatic brain injury in swine. Exp Neurol. 2017 Apr;290:85-94. doi: 10.1016/j.expneurol.2017.01.004. Epub 2017 Jan 9. PubMed PMID: 28081963; PubMed Central PMCID: PMC5529036.

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Ferraro NM, Dampier W, Weingarten MS, Spiller KL. Deconvolution of heterogeneous wound tissue samples into relative macrophage phenotype composition via models based on gene expression. Integr Biol (Camb). 2017 Apr 18;9(4):328-338. doi: 10.1039/c7ib00018a. PubMed PMID: 28290581; PubMed Central PMCID: PMC5719501.

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Lurier EB, Dalton D, Dampier W, Raman P, Nassiri S, Ferraro NM, Rajagopalan R, Sarmady M, Spiller KL. Transcriptome analysis of IL-10-stimulated (M2c) macrophages by next-generation sequencing. Immunobiology. 2017 Jul;222(7):847-856. doi: 10.1016/j.imbio.2017.02.006. Epub 2017 Feb 20. PubMed PMID: 28318799; PubMed Central PMCID: PMC5719494.

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Pentecost AE, Witherel CE, Gogotsi Y, Spiller KL. Anti-inflammatory effects of octadecylamine-functionalized nanodiamond on primary human macrophages. Biomater Sci. 2017 Sep 26;5(10):2131-2143. doi: 10.1039/c7bm00294g. PubMed PMID: 28875995; PubMed Central PMCID: PMC5719499.

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Witherel CE, Yu T, Concannon M, Dampier W, Spiller KL. Immunomodulatory Effects of Human Cryopreserved Viable Amniotic Membrane in a Pro-Inflammatory Environment In Vitro. Cell Mol Bioeng. 2017 Oct;10(5):451-462. doi: 10.1007/s12195-017-0494-7. Epub 2017 Aug 4. PubMed PMID: 29225709; PubMed Central PMCID: PMC5720175.

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Ng J, Spiller K, Bernhard J, Vunjak-Novakovic G. Biomimetic Approaches for Bone Tissue Engineering. Tissue Eng Part B Rev. 2017 Oct;23(5):480-493. doi: 10.1089/ten.TEB.2016.0289. Epub 2017 Jan 18. Review. PubMed PMID: 27912680; PubMed Central PMCID: PMC5653138.

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Zgheib C, Hodges MM, Allukian MW, Xu J, Spiller KL, Gorman JH 3rd, Gorman RC, Liechty KW. Cardiac Progenitor Cell Recruitment Drives Fetal Cardiac Regeneration by Enhanced Angiogenesis. Ann Thorac Surg. 2017 Dec;104(6):1968-1975. doi: 10.1016/j.athoracsur.2017.05.040. Epub 2017 Aug 16. PubMed PMID: 28821329.

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Spiller KL, Koh TJ. Macrophage-based therapeutic strategies in regenerative medicine. Adv Drug Deliv Rev. 2017 Dec 1;122:74-83. doi: 10.1016/j.addr.2017.05.010. Epub 2017 May 16. Review. PubMed PMID: 28526591; PubMed Central PMCID: PMC5690893.

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Witherel CE, Graney PL, Spiller KL. In Vitro Model of Macrophage-Biomaterial Interactions. Methods Mol Biol. 2018;1758:161-176. doi: 10.1007/978-1-4939-7741-3_13. PubMed PMID: 29679330.

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Nakazawa KR, Walter BA, Laudier DM, Krishnamoorthy D, Mosley GE, Spiller KL, Iatridis JC. Accumulation and localization of macrophage phenotypes with human intervertebral disc degeneration. Spine J. 2018 Feb;18(2):343-356. doi: 10.1016/j.spinee.2017.09.018. Epub 2017 Oct 12. PubMed PMID: 29031872; PubMed Central PMCID: PMC5815908.

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Witherel CE, Gurevich D, Collin JD, Martin P, Spiller KL. Host-Biomaterial Interactions in Zebrafish. ACS Biomater Sci Eng. 2018 Apr 9;4(4):1233-1240. doi: 10.1021/acsbiomaterials.6b00760. Epub 2017 Apr 19. PubMed PMID: 33418656.

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Karuppagounder V, Bajpai A, Meng S, Arumugam S, Sreedhar R, Giridharan VV, Guha A, Bhimaraj A, Youker KA, Palaniyandi SS, Karmouty-Quintana H, Kamal F, Spiller KL, Watanabe K, Thandavarayan RA. Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats. PLoS One. 2018;13(7):e0200697. doi: 10.1371/journal.pone.0200697. eCollection 2018. PubMed PMID: 30024944; PubMed Central PMCID: PMC6053176.

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Bajpai A, Nadkarni S, Neidrauer M, Weingarten MS, Lewin PA, Spiller KL. Effects of Non-thermal, Non-cavitational Ultrasound Exposure on Human Diabetic Ulcer Healing and Inflammatory Gene Expression in a Pilot Study. Ultrasound Med Biol. 2018 Sep;44(9):2043-2049. doi: 10.1016/j.ultrasmedbio.2018.05.011. Epub 2018 Jun 22. PubMed PMID: 29941215; PubMed Central PMCID: PMC6105501.

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Liu SL, Bajpai A, Hawthorne EA, Bae Y, Castagnino P, Monslow J, Puré E, Spiller KL, Assoian RK. Cardiovascular protection in females linked to estrogen-dependent inhibition of arterial stiffening and macrophage MMP12. JCI Insight. 2019 Jan 10;4(1). doi: 10.1172/jci.insight.122742. PubMed PMID: 30626744; PubMed Central PMCID: PMC6485356.

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Witherel CE, Abebayehu D, Barker TH, Spiller KL. Macrophage and Fibroblast Interactions in Biomaterial-Mediated Fibrosis. Adv Healthc Mater. 2019 Feb;8(4):e1801451. doi: 10.1002/adhm.201801451. Epub 2019 Jan 18. Review. PubMed PMID: 30658015; PubMed Central PMCID: PMC6415913.

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Alhamdi JR, Peng T, Al-Naggar IM, Hawley KL, Spiller KL, Kuhn LT. Controlled M1-to-M2 transition of aged macrophages by calcium phosphate coatings. Biomaterials. 2019 Mar;196:90-99. doi: 10.1016/j.biomaterials.2018.07.012. Epub 2018 Jul 17. PubMed PMID: 30075952; PubMed Central PMCID: PMC6336526.

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Paige JT, Kremer M, Landry J, Hatfield SA, Wathieu D, Brug A, Lightell DJ, Spiller KL, Woods TC. Modulation of inflammation in wounds of diabetic patients treated with porcine urinary bladder matrix. Regen Med. 2019 May;14(4):269-277. doi: 10.2217/rme-2019-0009. Epub 2019 Apr 25. PubMed PMID: 31020913; PubMed Central PMCID: PMC6886567.

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Wofford KL, Cullen DK, Spiller KL. Modulation of macrophage phenotype via phagocytosis of drug-loaded microparticles. J Biomed Mater Res A. 2019 Jun;107(6):1213-1224. doi: 10.1002/jbm.a.36617. Epub 2019 Feb 11. PubMed PMID: 30672109; PubMed Central PMCID: PMC6499658.

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Pentecost A, Kim MJ, Jeon S, Ko YJ, Kwon IC, Gogotsi Y, Kim K, Spiller KL. Immunomodulatory nanodiamond aggregate-based platform for the treatment of rheumatoid arthritis. Regen Biomater. 2019 Jun;6(3):163-174. doi: 10.1093/rb/rbz012. Epub 2019 Apr 19. PubMed PMID: 31198584; PubMed Central PMCID: PMC6547310.

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Kathawala MH, Ng WL, Liu D, Naing MW, Yeong WY, Spiller KL, Van Dyke M, Ng KW. Healing of Chronic Wounds: An Update of Recent Developments and Future Possibilities. Tissue Eng Part B Rev. 2019 Oct;25(5):429-444. doi: 10.1089/ten.TEB.2019.0019. Epub 2019 Sep 11. Review. PubMed PMID: 31068101.

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Deusenbery CB, Kalan L, Meisel JS, Gardner SE, Grice EA, Spiller KL. Human macrophage response to microbial supernatants from diabetic foot ulcers. Wound Repair Regen. 2019 Nov;27(6):598-608. doi: 10.1111/wrr.12752. Epub 2019 Aug 10. PubMed PMID: 31343792.

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Wofford KL, Singh BS, Cullen DK, Spiller KL. Biomaterial-mediated reprogramming of monocytes via microparticle phagocytosis for sustained modulation of macrophage phenotype. Acta Biomater. 2020 Jan 1;101:237-248. doi: 10.1016/j.actbio.2019.11.021. Epub 2019 Nov 13. PubMed PMID: 31731024; PubMed Central PMCID: PMC6960335.