My Bibliography

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Batatinha H, Valenzuela AM, Filioglou D, Wilde P, Leite G, Kistner TM, Baker FL, Katsanis E, Simpson RJ. Exercise-Mobilized Lymphocytes Enhance the Function of Cytokine-Induced Memory-like NK-cells Against Myeloid Leukemia. Blood Adv. 2026 Jan 15;. doi: 10.1182/bloodadvances.2025018345. [Epub ahead of print] PubMed PMID: 41538301.

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Helena Batatinha, Nicole A. Peña, Giovannah A. Hoskin, Timothy M. Kistner, Douglass M. Diak, Grace M. Niemiro, Emmanuel Katsanis, Richard J. Simpson. Exercise Delays Human Leukemia Progression and Mitigates Graft-Versus-Host Disease After Donor Lymphocyte Infusion in Xenogeneic Mice. Cancers. 2025 August. doi: 10.3390/cancers17172826.

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Helena Batatinha, Nicole A. Peña, Giovannah A. Hoskin, Timothy M. Kistner, Douglass M. Diak, Grace M. Niemiro, Emmanuel Katsanis, Richard J. Simpson. Exercise Delays Human Leukemia Progression and Mitigates Graft-Versus-Host Disease After Donor Lymphocyte Infusion in Xenogeneic Mice. Cancers. 2025 August. doi: 10.3390/cancers17172826.

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Batatinha H, Niemiro GM, Peña NA, Hoskin GA, Zúñiga TM, Smith KA, Baker FL, Diak DM, Mylabathula PL, Kistner TM, Seckeler MD, Katsanis E, Simpson RJ. Isoproterenol infusion enhances composition and function of G-CSF mobilized allogeneic peripheral blood hematopoietic cell grafts. Stem Cell Res Ther. 2025 Nov 5;16(1):614. doi: 10.1186/s13287-025-04725-4. PubMed PMID: 41194247; PubMed Central PMCID: PMC12587703.

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Batatinha H, Peña NA, Hoskin GA, Kistner TM, Diak DM, Niemiro GM, Katsanis E, Simpson RJ. Exercise Delays Human Leukemia Progression and Mitigates Graft-Versus-Host Disease After Donor Lymphocyte Infusion in Xenogeneic Mice. Cancers (Basel). 2025 Aug 29;17(17). doi: 10.3390/cancers17172826. PubMed PMID: 40940923; PubMed Central PMCID: PMC12427206.

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Filioglou D, Leite GSF, Batatinha H, Santa-Cruz N, Davini DW, Baker FL, Simpson RJ, Katsanis E. Cytokine-induced memory-like NK cells combined with Tafasitamab demonstrate efficacy against B-cell acute lymphoblastic leukemia. Immunother Adv. 2025;5(1):ltaf025. doi: 10.1093/immadv/ltaf025. eCollection 2025. PubMed PMID: 40672109; PubMed Central PMCID: PMC12264592.

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Baker FL, Stokes J, Cracchiolo MJ, Davini D, Simpson RJ, Katsanis E. Correction: Impact of post-transplant cyclophosphamide with bendamustine on immune reconstitution in young patients undergoing T-cell replete haploidentical bone marrow transplantation: results from a phase Ia/Ib clinical trial. Front Immunol. 2025;16:1633590. doi: 10.3389/fimmu.2025.1633590. eCollection 2025. PubMed PMID: 40642084; PubMed Central PMCID: PMC12242843.

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McDougal LM, Baker FL, Gustafson MP, Katsanis E, Simpson RJ. Exercise-mobilized donor lymphocyte infusions enhanced with cytokine stimulation for the prevention and treatment of leukemic relapse after allogeneic hematopoietic cell transplantation. Front Immunol. 2025;16:1563972. doi: 10.3389/fimmu.2025.1563972. eCollection 2025. Review. PubMed PMID: 40574863; PubMed Central PMCID: PMC12198174.

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Filioglou D, Santa-Cruz N, Leite GSF, Davini DW, Cracchiolo MJ, Baker FL, Husnain M, Simpson RJ, Voudouris V, Katsanis E. A Triple Oral Combination of Bendamustine, Acalabrutinib, and Venetoclax Demonstrates Efficacy Against Mantle Cell Lymphoma In Vitro and In Vivo. Cancers (Basel). 2025 Jun 5;17(11). doi: 10.3390/cancers17111889. PubMed PMID: 40507368; PubMed Central PMCID: PMC12153862.

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Smith KA, Batatinha H, Niemiro GM, Baker FL, Zúñiga TM, Diak DM, Mylabathula PL, Kistner TM, Davini D, Hoffman E, Colombo JN, Seckeler MD, Bond RA, Katsanis E, Simpson RJ. Exercise-induced β(2)-adrenergic receptor activation enhances effector lymphocyte mobilization in humans and suppresses lymphoma growth in mice through NK-cells. Brain Behav Immun. 2025 Aug;128:751-765. doi: 10.1016/j.bbi.2025.04.040. Epub 2025 Apr 29. PubMed PMID: 40311885; NIHMSID:NIHMS2150319.

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Baker FL, Stokes J, Cracchiolo MJ, Davini D, Simpson RJ, Katsanis E. Impact of post-transplant cyclophosphamide with bendamustine on immune reconstitution in young patients undergoing T-cell replete haploidentical bone marrow transplantation: results from a phase Ia/Ib clinical trial. Front Immunol. 2025;16:1568862. doi: 10.3389/fimmu.2025.1568862. eCollection 2025. PubMed PMID: 40270968; PubMed Central PMCID: PMC12014643.

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Megan J. Cracchiolo, Lisa Davis, Andrew P. Matiatos, Dan W. Davini, Muhammad Husnain, Richard J. Simpson, Vasilios Voudouris, Emmanuel Katsanis. Comparable efficacy of oral bendamustine versus intravenous administration in treating hematologic malignancies. Cancer Chemotherapy and Pharmacology. 2024 September. doi: 10.1007/s00280-024-04688-y.

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Cracchiolo MJ, Davis L, Matiatos AP, Davini DW, Husnain M, Simpson RJ, Voudouris V, Katsanis E. Comparable efficacy of oral bendamustine versus intravenous administration in treating hematologic malignancies. Cancer Chemother Pharmacol. 2024 Sep;94(3):361-372. doi: 10.1007/s00280-024-04688-y. Epub 2024 Jun 15. PubMed PMID: 38878208; PubMed Central PMCID: PMC12183798.

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Baker FL, Smith KA, Mylabathula PL, Zúñiga TM, Diak DM, Batatinha H, Niemiro GM, Seckeler MD, Pedlar CR, O'Connor DP, Colombo J, Katsanis E, Simpson RJ. Exercise-induced β2-adrenergic Receptor Activation Enhances the Antileukemic Activity of Expanded γδ T-Cells via DNAM-1 Upregulation and PVR/Nectin-2 Recognition. Cancer Res Commun. 2024 May 13;4(5):1253-1267. doi: 10.1158/2767-9764.CRC-23-0570. PubMed PMID: 38592213; PubMed Central PMCID: PMC11090081.

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Gunning JA, Gilman KE, Zúñiga TM, Simpson RJ, Limesand KH. Parotid glands have a dysregulated immune response following radiation therapy. PLoS One. 2024;19(3):e0297387. doi: 10.1371/journal.pone.0297387. eCollection 2024. PubMed PMID: 38470874; PubMed Central PMCID: PMC10931461.

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Fiuza-Luces C, Valenzuela PL, Gálvez BG, Ramírez M, López-Soto A, Simpson RJ, Lucia A. Author Correction: The effect of physical exercise on anticancer immunity. Nat Rev Immunol. 2024 Mar;24(3):229. doi: 10.1038/s41577-024-00999-6. PubMed PMID: 38302654.

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Cracchiolo MJ, Davis L, Matiatos AP, Davini DW, Husnain M, Simpson RJ, Voudouris V, Katsanis E. Comparable Efficacy of Oral Bendamustine versus Intravenous Administration in Treating Hematologic Malignancies. Res Sq. 2024 Jan 16;. doi: 10.21203/rs.3.rs-3848777/v1. PubMed PMID: 38313301; PubMed Central PMCID: PMC10836110.

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Justin C. Crane, Max J. Gordon, Karen Basen‐Engquist, Alessandra Ferrajoli, Melissa M. Markofski, Che Young Lee, Sara Fares, Richard J. Simpson, Emily C. LaVoy. Relationships between T‐lymphocytes and physical function in adults with chronic lymphocytic leukemia: Results from the HEALTH4CLL pilot study. European Journal of Haematology. 2023 June. doi: 10.1111/ejh.13958.

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Filioglou D, Husnain M, Khurana S, Simpson RJ, Katsanis E. Has the shortage of fludarabine altered the current paradigm of lymphodepletion in favor of bendamustine?. Front Immunol. 2023;14:1329850. doi: 10.3389/fimmu.2023.1329850. eCollection 2023. Review. PubMed PMID: 38077398; PubMed Central PMCID: PMC10702755.

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Fiuza-Luces C, Valenzuela PL, Gálvez BG, Ramírez M, López-Soto A, Simpson RJ, Lucia A. The effect of physical exercise on anticancer immunity. Nat Rev Immunol. 2024 Apr;24(4):282-293. doi: 10.1038/s41577-023-00943-0. Epub 2023 Oct 4. Review. PubMed PMID: 37794239.

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Smith KA, Zúñiga TM, Baker FL, Batatinha H, Pedlar CR, Burgess SC, Gustafson MP, Katsanis E, Simpson RJ. COVID-19 vaccination produces exercise-responsive SARS-CoV-2 specific T-cells regardless of infection history. J Sport Health Sci. 2024 Jan;13(1):99-107. doi: 10.1016/j.jshs.2023.06.006. Epub 2023 Jul 1. PubMed PMID: 37399887; PubMed Central PMCID: PMC10818112.

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Batatinha H, Diak DM, Niemiro GM, Baker FL, Smith KA, Zúñiga TM, Mylabathula PL, Seckeler MD, Lau B, LaVoy EC, Gustafson MP, Katsanis E, Simpson RJ. Human lymphocytes mobilized with exercise have an anti-tumor transcriptomic profile and exert enhanced graft-versus-leukemia effects in xenogeneic mice. Front Immunol. 2023;14:1067369. doi: 10.3389/fimmu.2023.1067369. eCollection 2023. PubMed PMID: 37077913; PubMed Central PMCID: PMC10109447.

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Crane JC, Gordon MJ, Basen-Engquist K, Ferrajoli A, Markofski MM, Lee CY, Fares S, Simpson RJ, LaVoy EC. Relationships between T-lymphocytes and physical function in adults with chronic lymphocytic leukemia: Results from the HEALTH4CLL pilot study. Eur J Haematol. 2023 Jun;110(6):732-742. doi: 10.1111/ejh.13958. Epub 2023 Mar 31. PubMed PMID: 36946440; PubMed Central PMCID: PMC10929688.

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Gilman KE, Matiatos AP, Cracchiolo MJ, Moon AG, Davini DW, Simpson RJ, Katsanis E. Multiagent Intratumoral Immunotherapy Can Be Effective in A20 Lymphoma Clearance and Generation of Systemic T Cell Immunity. Cancers (Basel). 2023 Mar 24;15(7). doi: 10.3390/cancers15071951. PubMed PMID: 37046612; PubMed Central PMCID: PMC10093573.

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Baker FL, Zúñiga TM, Smith KA, Batatinha H, Kulangara TS, Seckeler MD, Burgess SC, Katsanis E, Simpson RJ. Exercise mobilizes diverse antigen specific T-cells and elevates neutralizing antibodies in humans with natural immunity to SARS CoV-2. Brain Behav Immun Health. 2023 Mar;28:100600. doi: 10.1016/j.bbih.2023.100600. Epub 2023 Jan 31. PubMed PMID: 36743994; PubMed Central PMCID: PMC9886396.

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Zúñiga TM, Baker FL, Smith KA, Batatinha H, Lau B, Burgess SC, Gustafson MP, Katsanis E, Simpson RJ. Clonal Kinetics and Single-Cell Transcriptional Profiles of T Cells Mobilized to Blood by Acute Exercise. Med Sci Sports Exerc. 2023 Jun 1;55(6):991-1002. doi: 10.1249/MSS.0000000000003130. Epub 2023 Jan 26. PubMed PMID: 36719647.

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Rosa-Neto JC, Lira FS, Little JP, Landells G, Islam H, Chazaud B, Pyne DB, Teixeira AM, Batatinha H, Moura Antunes B, Guerra Minuzzi L, Palmowski J, Simpson RJ, Krüger K. Immunometabolism-fit: How exercise and training can modify T cell and macrophage metabolism in health and disease. Exerc Immunol Rev. 2022;28:29-46. PubMed PMID: 35452394.

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Gilman KE, Cracchiolo MJ, Matiatos AP, Davini DW, Simpson RJ, Katsanis E. Partially replacing cyclophosphamide with bendamustine in combination with cyclosporine A improves survival and reduces xenogeneic graft-versus-host-disease. Front Immunol. 2022;13:1045710. doi: 10.3389/fimmu.2022.1045710. eCollection 2022. PubMed PMID: 36700195; PubMed Central PMCID: PMC9868157.

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Helena Batatinha, Forrest L. Baker, Kyle A. Smith, Tiffany M. Zúñiga, Charles R. Pedlar, Shane C. Burgess, Emmanuel Katsanis, Richard J. Simpson. Recent COVID-19 vaccination has minimal effects on the physiological responses to graded exercise in physically active healthy people. Journal of Applied Physiology. 2022 February; 132(2):275--282. doi: 10.1152/japplphysiol.00629.2021.

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Emmanuel Katsanis, Baldassarre Stea, Kristen Kovacs, Laurel Truscott, Muhammad Husnain, Sharad Khurana, Denise J. Roe, Richard J. Simpson. Feasibility and efficacy of partially replacing post-transplant cyclophosphamide with bendamustine in pediatric and young adult patients undergoing haploidentical bone marrow transplantation. Transplantation and Cellular Therapy. 2022 April. doi: 10.1016/j.jtct.2022.04.015.

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Zúñiga TM, Baker FL, Smith KA, Batatinha H, Lau B, Gustafson MP, Katsanis E, Simpson RJ. Acute exercise mobilizes NKT-like cells with a cytotoxic transcriptomic profile but does not augment the potency of cytokine-induced killer (CIK) cells. Front Immunol. 2022;13:938106. doi: 10.3389/fimmu.2022.938106. eCollection 2022. PubMed PMID: 36189306; PubMed Central PMCID: PMC9519182.

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Molina MS, Hoffman EA, Stokes J, Kummet N, Simpson RJ, Katsanis E. Murine precursors to type 1 conventional dendritic cells induce tumor cytotoxicity and exhibit activated PD-1/PD-L1 pathway. PLoS One. 2022;17(8):e0273075. doi: 10.1371/journal.pone.0273075. eCollection 2022. PubMed PMID: 35980974; PubMed Central PMCID: PMC9387840.

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Mylabathula PL, Diak DM, Baker FL, Niemiro GM, Markofski MM, Crucian BE, Katsanis E, Simpson RJ. IL-2 and Zoledronic Acid Therapy Restores the In Vivo Anti-Leukemic Activity of Human Lymphocytes Pre-Exposed to Simulated Microgravity. Front Biosci (Landmark Ed). 2022 Jul 8;27(7):215. doi: 10.31083/j.fbl2707215. PubMed PMID: 35866402.

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Batatinha H, Simpson RJ. Reply to Ewell and Abbotts. J Appl Physiol (1985). 2022 Jul 1;133(1):168-169. doi: 10.1152/japplphysiol.00243.2022. PubMed PMID: 35776895; PubMed Central PMCID: PMC9255702.

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Niemiro GM, Coletta AM, Agha NH, Mylabathula PL, Baker FL, Brewster AM, Bevers TB, Fuentes-Mattei E, Basen-Engquist K, Katsanis E, Gilchrist SC, Simpson RJ. Correction: Salutary effects of moderate but not high intensity aerobic exercise training on the frequency of peripheral T-cells associated with immunosenescence in older women at high risk of breast cancer: a randomized controlled trial. Immun Ageing. 2022 Jun 8;19(1):30. doi: 10.1186/s12979-022-00276-x. PubMed PMID: 35676680; PubMed Central PMCID: PMC9175449.

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Katsanis E, Stea B, Kovacs K, Truscott L, Husnain M, Khurana S, Roe DJ, Simpson RJ. Feasibility and Efficacy of Partially Replacing Post-Transplantation Cyclophosphamide with Bendamustine in Pediatric and Young Adult Patients Undergoing Haploidentical Bone Marrow Transplantation. Transplant Cell Ther. 2022 Jul;28(7):390.e1-390.e10. doi: 10.1016/j.jtct.2022.04.015. Epub 2022 Apr 20. PubMed PMID: 35460929; PubMed Central PMCID: PMC9253073.

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Stokes J, Simpson RJ, Katsanis E. Commentary: Post-Transplantation Cyclophosphamide Uniquely Restrains Alloreactive CD4+ T-Cell Proliferation and Differentiation After Murine MHC-Haploidentical Hematopoietic Cell Transplantation. Front Immunol. 2022;13:887648. doi: 10.3389/fimmu.2022.887648. eCollection 2022. PubMed PMID: 35493453; PubMed Central PMCID: PMC9046566.

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Niemiro GM, Coletta AM, Agha NH, Mylabathula PL, Baker FL, Brewster AM, Bevers TB, Fuentes-Mattei E, Basen-Engquist K, Katsanis E, Gilchrist SC, Simpson RJ. Salutary effects of moderate but not high intensity aerobic exercise training on the frequency of peripheral T-cells associated with immunosenescence in older women at high risk of breast cancer: a randomized controlled trial. Immun Ageing. 2022 Mar 23;19(1):17. doi: 10.1186/s12979-022-00266-z. PubMed PMID: 35321743; PubMed Central PMCID: PMC8941789.

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Valenzuela PL, Saco-Ledo G, Santos-Lozano A, Morales JS, Castillo-García A, Simpson RJ, Lucia A, Fiuza-Luces C. Exercise Training and Natural Killer Cells in Cancer Survivors: Current Evidence and Research Gaps Based on a Systematic Review and Meta-analysis. Sports Med Open. 2022 Mar 4;8(1):36. doi: 10.1186/s40798-022-00419-w. PubMed PMID: 35244811; PubMed Central PMCID: PMC8897541.

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Katsanis E, Hanley PJ, Simpson RJ. Editorial: Advances in Pediatric Hematopoietic Cell Therapies and Transplantation. Front Pediatr. 2022;10:847288. doi: 10.3389/fped.2022.847288. eCollection 2022. PubMed PMID: 35155311; PubMed Central PMCID: PMC8832116.

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Forrest L. Baker, Kyle A. Smith, Tiffany M. Zúñiga, Helena Batatinha, Grace M. Niemiro, Charles R. Pedlar, Shane C. Burgess, Emmanuel Katsanis, Richard J. Simpson. Acute exercise increases immune responses to SARS CoV-2 in a previously infected man. Brain, Behavior, & Immunity - Health. 2021 December. doi: 10.1016/j.bbih.2021.100343.

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Batatinha H, Baker FL, Smith KA, Zúñiga TM, Pedlar CR, Burgess SC, Katsanis E, Simpson RJ. Recent COVID-19 vaccination has minimal effects on the physiological responses to graded exercise in physically active healthy people. J Appl Physiol (1985). 2022 Feb 1;132(2):275-282. doi: 10.1152/japplphysiol.00629.2021. Epub 2021 Dec 9. PubMed PMID: 34882029; PubMed Central PMCID: PMC8799387.

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Baker FL, Smith KA, Zúñiga TM, Batatinha H, Niemiro GM, Pedlar CR, Burgess SC, Katsanis E, Simpson RJ. Acute exercise increases immune responses to SARS CoV-2 in a previously infected man. Brain Behav Immun Health. 2021 Dec;18:100343. doi: 10.1016/j.bbih.2021.100343. Epub 2021 Sep 8. PubMed PMID: 34514439; PubMed Central PMCID: PMC8423674.

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Krieger SS, Zwart SR, Mehta S, Wu H, Simpson RJ, Smith SM, Crucian B. Alterations in Saliva and Plasma Cytokine Concentrations During Long-Duration Spaceflight. Front Immunol. 2021;12:725748. doi: 10.3389/fimmu.2021.725748. eCollection 2021. PubMed PMID: 34504500; PubMed Central PMCID: PMC8422944.

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Elzayat MT, Markofski MM, Simpson RJ, Laughlin M, LaVoy EC. No Effect of Acute Eccentric Resistance Exercise on Immune Responses to Influenza Vaccination in Older Adults: A Randomized Control Trial. Front Physiol. 2021;12:713183. doi: 10.3389/fphys.2021.713183. eCollection 2021. PubMed PMID: 34456752; PubMed Central PMCID: PMC8388854.

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Simpson RJ, Boßlau TK, Weyh C, Niemiro GM, Batatinha H, Smith KA, Krüger K. Exercise and adrenergic regulation of immunity. Brain Behav Immun. 2021 Oct;97:303-318. doi: 10.1016/j.bbi.2021.07.010. Epub 2021 Jul 21. Review. PubMed PMID: 34302965.

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Gustafson MP, Wheatley-Guy CM, Rosenthal AC, Gastineau DA, Katsanis E, Johnson BD, Simpson RJ. Exercise and the immune system: taking steps to improve responses to cancer immunotherapy. J Immunother Cancer. 2021 Jul;9(7). doi: 10.1136/jitc-2020-001872. Review. PubMed PMID: 34215686; PubMed Central PMCID: PMC8256759.

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Molina MS, Hoffman EA, Stokes J, Kummet N, Smith KA, Baker F, Zúñiga TM, Simpson RJ, Katsanis E. Regulatory Dendritic Cells Induced by Bendamustine Are Associated With Enhanced Flt3 Expression and Alloreactive T-Cell Death. Front Immunol. 2021;12:699128. doi: 10.3389/fimmu.2021.699128. eCollection 2021. PubMed PMID: 34249005; PubMed Central PMCID: PMC8264365.

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Simpson RJ, Pawelec G. Is mechanical loading essential for exercise to preserve the aging immune system?. Immun Ageing. 2021 Jun 5;18(1):26. doi: 10.1186/s12979-021-00238-9. PubMed PMID: 34090455; PubMed Central PMCID: PMC8178824.

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Stokes J, Molina MS, Hoffman EA, Simpson RJ, Katsanis E. Immunomodulatory Effects of Bendamustine in Hematopoietic Cell Transplantation. Cancers (Basel). 2021 Apr 3;13(7). doi: 10.3390/cancers13071702. Review. PubMed PMID: 33916711; PubMed Central PMCID: PMC8038415.